URL of this page: https://www.nlm.nih.gov/medlineplus/druginfo/natural/662.html


What is it?

Turmeric is a plant. You probably know turmeric as the main spice in curry. It has a warm, bitter taste and is frequently used to flavor or color curry powders, mustards, butters, and cheeses. But the root of turmeric is also used widely to make medicine.

Turmeric is used for arthritis, heartburn (dyspepsia), stomach pain, diarrhea, intestinal gas, stomach bloating, loss of appetite, jaundice, liver problems and gallbladder disorders.

It is also used for headaches, bronchitis, colds, lung infections, fibromyalgia, leprosy, fever, menstrual problems, and cancer. Other uses include depression, Alzheimer’s disease, water retention, worms, and kidney problems.

Some people apply turmeric to the skin for pain, ringworm, bruising, leech bites, eye infections, inflammatory skin conditions, soreness inside of the mouth, and infected wounds.

In food and manufacturing, the essential oil of turmeric is used in perfumes, and its resin is used as a flavor and color component in foods.

Don’t confuse turmeric with Javanese turmeric root (Curcuma zedoaria).

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for TURMERIC are as follows:

Possibly effective for...

  • Osteoarthritis. Some research shows that taking turmeric extracts, alone or in combination with other herbal ingredients, can reduce the pain caused by osteoarthritis. In one study, turmeric worked about as well as ibuprofen for reducing osteoarthritis pain.

Insufficient evidence to rate effectiveness for...

  • Alzheimer’s disease. Early research shows that taking curcumin, a chemical found in turmeric, daily for 6 months does not benefit people with Alzheimer’s disease.
  • Eye inflammation (anterior uveitis). Early research suggests that taking curcumin, a chemical found in turmeric, might improve symptoms of long-term inflammation in the middle layer of the eye.
  • Colorectal cancer. Early research suggests that taking turmeric might stabilize some measures for colon cancer. There is also early evidence that taking curcumin, a chemical found in turmeric, daily for 30 days can reduce the number of precancerous glands in the colon of people at high risk of cancer.
  • Bypass surgery (coronary artery bypass graft surgery). Early research suggests that taking curcumin, a chemical found in turmeric, 3 days before surgery and continuing for 5 days after surgery can lower the risk of a heart attack following bypass surgery.
  • A type of inflammatory bowel disease called Crohn’s disease. Some evidence suggests that taking curcumin, a chemical found in turmeric, daily for one month can reduce bowel movements, diarrhea, and stomach pain in people with Crohn’s disease.
  • Diabetes. Early research suggests that taking turmeric daily for 9 months can reduce the number of people with prediabetes who develop diabetes.
  • Stomach upset (dyspepsia). Some research shows that taking turmeric by mouth might help improve an upset stomach.
  • Gum disease (gingivitis). Early research suggests that using a turmeric mouthwash is as effective as a drug-therapy mouthwash for reducing gum disease and bacteria levels in the mouth, but not for reducing plaque.
  • Stomach ulcers caused by Helicobacter pylori (H pylori) infection. Early research suggests that taking turmeric daily for 4 weeks is less effective than conventional treatment for eliminating certain bacteria (H. pylori) that can cause stomach ulcers.
  • Irritable bowel syndrome (IBS). Early research suggests that taking a turmeric extract daily for 8 weeks reduces the occurrence of IBS in people with IBS who are otherwise healthy.
  • Skin rash (Lichen planus). Taking a certain product containing chemicals found in turmeric daily for 12 days can reduce skin irritation caused by lichen planus.
  • Kidney inflammation (Lupus nephritis). Early research suggests that taking turmeric daily for 3 months can reduce blood pressure and improve kidney function in people with kidney inflammation.
  • Stomach ulcers (peptic ulcer disease). Early research suggests that taking turmeric daily for 4 weeks does help heal stomach ulcers.
  • Itchy skin (pruritus). Early research suggests that taking a specific product (C3 Complex) that contains curcumin, a chemical found in turmeric, and an extract of black or long pepper (Bioperine) can reduce skin itching and improve quality of life in people with chronic itching.
  • Rheumatoid arthritis (RA). Early research suggests that curcumin, a chemical in turmeric, might help reduce some symptoms of rheumatoid arthritis.
  • Skin wounds due to cancer. Early research suggests that applying a turmeric ointment might help to relieve odor and itching caused by wounds associated with different types of cancer.
  • Recover from surgery. Early research suggests that taking curcumin, a chemical found in turmeric, daily for up to one week after surgery can reduce pain, fatigue, and the need for pain medications.
  • Tuberculosis. Early research suggests that taking a product containing turmeric and Tinospora cordifolia can reduce bacteria levels, improve wound healing, and reduce liver toxicity in people with tuberculosis who are also receiving antituberculosis therapy.
  • A type of inflammatory bowel disease called ulcerative colitis. Early research suggests that taking curcumin, a chemical found in turmeric, daily for up to 6 months can reduce symptoms and the recurrence of ulcerative colitis when used in combination with conventional treatments.
  • Jaundice.
  • Hepatitis.
  • Diarrhea.
  • Fibromyalgia.
  • Liver and gallbladder problems.
  • Headache.
  • Menstrual problems.
  • Pain.
  • Ringworm.
  • Bruising.
  • Other conditions.
More evidence is needed to rate turmeric for these uses.

How does it work?

The chemicals in turmeric might decrease swelling (inflammation).

Are there safety concerns?

Turmeric is LIKELY SAFE when taken by mouth or applied to the skin appropriately for up to 8 months.

Turmeric usually does not cause significant side effects; however, some people can experience stomach upset, nausea, dizziness, or diarrhea.

In one report, a person who took very high amounts of turmeric, over 1500 mg twice daily, experienced a dangerous abnormal heart rhythm. However, it is unclear if turmeric was the actual cause of this side effect. Until more is known, avoid taking excessively large doses of turmeric.

Special precautions & warnings:

Pregnancy and breast-feeding: During pregnancy and while breast-feeding, turmeric is LIKELY SAFE when taken by mouth in amounts commonly found in food. However, turmeric is LIKELY UNSAFE when taken by mouth in medicinal amounts during pregnancy. It might promote a menstrual period or stimulate the uterus, putting the pregnancy at risk. Do not take medicinal amounts of turmeric if you are pregnant. There is not enough information to rate the safety of medicinal amounts of turmeric during breast-feeding. It is best not to use it.

Gallbladder problems: Turmeric can make gallbladder problems worse. Do not use turmeric if you have gallstones or a bile duct obstruction.

Bleeding problems: Taking turmeric might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.

Diabetes: Curcumin, a chemical in turmeric, might decrease blood sugar in people with diabetes. Use with caution in people with diabetes as it might make blood sugar too low.

A stomach disorder called gastroesophageal reflux disease (GERD): Turmeric can cause stomach upset in some people. It might make stomach problems such as GERD worse. Do not take turmeric if it worsens symptoms of GERD.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Turmeric contains a chemical called curcumin, which might act like the hormone estrogen. In theory, turmeric might make hormone-sensitive conditions worse. However, some research shows that turmeric reduces the effects of estrogen in some hormone-sensitive cancer cells. Therefore, turmeric might have beneficial effects on hormone-sensitive conditions. Until more is known, use cautiously if you have a condition that might be made worse by exposure to hormones.

Infertility: Turmeric might lower testosterone levels and decrease sperm movement when taken by mouth by men. This might reduce fertility. Turmeric should be used cautiously by people trying to have a baby.

Iron deficiency: Taking high amounts of turmeric might prevent the absorption of iron. Turmeric should be used with caution in people with iron deficiency.

Surgery: Turmeric might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using turmeric at least 2 weeks before a scheduled surgery.

Are there interactions with medications?

Be cautious with this combination.
Azulfidine EN-Tabs (Sulfasalazine)
Turmeric might increase how much Azulfidine EN-Tabs (Sulfasalazine) the body absorbs. Taking turmeric while taking Azulfidine EN-Tabs (Sulfasalazine) might increase the effects and side effects of Azulfidine EN-Tabs (Sulfasalazine).
Medications for diabetes (Antidiabetes drugs)
Turmeric might decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking turmeric along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Turmeric might slow blood clotting. Taking turmeric along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Turmeric might decrease how much Talinolol the body absorbs. Taking turmeric while taking Talinolol might decrease the effects and side effects of Talinolol.
Be watchful with this combination.
Abraxane (Paclitaxel)
Turmeric might increase how much abraxane (Paclitaxel) the body absorbs. Taking turmeric while taking abraxane (Paclitaxel) might increase the effects and side effects of abraxane (Paclitaxel). However, there is not enough information to know if this is a big concern.
Large amounts of turmeric might have some of the same effects as estrogen. However, large amounts of turmeric are not as strong as estrogen pills. Taking turmeric along with estrogen pills might decrease the effects of estrogen pills.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.
br/> Some medications that are changed by the liver include chlorzoxazone, theophylline, and bufuralol.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and others.
Medications moved by pumps in cells (P-Glycoprotein Substrates)
Some medications are moved by pumps in cells. Turmeric might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Noroxin (Norfloxacin)
Turmeric might increase how much noroxin (Norfloxacin) the body absorbs. Taking turmeric while taking noroxin (Norfloxacin) might increase the effects and side effects of noroxin (Norfloxacin).
Taxotere (Docetaxel)
Turmeric might increase how much taxotere (Docetaxel) the body absorbs. Taking turmeric while taking taxotere (Docetaxel) might increase the effects and side effects of taxotere (Docetaxel).

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood sugar
Turmeric might lower blood sugar. Using it along with other herbs and supplements that have the same effect might cause blood sugar to drop too low in some people. Some of these products include devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.
Herbs and supplements that might slow blood clotting
Turmeric might slow blood clotting. Taking turmeric along with herbs that also slow clotting might increase the chances of bruising and bleeding. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, willow, and others.
Turmeric and curcumin, a chemical found in turmeric, might prevent the body from absorbing iron. This does not appear to occur when turmeric is consumed in levels commonly found in food. However, in theory, taking high doses of turmeric or curcumin might decrease the body's absorption of iron.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

BY MOUTH: For upset stomach (dyspepsia): 500 mg of turmeric four times daily.
For osteoarthritis: 500 mg twice daily of a specific turmeric extract (Meriva, Indena); 500 mg four times daily of a non-commercial product has also been used.
For rheumatoid arthritis (RA): 500mg twice daily of a specific formulation of the turmeric constituent, curcumin (BCM-95®, Arjuna Natural Extracts, India), has been used.

Other names

Curcuma, Curcuma aromatica, Curcuma domestica, Curcumae longa, Curcumae Longae Rhizoma, Curcumin, Curcumine, Curcuminoid, Curcuminoïde, Curcuminoïdes, Curcuminoids, Halada, Haldi, Haridra, Indian Saffron, Nisha, Pian Jiang Huang, Racine de Curcuma, Radix Curcumae, Rajani, Rhizoma Cucurmae Longae, Safran Bourbon, Safran de Batallita, Safran des Indes, Turmeric Root, Yu Jin.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


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  320. El-Moselhy, M. A., Taye, A., Sharkawi, S. S., El-Sisi, S. F., and Ahmed, A. F. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-alpha and free fatty acids. Food Chem Toxicol 2011;49:1129-1140. View abstract.
  321. Guimaraes, M. R., Coimbra, L. S., de Aquino, S. G., Spolidorio, L. C., Kirkwood, K. L., and Rossa, C., Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46:269-279. View abstract.
  322. Sawatpanich, T., Petpiboolthai, H., Punyarachun, B., and Anupunpisit, V. Effect of curcumin on vascular endothelial growth factor expression in diabetic mice kidney induced by streptozotocin. J Med Assoc Thai 2010;93 Suppl 2:S1-S8. View abstract.
  323. Gou, M., Men, K., Shi, H., Xiang, M., Zhang, J., Song, J., Long, J., Wan, Y., Luo, F., Zhao, X., and Qian, Z. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 2011;3:1558-1567. View abstract.
  324. Gomez-Pinilla, F. The combined effects of exercise and foods in preventing neurological and cognitive disorders. Prev Med 2011;52 Suppl 1:S75-S80. View abstract.
  325. Chanpoo, M., Petchpiboonthai, H., Panyarachun, B., and Anupunpisit, V. Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice. J Med Assoc Thai 2010;93 Suppl 6:S152-S159. View abstract.
  326. Ali, E. H. and Arafa, N. M. Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction. Fitoterapia 2011;82:601-608. View abstract.
  327. Kumar, A., Prakash, A., and Dogra, S. Protective effect of curcumin (Curcuma longa) against D-galactose-induced senescence in mice. J Asian Nat.Prod Res 2011;13:42-55. View abstract.
  328. Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., and Oguzturk, H. Antioxidative effects of curcumin, beta-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicol Ind Health 2011;27:447-453. View abstract.
  329. Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., and Diederich, M. Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 2011;38:603-611. View abstract.
  330. Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. B., and Srichairatanakool, S. Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids. Med Chem 2011;7:62-69. View abstract.
  331. Lin, M. S., Hung, K. S., Chiu, W. T., Sun, Y. Y., Tsai, S. H., Lin, J. W., and Lee, Y. H. Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. Prog.Neuropsychopharmacol.Biol Psychiatry 6-1-2011;35:931-938. View abstract.
  332. Lin, J. and Chen, A. Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. Mol.Cell Endocrinol 2-20-2011;333:160-171. View abstract.
  333. Reynolds, J. V., Donohoe, C. L., and Doyle, S. L. Diet, obesity and cancer. Ir.J Med Sci 2011;180:521-527. View abstract.
  334. Ponnurangam, S., Mondalek, F. G., Govind, J., Subramaniam, D., Houchen, C. W., Anant, S., Pantazis, P., and Ramanujam, R. P. Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay. In Vivo 2010;24:861-864. View abstract.
  335. Madkor, H. R., Mansour, S. W., and Ramadan, G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105:1210-1217. View abstract.
  336. Weissenberger, J., Priester, M., Bernreuther, C., Rakel, S., Glatzel, M., Seifert, V., and Kogel, D. Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Clin Cancer Res 12-1-2010;16:5781-5795. View abstract.
  337. Kakkar, V., Singh, S., Singla, D., Sahwney, S., Chauhan, A. S., Singh, G., and Kaur, I. P. Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats. J Chromatogr.B Analyt.Technol Biomed.Life Sci 12-15-2010;878:3427-3431. View abstract.
  338. Folwarczna, J., Zych, M., and Trzeciak, H. I. Effects of curcumin on the skeletal system in rats. Pharmacol Rep. 2010;62:900-909. View abstract.
  339. Balakrishnan, S., Manoharan, S., Alias, L. M., and Nirmal, M. R. Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Indian J Biochem Biophys 2010;47:7-12. View abstract.
  340. Chen, L. X., He, Y. J., Zhao, S. Z., Wu, J. G., Wang, J. T., Zhu, L. M., Lin, T. T., Sun, B. C., and Li, X. R. Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther 1-15-2011;11:229-235. View abstract.
  341. Schrader, C., Schiborr, C., Frank, J., and Rimbach, G. Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Br J Nutr 2011;105:167-170. View abstract.
  342. Ma, J., Phillips, L., Wang, Y., Dai, T., LaPage, J., Natarajan, R., and Adler, S. G. Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC. BMC Complement Altern Med 2010;10:67. View abstract.
  343. Rogers, N. M., Kireta, S., and Coates, P. T. Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010;162:460-473. View abstract.
  344. Zhang, Y., Cao, H., Hu, Y. Y., Wang, H., and Zhang, C. J. Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis. Int J Mol.Med 2011;27:87-94. View abstract.
  345. Seo, S. W., Bae, G. S., Kim, S. G., Yun, S. W., Kim, M. S., Yun, K. J., Park, R. K., Song, H. J., and Park, S. J. Protective effects of Curcuma longa against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Int J Mol.Med 2011;27:53-61. View abstract.
  346. Maher, D. M., Bell, M. C., O'Donnell, E. A., Gupta, B. K., Jaggi, M., and Chauhan, S. C. Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol.Carcinog. 2011;50:47-57. View abstract.
  347. Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 2010;62:1137-1141. View abstract.
  348. El-Beshbishy, H. A., Mohamadin, A. M., Nagy, A. A., and Abdel-Naim, A. B. Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. Indian J Exp Biol 2010;48:280-288. View abstract.
  349. Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X., and Lee, K. C. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int J Pharm 1-17-2011;403(1-2):285-291. View abstract.
  350. Tang, Y. and Chen, A. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Br J Pharmacol 2010;161:1137-1149. View abstract.
  351. Agarwal, B. B. Do dietary spices impair the patient-reported outcomes for stapled hemorrhoidopexy? A randomized controlled study. Surg Endosc. 2011;25:1535-1540. View abstract.
  352. Voznesens'ka, T. I., Bryzhina, T. M., Sukhina, V. S., Makohon, N. V., and Aleksieieva, I. M. [Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice]. Fiziol.Zh. 2010;56:96-101. View abstract.
  353. Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., and Fathollahi, Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011;65:572-582. View abstract.
  354. Sun, Z. J., Chen, G., Zhang, W., Hu, X., Liu, Y., Zhou, Q., Zhu, L. X., and Zhao, Y. F. Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-kappaB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaB kinase complex signaling axis in adenoid cystic carcinoma. Mol.Pharmacol 2011;79:106-118. View abstract.
  355. Khuwaja, G., Khan, M. M., Ishrat, T., Ahmad, A., Raza, S. S., Ashafaq, M., Javed, H., Khan, M. B., Khan, A., Vaibhav, K., Safhi, M. M., and Islam, F. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Brain Res 1-12-2011;1368:254-263. View abstract.
  356. Rungseesantivanon, S., Thenchaisri, N., Ruangvejvorachai, P., and Patumraj, S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010;10:57. View abstract.
  357. Singh, M. and Singh, N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol.Cell Biochem 2011;347(1-2):1-11. View abstract.
  358. Kakkar, V., Singh, S., Singla, D., and Kaur, I. P. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol.Nutr Food Res 2011;55:495-503. View abstract.
  359. Lima, C. F., Pereira-Wilson, C., and Rattan, S. I. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol.Nutr Food Res 2011;55:430-442. View abstract.
  360. Wickenberg, J., Ingemansson, S. L., and Hlebowicz, J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J 2010;9:43. View abstract.
  361. Wei, S., Xu, H., Xia, D., and Zhao, R. Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig. Domest.Anim Endocrinol 2010;39:231-239. View abstract.
  362. Lee, H. S., Li, L., Kim, H. K., Bilehal, D., Li, W., Lee, D. S., and Kim, Y. H. The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol.Biotechnol. 2010;20:1331-1338. View abstract.
  363. Bhartiya, U. S., Joseph, L. J., Raut, Y. S., and Rao, B. S. Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. Indian J Exp Biol 2010;48:566-571. View abstract.
  364. Schiborr, C., Eckert, G. P., Weissenberger, J., Muller, W. E., Schwamm, D., Grune, T., Rimbach, G., and Frank, J. Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol. 2010;11:861-867. View abstract.
  365. Singh, R. S., Das, U., Dimmock, J. R., and Alcorn, J. A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices. J Chromatogr.B Analyt.Technol Biomed.Life Sci 10-15-2010;878:2796-2802. View abstract.
  366. Matteucci, A., Cammarota, R., Paradisi, S., Varano, M., Balduzzi, M., Leo, L., Bellenchi, G. C., De, Nuccio C., Carnovale-Scalzo, G., Scorcia, G., Frank, C., Mallozzi, C., Di Stasi, A. M., Visentin, S., and Malchiodi-Albedi, F. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit. Invest Ophthalmol.Vis.Sci 2011;52:1070-1077. View abstract.
  367. Kanai, M., Yoshimura, K., Asada, M., Imaizumi, A., Suzuki, C., Matsumoto, S., Nishimura, T., Mori, Y., Masui, T., Kawaguchi, Y., Yanagihara, K., Yazumi, S., Chiba, T., Guha, S., and Aggarwal, B. B. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother.Pharmacol 2011;68:157-164. View abstract.
  368. Villegas, I., Sanchez-Fidalgo, S., and de la Lastra, C. A. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Mol.Nutr Food Res 2011;55:259-267. View abstract.
  369. Mehla, J., Reeta, K. H., Gupta, P., and Gupta, Y. K. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 11-20-2010;87(19-22):596-603. View abstract.
  370. Prakobwong, S., Khoontawad, J., Yongvanit, P., Pairojkul, C., Hiraku, Y., Sithithaworn, P., Pinlaor, P., Aggarwal, B. B., and Pinlaor, S. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer 7-1-2011;129:88-100. View abstract.
  371. Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99:4992-5010. View abstract.
  372. Karatepe, O., Acet, E., Battal, M., Adas, G., Kemik, A., Altiok, M., Kamali, G., Koculu, S., Catay, A., Kamali, S., and Karahan, S. Effects of glutamine and curcumin on bacterial translocation in jaundiced rats. World J Gastroenterol. 9-14-2010;16:4313-4320. View abstract.
  373. Sharma, S., Ying, Z., and Gomez-Pinilla, F. A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. Exp Neurol. 2010;226:191-199. View abstract.
  374. Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., and Huang, B. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm 11-15-2010;400(1-2):211-220. View abstract.
  375. Yousef, M. I., Omar, S. A., El-Guendi, M. I., and Abdelmegid, L. A. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 2010;48:3246-3261. View abstract.
  376. Dayton, A., Selvendiran, K., Kuppusamy, M. L., Rivera, B. K., Meduru, S., Kalai, T., Hideg, K., and Kuppusamy, P. Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer Biol Ther 2010;10:1027-1032. View abstract.
  377. Sahebkar, A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil.Steril. 2010;94:e75-e76. View abstract.
  378. Wu, X., Xu, J., Huang, X., and Wen, C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 2011;37:15-23. View abstract.
  379. Quiroga, A., Quiroga, P. L., Martinez, E., Soria, E. A., and Valentich, M. A. Anti-breast cancer activity of curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition. J Exp Ther Oncol 2010;8:261-266. View abstract.
  380. Mohankumar, S. and McFarlane, J. R. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res 2011;25:396-401. View abstract.
  381. Sintara, K., Thong-Ngam, D., Patumraj, S., Klaikeaw, N., and Chatsuwan, T. Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol. 8-28-2010;16:4039-4046. View abstract.
  382. Yadav, B., Taurin, S., Rosengren, R. J., Schumacher, M., Diederich, M., Somers-Edgar, T. J., and Larsen, L. Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin. Bioorg.Med Chem 9-15-2010;18:6701-6707. View abstract.
  383. Yan, Y. D., Kim, D. H., Sung, J. H., Yong, C. S., and Choi, H. G. Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin. Int J Pharm 10-31-2010;399(1-2):116-120. View abstract.
  384. Hsu, Y. C., Chen, M. J., Yu, Y. M., Ko, S. Y., and Chang, C. C. Suppression of TGF-beta1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid. Arch Dermatol Res 2010;302:717-724. View abstract.
  385. Wright, L. E., Frye, J. B., Timmermann, B. N., and Funk, J. L. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition. J Agric.Food Chem 9-8-2010;58:9498-9504. View abstract.
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  387. Vachharajani, V., Wang, S. W., Mishra, N., El, Gazzar M., Yoza, B., and McCall, C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17:407-416. View abstract.
  388. Wong, T. S., Chan, W. S., Li, C. H., Liu, R. W., Tang, W. W., Tsao, S. W., Tsang, R. K., Ho, W. K., Wei, W. I., and Chan, J. Y. Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Res 2010;30:2851-2856. View abstract.
  389. Choi, H. Y., Lim, J. E., and Hong, J. H. Curcumin interrupts the interaction between the androgen receptor and Wnt/beta-catenin signaling pathway in LNCaP prostate cancer cells. Prostate Cancer Prostatic.Dis 2010;13:343-349. View abstract.
  390. Ibrahim, A., El-Meligy, A., Fetaih, H., Dessouki, A., Stoica, G., and Barhoumi, R. Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In Vivo 2010;24:401-408. View abstract.
  391. Boonrao, M., Yodkeeree, S., Ampasavate, C., Anuchapreeda, S., and Limtrakul, P. The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. Arch Pharm Res 2010;33:989-998. View abstract.
  392. Tang, Y. and Chen, A. Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 2010;151:4168-4177. View abstract.
  393. Setthacheewakul, S., Mahattanadul, S., Phadoongsombut, N., Pichayakorn, W., and Wiwattanapatapee, R. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm. 2010;76:475-485. View abstract.
  394. Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., and Appendino, G. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010;52(2 Suppl 1):55-62. View abstract.
  395. Peeyush, Kumar T., Antony, S., Soman, S., Kuruvilla, K. P., George, N., and Paulose, C. S. Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats. Mol.Cell Endocrinol 1-1-2011;331:1-10. View abstract.
  396. Yang, M. W., Wang, T. H., Yan, P. P., Chu, L. W., Yu, J., Gao, Z. D., Li, Y. Z., and Guo, B. L. Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine. 1-15-2011;18(2-3):205-213. View abstract.
  397. Ammon, H. P. and Wahl, M. A. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7. View abstract.
  398. Larmonier, C. B., Midura-Kiela, M. T., Ramalingam, R., Laubitz, D., Janikashvili, N., Larmonier, N., Ghishan, F. K., and Kiela, P. R. Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease. Inflamm.Bowel.Dis 2011;17:503-515. View abstract.
  399. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., and Kazeminejad, B. Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 2010;96:378-385. View abstract.
  400. Biswas, J., Roy, S., Mukherjee, S., Sinha, D., and Roy, M. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pac.J Cancer Prev 2010;11:239-247. View abstract.
  401. Tang, H., Murphy, C. J., Zhang, B., Shen, Y., Van Kirk, E. A., Murdoch, W. J., and Radosz, M. Curcumin polymers as anticancer conjugates. Biomaterials 2010;31:7139-7149. View abstract.
  402. Bielak-Zmijewska, A., Sikora-Polaczek, M., Nieznanski, K., Mosieniak, G., Kolano, A., Maleszewski, M., Styrna, J., and Sikora, E. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity. Cell Prolif. 2010;43:354-364. View abstract.
  403. Rai, B., Kaur, J., Jacobs, R., and Singh, J. Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. J Oral Sci. 2010;52:251-256. View abstract.
  404. Jena, S. and Chainy, G. B. Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L: -thyroxine-induced oxidative stress in rat renal cortex. Mol.Biol.Rep. 6-24-2010; View abstract.
  405. Yallapu, M. M., Jaggi, M., and Chauhan, S. C. Poly(beta-cyclodextrin)/Curcumin Self-Assembly: A Novel Approach to Improve Curcumin Delivery and its Therapeutic Efficacy in Prostate Cancer Cells. Macromol.Biosci. 6-22-2010; View abstract.
  406. Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., and Zhang, H. G. A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes. Mol.Ther. 6-22-2010; View abstract.
  407. Bharti, A. C., Panigrahi, A., Sharma, P. K., Gupta, N., Kumar, R., Shukla, S., Bhowmik, D. M., Agarwal, S. K., Guleria, S., and Mehra, N. K. Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp.Clin Transplant. 2010;8:161-171. View abstract.
  408. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., Ataee, R., and Moghaddam, S. N. Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain. J Med.Food 6-16-2010; View abstract.
  409. Jutooru, I., Chadalapaka, G., Lei, P., and Safe, S. Inhibition of NF{kappa}B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation. J Biol.Chem. 6-9-2010; View abstract.
  410. Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 6-9-2010; View abstract.
  411. Cemil, B., Topuz, K., Demircan, M. N., Kurt, G., Tun, K., Kutlay, M., Ipcioglu, O., and Kucukodaci, Z. Curcumin improves early functional results after experimental spinal cord injury. Acta Neurochir.(Wien.) 6-10-2010; View abstract.
  412. Pisano, M., Pagnan, G., Dettori, M. A., Cossu, S., Caffa, I., Sassu, I., Emionite, L., Fabbri, D., Cilli, M., Pastorino, F., Palmieri, G., Delogu, G., Ponzoni, M., and Rozzo, C. Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. Mol.Cancer 6-3-2010;9:137. View abstract.
  413. Suresh, D. and Srinivasan, K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med.Res 2010;131:682-691. View abstract.
  414. Kumar, T. P., Antony, S., Gireesh, G., George, N., and Paulose, C. S. Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. J Biomed.Sci. 2010;17:43. View abstract.
  415. Sharma, V., Nehru, B., Munshi, A., and Jyothy, A. Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. Methods Find.Exp.Clin Pharmacol 2010;32:227-232. View abstract.
  416. Ide, H., Tokiwa, S., Sakamaki, K., Nishio, K., Isotani, S., Muto, S., Hama, T., Masuda, H., and Horie, S. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate 7-1-2010;70:1127-1133. View abstract.
  417. Zhao, J. Y., Lu, N., Yan, Z., and Wang, N. SAHA and curcumin combinations co-enhance histone acetylation in human cancer cells but operate antagonistically in exerting cytotoxic effects. J Asian Nat.Prod.Res 2010;12:335-348. View abstract.
  418. Chen, Y., Liu, W. H., Chen, B. L., Fan, L., Han, Y., Wang, G., Hu, D. L., Tan, Z. R., Zhou, G., Cao, S., and Zhou, H. H. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann.Pharmacother. 2010;44:1038-1045. View abstract.
  419. Yadav, R. S., Shukla, R. K., Sankhwar, M. L., Patel, D. K., Ansari, R. W., Pant, A. B., Islam, F., and Khanna, V. K. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. Neurotoxicology 5-11-2010; View abstract.
  420. Rajagopalan, R., Sridharana, S., and Menon, V. P. Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats. Toxicol Mech.Methods 2010;20:252-259. View abstract.
  421. Shahani, K., Swaminathan, S. K., Freeman, D., Blum, A., Ma, L., and Panyam, J. Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res 6-1-2010;70:4443-4452. View abstract.
  422. Yallapu, M. M., Jaggi, M., and Chauhan, S. C. beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. Colloids Surf.B Biointerfaces. 8-1-2010;79:113-125. View abstract.
  423. Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., and Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10:815-818. View abstract.
  424. Chen, K. H., Chao, D., Liu, C. F., Chen, C. F., and Wang, D. Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. Transplant.Proc. 2010;42:744-747. View abstract.
  425. Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173:590-601. View abstract.
  426. Pinlaor, S., Prakobwong, S., Hiraku, Y., Pinlaor, P., Laothong, U., and Yongvanit, P. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. Eur.J Pharmacol 7-25-2010;638(1-3):134-141. View abstract.
  427. He, L. F., Chen, H. J., Qian, L. H., Chen, G. Y., and Buzby, J. S. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain Res 6-21-2010;1339:60-69. View abstract.
  428. Jung, I. D., Jeong, Y. I., Lee, C. M., Noh, K. T., Jeong, S. K., Chun, S. H., Choi, O. H., Park, W. S., Han, J., Shin, Y. K., Kim, H. W., Yun, C. H., and Park, Y. M. COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells. Int.Immunopharmacol. 4-22-2010; View abstract.
  429. El Deen, N. A. and Eid, M. Efficacy of curcumin to reduce hepatic damage induced by alcohol and thermally treated oil in rats. Vet.Ital. 2010;46:83-92. View abstract.
  430. Lin, Y. C., Chen, H. W., Kuo, Y. C., Chang, Y. F., Lee, Y. J., and Hwang, J. J. Therapeutic efficacy evaluation of curcumin on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am.J Chin Med. 2010;38:343-358. View abstract.
  431. Hua, W. F., Fu, Y. S., Liao, Y. J., Xia, W. J., Chen, Y. C., Zeng, Y. X., Kung, H. F., and Xie, D. Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur.J Pharmacol 7-10-2010;637(1-3):16-21. View abstract.
  432. Abdel Fattah, E. A., Hashem, H. E., Ahmed, F. A., Ghallab, M. A., Varga, I., and Polak, S. Prophylactic role of curcumin against cyclosporine-induced nephrotoxicity: Histological and immunohistological study. Gen.Physiol Biophys. 2010;29:85-94. View abstract.
  433. Rinwa, P., Kaur, B., Jaggi, A. S., and Singh, N. Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. Naunyn Schmiedebergs Arch.Pharmacol 2010;381:529-539. View abstract.
  434. Hilchie, A. L., Furlong, S. J., Sutton, K., Richardson, A., Robichaud, M. R., Giacomantonio, C. A., Ridgway, N. D., and Hoskin, D. W. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria. Nutr.Cancer 2010;62:379-389. View abstract.
  435. Okazaki, Y., Han, Y., Kayahara, M., Watanabe, T., Arishige, H., and Kato, N. Consumption of curcumin elevates fecal immunoglobulin a, an index of intestinal immune function, in rats fed a high-fat diet. J Nutr.Sci.Vitaminol.(Tokyo) 2010;56:68-71. View abstract.
  436. Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20:2549-2551. View abstract.
  437. Wu, H., Hsieh, M. C., Lo, C. Y., Liu, C. B., Sang, S., Ho, C. T., and Pan, M. H. 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Mol.Nutr.Food Res 3-24-2010; View abstract.
  438. Baghdasaryan, A., Claudel, T., Kosters, A., Gumhold, J., Silbert, D., Thuringer, A., Leski, K., Fickert, P., Karpen, S. J., and Trauner, M. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010;59:521-530. View abstract.
  439. Hashem, M. M., Atta, A. H., Arbid, M. S., Nada, S. A., and Asaad, G. F. Immunological studies on Amaranth, Sunset Yellow and Curcumin as food colouring agents in albino rats. Food Chem.Toxicol 2010;48:1581-1586. View abstract.
  440. Saydmohammed, M., Joseph, D., and Syed, V. Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells. J Cell Biochem. 5-15-2010;110:447-456. View abstract.
  441. Yu, S., Zheng, W., Xin, N., Chi, Z. H., Wang, N. Q., Nie, Y. X., Feng, W. Y., and Wang, Z. Y. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation.Res 2010;13:55-64. View abstract.
  442. Agarwal, R., Goel, S. K., and Behari, J. R. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl.Toxicol 3-12-2010; View abstract.
  443. Li, J. M., Li, Y. C., Kong, L. D., and Hu, Q. H. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010;51:1555-1566. View abstract.
  444. Pyrzanowska, J., Piechal, A., Blecharz-Klin, K., Lehner, M., Skorzewska, A., Turzynska, D., Sobolewska, A., Plaznik, A., and Widy-Tyszkiewicz, E. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem.Behav. 2010;95:351-358. View abstract.
  445. Kim, J. H., Park, J. M., Kim, E. K., Lee, J. O., Lee, S. K., Jung, J. H., You, G. Y., Park, S. H., Suh, P. G., and Kim, H. S. Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells. J Cell Physiol 2010;223:771-778. View abstract.
  446. Jia, S. H., Wei, H., Yu, J. L., Wei, X. D., Zhang, X. P., and Li, J. C. [Protective effects of curcumin on neonatal rats with necrotizing enterocolitis]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2010;12:132-136. View abstract.
  447. Moon, D. O., Kim, M. O., Choi, Y. H., Park, Y. M., and Kim, G. Y. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int.Immunopharmacol. 2010;10:605-610. View abstract.
  448. Sharma, P. and Singh, R. Protective role of curcumin on lindane induced reproductive toxicity in male Wistar rats. Bull.Environ.Contam Toxicol 2010;84:378-384. View abstract.
  449. Zhang, Q. Y., Mo, Z. N., and Liu, X. D. [Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis]. Zhonghua Nan.Ke.Xue. 2010;16:84-88. View abstract.
  450. Cheng, T. C., Lu, C. C., Chung, H. H., Hsu, C. C., Kakizawa, N., Yamada, S., and Cheng, J. T. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci.Lett. 4-5-2010;473:107-109. View abstract.
  451. Manikandan, R., Thiagarajan, R., Beulaja, S., Sudhandiran, G., and Arumugam, M. Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. Curr.Eye Res 2010;35:122-129. View abstract.
  452. Laird, M. D., Sukumari-Ramesh, S., Swift, A. E., Meiler, S. E., Vender, J. R., and Dhandapani, K. M. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem. 5-1-2010;113:637-648. View abstract.
  453. Wu, S. J., Tam, K. W., Tsai, Y. H., Chang, C. C., and Chao, J. C. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am.J Chin Med. 2010;38:99-111. View abstract.
  454. Chang, K. W., Hung, P. S., Lin, I. Y., Hou, C. P., Chen, L. K., Tsai, Y. M., and Lin, S. C. Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int.J Cancer 7-1-2010;127:9-20. View abstract.
  455. Tanwar, V., Sachdeva, J., Golechha, M., Kumari, S., and Arya, D. S. Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. J Cardiovasc.Pharmacol 2010;55:377-384. View abstract.
  456. El Agamy, D. S. Comparative effects of curcumin and resveratrol on aflatoxin B-induced liver injury in rats. Arch.Toxicol 2010;84:389-396. View abstract.
  457. Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., and Agarwal, M. G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric.Food Chem 2-24-2010;58:2095-2099. View abstract.
  458. Fong, D., Yeh, A., Naftalovich, R., Choi, T. H., and Chan, M. M. Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals. Cancer Lett. 7-1-2010;293:65-72. View abstract.
  459. Perry, M. C., Demeule, M., Regina, A., Moumdjian, R., and Beliveau, R. Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Mol.Nutr.Food Res 1-19-2010; View abstract.
  460. Becatti, M., Prignano, F., Fiorillo, C., Pescitelli, L., Nassi, P., Lotti, T., and Taddei, N. The Involvement of Smac/DIABLO, p53, NF-kB, and MAPK Pathways in Apoptosis of Keratinocytes from Perilesional Vitiligo Skin: Protective Effects of Curcumin and Capsaicin. Antioxid.Redox.Signal. 4-20-2010; View abstract.
  461. Bao, W., Li, K., Rong, S., Yao, P., Hao, L., Ying, C., Zhang, X., Nussler, A., and Liu, L. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol. 3-24-2010;128:549-553. View abstract.
  462. Wang, B. M., Zhai, C. Y., Fang, W. L., Chen, X., Jiang, K., and Wang, Y. M. [The inhibitory effect of curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid]. Zhonghua Nei Ke.Za Zhi. 2009;48:760-763. View abstract.
  463. Su, C. C., Yang, J. S., Lu, C. C., Chiang, J. H., Wu, C. L., Lin, J. J., Lai, K. C., Hsia, T. C., Lu, H. F., Fan, M. J., and Chung, J. G. Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. Phytother.Res 2010;24:189-192. View abstract.
  464. Varghese, K., Molnar, P., Das, M., Bhargava, N., Lambert, S., Kindy, M. S., and Hickman, J. J. A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS.One. 2010;5:e8643. View abstract.
  465. Smith, M. R., Gangireddy, S. R., Narala, V. R., Hogaboam, C. M., Standiford, T. J., Christensen, P. J., Kondapi, A. K., and Reddy, R. C. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am.J Physiol Lung Cell Mol.Physiol 1-8-2010; View abstract.
  466. Kwon, S. J., Kim, M. I., Ku, B., Coulombel, L., Kim, J. H., Shawky, J. H., Linhardt, R. J., and Dordick, J. S. Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells. Chembiochem. 3-1-2010;11:573-580. View abstract.
  467. Dairaku, I., Han, Y., Yanaka, N., and Kato, N. Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents. Biosci.Biotechnol.Biochem. 2010;74:185-187. View abstract.
  468. Bansal, S. and Chhibber, S. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice. J Med.Microbiol. 2010;59(Pt 4):429-437. View abstract.
  469. Biswas, J., Sinha, D., Mukherjee, S., Roy, S., Siddiqi, M., and Roy, M. Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal. Hum.Exp.Toxicol 2010;29:513-524. View abstract.
  470. Wang, W. Z., Zhang, B. Y., Mei, W. J., Mao, J. W., and Li, M. [Effect of p21-targeted shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells]. Yao Xue.Xue.Bao. 2009;44:1102-1106. View abstract.
  471. Sou, K., Oyajobi, B., Goins, B., Phillips, W. T., and Tsuchida, E. Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol). J Biomed.Nanotechnol. 2009;5:202-208. View abstract.
  472. Singla, N. and Dhawan, D. K. Modulation of carbohydrate metabolism during N-methyl N-nitrosourea induced neurotoxicity in mice: role of curcumin. Neurochem.Res 2010;35:660-665. View abstract.
  473. Antony, B., Merina, B., Iyer, V. S., Judy, N., Lennertz, K., and Joyal, S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008;70:445-449. View abstract.
  474. Chen, Q., Wang, Y., Xu, K., Lu, G., Ying, Z., Wu, L., Zhan, J., Fang, R., Wu, Y., and Zhou, J. Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Oncol.Rep. 2010;23:397-403. View abstract.
  475. Singh, R., Singh, N., Saini, B. S., and Rao, H. S. In vitro antioxidant activity of pet ether extract of black pepper. Indian J Pharmacol 2008;40:147-151. View abstract.
  476. Yeon, K. Y., Kim, S. A., Kim, Y. H., Lee, M. K., Ahn, D. K., Kim, H. J., Kim, J. S., Jung, S. J., and Oh, S. B. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent.Res 2010;89:170-174. View abstract.
  477. Giommarelli, C., Zuco, V., Favini, E., Pisano, C., Dal Piaz, F., De Tommasi, N., and Zunino, F. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol.Life Sci. 2010;67:995-1004. View abstract.
  478. Yoon, M. J., Kim, E. H., Lim, J. H., Kwon, T. K., and Choi, K. S. Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Free Radic.Biol.Med. 3-1-2010;48:713-726. View abstract.
  479. Singh, R. K., Rai, D., Yadav, D., Bhargava, A., Balzarini, J., and De Clercq, E. Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur.J Med.Chem. 2010;45:1078-1086. View abstract.
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  481. Bachmeier, B. E., Iancu, C. M., Killian, P. H., Kronski, E., Mirisola, V., Angelini, G., Jochum, M., Nerlich, A. G., and Pfeffer, U. Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells. Mol.Cancer 2009;8:129. View abstract.
  482. Tanwar, V., Sachdeva, J., Kishore, K., Mittal, R., Nag, T. C., Ray, R., Kumari, S., and Arya, D. S. Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Cell Biochem.Funct. 2010;28:74-82. View abstract.
  483. Hemeida, R. A. and Mohafez, O. M. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. J Egypt Natl.Canc.Inst. 2008;20:141-148. View abstract.
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  489. Elamin, M. H., Shinwari, Z., Hendrayani, S. F., Al Hindi, H., Al Shail, E., Khafaga, Y., Al Kofide, A., and Aboussekhra, A. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Mol.Carcinog. 2010;49:302-314. View abstract.
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  494. Sharma, M., Manoharlal, R., Puri, N., and Prasad, R. Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci.Rep. 12-17-2009; View abstract.
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  496. Fiala, M. Re-Balancing of Inflammation and A Immunity as a Therapeutic for Alzheimer's Disease-View from the Bedside. CNS.Neurol.Disord.Drug Targets. 10-7-2009; View abstract.
  497. Changtam, C., de Koning, H. P., Ibrahim, H., Sajid, M. S., Gould, M. K., and Suksamrarn, A. Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur.J Med.Chem. 2010;45:941-956. View abstract.
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  501. Ning, L., Wentworth, L., Chen, H., and Weber, S. M. Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. Am.J Transl.Res 2009;1:358-366. View abstract.
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  503. Prasad, C. P., Rath, G., Mathur, S., Bhatnagar, D., and Ralhan, R. Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. Chem.Biol.Interact. 2-12-2010;183:455-461. View abstract.
  504. Landvik, N. E., Arlt, V. M., Nagy, E., Solhaug, A., Tekpli, X., Schmeiser, H. H., Refsnes, M., Phillips, D. H., Lagadic-Gossmann, D., and Holme, J. A. 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. Mutat.Res 2-3-2010;684(1-2):11-23. View abstract.
  505. Kang, B. Y., Khan, J. A., Ryu, S., Shekhar, R., Seung, K. B., and Mehta, J. L. Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition. J Cardiovasc.Pharmacol 2010;55:176-183. View abstract.
  506. Pavithra, B. H., Prakash, N., and Jayakumar, K. Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. J Vet.Sci. 2009;10:293-297. View abstract.
  507. Manikandan, R., Thiagarajan, R., Beulaja, S., Sudhandiran, G., and Arumugam, M. Curcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium. Free Radic.Biol.Med. 2-15-2010;48:483-492. View abstract.
  508. Bhatt, K. H., Pandey, R. K., Dahiya, Y., and Sodhi, A. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Mol.Immunol. 2010;47:861-870. View abstract.
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  510. Dwivedi, S. and Aggarwal, A. Indigenous drugs in ischemic heart disease in patients with diabetes. J Altern.Complement Med. 2009;15:1215-1221. View abstract.
  511. Wang, Z., Leung, M. H., Kee, T. W., and English, D. S. The role of charge in the surfactant-assisted stabilization of the natural product curcumin. Langmuir 4-20-2010;26:5520-5526. View abstract.
  512. Kheradpezhouh, E., Panjehshahin, M. R., Miri, R., Javidnia, K., Noorafshan, A., Monabati, A., and Dehpour, A. R. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. Eur.J Pharmacol 2-25-2010;628(1-3):274-281. View abstract.
  513. Karatepe, O., Gulcicek, O. B., Ugurlucan, M., Adas, G., Battal, M., Kemik, A., Kamali, G., Altug, T., and Karahan, S. Curcumin nutrition for the prevention of mesenteric ischemia-reperfusion injury: an experimental rodent model. Transplant.Proc. 2009;41:3611-3616. View abstract.
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  515. Guangwei, X., Rongzhu, L., Wenrong, X., Suhua, W., Xiaowu, Z., Shizhong, W., Ye, Z., Aschner, M., Kulkarni, S. K., and Bishnoi, M. Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology 1-12-2010;267(1-3):140-146. View abstract.
  516. Yang, J., Cao, Y., Sun, J., and Zhang, Y. Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells. Med.Oncol. 11-12-2009; View abstract.
  517. Yarru, L. P., Settivari, R. S., Gowda, N. K., Antoniou, E., Ledoux, D. R., and Rottinghaus, G. E. Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poult.Sci. 2009;88:2620-2627. View abstract.
  518. Chen, S., Feng, B., George, B., Chakrabarti, R., Chen, M., and Chakrabarti, S. Transcriptional Co-activator p300 Regulates Glucose Induced Gene Expression in the Endothelial Cells. Am.J Physiol Endocrinol.Metab 11-10-2009; View abstract.
  519. Kamat, A. M., Tharakan, S. T., Sung, B., and Aggarwal, B. B. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 12-1-2009;69:8958-8966. View abstract.
  520. Bisht, K., Wagner, K. H., and Bulmer, A. C. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. Toxicology 11-10-2009; View abstract.
  521. Vizzutti, F., Provenzano, A., Galastri, S., Milani, S., Delogu, W., Novo, E., Caligiuri, A., Zamara, E., Arena, U., Laffi, G., Parola, M., Pinzani, M., and Marra, F. Curcumin limits the fibrogenic evolution of experimental steatohepatitis. Lab Invest 2010;90:104-115. View abstract.
  522. Bayet-Robert, M., Kwiatkowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C., Mouret-Reynier, M. A., Durando, X., Barthomeuf, C., and Chollet, P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol.Ther. 2010;9:8-14. View abstract.
  523. Kalpravidh, R. W., Siritanaratkul, N., Insain, P., Charoensakdi, R., Panichkul, N., Hatairaktham, S., Srichairatanakool, S., Phisalaphong, C., Rachmilewitz, E., and Fucharoen, S. Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids. Clin Biochem. 2010;43(4-5):424-429. View abstract.
  524. Thiyagarajan, S., Thirumalai, K., Nirmala, S., Biswas, J., and Krishnakumar, S. Effect of curcumin on lung resistance-related protein (LRP) in retinoblastoma cells. Curr.Eye Res 2009;34:845-851. View abstract.
  525. Hamaguchi, T., Ono, K., Murase, A., and Yamada, M. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am.J Pathol. 2009;175:2557-2565. View abstract.
  526. Zaidi, S. F., Yamamoto, T., Refaat, A., Ahmed, K., Sakurai, H., Saiki, I., Kondo, T., Usmanghani, K., Kadowaki, M., and Sugiyama, T. Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells. Helicobacter. 2009;14:588-595. View abstract.
  527. Cartiera, M. S., Ferreira, E. C., Caputo, C., Egan, M. E., Caplan, M. J., and Saltzman, W. M. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol.Pharm 2-1-2010;7:86-93. View abstract.
  528. Kulkarni, S., Dhir, A., and Akula, K. K. Potentials of curcumin as an antidepressant. ScientificWorldJournal. 2009;9:1233-1241. View abstract.
  529. Ortiz-Ortiz, M. A., Moran, J. M., Ruiz-Mesa, L. M., Niso-Santano, M., Bravo-SanPedro, J. M., Gomez-Sanchez, R., Gonzalez-Polo, R. A., and Fuentes, J. M. Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neurosci.Lett. 1-4-2010;468:120-124. View abstract.
  530. Wang, R., Li, Y. H., Xu, Y., Li, Y. B., Wu, H. L., Guo, H., Zhang, J. Z., Zhang, J. J., Pan, X. Y., and Li, X. J. Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons. Prog.Neuropsychopharmacol.Biol.Psychiatry 2-1-2010;34:147-153. View abstract.
  531. Epstein, J., Docena, G., Macdonald, T. T., and Sanderson, I. R. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br.J Nutr. 2010;103:824-832. View abstract.
  532. Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35:599-606. View abstract.
  533. Singh, M., Pandey, A., Karikari, C. A., Singh, G., and Rakheja, D. Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1. Med.Oncol. 10-27-2009; View abstract.
  534. Yun, S. S., Kim, S. P., Kang, M. Y., and Nam, S. H. Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock. Biotechnol.Lett. 2010;32:209-214. View abstract.
  535. Muthenna, P., Suryanarayana, P., Gunda, S. K., Petrash, J. M., and Reddy, G. B. Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance. FEBS Lett. 11-19-2009;583:3637-3642. View abstract.
  536. Mukerjee, A. and Vishwanatha, J. K. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 2009;29:3867-3875. View abstract.
  537. Lin, J., Zheng, S., and Chen, A. Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress. Lab Invest 2009;89:1397-1409. View abstract.
  538. Cong, Y., Wang, L., Konrad, A., Schoeb, T., and Elson, C. O. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. Eur.J Immunol. 2009;39:3134-3146. View abstract.
  539. Henrotin, Y., Clutterbuck, A. L., Allaway, D., Lodwig, E. M., Harris, P., Mathy-Hartert, M., Shakibaei, M., and Mobasheri, A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis.Cartilage. 2010;18:141-149. View abstract.
  540. Sirat, H. M., Jamil, S., and Rahman, A. A. Sesquiterpenes from the rhizomes of Curcuma ochrorhiza. Nat.Prod.Commun. 2009;4:1171. View abstract.
  541. Burgos-Moron, E., Calderon-Montano, J. M., Salvador, J., Robles, A., and Lopez-Lazaro, M. The dark side of curcumin. Int.J Cancer 4-1-2010;126:1771-1775. View abstract.
  542. Onoue, S., Takahashi, H., Kawabata, Y., Seto, Y., Hatanaka, J., Timmermann, B., and Yamada, S. Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci. 2010;99:1871-1881. View abstract.
  543. Chen, L., Tian, G., Shao, C., Cobos, E., and Gao, W. Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Mol.Biol.Rep. 10-15-2009; View abstract.
  544. Ciftci, O., Tanyildizi, S., and Godekmerdan, A. Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Immunopharmacol.Immunotoxicol. 2010;32:99-104. View abstract.
  545. Yodkeeree, S., Ampasavate, C., Sung, B., Aggarwal, B. B., and Limtrakul, P. Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. Eur.J Pharmacol 2-10-2010;627(1-3):8-15. View abstract.
  546. Somers-Edgar, T. J., Taurin, S., Larsen, L., Chandramouli, A., Nelson, M. A., and Rosengren, R. J. Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. Invest New Drugs 10-9-2009; View abstract.
  547. Rivera-Espinoza, Y. and Muriel, P. Pharmacological actions of curcumin in liver diseases or damage. Liver Int. 2009;29:1457-1466. View abstract.
  548. Gupta, Y. K., Briyal, S., and Sharma, M. Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian J Physiol Pharmacol 2009;53:39-46. View abstract.
  549. Rowe, D. L., Ozbay, T., O'Regan, R. M., and Nahta, R. Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin. Breast Cancer 9-2-2009;3:61-75. View abstract.
  550. Kang, Q. and Chen, A. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 2009;150:5384-5394. View abstract.
  551. Peeyush, K. T., Gireesh, G., Jobin, M., and Paulose, C. S. Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Life Sci. 11-4-2009;85(19-20):704-710. View abstract.
  552. Li, W., Xiao, H., Wang, L., and Liang, X. [Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry]. Se.Pu. 2009;27:264-269. View abstract.
  553. Shen, L. and Ji, H. F. Insights into the inhibition of xanthine oxidase by curcumin. Bioorg.Med.Chem.Lett. 11-1-2009;19:5990-5993. View abstract.
  554. Moghaddam, S. J., Barta, P., Mirabolfathinejad, S. G., Ammar-Aouchiche, Z., Garza, N. T., Vo, T. T., Newman, R. A., Aggarwal, B. B., Evans, C. M., Tuvim, M. J., Lotan, R., and Dickey, B. F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009;30:1949-1956. View abstract.
  555. Reddy, B. V., Sivagama, Sundari J., Balamurugan, E., and Menon, V. P. Antihyperlipidemic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione, a curcumin analog, on nicotine and streptozotocin treated rats. Mol.Cell Biochem. 2010;335(1-2):249-254. View abstract.
  556. Agrawal, S. S. and Ittiyavirah, S. P. Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats. Immunopharmacol.Immunotoxicol. 2010;32:92-98. View abstract.
  557. Tang, Y. H., Bao, M. W., Yang, B., Zhang, Y., Zhang, B. S., Zhou, Q., Chen, J. L., and Huang, C. X. [Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure.]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 2009;37:262-267. View abstract.
  558. Wang, L., Shen, Y., Song, R., Sun, Y., Xu, J., and Xu, Q. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol.Pharmacol 2009;76:1238-1245. View abstract.
  559. Shin, H. K., Kim, J., Lee, E. J., and Kim, S. H. Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations. Phytother.Res 2010;24:577-582. View abstract.
  560. Wang, Y., Lu, Z., Wu, H., and Lv, F. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int.J Food Microbiol. 11-30-2009;136:71-74. View abstract.
  561. Zhao, J., Yu, S., Zheng, W., Feng, G., Luo, G., Wang, L., and Zhao, Y. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem.Res 2010;35:374-379. View abstract.
  562. Zhao, Z. D. and Huang, Z. S. [Study on effects of curcumin on expressions of PDGF-BB, PDGFRbeta and ERK1 of HSC]. Zhong.Yao Cai. 2009;32:732-735. View abstract.
  563. Zhou, Q. M., Su, S. B., Zhang, H., and Lu, Y. Y. [Regulation of protein kinases on signal pathway in breast cancer cell MCF-7 by curcumin]. Zhong.Yao Cai. 2009;32:728-732. View abstract.
  564. Lim, J. H. and Kwon, T. K. Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Food Chem.Toxicol 2010;48:47-52. View abstract.
  565. Reeta, K. H., Mehla, J., and Gupta, Y. K. Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Res 12-8-2009;1301:52-60. View abstract.
  566. Cheng, T. C., Lin, C. S., Hsu, C. C., Chen, L. J., Cheng, K. C., and Cheng, J. T. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci.Lett. 11-20-2009;465:238-241. View abstract.
  567. Schrenk, D. Dietary fiber, low-molecular-weight food constituents and colo-rectal inflammation in animal models -- a review. Mol.Nutr.Food Res 2009;53:1281-1288. View abstract.
  568. Mun, S. H., Kim, H. S., Kim, J. W., Ko, N. Y., Kim, do K., Lee, B. Y., Kim, B., Won, H. S., Shin, H. S., Han, J. W., Lee, H. Y., Kim, Y. M., and Choi, W. S. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci. 2009;111:13-21. View abstract.
  569. Hushmendy, S., Jayakumar, L., Hahn, A. B., Bhoiwala, D., Bhoiwala, D. L., and Crawford, D. R. Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation. Nutr.Res 2009;29:568-578. View abstract.
  570. Patel, S. S., Shah, R. S., and Goyal, R. K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp.Biol. 2009;47:564-570. View abstract.
  571. Takahashi, M., Uechi, S., Takara, K., Asikin, Y., and Wada, K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric.Food Chem. 10-14-2009;57:9141-9146. View abstract.
  572. Xiao, H., Xiao, Q., Zhang, K., Zuo, X., and Shrestha, U. K. Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R. Ann.Hematol. 2010;89:399-404. View abstract.
  573. Pinlaor, S., Yongvanit, P., Prakobwong, S., Kaewsamut, B., Khoontawad, J., Pinlaor, P., and Hiraku, Y. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol.Nutr.Food Res 2009;53:1316-1328. View abstract.
  574. Lee, J. H. and Chung, I. K. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 4-1-2010;290:76-86. View abstract.
  575. Nardo, L., Andreoni, A., Bondani, M., Masson, M., and Hjorth, Tonnesen H. Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue. J Photochem.Photobiol.B 11-9-2009;97:77-86. View abstract.
  576. Hong, D., Zeng, X., Xu, W., Ma, J., Tong, Y., and Chen, Y. Altered profiles of gene expression in curcumin-treated rats with experimentally induced myocardial infarction. Pharmacol Res 2010;61:142-148. View abstract.
  577. Bernard, K., Wang, W., Narlawar, R., Schmidt, B., and Kirk, K. L. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol.Chem. 11-6-2009;284:30754-30765. View abstract.
  578. Golombick, T., Diamond, T. H., Badmaev, V., Manoharan, A., and Ramakrishna, R. The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker. Clin Cancer Res 9-15-2009;15:5917-5922. View abstract.
  579. Feng, J. Y. and Liu, Z. Q. Phenolic and enolic hydroxyl groups in curcumin: which plays the major role in scavenging radicals? J Agric.Food Chem. 11-25-2009;57:11041-11046. View abstract.
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  581. Sandur, S. K., Deorukhkar, A., Pandey, M. K., Pabon, A. M., Shentu, S., Guha, S., Aggarwal, B. B., and Krishnan, S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int.J Radiat.Oncol.Biol.Phys. 10-1-2009;75:534-542. View abstract.
  582. Anand, P., Nair, H. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., Tekmal, R. R., and Aggarwal, B. B. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem.Pharmacol 2-1-2010;79:330-338. View abstract.
  583. Leow, P. C., Tian, Q., Ong, Z. Y., Yang, Z., and Ee, P. L. Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/beta-catenin antagonists against human osteosarcoma cells. Invest New Drugs 9-3-2009; View abstract.
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  585. Seugnet, L., Galvin, J. E., Suzuki, Y., Gottschalk, L., and Shaw, P. J. Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease. Sleep 8-1-2009;32:984-992. View abstract.
  586. Bill, M. A., Bakan, C., Benson, D. M., Jr., Fuchs, J., Young, G., and Lesinski, G. B. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol.Cancer Ther. 2009;8:2726-2735. View abstract.
  587. Lee, Y. K., Park, S. Y., Kim, Y. M., and Park, O. J. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann.N.Y Acad.Sci. 2009;1171:489-494. View abstract.
  588. Reuter, S., Charlet, J., Juncker, T., Teiten, M. H., Dicato, M., and Diederich, M. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:436-447. View abstract.
  589. Clutterbuck, A. L., Mobasheri, A., Shakibaei, M., Allaway, D., and Harris, P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann.N.Y Acad.Sci. 2009;1171:428-435. View abstract.
  590. Teiten, M. H., Eifes, S., Reuter, S., Duvoix, A., Dicato, M., and Diederich, M. Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:391-398. View abstract.
  591. Patil, B. S., Jayaprakasha, G. K., Chidambara Murthy, K. N., and Vikram, A. Bioactive compounds: historical perspectives, opportunities, and challenges. J Agric.Food Chem. 9-23-2009;57:8142-8160. View abstract.
  592. Shytle, R. D., Bickford, P. C., Rezai-zadeh, K., Hou, L., Zeng, J., Tan, J., Sanberg, P. R., Sanberg, C. D., Roschek, B., Jr., Fink, R. C., and Alberte, R. S. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr.Alzheimer Res 2009;6:564-571. View abstract.
  593. Matsunaga, T., Endo, S., Soda, M., Zhao, H. T., El Kabbani, O., Tajima, K., and Hara, A. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem.Biophys.Res Commun. 11-6-2009;389:128-132. View abstract.
  594. Hie, M., Yamazaki, M., and Tsukamoto, I. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur.J Pharmacol 10-25-2009;621(1-3):1-9. View abstract.
  595. Koppolu, B., Rahimi, M., Nattama, S., Wadajkar, A., and Nguyen, K. T. Development of multiple-layer polymeric particles for targeted and controlled drug delivery. Nanomedicine. 2010;6:355-361. View abstract.
  596. Graham, A. Curcumin adds spice to the debate: lipid metabolism in liver disease. Br.J Pharmacol 2009;157:1352-1353. View abstract.
  597. Watson, J. L., Greenshields, A., Hill, R., Hilchie, A., Lee, P. W., Giacomantonio, C. A., and Hoskin, D. W. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Mol.Carcinog. 2010;49:13-24. View abstract.
  598. Koeberle, A., Northoff, H., and Werz, O. Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol.Cancer Ther. 2009;8:2348-2355. View abstract.
  599. Kim, T., Davis, J., Zhang, A. J., He, X., and Mathews, S. T. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem.Biophys.Res Commun. 10-16-2009;388:377-382. View abstract.
  600. Johnson, S. M., Gulhati, P., Arrieta, I., Wang, X., Uchida, T., Gao, T., and Evers, B. M. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res 2009;29:3185-3190. View abstract.
  601. Ray, B. and Lahiri, D. K. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr.Opin.Pharmacol 2009;9:434-444. View abstract.
  602. Girish, C., Koner, B. C., Jayanthi, S., Ramachandra, Rao K., Rajesh, B., and Pradhan, S. C. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam.Clin Pharmacol 2009;23:735-745. View abstract.
  603. Khafif, A., Lev-Ari, S., Vexler, A., Barnea, I., Starr, A., Karaush, V., Haif, S., and Ben Yosef, R. Curcumin: a potential radio-enhancer in head and neck cancer. Laryngoscope 2009;119:2019-2026. View abstract.
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  605. Jackson, L. N. and Evers, B. M. Regulation of proliferation, apoptosis and cell cycle in gastrointestinal disorders. Curr.Opin.Pharmacol 2009;9:708-714. View abstract.
  606. Seo, J. H., Jeong, K. J., Oh, W. J., Sul, H. J., Sohn, J. S., Kim, Y. K., Cho, do Y., Kang, J. K., Park, C. G., and Lee, H. Y. Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin. Cancer Lett. 2-1-2010;288:50-56. View abstract.
  607. Narala, V. R., Smith, M. R., Adapala, R. K., Ranga, R., Panati, K., Moore, B. B., Leff, T., Reddy, V. D., Kondapi, A. K., and Reddy, R. C. Curcumin is not a ligand for peroxisome proliferator-activated receptor-gamma. Gene Ther.Mol.Biol. 4-1-2009;13:20-25. View abstract.
  608. Boonjaraspinyo, S., Boonmars, T., Aromdee, C., Srisawangwong, T., Kaewsamut, B., Pinlaor, S., Yongvanit, P., and Puapairoj, A. Turmeric reduces inflammatory cells in hamster opisthorchiasis. Parasitol.Res 2009;105:1459-1463. View abstract.
  609. Yadav, R. S., Sankhwar, M. L., Shukla, R. K., Chandra, R., Pant, A. B., Islam, F., and Khanna, V. K. Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicol Appl.Pharmacol 11-1-2009;240:367-376. View abstract.
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  612. Hegge, A. B., Masson, M., Kristensen, S., and Tonnesen, H. H. Investigation of curcumin-cyclodextrin inclusion complexation in aqueous solutions containing various alcoholic co-solvents and alginates using an UV-VIS titration method. Studies of curcumin and curcuminoides, XXXV. Pharmazie 2009;64:382-389. View abstract.
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  614. Harikrishnan, R., Balasundaram, C., Kim, M. C., Kim, J. S., Han, Y. J., and Heo, M. S. Innate immune response and disease resistance in Carassius auratus by triherbal solvent extracts. Fish.Shellfish.Immunol. 2009;27:508-515. View abstract.
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  616. Kumar, A., Dogra, S., and Prakash, A. Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav.Brain Res 12-28-2009;205:384-390. View abstract.
  617. Ahmed, T., Tripathi, A. K., Suke, S. G., Kumar, V., Ahmed, R. S., Das, S., and Banerjee, B. D. Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: ameliorating effect of N-acetylcysteine and curcumin. Toxicol In Vitro 2009;23:1319-1325. View abstract.
  618. Samuhasaneeto, S., Thong-Ngam, D., Kulaputana, O., Suyasunanont, D., and Klaikeaw, N. Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. J Biomed.Biotechnol. 2009;2009:981963. View abstract.
  619. Ma, Q. L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., Vinters, H. V., Frautschy, S. A., and Cole, G. M. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 7-15-2009;29:9078-9089. View abstract.
  620. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2009;119:2113. View abstract.
  621. Kang, Q. and Chen, A. Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br.J Pharmacol 2009;157:1354-1367. View abstract.
  622. Jurenka, J. S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern.Med.Rev. 2009;14:141-153. View abstract.
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  624. Mei, X., Luo, X., Xu, S., Xu, D., Zheng, Y., Xu, S., and Lv, J. Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats. Chem.Biol.Interact. 10-30-2009;181:316-321. View abstract.
  625. Kurien, B. T. and Scofield, R. H. Curry spice curcumin and prostate cancer. Mol.Nutr.Food Res 2009;53:939-940. View abstract.
  626. Mathy-Hartert, M., Jacquemond-Collet, I., Priem, F., Sanchez, C., Lambert, C., and Henrotin, Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm.Res 2009;58:899-908. View abstract.
  627. Sumiyoshi, M. and Kimura, Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Phytomedicine. 2009;16:1137-1143. View abstract.
  628. An, J. B., Ma, J. X., Liu, D. Y., Gao, Y. J., Sheng, M. Y., Wang, H. X., and Liu, L. Y. [The effect of curcumin on DNA content, mitochondrial transmembrane potential and calcium of rabbit cultured retinal pigment epithelial cells]. Zhonghua Yan.Ke.Za Zhi. 2009;45:210-215. View abstract.
  629. Prasad, C. P., Rath, G., Mathur, S., Bhatnagar, D., and Ralhan, R. Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling. Chem.Biol.Interact. 10-7-2009;181:263-271. View abstract.
  630. Li, W., Wang, S., Feng, J., Xiao, Y., Xue, X., Zhang, H., Wang, Y., and Liang, X. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson.Chem. 2009;47:902-908. View abstract.
  631. DU, P., Li, X., Lin, H. J., Peng, W. F., Liu, J. Y., Ma, Y., Fan, W., and Wang, X. Curcumin inhibits amygdaloid kindled seizures in rats. Chin Med.J (Engl) 6-20-2009;122:1435-1438. View abstract.
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  633. Cheng, D. Q., Wo, X. D., Pan, P. L., Yu, S. B., and Xu, B. H. [Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus]. Zhong.Yao Cai. 2009;32:388-391. View abstract.
  634. Xiao, H., Zhang, K. J., and Zuo, X. L. [Reversal of multidrug resistance of the drug resistant human multiple myeloma cell line MOLP-2/R by curcumin and its relation with FA/BRCA pathway]. Zhonghua Xue.Ye.Xue.Za Zhi. 2009;30:33-37. View abstract.
  635. Srinivasan, L., Mathew, N., and Muthuswamy, K. In vitro antifilarial activity of glutathione S-transferase inhibitors. Parasitol.Res 2009;105:1179-1182. View abstract.
  636. Sarkar, N., Singh, A. N., and Dubey, V. K. Effect of curcumin on amyloidogenic property of molten globule-like intermediate state of 2,5-diketo-D-gluconate reductase A. Biol.Chem. 2009;390:1057-1061. View abstract.
  637. Shahiduzzaman, M., Dyachenko, V., Khalafalla, R. E., Desouky, A. Y., and Daugschies, A. Effects of curcumin on Cryptosporidium parvum in vitro. Parasitol.Res 2009;105:1155-1161. View abstract.
  638. Shu, J. C., He, Y. J., Lv, X., Ye, G. R., and Wang, L. X. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. J Nat.Med. 2009;63:415-420. View abstract.
  639. Mahfouz, M. M., Zhou, S. Q., and Kummerow, F. A. Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture. Prostaglandins Other Lipid Mediat. 2009;90(1-2):13-20. View abstract.
  640. Pan, C. J., Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents. Colloids Surf.B Biointerfaces. 10-15-2009;73:199-206. View abstract.
  641. Xu, Y., Lin, D., Li, S., Li, G., Shyamala, S. G., Barish, P. A., Vernon, M. M., Pan, J., and Ogle, W. O. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology 2009;57:463-471. View abstract.
  642. Sompamit, K., Kukongviriyapan, U., Nakmareong, S., Pannangpetch, P., and Kukongviriyapan, V. Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. Eur.J Pharmacol 8-15-2009;616(1-3):192-199. View abstract.
  643. Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic.Biol.Med. 10-1-2009;47:924-931. View abstract.
  644. Xie, L., Li, X. K., Funeshima-Fuji, N., Kimura, H., Matsumoto, Y., Isaka, Y., and Takahara, S. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int.Immunopharmacol. 2009;9:575-581. View abstract.
  645. Katz, P. S., Trask, A. J., and Lucchesi, P. A. Curcuminoids: Spicing up sympathovagal tone. Nutrition 2009;25(7-8):879-880. View abstract.
  646. Smitha, S., Dhananjaya, B. L., Dinesha, R., and Srinivas, L. Purification and characterization of a approximately 34 kDa antioxidant protein (beta-turmerin) from turmeric (Curcuma longa) waste grits. Biochimie 2009;91:1156-1162. View abstract.
  647. Sampaio, F. J. Anti-neoplastic activity of curcumin in PCa. Int.Braz.J Urol. 2009;35:254-255. View abstract.
  648. Khan, M. S., Priyadarshini, M., and Bano, B. Preventive effect of curcumin and quercetin against nitric oxide mediated modification of goat lung cystatin. J Agric.Food Chem. 7-22-2009;57:6055-6059. View abstract.
  649. Shutava, T. G., Balkundi, S. S., Vangala, P., Steffan, J. J., Bigelow, R. L., Cardelli, J. A., O'Neal, D. P., and Lvov, Y. M. Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. ACS Nano. 6-17-2009; View abstract.
  650. Kim, H. J. and Jang, Y. P. Direct analysis of curcumin in turmeric by DART-MS. Phytochem.Anal. 2009;20:372-377. View abstract.
  651. Kurien, B. T. Comment on Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric.Food Chem. 6-24-2009;57:5644-5646. View abstract.
  652. Liu, Q., Loo, W. T., Sze, S. C., and Tong, Y. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine. 2009;16:916-922. View abstract.
  653. Kurien, B. T. and Scofield, R. H. Increasing aqueous solubility of curcumin for improving bioavailability. Trends Pharmacol Sci. 2009;30:334-335. View abstract.
  654. Binion, D. G., Heidemann, J., Li, M. S., Nelson, V. M., Otterson, M. F., and Rafiee, P. Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. Am.J Physiol Gastrointest.Liver Physiol 2009;297:G259-G268. View abstract.
  655. Hanai, H. and Sugimoto, K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr.Pharm Des 2009;15:2087-2094. View abstract.
  656. Gupta, V., Aseh, A., Rios, C. N., Aggarwal, B. B., and Mathur, A. B. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int.J Nanomedicine. 2009;4:115-122. View abstract.
  657. Ung, V. Y., Foshaug, R. R., MacFarlane, S. M., Churchill, T. A., Doyle, J. S., Sydora, B. C., and Fedorak, R. N. Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD. Dig.Dis.Sci. 2010;55:1272-1277. View abstract.
  658. Lu, H. F., Lai, K. C., Hsu, S. C., Lin, H. J., Yang, M. D., Chen, Y. L., Fan, M. J., Yang, J. S., Cheng, P. Y., Kuo, C. L., and Chung, J. G. Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells. Oncol.Rep. 2009;22:97-104. View abstract.
  659. Liu, Z. J., Han, G., Yu, J. G., and Dai, H. G. [Preparation and drug releasing property of curcumin nanoparticles]. Zhong.Yao Cai. 2009;32:277-279. View abstract.
  660. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81:73-78. View abstract.
  661. Bisht, S. and Maitra, A. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr.Drug Discov.Technol. 2009;6:192-199. View abstract.
  662. Jang, H. S., Nam, H. Y., Kim, J. M., Hahm, D. H., Nam, S. H., Kim, K. L., Joo, J. R., Suh, W., Park, J. S., Kim, D. K., and Gwon, H. C. Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model. Catheter.Cardiovasc.Interv. 11-15-2009;74:881-888. View abstract.
  663. Mohammadi, F., Bordbar, A. K., Divsalar, A., Mohammadi, K., and Saboury, A. A. Analysis of binding interaction of curcumin and diacetylcurcumin with human and bovine serum albumin using fluorescence and circular dichroism spectroscopy. Protein J 2009;28(3-4):189-196. View abstract.
  664. Mulik, R., Mahadik, K., and Paradkar, A. Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study. Eur.J Pharm Sci. 6-28-2009;37(3-4):395-404. View abstract.
  665. Shaikh, J., Ankola, D. D., Beniwal, V., Singh, D., and Kumar, M. N. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur.J Pharm Sci. 6-28-2009;37(3-4):223-230. View abstract.
  666. Li, J., Jiang, Y., Wen, J., Fan, G., Wu, Y., and Zhang, C. A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome. Biomed.Chromatogr. 2009;23:1201-1207. View abstract.
  667. Seehofer, D., Schirmeier, A., Bengmark, S., Carter, J., Koch, M., Glanemann, M., Nussler, A. K., Neuhaus, P., and Menger, M. D. Inhibitory effect of curcumin on early liver regeneration following partial hepatectomy in rats. J Surg.Res 2009;155:195-200. View abstract.
  668. Adaramoye, O. A., Anjos, R. M., Almeida, M. M., Veras, R. C., Silvia, D. F., Oliveira, F. A., Cavalcante, K. V., Araujo, I. G., Oliveira, A. P., and Medeiros, I. A. Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Curcuma longa L. in rats. J Ethnopharmacol. 7-30-2009;124:457-462. View abstract.
  669. Manikandan, R., Thiagarajan, R., Beulaja, S., Chindhu, S., Mariammal, K., Sudhandiran, G., and Arumugam, M. Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens. Chem.Biol.Interact. 10-7-2009;181:202-209. View abstract.
  670. Rawal, R. C., Shah, B. J., Jayaraaman, A. M., and Jaiswal, V. Clinical evaluation of an Indian polyherbal topical formulation in the management of eczema. J Altern.Complement Med. 2009;15:669-672. View abstract.
  671. Lin, S. S., Lai, K. C., Hsu, S. C., Yang, J. S., Kuo, C. L., Lin, J. P., Ma, Y. S., Wu, C. C., and Chung, J. G. Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF). Cancer Lett. 11-28-2009;285:127-133. View abstract.
  672. Fang, X. D., Yang, F., Zhu, L., Shen, Y. L., Wang, L. L., and Chen, Y. Y. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp.Pharmacol Physiol 2009;36:1177-1182. View abstract.
  673. Merrell, J. G., McLaughlin, S. W., Tie, L., Laurencin, C. T., Chen, A. F., and Nair, L. S. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp.Pharmacol Physiol 2009;36:1149-1156. View abstract.
  674. Sharma, M., Manoharlal, R., Shukla, S., Puri, N., Prasad, T., Ambudkar, S. V., and Prasad, R. Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob.Agents Chemother. 2009;53:3256-3265. View abstract.
  675. Jang, J. Y., Lee, J. H., Jeong, S. Y., Chung, K. T., Choi, Y. H., and Choi, B. T. Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells. Exp.Dermatol. 2009;18:689-694. View abstract.
  676. Wang, J., Du, X. X., Jiang, H., and Xie, J. X. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem.Pharmacol 7-15-2009;78:178-183. View abstract.
  677. Wang, S. L., Li, Y., Wen, Y., Chen, Y. F., Na, L. X., Li, S. T., and Sun, C. H. Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomed.Environ.Sci. 2009;22:32-39. View abstract.
  678. Deng, Y. T., Chen, H. M., Cheng, S. J., Chiang, C. P., and Kuo, M. Y. Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin. Oral Oncol. 2009;45:e99-e105. View abstract.
  679. Shin, H. W., Park, S. Y., Lee, K. B., and Jang, J. J. Down-regulation of Wnt signaling during apoptosis of human hepatic stellate cells. Hepatogastroenterology 2009;56:208-212. View abstract.
  680. Cai, X. Z., Wang, J., Li, X. D., Wang, G. L., Liu, F. N., Cheng, M. S., and Li, F. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biol.Ther. 2009;8:1360-1368. View abstract.
  681. Yu, Y. M. and Lin, H. C. Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr.Metab Cardiovasc.Dis. 2010;20:125-132. View abstract.
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  684. Mishra, R. K. and Singh, S. K. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 2009;79:479-487. View abstract.
  685. Dutta, K., Ghosh, D., and Basu, A. Curcumin protects neuronal cells from Japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system. J Neuroimmune.Pharmacol 2009;4:328-337. View abstract.
  686. Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Espinosa-Jeffrey, A., Mahanian, M., Liu, P. T., Hewison, M., Mizwickie, M., Cashman, J., and Fiala, M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2009;17:703-717. View abstract.
  687. Pae, H. O., Jeong, S. O., Zheng, M., Ha, H. Y., Lee, K. M., Kim, E. C., Kim, D. H., Hwang, S. Y., and Chung, H. T. Curcumin attenuates ethanol-induced toxicity in HT22 hippocampal cells by activating mitogen-activated protein kinase phosphatase-1. Neurosci.Lett. 4-10-2009;453:186-189. View abstract.
  688. Kita, T., Imai, S., Sawada, H., and Seto, H. Isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (Curcuma longa). Biosci.Biotechnol.Biochem. 2009;73:1113-1117. View abstract.
  689. Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., Choi, H., Min, J. S., Kim, Y. S., Yoon, S. W., and Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 7-15-2009;124:189-196. View abstract.
  690. Wichitnithad, W., Jongaroonngamsang, N., Pummangura, S., and Rojsitthisak, P. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochem.Anal. 2009;20:314-319. View abstract.
  691. Sahu, R. P., Batra, S., and Srivastava, S. K. Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br.J Cancer 5-5-2009;100:1425-1433. View abstract.
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  694. Chin, S. F., Iyer, K. S., Saunders, M., St Pierre, T. G., Buckley, C., Paskevicius, M., and Raston, C. L. Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs. Chemistry 6-2-2009;15:5661-5665. View abstract.
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  696. Mendonca, L. M., Dos Santos, G. C., Antonucci, G. A., Dos Santos, A. C., Bianchi, Mde L., and Antunes, L. M. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat.Res 4-30-2009;675(1-2):29-34. View abstract.
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  700. Jancinova, V., Perecko, T., Nosal, R., Kostalova, D., Bauerova, K., and Drabikova, K. Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition. Eur.J Pharmacol 6-10-2009;612(1-3):161-166. View abstract.
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  703. Hegde, M. L., Bharathi, P., Suram, A., Venugopal, C., Jagannathan, R., Poddar, P., Srinivas, P., Sambamurti, K., Rao, K. J., Scancar, J., Messori, L., Zecca, L., and Zatta, P. Challenges associated with metal chelation therapy in Alzheimer's disease. J Alzheimers.Dis. 2009;17:457-468. View abstract.
  704. Dance-Barnes, S. T., Kock, N. D., Moore, J. E., Lin, E. Y., Mosley, L. J., D'Agostino, R. B., Jr., McCoy, T. P., Townsend, A. J., and Miller, M. S. Lung tumor promotion by curcumin. Carcinogenesis 2009;30:1016-1023. View abstract.
  705. Herebian, D., Choi, J. H., Abd El-Aty, A. M., Shim, J. H., and Spiteller, M. Metabolite analysis in Curcuma domestica using various GC-MS and LC-MS separation and detection techniques. Biomed.Chromatogr. 2009;23:951-965. View abstract.
  706. Sanderson, R. O., Beata, C., Flipo, R. M., Genevois, J. P., Macias, C., Tacke, S., Vezzoni, A., and Innes, J. F. Systematic review of the management of canine osteoarthritis. Vet.Rec. 4-4-2009;164:418-424. View abstract.
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  709. Bas, M., Tugcu, V., Kemahli, E., Ozbek, E., Uhri, M., Altug, T., and Tasci, A. I. Curcumin prevents shock-wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats. Urol.Res 2009;37:159-164. View abstract.
  710. Chaturvedi, T. P. Uses of turmeric in dentistry: an update. Indian J Dent.Res 2009;20:107-109. View abstract.
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  712. Ji, H. F. and Shen, L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg.Med.Chem.Lett. 5-1-2009;19:2453-2455. View abstract.
  713. Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., and Islam, F. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). Eur.Neuropsychopharmacol. 2009;19:636-647. View abstract.
  714. Avagyan, H., Goldenson, B., Tse, E., Masoumi, A., Porter, V., Wiedau-Pazos, M., Sayre, J., Ong, R., Mahanian, M., Koo, P., Bae, S., Micic, M., Liu, P. T., Rosenthal, M. J., and Fiala, M. Immune blood biomarkers of Alzheimer disease patients. J.Neuroimmunol. 5-29-2009;210(1-2):67-72. View abstract.
  715. Kim, W., Fan, Y. Y., Smith, R., Patil, B., Jayaprakasha, G. K., McMurray, D. N., and Chapkin, R. S. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J Nutr. 2009;139:1042-1048. View abstract.
  716. Seehofer, D., Schirmeier, A., Bengmark, S., Cho, S. Y., Koch, M., Lederer, A., Rayes, N., Menger, M. D., Neuhaus, P., and Nussler, A. K. Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats. J Surg.Res 2010;159:497-502. View abstract.
  717. Leung, M. H. and Kee, T. W. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir 5-19-2009;25:5773-5777. View abstract.
  718. Ali, M. S., Mudagal, M. P., and Goli, D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie 2009;64:132-136. View abstract.
  719. Lam, J. B., Chow, K. H., Xu, A., Lam, K. S., Liu, J., Wong, N. S., Moon, R. T., Shepherd, P. R., Cooper, G. J., and Wang, Y. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS.One. 2009;4:e4968. View abstract.
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  722. Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., and Kong, L. D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog.Neuropsychopharmacol.Biol.Psychiatry 4-30-2009;33:435-449. View abstract.
  723. Tang, Y., Zheng, S., and Chen, A. Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009;150:3011-3020. View abstract.
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  725. Wang, J. B., Qi, L. L., Zheng, S. D., Wang, H. Z., and Wu, T. X. Curcumin suppresses PPARdelta expression and related genes in HT-29 cells. World J Gastroenterol. 3-21-2009;15:1346-1352. View abstract.
  726. Heo, H. J., Lee, S. Y., Lee, M. N., Lee, H. J., Seok, J. H., and Lee, C. J. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother.Res 2009;23:1458-1461. View abstract.
  727. Chiu, T. L. and Su, C. C. Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells. Int.J Mol.Med. 2009;23:469-475. View abstract.
  728. Arafa, H. M., Hemeida, R. A., El Bahrawy, A. I., and Hamada, F. M. Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model. Food Chem.Toxicol 2009;47:1311-1317. View abstract.
  729. Zhang, J., Jinnai, S., Ikeda, R., Wada, M., Hayashida, S., and Nakashima, K. A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products. Anal.Sci. 2009;25:385-388. View abstract.
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  732. Rezende, L. F., Vieira, A. S., Negro, A., Langone, F., and Boschero, A. C. Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine 2009;46:65-71. View abstract.
  733. Pullakhandam, R., Srinivas, P. N., Nair, M. K., and Reddy, G. B. Binding and stabilization of transthyretin by curcumin. Arch.Biochem.Biophys. 5-15-2009;485:115-119. View abstract.
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  735. Chen, Q., Lu, G., Wang, Y., Xu, Y., Zheng, Y., Yan, L., Jiang, Z., Yang, L., Zhan, J., Wu, Y., and Zhou, J. Cytoskeleton disorganization during apoptosis induced by curcumin in A549 lung adenocarcinoma cells. Planta Med. 2009;75:808-813. View abstract.
  736. Capini, C., Jaturanpinyo, M., Chang, H. I., Mutalik, S., McNally, A., Street, S., Steptoe, R., O'Sullivan, B., Davies, N., and Thomas, R. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 3-15-2009;182:3556-3565. View abstract.
  737. Lu, H. F., Yang, J. S., Lai, K. C., Hsu, S. C., Hsueh, S. C., Chen, Y. L., Chiang, J. H., Lu, C. C., Lo, C., Yang, M. D., and Chung, J. G. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18). Neurochem.Res 2009;34:1491-1497. View abstract.
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  739. Barry, J., Fritz, M., Brender, J. R., Smith, P. E., Lee, D. K., and Ramamoorthy, A. Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am.Chem.Soc. 4-1-2009;131:4490-4498. View abstract.
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  744. Isik, A. T., Celik, T., Ulusoy, G., Ongoru, O., Elibol, B., Doruk, H., Bozoglu, E., Kayir, H., Mas, M. R., and Akman, S. Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model. Age (Dordr.) 2009;31:39-49. View abstract.
  745. Wongcharoen, W. and Phrommintikul, A. The protective role of curcumin in cardiovascular diseases. Int.J Cardiol. 4-3-2009;133:145-151. View abstract.
  746. Ghosh, A. K., Kay, N. E., Secreto, C. R., and Shanafelt, T. D. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 2-15-2009;15:1250-1258. View abstract.
  747. Gouda, E. M., Elbehairy, A. M., and Ghoneim, M. A. Antimutagenic efficacy of some natural compounds on cyclophosphamide-induced p53 alterations. Z.Naturforsch.C. 2008;63(11-12):857-863. View abstract.
  748. Harikumar, K. B., Kuttan, G., and Kuttan, R. Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. J Exp.Ther.Oncol. 2008;7:275-284. View abstract.
  749. Yadav, V. R., Suresh, S., Devi, K., and Yadav, S. Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol 2009;61:311-321. View abstract.
  750. Cohen, A. N., Veena, M. S., Srivatsan, E. S., and Wang, M. B. Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase. Arch.Otolaryngol.Head Neck Surg. 2009;135:190-197. View abstract.
  751. Mishra, K., Dash, A. P., Swain, B. K., and Dey, N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar.J 2009;8:26. View abstract.
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  753. Al Zanbagi, N. A. and Zelai, N. T. Two methods for attenuating Toxoplasma gondii tachyzoites RH strain by using ethanol extract of Curcuma longa. J Egypt Soc.Parasitol. 2008;38:965-976. View abstract.
  754. De, R., Kundu, P., Swarnakar, S., Ramamurthy, T., Chowdhury, A., Nair, G. B., and Mukhopadhyay, A. K. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob.Agents Chemother. 2009;53:1592-1597. View abstract.
  755. Kim, Y., Lee, J. H., Ryu, J., and Kim, D. J. Multivalent & multifunctional ligands to beta-amyloid. Curr.Pharm Des 2009;15:637-658. View abstract.
  756. Nakagawa, M. [Hereditary neuropathy: recent advance]. Rinsho Shinkeigaku 2008;48:1019-1022. View abstract.
  757. Kurien, B. T. and Scofield, R. H. Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification. Mol.Nutr.Food Res 2009;53:308. View abstract.
  758. Glienke, W., Maute, L., Wicht, J., and Bergmann, L. Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells. Eur.J Cancer 2009;45:874-880. View abstract.
  759. Sun, A. Y., Wang, Q., Simonyi, A., and Sun, G. Y. Botanical phenolics and brain health. Neuromolecular.Med. 2008;10:259-274. View abstract.
  760. Mohammadi, F., Bordbar, A. K., Divsalar, A., Mohammadi, K., and Saboury, A. A. Interaction of curcumin and diacetylcurcumin with the lipocalin member beta-lactoglobulin. Protein J 2009;28(3-4):117-123. View abstract.
  761. Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N., Tungsinmunkong, K., and Bouking, P. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. Phytomedicine. 2009;16:342-351. View abstract.
  762. Sun, Y., Hung, W. C., Chen, F. Y., Lee, C. C., and Huang, H. W. Interaction of tea catechin (-)-epigallocatechin gallate with lipid bilayers. Biophys.J 2009;96:1026-1035. View abstract.
  763. Braumann, C., Guenther, N., Loeffler, L. M., and Dubiel, W. Liver metastases after colonic carcinoma--palliative chemotherapy plus curcumin. Int.J Colorectal Dis. 2009;24:859-860. View abstract.
  764. Lavoie, S., Chen, Y., Dalton, T. P., Gysin, R., Cuenod, M., Steullet, P., and Do, K. Q. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem. 2009;108:1410-1422. View abstract.
  765. Beevers, C. S., Chen, L., Liu, L., Luo, Y., Webster, N. J., and Huang, S. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res 2-1-2009;69:1000-1008. View abstract.
  766. Yu, Y., Hu, S. K., and Yan, H. [The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42:818-822. View abstract.
  767. Zhou, H., Li, X., and Gao, M. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol 2009;104:236-240. View abstract.
  768. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats. Life Sci. 3-13-2009;84(11-12):372-379. View abstract.
  769. Inoue, K., Nakagawa, A., Hino, T., and Oka, H. Screening assay for metal-catalyzed oxidation inhibitors using liquid chromatography-mass spectrometry with an N-terminal beta-amyloid peptide. Anal.Chem. 3-1-2009;81:1819-1825. View abstract.
  770. Dai, F., Chen, W. F., Zhou, B., Yang, L., and Liu, Z. L. Antioxidative effects of curcumin and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. Phytother.Res 2009;23:1220-1228. View abstract.
  771. Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Odajima, N., Moriyama, C., Nasuhara, Y., and Nishimura, M. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am.J Physiol Lung Cell Mol.Physiol 2009;296:L614-L623. View abstract.
  772. Iqbal, M., Okazaki, Y., and Okada, S. Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. Mol.Cell Biochem. 2009;324(1-2):157-164. View abstract.
  773. Conboy, L., Foley, A. G., O'Boyle, N. M., Lawlor, M., Gallagher, H. C., Murphy, K. J., and Regan, C. M. Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats. Biochem.Pharmacol 4-1-2009;77:1254-1265. View abstract.
  774. Khalooghi, K., Hashemi, S., Mehraban, N., Amiri, P., Bazzaz, J. T., Larijani, B., and Amoli, M. M. In vitro modulation of TCF7L2 gene expression in human pancreatic cells. Mol.Biol.Rep. 2009;36:2329-2332. View abstract.
  775. Srivastava, G. and Mehta, J. L. Currying the heart: curcumin and cardioprotection. J Cardiovasc.Pharmacol Ther. 2009;14:22-27. View abstract.
  776. Lin, Y. L., Lin, C. Y., Chi, C. W., and Huang, Y. T. Study on antifibrotic effects of curcumin in rat hepatic stellate cells. Phytother.Res 2009;23:927-932. View abstract.
  777. Marczylo, T. H., Steward, W. P., and Gescher, A. J. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric.Food Chem. 2-11-2009;57:797-803. View abstract.
  778. Alwi, I., Santoso, T., Suyono, S., Sutrisna, B., Suyatna, F. D., Kresno, S. B., and Ernie, S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med.Indones. 2008;40:201-210. View abstract.
  779. Kurien, B. T. and Scofield, R. H. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 1-15-2009;15:747. View abstract.
  780. Shoheib, Z. S., El Nouby, K. A., Deyab, F. A., Dar, Y. D., and Kabbash, A. M. Potential effect of Curcuma longa extract on infectivity and pathogenicity of Schistosoma mansoni cercariae. J Egypt Soc.Parasitol. 2008;38:141-159. View abstract.
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  784. Farinacci, M., Colitti, M., and Stefanon, B. Modulation of ovine neutrophil function and apoptosis by standardized extracts of Echinacea angustifolia, Butea frondosa and Curcuma longa. Vet.Immunol.Immunopathol. 4-15-2009;128:366-373. View abstract.
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  787. Adaramoye, O. A. and Medeiros, I. A. Involvement of Na(+)-Ca exchanger in the endothelium-independent vasorelaxation induced by Curcuma longa L. in isolated rat superior mesenteric arteries. J Smooth Muscle Res 2008;44:151-158. View abstract.
  788. Mandal, M. N., Patlolla, J. M., Zheng, L., Agbaga, M. P., Tran, J. T., Wicker, L., Kasus-Jacobi, A., Elliott, M. H., Rao, C. V., and Anderson, R. E. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic.Biol.Med. 3-1-2009;46:672-679. View abstract.
  789. Cucuzza, L. S., Motta, M., Miretti, S., Accornero, P., and Baratta, M. Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling. Exp.Mol.Med. 12-31-2008;40:647-657. View abstract.
  790. Zhang, K. S., Li, G. C., He, Y. W., Yi, Y. M., Liao, S. L., Wang, Z., and Du, J. [Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells]. Zhong.Yao Cai. 2008;31:1207-1211. View abstract.
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  793. Jyoti, A., Sethi, P., and Sharma, D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav. 2009;14:300-308. View abstract.
  794. Magalhaes, L. G., Machado, C. B., Morais, E. R., Moreira, E. B., Soares, C. S., da Silva, S. H., Silva Filho, A. A., and Rodrigues, V. In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. Parasitol.Res 2009;104:1197-1201. View abstract.
  795. Di Giorgio, A. M., Hou, Y., Zhao, X., Zhang, B., Lyeth, B. G., and Russell, M. J. Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model. Restor.Neurol.Neurosci. 2008;26:501-507. View abstract.
  796. Kwon, Y. and Magnuson, B. A. Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats. Food Chem.Toxicol 2009;47:377-385. View abstract.
  797. Lee, Y. K., Lee, W. S., Hwang, J. T., Kwon, D. Y., Surh, Y. J., and Park, O. J. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric.Food Chem. 1-14-2009;57:305-310. View abstract.
  798. Tian, Y. M., Zhou, D., Zhang, W., and Cheng, C. G. [Comparison and correlative analysis of trace elements in five kinds of radix curcumae]. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. 2008;28:2192-2195. View abstract.
  799. Cashman, J. R., Ghirmai, S., Abel, K. J., and Fiala, M. Immune defects in Alzheimer's disease: new medications development. BMC.Neurosci. 2008;9 Suppl 2:S13. View abstract.
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  801. Conney, A. H., Lysz, T., Ferraro, T., Abidi, T. F., Manchand, P. S., Laskin, J. D., and Huang, M. T. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. Adv.Enzyme Regul. 1991;31:385-396. View abstract.
  802. Li, X., Hu, Y. B., and Peng, J. W. [Silicon dioxide-upregulated plasminogen activators inhibitor-1 protein expression is dependent on activation of extracellular signal-regulated kinase/activator protein-1 signaling pathway]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:387-390. View abstract.
  803. Shapiro, H. and Bruck, R. Therapeutic potential of curcumin in non-alcoholic steatohepatitis. Nutr.Res Rev. 2005;18:212-221. View abstract.
  804. Ono, K., Hirohata, M., and Yamada, M. Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders. Curr.Pharm Des 2008;14:3247-3266. View abstract.
  805. Rafiee, P., Nelson, V. M., Manley, S., Wellner, M., Floer, M., Binion, D. G., and Shaker, R. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Am.J Physiol Gastrointest.Liver Physiol 2009;296:G388-G398. View abstract.
  806. Farooqui, T. and Farooqui, A. A. Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech.Ageing Dev. 2009;130:203-215. View abstract.
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  808. Priya, S. and Sudhakaran, P. R. Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. Indian J Biochem.Biophys. 2008;45:317-325. View abstract.
  809. Zhu, R. F., Zhou, M., He, J. L., Ding, F. Y., Yu, S. Q., and Xu, G. L. [Protective effect of curcumin on oleic-induced acute lung injury in rats]. Zhongguo Zhong.Yao Za Zhi. 2008;33:2141-2145. View abstract.
  810. Liu, A. C., Zhao, L. X., Zhai, G. X., Lou, H. X., and Du, J. S. [An investigation on formation mechanisms and preparation of curcumin phospholipid complex]. Zhongguo Zhong.Yao Za Zhi. 2008;33:2112-2117. View abstract.
  811. Chen, Z., Zhu, L., Song, T., Chen, J., and Guo, Z. A novel curcumin assay with the metal ion Cu (II) as a simple probe by resonance light scattering technique. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2009;72:518-522. View abstract.
  812. Madden, K., Flowers, L., Salani, R., Horowitz, I., Logan, S., Kowalski, K., Xie, J., and Mohammed, S. I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot.Essent.Fatty Acids 2009;80:9-18. View abstract.
  813. Verma, R. J., Chakraborty, B. S., Patel, C., and Mathuria, N. Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice. Acta Pol.Pharm 2008;65:415-419. View abstract.
  814. Girish, C. and Pradhan, S. C. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. Fundam.Clin Pharmacol 2008;22:623-632. View abstract.
  815. Martins, C. V., da Silva, D. L., Neres, A. T., Magalhaes, T. F., Watanabe, G. A., Modolo, L. V., Sabino, A. A., de Fatima, A., and de Resende, M. A. Curcumin as a promising antifungal of clinical interest. J Antimicrob.Chemother. 2009;63:337-339. View abstract.
  816. Krasovsky, J., Chang, D. H., Deng, G., Yeung, S., Lee, M., Leung, P. C., Cunningham-Rundles, S., Cassileth, B., and Dhodapkar, M. V. Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa). Planta Med. 2009;75:312-315. View abstract.
  817. Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., and Kondo, T. Effect of dietary turmeric on breath hydrogen. Dig.Dis.Sci. 2009;54:1725-1729. View abstract.
  818. Rastogi, M., Ojha, R. P., Rajamanickam, G. V., Agrawal, A., Aggarwal, A., and Dubey, G. P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. Free Radic.Res 2008;42(11-12):999-1005. View abstract.
  819. Sharma, D., Sethi, P., Hussain, E., and Singh, R. Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions. Biogerontology. 2009;10:489-502. View abstract.
  820. Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., and Wan, Y. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol.Rep. 2008;20:1553-1559. View abstract.
  821. Choi, H., Chun, Y. S., Shin, Y. J., Ye, S. K., Kim, M. S., and Park, J. W. Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT. Cancer Sci. 2008;99:2518-2524. View abstract.
  822. Cao, J., Liu, Y., Jia, L., Jiang, L. P., Geng, C. Y., Yao, X. F., Kong, Y., Jiang, B. N., and Zhong, L. F. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric.Food Chem. 12-24-2008;56:12059-12063. View abstract.
  823. Kozuki, Y., Miura, Y., and Yagasaki, K. Inhibitory effect of curcumin on the invasion of rat ascites hepatoma cells in vitro and ex vivo. Cytotechnology 2001;35:57-63. View abstract.
  824. Guzel, A., Kanter, M., Aksu, B., Basaran, U. N., Yalcin, O., Guzel, A., Uzun, H., Konukoglu, D., and Karasalihoglu, S. Preventive effects of curcumin on different aspiration material-induced lung injury in rats. Pediatr.Surg.Int. 2009;25:83-92. View abstract.
  825. Lubbad, A., Oriowo, M. A., and Khan, I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol.Cell Biochem. 2009;322(1-2):127-135. View abstract.
  826. Ryu, M. J., Cho, M., Song, J. Y., Yun, Y. S., Choi, I. W., Kim, D. E., Park, B. S., and Oh, S. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem.Biophys.Res Commun. 12-26-2008;377:1304-1308. View abstract.
  827. Rosello, D. M., Balestrasse, K., Coll, C., Coll, S., Tallis, S., Gurni, A., Tomaro, M. L., Lemberg, A., and Perazzo, J. C. Oxidative stress and hippocampus in a low-grade hepatic encephalopathy model: protective effects of curcumin. Hepatol.Res 2008;38:1148-1153. View abstract.
  828. Cutler, W. B. Re: Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cell. Menopause. 2008;15:1195. View abstract.
  829. Agrawal, D. K., Saikia, D., Tiwari, R., Ojha, S., Shanker, K., Kumar, J. K., Gupta, A. K., Tandon, S., Negi, A. S., and Khanuja, S. P. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008;74:1828-1831. View abstract.
  830. Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 2-1-1991;51:813-819. View abstract.
  831. Quitschke, W. W. Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications. BMC.Biotechnol. 2008;8:84. View abstract.
  832. Ng, S. C. and Kamm, M. A. Therapeutic strategies for the management of ulcerative colitis. Inflamm.Bowel.Dis. 2009;15:935-950. View abstract.
  833. Jain, S. K., Rains, J., Croad, J., Larson, B., and Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid.Redox.Signal. 2009;11:241-249. View abstract.
  834. Chang, L. Y., Wan, H. C., Lai, Y. L., Kuo, Y. F., Liu, T. Y., Chen, Y. T., and Hung, S. L. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. J Periodontal Res 2009;44:175-183. View abstract.
  835. Liu, Y., Yang, Z., Du, J., Yao, X., Lei, R., Zheng, X., Liu, J., Hu, H., and Li, H. Interaction of curcumin with intravenous immunoglobulin: a fluorescence quenching and Fourier transformation infrared spectroscopy study. Immunobiology 2008;213:651-661. View abstract.
  836. Nanditha, B. and Prabhasankar, P. Antioxidants in bakery products: a review. Crit Rev.Food Sci.Nutr. 2009;49:1-27. View abstract.
  837. Harikrishnan, R. and Balasundaram, C. In vitro and in vivo studies of the use of some medicinal herbals against the pathogen Aeromonas hydrophila in goldfish. J Aquat.Anim Health 2008;20:165-176. View abstract.
  838. Jang, E. M., Choi, M. S., Jung, U. J., Kim, M. J., Kim, H. J., Jeon, S. M., Shin, S. K., Seong, C. N., and Lee, M. K. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism 2008;57:1576-1583. View abstract.
  839. Muriel, P. NF-kappaB in liver diseases: a target for drug therapy. J Appl.Toxicol 2009;29:91-100. View abstract.
  840. Ahmed, T. and Gilani, A. H. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem.Behav. 2009;91:554-559. View abstract.
  841. Youn, Y. N., Lim, E., Lee, N., Kim, Y. S., Koo, M. S., and Choi, S. Y. Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro. Genes Nutr. 2008;2:375-380. View abstract.
  842. Chen, D., Nie, M., Fan, M. W., and Bian, Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology 2008;82:264-269. View abstract.
  843. Shukla, S., Zaher, H., Hartz, A., Bauer, B., Ware, J. A., and Ambudkar, S. V. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res 2009;26:480-487. View abstract.
  844. Chen, C., Johnston, T. D., Jeon, H., Gedaly, R., McHugh, P. P., Burke, T. G., and Ranjan, D. An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells. Int.J Pharm 1-21-2009;366(1-2):133-139. View abstract.
  845. Zhang, L. J., Wu, C. F., Meng, X. L., Yuan, D., Cai, X. D., Wang, Q. L., and Yang, J. Y. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neurosci.Lett. 12-5-2008;447:48-53. View abstract.
  846. Zhao, C. J., Niu, J. Z., Wang, J. F., Zhou, G., and Tang, B. H. [Effects of curcumin on bleomycin-induced damages in pulmonary functions in rats]. Zhongguo Zhong.Yao Za Zhi. 2008;33:1434-1438. View abstract.
  847. Lubbad, A. S., Oriowo, M. A., and Khan, I. Curcumin reverses attenuated carbachol-induced contraction of the colon in a rat model of colitis. Scand.J Gastroenterol. 2009;44:187-194. View abstract.
  848. Dohare, P., Garg, P., Sharma, U., Jagannathan, N. R., and Ray, M. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC.Complement Altern.Med. 2008;8:55. View abstract.
  849. Inoue, K., Nomura, C., Ito, S., Nagatsu, A., Hino, T., and Oka, H. Purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography. J Agric.Food Chem. 10-22-2008;56:9328-9336. View abstract.
  850. Wang, L. Y., Zhang, M., Zhang, C. F., and Wang, Z. T. Alkaloid and sesquiterpenes from the root tuber of Curcuma longa. Yao Xue.Xue.Bao. 2008;43:724-727. View abstract.
  851. Larmonier, C. B., Uno, J. K., Lee, K. M., Karrasch, T., Laubitz, D., Thurston, R., Midura-Kiela, M. T., Ghishan, F. K., Sartor, R. B., Jobin, C., and Kiela, P. R. Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection. Am.J Physiol Gastrointest.Liver Physiol 2008;295:G1079-G1091. View abstract.
  852. Barnes, P. J. Role of HDAC2 in the pathophysiology of COPD. Annu.Rev.Physiol 2009;71:451-464. View abstract.
  853. Tajik, H., Tamaddonfard, E., and Hamzeh-Gooshchi, N. The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. Pak.J Biol.Sci. 1-15-2008;11:312-314. View abstract.
  854. Moosajee, M., Gregory-Evans, K., Ellis, C. D., Seabra, M. C., and Gregory-Evans, C. Y. Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum.Mol.Genet. 12-15-2008;17:3987-4000. View abstract.
  855. Kapoor, P., Ansari, M. N., and Bhandari, U. Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats. Indian J Exp.Biol. 2008;46:534-540. View abstract.
  856. Sun, J., Yang, D., Li, S., Xu, Z., Wang, X., and Bai, C. Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats. Eur.Respir.J 2009;33:398-404. View abstract.
  857. Tharappel, J. C., Lehmler, H. J., Srinivasan, C., Robertson, L. W., Spear, B. T., and Glauert, H. P. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem.Toxicol 2008;46:3467-3474. View abstract.
  858. Adapala, N. and Chan, M. M. Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model. Lab Invest 2008;88:1329-1339. View abstract.
  859. Chen, H. W., Lee, J. Y., Huang, J. Y., Wang, C. C., Chen, W. J., Su, S. F., Huang, C. W., Ho, C. C., Chen, J. J., Tsai, M. F., Yu, S. L., and Yang, P. C. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 9-15-2008;68:7428-7438. View abstract.
  860. Milacic, V., Banerjee, S., Landis-Piwowar, K. R., Sarkar, F. H., Majumdar, A. P., and Dou, Q. P. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res 9-15-2008;68:7283-7292. View abstract.
  861. Ren, L., Wang, J., Tang, J., Pan, C., and Huang, N. [Influence of curcumin--loaded poly (lactide-co-glycolide) films on the proliferation of vascular smooth muscle cells]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:874-878. View abstract.
  862. Yu, S., Shen, G., Khor, T. O., Kim, J. H., and Kong, A. N. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol.Cancer Ther. 2008;7:2609-2620. View abstract.
  863. Sahu, A., Kasoju, N., and Bora, U. Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules. 2008;9:2905-2912. View abstract.
  864. Patel, N. A., Patel, N. J., and Patel, R. P. Design and evaluation of transdermal drug delivery system for curcumin as an anti-inflammatory drug. Drug Dev.Ind.Pharm 2009;35:234-242. View abstract.
  865. Kelley, B. J. and Knopman, D. S. Alternative medicine and Alzheimer disease. Neurologist. 2008;14:299-306. View abstract.
  866. Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan, S. T., Misra, K., Priyadarsini, I. K., Rajasekharan, K. N., and Aggarwal, B. B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem.Pharmacol 12-1-2008;76:1590-1611. View abstract.
  867. Hegge, A. B., Schuller, R. B., Kristensen, S., and Tonnesen, H. H. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie 2008;63:585-592. View abstract.
  868. Aggarwal, B. B. Prostate cancer and curcumin: add spice to your life. Cancer Biol.Ther. 2008;7:1436-1440. View abstract.
  869. Tanaka, K., Kuba, Y., Sasaki, T., Hiwatashi, F., and Komatsu, K. Quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis. J Agric.Food Chem. 10-8-2008;56:8787-8792. View abstract.
  870. von, Metzler, I, Krebbel, H., Kuckelkorn, U., Heider, U., Jakob, C., Kaiser, M., Fleissner, C., Terpos, E., and Sezer, O. Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase. J Cancer Res Clin Oncol. 2009;135:173-179. View abstract.
  871. Kulkarni, S. K., Bhutani, M. K., and Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008;201:435-442. View abstract.
  872. Reuter, S., Eifes, S., Dicato, M., Aggarwal, B. B., and Diederich, M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem.Pharmacol 12-1-2008;76:1340-1351. View abstract.
  873. Memis, D., Hekimoglu, S., Sezer, A., Altaner, S., Sut, N., and Usta, U. Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. Nutrition 2008;24(11-12):1133-1138. View abstract.
  874. Wakade, C., King, M. D., Laird, M. D., Alleyne, C. H., Jr., and Dhandapani, K. M. Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice. Antioxid.Redox.Signal. 2009;11:35-45. View abstract.
  875. Chen, B., Zhang, D. P., and Gao, W. [Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1mRNA in pulmonary fibrosis rats]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:257-261. View abstract.
  876. Sahoo, D. K., Roy, A., and Chainy, G. B. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem.Biol.Interact. 11-25-2008;176(2-3):121-128. View abstract.
  877. Zhang, J. S., Guan, J., Yang, F. Q., Liu, H. G., Cheng, X. J., and Li, S. P. Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. J Pharm Biomed.Anal. 11-4-2008;48:1024-1028. View abstract.
  878. Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14:4753-4762. View abstract.
  879. Foller, M., Huber, S. M., and Lang, F. Erythrocyte programmed cell death. IUBMB.Life 2008;60:661-668. View abstract.
  880. Dempe, J. S., Pfeiffer, E., Grimm, A. S., and Metzler, M. Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells. Mol.Nutr.Food Res 2008;52:1074-1081. View abstract.
  881. Thangapazham, R. L., Shaheduzzaman, S., Kim, K. H., Passi, N., Tadese, A., Vahey, M., Dobi, A., Srivastava, S., and Maheshwari, R. K. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome. Cancer Biol.Ther. 2008;7:1427-1435. View abstract.
  882. Oh, S., Kyung, T. W., and Choi, H. S. Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol.Cells 11-30-2008;26:486-489. View abstract.
  883. Ghoneim, A. I. Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c. Naunyn Schmiedebergs Arch.Pharmacol 2009;379:47-60. View abstract.
  884. Moon, D. O., Kim, M. O., Lee, H. J., Choi, Y. H., Park, Y. M., Heo, M. S., and Kim, G. Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem.Biophys.Res Commun. 10-17-2008;375:275-279. View abstract.
  885. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam.Clin Pharmacol 2008;22:417-427. View abstract.
  886. Dou, X., Fan, C., Wo, L., Yan, J., Qian, Y., and Wo, X. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med. 2008;74:1374-1379. View abstract.
  887. Pan, R., Qiu, S., Lu, D. X., and Dong, J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med.J (Engl) 5-5-2008;121:832-839. View abstract.
  888. Illouz, S., Alexandre, E., Pattenden, C., Mark, L., Bachellier, P., Webb, M., Berry, D., Dennison, A., and Richert, L. Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother.Res 2008;22:1688-1691. View abstract.
  889. Kanitkar, M., Gokhale, K., Galande, S., and Bhonde, R. R. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br.J Pharmacol 2008;155:702-713. View abstract.
  890. Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., and Sugimoto, H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 8-27-2008;19:1329-1333. View abstract.
  891. Garg, R., Ingle, A., and Maru, G. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicol Appl.Pharmacol 11-1-2008;232:428-439. View abstract.
  892. Eybl, V., Kotyzova, D., Cerna, P., and Koutensky, J. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats. Hum.Exp.Toxicol 2008;27:347-353. View abstract.
  893. Wang, W. X., Sun, S. Z., Guo, X. L., and Song, Y. [Effect of curcumin on invasion and migration of tongue squamous cell carcinoma cell line Tca8113]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 2008;43:101-104. View abstract.
  894. Sotanaphun, U., Phattanawasin, P., and Sriphong, L. Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa). Phytochem.Anal. 2009;20:19-23. View abstract.
  895. Tsui, K. H., Feng, T. H., Lin, C. M., Chang, P. L., and Juang, H. H. Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells. J Androl 2008;29:661-668. View abstract.
  896. Davis, C. D. and Ross, S. A. Evidence for dietary regulation of microRNA expression in cancer cells. Nutr.Rev. 2008;66:477-482. View abstract.
  897. Aggarwal, B. B. and Harikumar, K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int.J Biochem.Cell Biol. 2009;41:40-59. View abstract.
  898. Zhang, X. G., Wang, D. M., and Huang, Q. [Study on extracting process for Tiao ZhiAn mixture]. Zhong.Yao Cai. 2008;31:594-597. View abstract.
  899. Han, G., Bi, R., Le, Q., Zhao, L. L., Dong, Y., and Lin, Q. H. [Study on effect of demethoxycurcumin in Curcuma long on stability of curcumin]. Zhong.Yao Cai. 2008;31:592-594. View abstract.
  900. Bharal, N., Sahaya, K., Jain, S., Mediratta, P. K., and Sharma, K. K. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother.Res 2008;22:1660-1664. View abstract.
  901. Sameermahmood, Z., Balasubramanyam, M., Saravanan, T., and Rema, M. Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs). Invest Ophthalmol.Vis.Sci. 2008;49:3305-3311. View abstract.
  902. Mattson, M. P., Son, T. G., and Camandola, S. Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose.Response 2007;5:174-186. View abstract.
  903. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in serum of mice. Acta Pol.Pharm 2008;65:339-343. View abstract.
  904. Zhao, J., Zhao, Y., Zheng, W., Lu, Y., Feng, G., and Yu, S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 9-10-2008;1229:224-232. View abstract.
  905. Shirley, S. A., Montpetit, A. J., Lockey, R. F., and Mohapatra, S. S. Curcumin prevents human dendritic cell response to immune stimulants. Biochem.Biophys.Res Commun. 9-26-2008;374:431-436. View abstract.
  906. Maher, P., Akaishi, T., Schubert, D., and Abe, K. A pyrazole derivative of curcumin enhances memory. Neurobiol.Aging 2010;31:706-709. View abstract.
  907. Fiorillo, C., Becatti, M., Pensalfini, A., Cecchi, C., Lanzilao, L., Donzelli, G., Nassi, N., Giannini, L., Borchi, E., and Nassi, P. Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways. Free Radic.Biol.Med. 9-15-2008;45:839-846. View abstract.
  908. Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., and Kurzrock, R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 7-15-2008;14:4491-4499. View abstract.
  909. Li, Y., Li, S., Han, Y., Liu, J., Zhang, J., Li, F., Wang, Y., Liu, X., and Yao, L. Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells. Eur.J Pharmacol 9-4-2008;591(1-3):252-258. View abstract.
  910. Hong, W., Chen, D. W., Zhao, X. L., Qiao, M. X., and Hu, H. Y. [Preparation and study in vitro of long-circulating nanoliposomes of curcumin]. Zhongguo Zhong.Yao Za Zhi. 2008;33:889-892. View abstract.
  911. Xu, D. H., Wang, S., Mei, X. T., Luo, X. J., and Xu, S. B. [Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30]. Zhong.Yao Cai. 2008;31:438-442. View abstract.
  912. Dohare, P., Garg, P., Jain, V., Nath, C., and Ray, M. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. Behav.Brain Res 11-21-2008;193:289-297. View abstract.
  913. Wang, W. Z., Cheng, J., Luo, J., and Zhuang, S. M. Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett. 8-6-2008;582:2689-2695. View abstract.
  914. Sun, D. I., Nizamutdinova, I. T., Kim, Y. M., Cai, X. F., Lee, J. J., Kang, S. S., Kim, Y. S., Kang, K. M., Chai, G. Y., Chang, K. C., and Kim, H. J. Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int.Immunopharmacol. 2008;8:1272-1281. View abstract.
  915. Shishu, Gupta, N., and Aggarwal, N. Bioavailability enhancement and targeting of stomach tumors using gastro-retentive floating drug delivery system of curcumin--"a technical note". AAPS.PharmSciTech. 2008;9:810-813. View abstract.
  916. Srinivasan, M., Sudheer, A. R., Rajasekaran, K. N., and Menon, V. P. Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro. Chem.Biol.Interact. 10-22-2008;176:1-8. View abstract.
  917. Binion, D. G., Otterson, M. F., and Rafiee, P. Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 2008;57:1509-1517. View abstract.
  918. Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., III, Li, X., and Safe, S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 7-1-2008;68:5345-5354. View abstract.
  919. Narasimhan, M. and Ammanamanchi, S. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. Cancer Res 7-1-2008;68:5185-5192. View abstract.
  920. Usharani, P., Mateen, A. A., Naidu, M. U., Raju, Y. S., and Chandra, N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R.D. 2008;9:243-250. View abstract.
  921. Kumar, A. and Singh, A. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Phytomedicine. 2008;15:577-586. View abstract.
  922. Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci.Lett. 8-8-2008;440:344-347. View abstract.
  923. Park, S. Y., Kim, H. S., Cho, E. K., Kwon, B. Y., Phark, S., Hwang, K. W., and Sul, D. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem.Toxicol 2008;46:2881-2887. View abstract.
  924. Banerjee, A., Kunwar, A., Mishra, B., and Priyadarsini, K. I. Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs. Chem.Biol.Interact. 7-30-2008;174:134-139. View abstract.
  925. Pathak, N. and Khandelwal, S. Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice. Biometals 2008;21:649-661. View abstract.
  926. Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., and Brenner, D. E. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol.Biomarkers Prev. 2008;17:1411-1417. View abstract.
  927. Malik, M., Mendoza, M., Payson, M., and Catherino, W. H. Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil.Steril. 2009;91(5 Suppl):2177-2184. View abstract.
  928. Yang, C. S., Sang, S., Lambert, J. D., and Lee, M. J. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol.Nutr.Food Res 2008;52 Suppl 1:S139-S151. View abstract.
  929. Candan, N. and Tuzmen, N. Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection. Neurotoxicology 2008;29:708-713. View abstract.
  930. Gonzales, A. M. and Orlando, R. A. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr.Metab (Lond) 2008;5:17. View abstract.
  931. Ak, T. and Gulcin, I. Antioxidant and radical scavenging properties of curcumin. Chem.Biol.Interact. 7-10-2008;174:27-37. View abstract.
  932. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice--an in vitro study. Acta Pol.Pharm 2007;64:413-416. View abstract.
  933. Sahu, A., Bora, U., Kasoju, N., and Goswami, P. Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 2008;4:1752-1761. View abstract.
  934. Araki, Y., Fann, M., Wersto, R., and Weng, N. P. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol. 6-15-2008;180:8102-8108. View abstract.
  935. Papiez, M. A., Kaja, M., and Gebarowska, A. Age-dependent different action of curcumin in thyroid of rat. Folia Histochem.Cytobiol. 2008;46:205-211. View abstract.
  936. Sun, Y., Lee, C. C., Hung, W. C., Chen, F. Y., Lee, M. T., and Huang, H. W. The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys.J 2008;95:2318-2324. View abstract.
  937. Bandyopadhyaya, G., Sinha, S., Chattopadhyay, B. D., and Chakraborty, A. Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein. Eur.J Pharmacol 7-7-2008;588(2-3):151-157. View abstract.
  938. Das, R., Roy, A., Dutta, N., and Majumder, H. K. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis. 2008;13:867-882. View abstract.
  939. Tong, K. M., Shieh, D. C., Chen, C. P., Tzeng, C. Y., Wang, S. P., Huang, K. C., Chiu, Y. C., Fong, Y. C., and Tang, C. H. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. Cell Signal. 2008;20:1478-1488. View abstract.
  940. Bian, F., Zhang, M. C., and Zhu, Y. Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. Ophthalmologica 2008;222:178-186. View abstract.
  941. Lopez-Lazaro, M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol.Nutr.Food Res 2008;52 Suppl 1:S103-S127. View abstract.
  942. Yodkeeree, S., Chaiwangyen, W., Garbisa, S., and Limtrakul, P. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr.Biochem. 2009;20:87-95. View abstract.
  943. Bakhshi, J., Weinstein, L., Poksay, K. S., Nishinaga, B., Bredesen, D. E., and Rao, R. V. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 2008;13:904-914. View abstract.
  944. Gowda, N. K., Ledoux, D. R., Rottinghaus, G. E., Bermudez, A. J., and Chen, Y. C. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poult.Sci. 2008;87:1125-1130. View abstract.
  945. Dohare, P., Varma, S., and Ray, M. Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. Nitric.Oxide. 2008;19:1-11. View abstract.
  946. Pari, L., Tewas, D., and Eckel, J. Role of curcumin in health and disease. Arch.Physiol Biochem. 2008;114:127-149. View abstract.
  947. Kunnumakkara, A. B., Anand, P., and Aggarwal, B. B. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 10-8-2008;269:199-225. View abstract.
  948. Braumann, C., Tangermann, J., Jacobi, C. A., Muller, J. M., and Dubiel, W. Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini.Rev.Med.Chem. 2008;8:421-428. View abstract.
  949. Carroll, C. E., Ellersieck, M. R., and Hyder, S. M. Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells. Menopause. 2008;15:570-574. View abstract.
  950. Chearwae, W. and Bright, J. J. 15-deoxy-Delta-prostaglandin J and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol. 2008;28:558-570. View abstract.
  951. McPhee, D. Withdrawn paper: antibacterial effect of five Zingiberaceae essential oils by Laohakunjit et al., Molecules 2007, 12. Molecules. 2008;13:488-489. View abstract.
  952. Shen, Y. and Yu, L. C. Potential protection of curcumin against hypoxia-induced decreases in beta-III tubulin content in rat prefrontal cortical neurons. Neurochem.Res 2008;33:2112-2117. View abstract.
  953. Leung, M. H., Colangelo, H., and Kee, T. W. Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis. Langmuir 6-3-2008;24:5672-5675. View abstract.
  954. Boriwanwattanarak, P., Ingkaninan, K., Khorana, N., and Viyoch, J. Development of curcuminoids hydrogel patch using chitosan from various sources as controlled-release matrix. Int.J Cosmet.Sci. 2008;30:205-218. View abstract.
  955. Rolland, S. G. and Bruel, C. A. Sulphur and nitrogen regulation of the protease-encoding ACP1 gene in the fungus Botrytis cinerea: correlation with a phospholipase D activity. Microbiology 2008;154(Pt 5):1464-1473. View abstract.
  956. Miller, M., Chen, S., Woodliff, J., and Kansra, S. Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells. Endocrinology 2008;149:4158-4167. View abstract.
  957. Guo, L. Y., Cai, X. F., Lee, J. J., Kang, S. S., Shin, E. M., Zhou, H. Y., Jung, J. W., and Kim, Y. S. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch.Pharm Res 2008;31:490-496. View abstract.
  958. Kochhar, S. and Kochhar, V. K. Identification and characterization of a super-stable Cu-Zn SOD from leaves of turmeric (Curcuma longa L.). Planta 2008;228:307-318. View abstract.
  959. Zhu, J., Zeng, X., O'Neal, M., Schultz, G., Tucker, B., Coats, J., Bartholomay, L., and Xue, R. D. Mosquito larvicidal activity of botanical-based mosquito repellents. J Am.Mosq.Control Assoc. 2008;24:161-168. View abstract.
  960. Tang, J., Wang, J., Pan, C., Ren, L., and Huang, N. [Preparation and anticoagulation of curcumin/poly(lactic acid-co-glycol acid) composite films]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:113-116. View abstract.
  961. Yuan, H. Y., Kuang, S. Y., Zheng, X., Ling, H. Y., Yang, Y. B., Yan, P. K., Li, K., and Liao, D. F. Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin. 2008;29:555-563. View abstract.
  962. Thangapazham, R. L., Puri, A., Tele, S., Blumenthal, R., and Maheshwari, R. K. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int.J Oncol. 2008;32:1119-1123. View abstract.
  963. Meja, K. K., Rajendrasozhan, S., Adenuga, D., Biswas, S. K., Sundar, I. K., Spooner, G., Marwick, J. A., Chakravarty, P., Fletcher, D., Whittaker, P., Megson, I. L., Kirkham, P. A., and Rahman, I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am.J Respir.Cell Mol.Biol. 2008;39:312-323. View abstract.
  964. Wang, R., Li, Y. B., Li, Y. H., Xu, Y., Wu, H. L., and Li, X. J. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res 5-19-2008;1210:84-91. View abstract.
  965. Begum, A. N., Jones, M. R., Lim, G. P., Morihara, T., Kim, P., Heath, D. D., Rock, C. L., Pruitt, M. A., Yang, F., Hudspeth, B., Hu, S., Faull, K. F., Teter, B., Cole, G. M., and Frautschy, S. A. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp.Ther. 2008;326:196-208. View abstract.
  966. Feng, B., Chen, S., Chiu, J., George, B., and Chakrabarti, S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am.J Physiol Endocrinol.Metab 2008;294:E1119-E1126. View abstract.
  967. Huang, S., Zhao, L., Kim, K., Lee, D. S., and Hwang, D. H. Inhibition of Nod2 signaling and target gene expression by curcumin. Mol.Pharmacol 2008;74:274-281. View abstract.
  968. Vijayalakshmi, B., Kumar, G. S., and Salimath, P. V. Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats. J Diabetes Complications 2009;23:71-76. View abstract.
  969. Rajeswari, A. and Sabesan, M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology. 2008;16:96-99. View abstract.
  970. Weisberg, S. P., Leibel, R., and Tortoriello, D. V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008;149:3549-3558. View abstract.
  971. Kurup, V. P. and Barrios, C. S. Immunomodulatory effects of curcumin in allergy. Mol.Nutr.Food Res 2008;52:1031-1039. View abstract.
  972. Seo, K. I., Choi, M. S., Jung, U. J., Kim, H. J., Yeo, J., Jeon, S. M., and Lee, M. K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol.Nutr.Food Res 2008;52:995-1004. View abstract.
  973. Chen, W., Bacanamwo, M., and Harrison, D. G. Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. J Biol.Chem. 6-13-2008;283:16293-16298. View abstract.
  974. Yoysungnoen, P., Wirachwong, P., Changtam, C., Suksamrarn, A., and Patumraj, S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J Gastroenterol. 4-7-2008;14:2003-2009. View abstract.
  975. Lee, J. H., Kim, J. W., Ko, N. Y., Mun, S. H., Her, E., Kim, B. K., Han, J. W., Lee, H. Y., Beaven, M. A., Kim, Y. M., and Choi, W. S. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol. 2008;121:1225-1231. View abstract.
  976. Dong, J., Lu, D. X., Pan, R., and Tang, H. M. [Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats]. Xi.Bao.Yu Fen.Zi.Mian.Yi.Xue.Za Zhi. 2008;24:328-331. View abstract.
  977. Mukherjee, S., Roy, M., Dey, S., and Bhattacharya, R. K. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn. J Clin Biochem.Nutr. 2007;41:32-42. View abstract.
  978. Varalakshmi, Ch, Ali, A. M., Pardhasaradhi, B. V., Srivastava, R. M., Singh, S., and Khar, A. Immunomodulatory effects of curcumin: in-vivo. Int.Immunopharmacol. 2008;8:688-700. View abstract.
  979. Mackenzie, G. G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M., and Oteiza, P. I. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int.J Cancer 7-1-2008;123:56-65. View abstract.
  980. Freudlsperger, C., Greten, J., and Schumacher, U. Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB. Anticancer Res 2008;28(1A):209-214. View abstract.
  981. Kunnumakkara, A. B., Diagaradjane, P., Guha, S., Deorukhkar, A., Shentu, S., Aggarwal, B. B., and Krishnan, S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 4-1-2008;14:2128-2136. View abstract.
  982. Jia, L., Wang, H., Qu, S., Miao, X., and Zhang, J. CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma. IUBMB.Life 2008;60:57-63. View abstract.
  983. Sun, J., Guo, W., Ben, Y., Jiang, J., Tan, C., Xu, Z., Wang, X., and Bai, C. Preventive effects of curcumin and dexamethasone on lung transplantation-associated lung injury in rats. Crit Care Med. 2008;36:1205-1213. View abstract.
  984. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem.Biol.Interact. 5-28-2008;173:105-114. View abstract.
  985. Murugan, P., Pari, L., and Rao, C. A. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. J Biosci. 2008;33:63-72. View abstract.
  986. Bayrak, O., Uz, E., Bayrak, R., Turgut, F., Atmaca, A. F., Sahin, S., Yildirim, M. E., Kaya, A., Cimentepe, E., and Akcay, A. Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J Urol. 2008;26:285-291. View abstract.
  987. Elseweidy, M. M., Younis, N. N., Amin, R. S., Abdallah, F. R., Fathy, A. M., and Yousif, Z. A. Effect of some natural products either alone or in combination on gastritis induced in experimental rats. Dig.Dis.Sci. 2008;53:1774-1784. View abstract.
  988. Yang, S., Zhang, D., Yang, Z., Hu, X., Qian, S., Liu, J., Wilson, B., Block, M., and Hong, J. S. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem.Res 2008;33:2044-2053. View abstract.
  989. Kim, S. J., Son, T. G., Park, H. R., Park, M., Kim, M. S., Kim, H. S., Chung, H. Y., Mattson, M. P., and Lee, J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol.Chem. 5-23-2008;283:14497-14505. View abstract.
  990. Hsu, H. Y., Chu, L. C., Hua, K. F., and Chao, L. K. Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. J Cell Physiol 2008;215:603-612. View abstract.
  991. Novak, Kujundzic R., Grbesa, I., Ivkic, M., Katdare, M., and Gall-Troselj, K. Curcumin downregulates H19 gene transcription in tumor cells. J Cell Biochem. 8-1-2008;104:1781-1792. View abstract.
  992. Sun, M., Estrov, Z., Ji, Y., Coombes, K. R., Harris, D. H., and Kurzrock, R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol.Cancer Ther. 2008;7:464-473. View abstract.
  993. Ma, Q. L., Yang, F., Calon, F., Ubeda, O. J., Hansen, J. E., Weisbart, R. H., Beech, W., Frautschy, S. A., and Cole, G. M. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol.Chem. 5-16-2008;283:14132-14143. View abstract.
  994. Abu-Rizq, H. A., Mansour, M. H., Safer, A. M., and Afzal, M. Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology. 2008;16:87-95. View abstract.
  995. Lin, J. and Chen, A. Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 2008;88:529-540. View abstract.
  996. Antonio, A. M. and Druse, M. J. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 4-14-2008;1204:16-23. View abstract.
  997. Dinkova-Kostova, A. T. and Talalay, P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol.Nutr.Food Res 2008;52 Suppl 1:S128-S138. View abstract.
  998. Kim, K. M., Pae, H. O., Zhung, M., Ha, H. Y., Ha, Y. A., Chai, K. Y., Cheong, Y. K., Kim, J. M., and Chung, H. T. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. Biomed.Pharmacother. 2008;62:630-636. View abstract.
  999. Hatcher, H., Planalp, R., Cho, J., Torti, F. M., and Torti, S. V. Curcumin: from ancient medicine to current clinical trials. Cell Mol.Life Sci. 2008;65:1631-1652. View abstract.
  1000. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta Pol.Pharm 2007;64:497-502. View abstract.
  1001. Shu, J. C., Wang, H. L., Ye, G. R., He, Y. J., Lu, X., and Fang, L. [The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine]. Zhong.Yao Cai. 2007;30:1421-1425. View abstract.
  1002. Garg, R., Gupta, S., and Maru, G. B. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis 2008;29:1022-1032. View abstract.
  1003. Bichucher, A. M. and Kozlov, L. V. [Effect of medicinal preparations on the complement: inhibition of subcomponent C1q binding to a target]. Eksp.Klin.Farmakol. 2007;70:25-28. View abstract.
  1004. Choi, B. H., Kim, C. G., Bae, Y. S., Lim, Y., Lee, Y. H., and Shin, S. Y. p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 3-1-2008;68:1369-1377. View abstract.
  1005. Wu, C. Y., Hsieh, H. L., Sun, C. C., Tseng, C. P., and Yang, C. M. IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes. J Neurochem. 2008;105:1499-1512. View abstract.
  1006. Ding, Z. S., Jiang, F. S., Chen, N. P., Lv, G. Y., and Zhu, C. G. Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina. Molecules. 2008;13:220-229. View abstract.
  1007. Aravindan, N., Madhusoodhanan, R., Ahmad, S., Johnson, D., and Herman, T. S. Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol.Ther. 2008;7:569-576. View abstract.
  1008. Panchal, H. D., Vranizan, K., Lee, C. Y., Ho, J., Ngai, J., and Timiras, P. S. Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets. Neurochem.Res 2008;33:1701-1710. View abstract.
  1009. Morimoto, T., Sunagawa, Y., Kawamura, T., Takaya, T., Wada, H., Nagasawa, A., Komeda, M., Fujita, M., Shimatsu, A., Kita, T., and Hasegawa, K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008;118:868-878. View abstract.
  1010. Li, H. L., Liu, C., de Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A., and Liu, P. P. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008;118:879-893. View abstract.
  1011. Kaur, C. and Ling, E. A. Blood brain barrier in hypoxic-ischemic conditions. Curr.Neurovasc.Res 2008;5:71-81. View abstract.
  1012. Rudrappa, T. and Bais, H. P. Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J Agric.Food Chem. 3-26-2008;56:1955-1962. View abstract.
  1013. Jacob, A., Wu, R., Zhou, M., and Wang, P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR.Res 2007;2007:89369. View abstract.
  1014. Lee, S. S., Tsai, C. H., Ho, Y. C., and Chang, Y. C. The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncol. 2008;44:884-890. View abstract.
  1015. Lee, C. W., Lin, C. C., Luo, S. F., Lee, H. C., Lee, I. T., Aird, W. C., Hwang, T. L., and Yang, C. M. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. Mol.Pharmacol 2008;73:1454-1464. View abstract.
  1016. Song, W. B., Zhang, Z. S., and Xiao, B. [Protective effect of curcumin against methotrexate-induced small intestinal damage in rats]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2008;28:119-121. View abstract.
  1017. Wei, S. M., Yan, Z. Z., and Zhou, J. Curcumin attenuates ischemia-reperfusion injury in rat testis. Fertil.Steril. 2009;91:271-277. View abstract.
  1018. Fujiwara, H., Hosokawa, M., Zhou, X., Fujimoto, S., Fukuda, K., Toyoda, K., Nishi, Y., Fujita, Y., Yamada, K., Yamada, Y., Seino, Y., and Inagaki, N. Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract. 2008;80:185-191. View abstract.
  1019. Ji, C., Cao, C., Lu, S., Kivlin, R., Amaral, A., Kouttab, N., Yang, H., Chu, W., Bi, Z., Di, W., and Wan, Y. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother.Pharmacol 2008;62:857-865. View abstract.
  1020. Lee, H. S., Jung, K. K., Cho, J. Y., Rhee, M. H., Hong, S., Kwon, M., Kim, S. H., and Kang, S. Y. Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation. Pharmazie 2007;62:937-942. View abstract.
  1021. Kim, Y. S., Bahn, K. N., Hah, C. K., Gang, H. I., and Ha, Y. L. Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris. J Food Sci. 2008;73:T16-T20. View abstract.
  1022. Kadoma, Y. and Fujisawa, S. Comparative radical-scavenging activity of curcumin and tetrahydrocurcumin with thiols as measured by the induction period method. In Vivo 2007;21:979-982. View abstract.
  1023. Lee, M. H., Lin, H. Y., Chen, H. C., and Thomas, J. L. Ultrasound mediates the release of curcumin from microemulsions. Langmuir 3-4-2008;24:1707-1713. View abstract.
  1024. Shukla, P. K., Khanna, V. K., Ali, M. M., Khan, M. Y., and Srimal, R. C. Anti-ischemic effect of curcumin in rat brain. Neurochem.Res 2008;33:1036-1043. View abstract.
  1025. Tikoo, K., Meena, R. L., Kabra, D. G., and Gaikwad, A. B. Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br.J Pharmacol 2008;153:1225-1231. View abstract.
  1026. Billerey-Larmonier, C., Uno, J. K., Larmonier, N., Midura, A. J., Timmermann, B., Ghishan, F. K., and Kiela, P. R. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. Inflamm.Bowel.Dis. 2008;14:780-793. View abstract.
  1027. Riemer, C., Burwinkel, M., Schwarz, A., Gultner, S., Mok, S. W., Heise, I., Holtkamp, N., and Baier, M. Evaluation of drugs for treatment of prion infections of the central nervous system. J Gen.Virol. 2008;89(Pt 2):594-597. View abstract.
  1028. Dange, P., Sarma, H., Pandey, B. N., and Mishra, K. P. Radiation-induced incidence of thymic lymphoma in mice and its prevention by antioxidants. J Environ.Pathol.Toxicol Oncol. 2007;26:273-279. View abstract.
  1029. Mishra, S., Karmodiya, K., Surolia, N., and Surolia, A. Synthesis and exploration of novel curcumin analogues as anti-malarial agents. Bioorg.Med.Chem. 3-15-2008;16:2894-2902. View abstract.
  1030. Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373:239-247. View abstract.
  1031. Pandey, N., Strider, J., Nolan, W. C., Yan, S. X., and Galvin, J. E. Curcumin inhibits aggregation of alpha-synuclein. Acta Neuropathol. 2008;115:479-489. View abstract.
  1032. Liao, Y. F., Hung, H. C., Hour, T. C., Hsu, P. C., Kao, M. C., Tsay, G. J., and Liu, G. Y. Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci. 2-13-2008;82(7-8):367-375. View abstract.
  1033. Steward, W. P. and Gescher, A. J. Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research. Mol.Nutr.Food Res 2008;52:1005-1009. View abstract.
  1034. Lin, W. N., Luo, S. F., Wu, C. B., Lin, C. C., and Yang, C. M. Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway. Toxicol Appl.Pharmacol 4-15-2008;228:256-268. View abstract.
  1035. Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., and Priyadarsini, K. I. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim.Biophys.Acta 2008;1780:673-679. View abstract.
  1036. Riva, D. A., Fernandez-Larrosa, P. N., Dolcini, G. L., Martinez-Peralta, L. A., Coulombie, F. C., and Mersich, S. E. Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Arch.Virol. 2008;153:561-565. View abstract.
  1037. Jagatha, B., Mythri, R. B., Vali, S., and Bharath, M. M. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic.Biol.Med. 3-1-2008;44:907-917. View abstract.
  1038. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa. Fertil.Steril. 2008;90:775-780. View abstract.
  1039. Lv, B. H., Zhang, L., Zhu, C. C., and Liu, J. [Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells]. Zhongguo Zhong.Yao Za Zhi. 2007;32:2051-2055. View abstract.
  1040. Srivastava, R. K., Chen, Q., Siddiqui, I., Sarva, K., and Shankar, S. Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1). Cell Cycle 12-1-2007;6:2953-2961. View abstract.
  1041. SCHRAUFSTATTER, E. and BERNT, H. Antibacterial action of curcumin and related compounds. Nature 9-10-1949;164:456. View abstract.
  1042. Kanitkar, M. and Bhonde, R. R. Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation. Life Sci. 1-16-2008;82(3-4):182-189. View abstract.
  1043. Lopez-Lazaro, M., Willmore, E., Jobson, A., Gilroy, K. L., Curtis, H., Padget, K., and Austin, C. A. Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat.Prod. 2007;70:1884-1888. View abstract.
  1044. Srinivasan, K. and Sambaiah, K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int.J Vitam.Nutr.Res 1991;61:364-369. View abstract.
  1045. Sou, K., Inenaga, S., Takeoka, S., and Tsuchida, E. Loading of curcumin into macrophages using lipid-based nanoparticles. Int.J Pharm 3-20-2008;352(1-2):287-293. View abstract.
  1046. Sivalingam, N., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch.Toxicol 2008;82:471-481. View abstract.
  1047. Prunotto, M., Bacchetta, M., Jayaraman, S., Galloni, M., Van Eys, G., Gabbiani, G., and Bochaton-Piallat, M. L. Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations. FEBS Lett. 12-22-2007;581:5847-5851. View abstract.
  1048. Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., and Reddy, G. B. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med.Sci.Monit. 2007;13:BR286-BR292. View abstract.
  1049. O'Connell, M. A. and Rushworth, S. A. Curcumin: potential for hepatic fibrosis therapy? Br.J Pharmacol 2008;153:403-405. View abstract.
  1050. Pari, L. and Murugan, P. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes. Fundam.Clin Pharmacol 2007;21:665-671. View abstract.
  1051. Anuchapreeda, S., Tima, S., Duangrat, C., and Limtrakul, P. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines. Cancer Chemother.Pharmacol 2008;62:585-594. View abstract.
  1052. Bishnoi, M., Chopra, K., and Kulkarni, S. K. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain. Pharmacol Biochem.Behav. 2008;88:511-522. View abstract.
  1053. Wan, X. H., Li, Y. W., and Luo, X. P. [Curcumin attenuated the lipid peroxidation and apoptotic liver injury in copper-overloaded rats]. Zhonghua Er.Ke.Za Zhi. 2007;45:604-608. View abstract.
  1054. Fu, Y., Zheng, S., Lin, J., Ryerse, J., and Chen, A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol.Pharmacol 2008;73:399-409. View abstract.
  1055. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H., and Surh, Y. J. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem.Toxicol 2008;46:1279-1287. View abstract.
  1056. Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227:115-124. View abstract.
  1057. Verschoyle, R. D., Steward, W. P., and Gescher, A. J. Putative cancer chemopreventive agents of dietary origin-how safe are they? Nutr.Cancer 2007;59:152-162. View abstract.
  1058. Bachmeier, B. E., Mohrenz, I. V., Mirisola, V., Schleicher, E., Romeo, F., Hohneke, C., Jochum, M., Nerlich, A. G., and Pfeffer, U. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 2008;29:779-789. View abstract.
  1059. Anand, P., Kunnumakkara, A. B., Newman, R. A., and Aggarwal, B. B. Bioavailability of curcumin: problems and promises. Mol.Pharm 2007;4:807-818. View abstract.
  1060. Saja, K., Babu, M. S., Karunagaran, D., and Sudhakaran, P. R. Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells. Int.Immunopharmacol. 12-15-2007;7:1659-1667. View abstract.
  1061. Hafner-Bratkovic, I., Gaspersic, J., Smid, L. M., Bresjanac, M., and Jerala, R. Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation. J Neurochem. 2008;104:1553-1564. View abstract.
  1062. Pari, L. and Murugan, P. Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats. Ren Fail. 2007;29:881-889. View abstract.
  1063. Fahey, A. J., Adrian, Robins R., and Constantinescu, C. S. Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. J Cell Mol.Med. 2007;11:1129-1137. View abstract.
  1064. Usta, M., Wortelboer, H. M., Vervoort, J., Boersma, M. G., Rietjens, I. M., van Bladeren, P. J., and Cnubben, N. H. Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells. Chem.Res Toxicol 2007;20:1895-1902. View abstract.
  1065. Olszanecki, R., Gebska, A., and Korbut, R. The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin Pharmacol Toxicol 2007;101:411-415. View abstract.
  1066. Safavy, A., Raisch, K. P., Mantena, S., Sanford, L. L., Sham, S. W., Krishna, N. R., and Bonner, J. A. Design and development of water-soluble curcumin conjugates as potential anticancer agents. J Med.Chem. 11-29-2007;50:6284-6288. View abstract.
  1067. Muriel, P. and Rivera-Espinoza, Y. Beneficial drugs for liver diseases. J Appl.Toxicol 2008;28:93-103. View abstract.
  1068. Chen, A. and Zheng, S. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br.J Pharmacol 2008;153:557-567. View abstract.
  1069. Fukumori, S., Murata, T., Taguchi, M., and Hashimoto, Y. Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet. 2007;22:377-381. View abstract.
  1070. Shu, J. C., Ye, G. R., Lu, X., Fang, L., Wu, H. E., and Chen, X. J. [Therapeutic effects of curcumin treatment on hepatic fibrosis]. Zhonghua Gan Zang.Bing.Za Zhi. 2007;15:753-757. View abstract.
  1071. Sakla, M. S. and Lorson, C. L. Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum.Genet. 2008;122:635-643. View abstract.
  1072. Manjunatha, H. and Srinivasan, K. Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids 2007;42:1133-1142. View abstract.
  1073. Gomez, G., Mansouraty, G., Gardea, J., and Narayan, M. Acceleration of oxidative protein folding by curcumin through novel non-redox chemistry. Biochem.Biophys.Res Commun. 12-21-2007;364:561-566. View abstract.
  1074. Ma, Z., Haddadi, A., Molavi, O., Lavasanifar, A., Lai, R., and Samuel, J. Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed.Mater.Res A 2008;86:300-310. View abstract.
  1075. Rathore, P., Dohare, P., Varma, S., Ray, A., Sharma, U., Jagannathan, N. R., and Ray, M. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem.Res 2008;33:1672-1682. View abstract.
  1076. Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem.J 2-15-2008;410:147-155. View abstract.
  1077. Baum, L., Cheung, S. K., Mok, V. C., Lam, L. C., Leung, V. P., Hui, E., Ng, C. C., Chow, M., Ho, P. C., Lam, S., Woo, J., Chiu, H. F., Goggins, W., Zee, B., Wong, A., Mok, H., Cheng, W. K., Fong, C., Lee, J. S., Chan, M. H., Szeto, S. S., Lui, V. W., Tsoh, J., Kwok, T. C., Chan, I. H., and Lam, C. W. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 2007;56:509-514. View abstract.
  1078. El Banhawey, M. A., Ashry, M. A., El Ansary, A. K., and Aly, S. A. Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver--histological and histochemical study. Indian J Exp.Biol. 2007;45:877-889. View abstract.
  1079. Wang, R., Xu, Y., Wu, H. L., Li, Y. B., Li, Y. H., Guo, J. B., and Li, X. J. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur.J Pharmacol 1-6-2008;578:43-50. View abstract.
  1080. Raza, H., John, A., Brown, E. M., Benedict, S., and Kambal, A. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Appl.Pharmacol 1-15-2008;226:161-168. View abstract.
  1081. Chen, Y., Shu, W., Chen, W., Wu, Q., Liu, H., and Cui, G. Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 2007;101:427-433. View abstract.
  1082. Tomida, M., Ohtake, H., Yokota, T., Kobayashi, Y., and Kurosumi, M. Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol. 2008;134:551-559. View abstract.
  1083. Paramasivam, S., Thangaradjou, T., and Kannan, L. Effect of natural preservatives on the growth of histamine producing bacteria. J Environ.Biol. 2007;28:271-274. View abstract.
  1084. Mattson, M. P. Dietary factors, hormesis and health. Ageing Res Rev. 2008;7:43-48. View abstract.
  1085. El Ansary, A. K., Ahmed, S. A., and Aly, S. A. Antischistosomal and liver protective effects of Curcuma longa extract in Schistosoma mansoni infected mice. Indian J Exp.Biol. 2007;45:791-801. View abstract.
  1086. Meghana, K., Sanjeev, G., and Ramesh, B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur.J Pharmacol 12-22-2007;577(1-3):183-191. View abstract.
  1087. Gal, S., Lichtenberg, D., Bor, A., and Pinchuk, I. Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants. Chem.Phys.Lipids 2007;150:186-203. View abstract.
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  1089. Kumar, A., Naidu, P. S., Seghal, N., and Padi, S. S. Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. J Med.Food 2007;10:486-494. View abstract.
  1090. Marin, Y. E., Wall, B. A., Wang, S., Namkoong, J., Martino, J. J., Suh, J., Lee, H. J., Rabson, A. B., Yang, C. S., Chen, S., and Ryu, J. H. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res 2007;17:274-283. View abstract.
  1091. Jin, C. Y., Lee, J. D., Park, C., Choi, Y. H., and Kim, G. Y. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacol Sin. 2007;28:1645-1651. View abstract.
  1092. Thavara, U., Tawatsin, A., Bhakdeenuan, P., Wongsinkongman, P., Boonruad, T., Bansiddhi, J., Chavalittumrong, P., Komalamisra, N., Siriyasatien, P., and Mulla, M. S. Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian J Trop.Med.Public Health 2007;38:663-673. View abstract.
  1093. Zhang, X. C., Chen, J., Su, C. H., Yang, H. Y., and Lee, M. H. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 3-1-2008;103:1219-1230. View abstract.
  1094. Jagota, A. and Reddy, M. Y. The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal. Cell Mol.Neurobiol. 2007;27:997-1006. View abstract.
  1095. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. Basic Clin Pharmacol Toxicol 2007;101:241-245. View abstract.
  1096. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biol.Pharm Bull. 2007;30:1732-1739. View abstract.
  1097. Manjunatha, H. and Srinivasan, K. Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Can J Physiol Pharmacol 2007;85:588-596. View abstract.
  1098. Kuhad, A. and Chopra, K. Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. Eur.J Pharmacol 12-8-2007;576(1-3):34-42. View abstract.
  1099. Shinojima, N., Yokoyama, T., Kondo, Y., and Kondo, S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 2007;3:635-637. View abstract.
  1100. Kurien, B. T., Singh, A., Matsumoto, H., and Scofield, R. H. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay.Drug Dev.Technol. 2007;5:567-576. View abstract.
  1101. Hsu, Y. C., Weng, H. C., Lin, S., and Chien, Y. W. Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis. J Agric.Food Chem. 10-3-2007;55:8213-8222. View abstract.
  1102. Takahashi, M., Ishiko, T., Kamohara, H., Hidaka, H., Ikeda, O., Ogawa, M., and Baba, H. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators.Inflamm. 2007;2007:10767. View abstract.
  1103. Liu, B., Bai, Q. X., Chen, X. Q., Gao, G. X., and Gu, H. T. [Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line]. Zhongguo Shi Yan.Xue.Ye.Xue.Za Zhi. 2007;15:762-766. View abstract.
  1104. Franck, T., Kohnen, S., Grulke, S., Neven, P., Goutman, Y., Peters, F., Pirotte, B., Deby-Dupont, G., and Serteyn, D. Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiol Res 2008;57:577-587. View abstract.
  1105. Ingolfsson, H. I., Koeppe, R. E., and Andersen, O. S. Curcumin is a modulator of bilayer material properties. Biochemistry 9-11-2007;46:10384-10391. View abstract.
  1106. Khajavi, M., Shiga, K., Wiszniewski, W., He, F., Shaw, C. A., Yan, J., Wensel, T. G., Snipes, G. J., and Lupski, J. R. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy. Am.J Hum.Genet. 2007;81:438-453. View abstract.
  1107. Takahashi, M., Inafuku, K., Miyagi, T., Oku, H., Wada, K., Imura, T., and Kitamoto, D. Efficient preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method. J Oleo.Sci. 2006;56:35-42. View abstract.
  1108. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J Ethnopharmacol. 9-25-2007;113:479-486. View abstract.
  1109. Park, C., Moon, D. O., Choi, I. W., Choi, B. T., Nam, T. J., Rhu, C. H., Kwon, T. K., Lee, W. H., Kim, G. Y., and Choi, Y. H. Curcumin induces apoptosis and inhibits prostaglandin E production in synovial fibroblasts of patients with rheumatoid arthritis. Int.J Mol.Med. 2007;20:365-372. View abstract.
  1110. Poma, P., Notarbartolo, M., Labbozzetta, M., Maurici, A., Carina, V., Alaimo, A., Rizzi, M., Simoni, D., and D'Alessandro, N. The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis. Int.J Mol.Med. 2007;20:329-335. View abstract.
  1111. Kim, Y. S., Ahn, Y., Hong, M. H., Joo, S. Y., Kim, K. H., Sohn, I. S., Park, H. W., Hong, Y. J., Kim, J. H., Kim, W., Jeong, M. H., Cho, J. G., Park, J. C., and Kang, J. C. Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. J Cardiovasc.Pharmacol 2007;50:41-49. View abstract.
  1112. Mathuria, N. and Verma, R. J. Aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro. Acta Pol.Pharm 2007;64:165-168. View abstract.
  1113. Wen, C. C., Kuo, Y. H., Jan, J. T., Liang, P. H., Wang, S. Y., Liu, H. G., Lee, C. K., Chang, S. T., Kuo, C. J., Lee, S. S., Hou, C. C., Hsiao, P. W., Chien, S. C., Shyur, L. F., and Yang, N. S. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med.Chem. 8-23-2007;50:4087-4095. View abstract.
  1114. Mrudula, T., Suryanarayana, P., Srinivas, P. N., and Reddy, G. B. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem.Biophys.Res Commun. 9-21-2007;361:528-532. View abstract.
  1115. Mandel, S., Amit, T., Bar-Am, O., and Youdim, M. B. Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog.Neurobiol. 2007;82:348-360. View abstract.
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  1117. Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104:12849-12854. View abstract.
  1118. Hammamieh, R., Sumaida, D., Zhang, X., Das, R., and Jett, M. Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC.Cancer 2007;7:138. View abstract.
  1119. Pari, L. and Murugan, P. Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats. J Med.Food 2007;10:323-329. View abstract.
  1120. Cheng, Y., Ping, J., and Liu, C. [Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2007;27:439-443. View abstract.
  1121. Sandur, S. K., Ichikawa, H., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Sethi, G., and Aggarwal, B. B. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic.Biol.Med. 8-15-2007;43:568-580. View abstract.
  1122. Kang, E. S., Woo, I. S., Kim, H. J., Eun, S. Y., Paek, K. S., Kim, H. J., Chang, K. C., Lee, J. H., Lee, H. T., Kim, J. H., Nishinaka, T., Yabe-Nishimura, C., and Seo, H. G. Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic.Biol.Med. 8-15-2007;43:535-545. View abstract.
  1123. Martelli, L., Ragazzi, E., di Mario, F., Martelli, M., Castagliuolo, I., Dal Maschio, M., Palu, G., Maschietto, M., Scorzeto, M., Vassanelli, S., and Brun, P. A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol.Motil. 2007;19:668-674. View abstract.
  1124. Walle, T. and Walle, U. K. Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. J Pharm Pharmacol 2007;59:857-862. View abstract.
  1125. Ye, S. F., Hou, Z. Q., Zhong, L. M., and Zhang, Q. Q. Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action. Yao Xue.Xue.Bao. 2007;42:376-380. View abstract.
  1126. Hoehle, S. I., Pfeiffer, E., and Metzler, M. Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases. Mol.Nutr.Food Res 2007;51:932-938. View abstract.
  1127. Xu, Y., Ku, B., Cui, L., Li, X., Barish, P. A., Foster, T. C., and Ogle, W. O. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 8-8-2007;1162:9-18. View abstract.
  1128. Salmaso, S., Bersani, S., Semenzato, A., and Caliceti, P. New cyclodextrin bioconjugates for active tumour targeting. J Drug Target 2007;15:379-390. View abstract.
  1129. Ragunathan, I. and Panneerselvam, N. Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa. J Zhejiang.Univ Sci.B 2007;8:470-475. View abstract.
  1130. Huang, X. R., Qi, M. X., Wu, Z. Z., Yan, J., and Hu, Y. H. [Effect of Rhizoma Curcumae and arsenite trioxide on proliferation and signal transduction molecule of lens epithelial cell]. Zhongguo Zhong.Yao Za Zhi. 2007;32:725-728. View abstract.
  1131. Pae, H. O., Jeong, G. S., Jeong, S. O., Kim, H. S., Kim, S. A., Kim, Y. C., Yoo, S. J., Kim, H. D., and Chung, H. T. Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells. Exp.Mol.Med. 6-30-2007;39:267-277. View abstract.
  1132. Zheng, S., Yumei, F., and Chen, A. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic.Biol.Med. 8-1-2007;43:444-453. View abstract.
  1133. Dhandapani, K. M., Mahesh, V. B., and Brann, D. W. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem. 2007;102:522-538. View abstract.
  1134. Liu, E., Wu, J., Cao, W., Zhang, J., Liu, W., Jiang, X., and Zhang, X. Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J Neurooncol. 2007;85:263-270. View abstract.
  1135. Jain, V., Prasad, V., Pal, R., and Singh, S. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. J Pharm Biomed.Anal. 9-3-2007;44:1079-1086. View abstract.
  1136. Yu, Z. and Shah, D. M. Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells. Gynecol.Oncol. 2007;106:541-548. View abstract.
  1137. Adhvaryu, M. R., Reddy, N., and Parabia, M. H. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol. 6-21-2007;13:3199-3205. View abstract.
  1138. Cheng, Y., Kozubek, A., Ohlsson, L., Sternby, B., and Duan, R. D. Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells. Planta Med. 2007;73:725-730. View abstract.
  1139. Kim, S. J. and Hellerstein, M. K. Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats. Phytother.Res 2007;21:995-998. View abstract.
  1140. Zhang, D. P., Qiu, H., Zhuang, Y., and Meng, F. Q. [The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 2007;30:197-201. View abstract.
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  1143. Bright, J. J. Curcumin and autoimmune disease. Adv.Exp.Med.Biol. 2007;595:425-451. View abstract.
  1144. Venkatesan, N., Punithavathi, D., and Babu, M. Protection from acute and chronic lung diseases by curcumin. Adv.Exp.Med.Biol. 2007;595:379-405. View abstract.
  1145. Miriyala, S., Panchatcharam, M., and Rengarajulu, P. Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 2007;595:359-377. View abstract.
  1146. Thangapazham, R. L., Sharma, A., and Maheshwari, R. K. Beneficial role of curcumin in skin diseases. Adv.Exp.Med.Biol. 2007;595:343-357. View abstract.
  1147. Gautam, S. C., Gao, X., and Dulchavsky, S. Immunomodulation by curcumin. Adv.Exp.Med.Biol. 2007;595:321-341. View abstract.
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  1149. Rao, C. V. Regulation of COX and LOX by curcumin. Adv.Exp.Med.Biol. 2007;595:213-226. View abstract.
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  1151. Bhandarkar, S. S. and Arbiser, J. L. Curcumin as an inhibitor of angiogenesis. Adv.Exp.Med.Biol. 2007;595:185-195. View abstract.
  1152. Kuttan, G., Kumar, K. B., Guruvayoorappan, C., and Kuttan, R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 2007;595:173-184. View abstract.
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  1154. Mosley, C. A., Liotta, D. C., and Snyder, J. P. Highly active anticancer curcumin analogues. Adv.Exp.Med.Biol. 2007;595:77-103. View abstract.
  1155. Karmakar, S., Banik, N. L., and Ray, S. K. Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells. Neurochem.Res 2007;32:2103-2113. View abstract.
  1156. Zhang, H. G., Kim, H., Liu, C., Yu, S., Wang, J., Grizzle, W. E., Kimberly, R. P., and Barnes, S. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochim.Biophys.Acta 2007;1773:1116-1123. View abstract.
  1157. Zeng, Y., Qiu, F., Liu, Y., Qu, G., and Yao, X. Isolation and identification of phase 1 metabolites of demethoxycurcumin in rats. Drug Metab Dispos. 2007;35:1564-1573. View abstract.
  1158. Lin, Y. G., Kunnumakkara, A. B., Nair, A., Merritt, W. M., Han, L. Y., Armaiz-Pena, G. N., Kamat, A. A., Spannuth, W. A., Gershenson, D. M., Lutgendorf, S. K., Aggarwal, B. B., and Sood, A. K. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res 6-1-2007;13:3423-3430. View abstract.
  1159. Ibrahim, M. A., Elbehairy, A. M., Ghoneim, M. A., and Amer, H. A. Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene. Z.Naturforsch.C. 2007;62(3-4):215-222. View abstract.
  1160. Yamaguchi, M., Hamamoto, R., Uchiyama, S., and Ishiyama, K. Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro. Mol.Cell Biochem. 2007;303(1-2):83-88. View abstract.
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  1162. Teichmann, A., Heuschkel, S., Jacobi, U., Presse, G., Neubert, R. H., Sterry, W., and Lademann, J. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur.J Pharm Biopharm. 2007;67:699-706. View abstract.
  1163. Pugazhenthi, S., Akhov, L., Selvaraj, G., Wang, M., and Alam, J. Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am.J Physiol Endocrinol.Metab 2007;293:E645-E655. View abstract.
  1164. Vlahovic, P., Cvetkovic, T., Savic, V., and Stefanovic, V. Dietary curcumin does not protect kidney in glycerol-induced acute renal failure. Food Chem.Toxicol 2007;45:1777-1782. View abstract.
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  1166. Suresh, D. and Srinivasan, K. Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines. Food Chem.Toxicol 2007;45:1437-1442. View abstract.
  1167. Marwick, J. A., Ito, K., Adcock, I. M., and Kirkham, P. A. Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert.Opin.Ther.Targets. 2007;11:745-755. View abstract.
  1168. Xia, Y., Jin, L., Zhang, B., Xue, H., Li, Q., and Xu, Y. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells. Life Sci. 5-16-2007;80:2161-2169. View abstract.
  1169. Jayakumar, V., Bhaskaran, R., and Tsushima, S. Potential of plant extracts in combination with bacterial antagonist treatment as biocontrol agent of red rot of sugarcane. Can J Microbiol. 2007;53:196-206. View abstract.
  1170. Rema, M. and Pradeepa, R. Diabetic retinopathy: an Indian perspective. Indian J Med.Res 2007;125:297-310. View abstract.
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  1172. Tamvakopoulos, C., Sofianos, Z. D., Garbis, S. D., and Pantazis, P. Analysis of the in vitro metabolites of diferuloylmethane (curcumin) by liquid chromatography--tandem mass spectrometry on a hybrid quadrupole linear ion trap system: newly identified metabolites. Eur.J Drug Metab Pharmacokinet. 2007;32:51-57. View abstract.
  1173. Moss, A. C. Curcumin for maintenance therapy in ulcerative colitis. Clin Gastroenterol.Hepatol. 2007;5:642. View abstract.
  1174. Garcia-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., and Bacskai, B. J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007;102:1095-1104. View abstract.
  1175. Juan, H., Terhaag, B., Cong, Z., Bi-Kui, Z., Rong-Hua, Z., Feng, W., Fen-Li, S., Juan, S., Jing, T., and Wen-Xing, P. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur.J Clin Pharmacol 2007;63:663-668. View abstract.
  1176. Hauser, P. J., Han, Z., Sindhwani, P., and Hurst, R. E. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Anticancer Res 2007;27:737-740. View abstract.
  1177. Abuarqoub, H., Green, C. J., Foresti, R., and Motterlini, R. Curcumin reduces cold storage-induced damage in human cardiac myoblasts. Exp.Mol.Med. 4-30-2007;39:139-148. View abstract.
  1178. Shen, S. Q., Zhang, Y., Xiang, J. J., and Xiong, C. L. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol. 4-7-2007;13:1953-1961. View abstract.
  1179. Xu, P. H., Long, Y., Dai, F., and Liu, Z. L. The relaxant effect of curcumin on porcine coronary arterial ring segments. Vascul.Pharmacol 2007;47:25-30. View abstract.
  1180. Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A., and Maitra, A. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. J Nanobiotechnology. 2007;5:3. View abstract.
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  1184. Smith, D. G., Cappai, R., and Barnham, K. J. The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim.Biophys.Acta 2007;1768:1976-1990. View abstract.
  1185. Deguchi, Y., Andoh, A., Inatomi, O., Yagi, Y., Bamba, S., Araki, Y., Hata, K., Tsujikawa, T., and Fujiyama, Y. Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis. Dig.Dis.Sci. 2007;52:2993-2998. View abstract.
  1186. Neuss, H., Huang, X., Hetfeld, B. K., Deva, R., Henklein, P., Nigam, S., Mall, J. W., Schwenk, W., and Dubiel, W. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. J Mol.Med. 2007;85:961-970. View abstract.
  1187. Eguchi, A., Kaneko, Y., Murakami, A., and Ohigashi, H. Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. Biosci.Biotechnol.Biochem. 2007;71:935-945. View abstract.
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  1189. Yang, K. Y., Lin, L. C., Tseng, T. Y., Wang, S. C., and Tsai, T. H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 6-15-2007;853(1-2):183-189. View abstract.
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  1191. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim.Biophys.Acta 2007;1770:989-996. View abstract.
  1192. Best, L., Elliott, A. C., and Brown, P. D. Curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel. Biochem.Pharmacol 6-1-2007;73:1768-1775. View abstract.
  1193. Shih, P. C., Lee, H. H., Lai, S. C., Chen, K. M., Jiang, S. T., Chen, Y. F., and Shiow, S. J. Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. J Helminthol. 2007;81:1-5. View abstract.
  1194. Venkataranganna, M. V., Rafiq, M., Gopumadhavan, S., Peer, G., Babu, U. V., and Mitra, S. K. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS. World J Gastroenterol. 2-21-2007;13:1103-1107. View abstract.
  1195. Zhou, Y., Zheng, S., Lin, J., Zhang, Q. J., and Chen, A. The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest 2007;87:488-498. View abstract.
  1196. Lian, Q., Li, X., Shang, Y., Yao, S., Ma, L., and Jin, S. Protective effect of curcumin on endotoxin-induced acute lung injury in rats. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26:678-681. View abstract.
  1197. Bruck, R., Ashkenazi, M., Weiss, S., Goldiner, I., Shapiro, H., Aeed, H., Genina, O., Helpern, Z., and Pines, M. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 2007;27:373-383. View abstract.
  1198. Atsumi, T., Tonosaki, K., and Fujisawa, S. Comparative cytotoxicity and ROS generation by curcumin and tetrahydrocurcumin following visible-light irradiation or treatment with horseradish peroxidase. Anticancer Res 2007;27(1A):363-371. View abstract.
  1199. Sivalingam, N., Hanumantharaya, R., Faith, M., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin reduces indomethacin-induced damage in the rat small intestine. J Appl.Toxicol 2007;27:551-560. View abstract.
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  1202. Mitra, A., Chakrabarti, J., Banerji, A., Chatterjee, A., and Das, B. R. Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ.Pathol.Toxicol Oncol. 2006;25:679-690. View abstract.
  1203. Ma, Z., Shayeganpour, A., Brocks, D. R., Lavasanifar, A., and Samuel, J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed.Chromatogr. 2007;21:546-552. View abstract.
  1204. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on plasma antioxidants in streptozotocin-nicotinamide experimental diabetes. J Basic Clin Physiol Pharmacol 2006;17:231-244. View abstract.
  1205. Davis, J. M., Murphy, E. A., Carmichael, M. D., Zielinski, M. R., Groschwitz, C. M., Brown, A. S., Gangemi, J. D., Ghaffar, A., and Mayer, E. P. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am.J Physiol Regul.Integr.Comp Physiol 2007;292:R2168-R2173. View abstract.
  1206. Pan, C. J., Shao, Z. Y., Tang, J. J., Wang, J., and Huang, N. In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent materials. J Biomed.Mater.Res A 9-1-2007;82:740-746. View abstract.
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  1208. Bentzen, P. J., Lang, E., and Lang, F. Curcumin induced suicidal erythrocyte death. Cell Physiol Biochem. 2007;19(1-4):153-164. View abstract.
  1209. Deng, J., Grande, F., and Neamati, N. Small molecule inhibitors of Stat3 signaling pathway. Curr.Cancer Drug Targets. 2007;7:91-107. View abstract.
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  1212. Zhang, H. N., Yu, C. X., Zhang, P. J., Chen, W. W., Jiang, A. L., Kong, F., Deng, J. T., Zhang, J. Y., and Young, C. Y. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP. Acta Pharmacol Sin. 2007;28:423-430. View abstract.
  1213. Shin, H. J., Lee, J. Y., Son, E., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., and Roh, G. S. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neurosci.Lett. 4-6-2007;416:49-54. View abstract.
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  1217. Shi, P., Chen, W. W., Hu, X. Y., Yu, C. X., Zhang, P. J., Jiang, A. L., and Zhang, J. Y. [Up-regulates the expression of maspin gene in prostate cancer cell line LNCaP]. Yao Xue.Xue.Bao. 2006;41:1152-1156. View abstract.
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  1220. Cho, J. W., Lee, K. S., and Kim, C. W. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int.J Mol.Med. 2007;19:469-474. View abstract.
  1221. Byeon, S. R., Lee, J. H., Sohn, J. H., Kim, D. C., Shin, K. J., Yoo, K. H., Mook-Jung, I., Lee, W. K., and Kim, D. J. Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation. Bioorg.Med.Chem.Lett. 3-1-2007;17:1466-1470. View abstract.
  1222. Dairam, A., Limson, J. L., Watkins, G. M., Antunes, E., and Daya, S. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric.Food Chem. 2-7-2007;55:1039-1044. View abstract.
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  1227. Chen, C. C., Taniguchi, T., and D'Andrea, A. The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol.Med. 2007;85:497-509. View abstract.
  1228. Farombi, E. O., Abarikwu, S. O., Adedara, I. A., and Oyeyemi, M. O. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 2007;100:43-48. View abstract.
  1229. Jagetia, G. C. and Aggarwal, B. B. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27:19-35. View abstract.
  1230. Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., and Morales, N. P. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol.Pharm Bull. 2007;30:74-78. View abstract.
  1231. Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Mancuso, C., Butterfield, D. A., and Stella, A. G. Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochem.Res 2007;32(4-5):757-773. View abstract.
  1232. Kwon, Y. and Magnuson, B. A. Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. Scand.J Gastroenterol. 2007;42:72-80. View abstract.
  1233. Zhang, K. Z., Xu, J. H., Huang, X. W., Wu, L. X., Su, Y., and Chen, Y. Z. Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells. Acta Pharmacol Sin. 2007;28:105-110. View abstract.
  1234. Mythri, R. B., Jagatha, B., Pradhan, N., Andersen, J., and Bharath, M. M. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid.Redox.Signal. 2007;9:399-408. View abstract.
  1235. Gururajan, M., Dasu, T., Shahidain, S., Jennings, C. D., Robertson, D. A., Rangnekar, V. M., and Bondada, S. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol. 1-1-2007;178:111-121. View abstract.
  1236. Pinilla, F. G. The impact of diet and exercise on brain plasticity and disease. Nutr.Health 2006;18:277-284. View abstract.
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  1238. Mishra, S., Mishra, J. P., and Kumar, A. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. J Biol.Chem. 2-16-2007;282:4288-4300. View abstract.
  1239. Lee, C. W., Lin, C. C., Lin, W. N., Liang, K. C., Luo, S. F., Wu, C. B., Wang, S. W., and Yang, C. M. TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells. Am.J Physiol Lung Cell Mol.Physiol 2007;292:L799-L812. View abstract.
  1240. Liddle, M., Hull, C., Liu, C., and Powell, D. Contact urticaria from curcumin. Dermatitis 2006;17:196-197. View abstract.
  1241. Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol.Microcirc. 2006;35:481-489. View abstract.
  1242. Balasubramanian, S. and Eckert, R. L. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol.Chem. 3-2-2007;282:6707-6715. View abstract.
  1243. Ma, X. and Gang, D. R. Metabolic profiling of turmeric (Curcuma longa L.) plants derived from in vitro micropropagation and conventional greenhouse cultivation. J Agric.Food Chem. 12-13-2006;54:9573-9583. View abstract.
  1244. Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob.Agents Chemother. 2007;51:488-494. View abstract.
  1245. McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., and Wigmore, S. J. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int.J Mol.Med. 2007;19:165-172. View abstract.
  1246. Furusu, A., Nakayama, K., Xu, Q., Konta, T., and Kitamura, M. MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha. J Cell Physiol 2007;210:703-710. View abstract.
  1247. Suh, H. W., Kang, S., and Kwon, K. S. Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. Mol.Cell Biochem. 2007;298(1-2):187-194. View abstract.
  1248. Salimei, P. S., Marfe, G., Di Renzo, L., Di Stefano, C., Giganti, M. G., Filomeni, G., and Ciriolo, M. R. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Front Biosci. 2007;12:1308-1317. View abstract.
  1249. Mancuso, C., Scapagini, G., Curro, D., Giuffrida Stella, A. M., De Marco, C., Butterfield, D. A., and Calabrese, V. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci. 2007;12:1107-1123. View abstract.
  1250. Anuchapreeda, S., Thanarattanakorn, P., Sittipreechacharn, S., Tima, S., Chanarat, P., and Limtrakul, P. Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Arch.Pharm Res 2006;29:866-873. View abstract.
  1251. Yazawa, K., Kihara, T., Shen, H., Shimmyo, Y., Niidome, T., and Sugimoto, H. Distinct mechanisms underlie distinct polyphenol-induced neuroprotection. FEBS Lett. 12-11-2006;580(28-29):6623-6628. View abstract.
  1252. Honda, S., Aoki, F., Tanaka, H., Kishida, H., Nishiyama, T., Okada, S., Matsumoto, I., Abe, K., and Mae, T. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study. J Agric.Food Chem. 11-29-2006;54:9055-9062. View abstract.
  1253. Kurien, B. T. and Scofield, R. H. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification--an in vitro study. J Ethnopharmacol. 3-21-2007;110:368-373. View abstract.
  1254. Maiti, K., Mukherjee, K., Gantait, A., Saha, B. P., and Mukherjee, P. K. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int.J Pharm 2-7-2007;330(1-2):155-163. View abstract.
  1255. Ono, K., Naiki, H., and Yamada, M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr.Pharm Des 2006;12:4357-4375. View abstract.
  1256. Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4:1502-1506. View abstract.
  1257. Mukherjee Nee, Chakraborty S., Ghosh, U., Bhattacharyya, N. P., Bhattacharya, R. K., Dey, S., and Roy, M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol.Cell Biochem. 2007;297(1-2):31-39. View abstract.
  1258. Huang, X. R., Qi, M. X., and Kang, K. R. [Apoptosis of lens epithelial cell induced by curcumin and its mechanism]. Zhonghua Yan.Ke.Za Zhi. 2006;42:649-653. View abstract.
  1259. Ebert, B., Seidel, A., and Lampen, A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007;96:227-236. View abstract.
  1260. Pari, L. and Murugan, P. Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. Basic Clin Pharmacol Toxicol 2006;99:329-334. View abstract.
  1261. Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54:3452-3464. View abstract.
  1262. Gupta, K. K., Bharne, S. S., Rathinasamy, K., Naik, N. R., and Panda, D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J 2006;273:5320-5332. View abstract.
  1263. Marczylo, T. H., Verschoyle, R. D., Cooke, D. N., Morazzoni, P., Steward, W. P., and Gescher, A. J. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother.Pharmacol 2007;60:171-177. View abstract.
  1264. Pan, ChJ, Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation, characterization and anticoagulation of curcumin-eluting controlled biodegradable coating stents. J Control Release 2006;116:42-49. View abstract.
  1265. Tayyem, R. F., Heath, D. D., Al Delaimy, W. K., and Rock, C. L. Curcumin content of turmeric and curry powders. Nutr.Cancer 2006;55:126-131. View abstract.
  1266. Chen, C., Johnston, T. D., Wu, G., and Ranjan, D. Curcumin has potent liver preservation properties in an isolated perfusion model. Transplantation 10-15-2006;82:931-937. View abstract.
  1267. Khopde, M., Priyadarsini, K. I., Venkatesan, P., and Rao, M. N. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophys.Chem. 8-9-1999;80:85-91. View abstract.
  1268. Khan, A., Bryden, N. A., Polansky, M. M., and Anderson, R. A. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem.Res 1990;24:183-188. View abstract.
  1269. Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., and Li, X. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 11-29-2006;1122:56-64. View abstract.
  1270. Cheng, Y., Ping, J., Liu, C., Tan, Y. Z., and Chen, G. F. Study on effects of extracts from Salvia Miltiorrhiza and Curcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells. Chin J Integr.Med. 2006;12:207-211. View abstract.
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  1272. Mattson, M. P. and Cheng, A. Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci. 2006;29:632-639. View abstract.
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  1274. Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G., and Rosenthal, M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2006;10:1-7. View abstract.
  1275. Ganiger, S., Malleshappa, H. N., Krishnappa, H., Rajashekhar, G., Ramakrishna, Rao, V, and Sullivan, F. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem.Toxicol 2007;45:64-69. View abstract.
  1276. Ruiz-Torres, M. P., Perez-Rivero, G., Diez-Marques, M. L., Griera, M., Ortega, R., Rodriguez-Puyol, M., and Rodriguez-Puyol, D. Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity. Int.J Biochem.Cell Biol. 2007;39:133-145. View abstract.
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  1279. Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am.J Physiol Gastrointest.Liver Physiol 2007;292:G113-G123. View abstract.
  1280. Blasius, R., Reuter, S., Henry, E., Dicato, M., and Diederich, M. Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells. Biochem.Pharmacol 11-30-2006;72:1547-1554. View abstract.
  1281. Thompson, D. A. and Tan, B. B. Tetrahydracurcumin-related allergic contact dermatitis. Contact Dermatitis 2006;55:254-255. View abstract.
  1282. Niture, S. K., Velu, C. S., Smith, Q. R., Bhat, G. J., and Srivenugopal, K. S. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 2007;28:378-389. View abstract.
  1283. Weber, W. M., Hunsaker, L. A., Gonzales, A. M., Heynekamp, J. J., Orlando, R. A., Deck, L. M., and Vander Jagt, D. L. TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. Biochem.Pharmacol 10-16-2006;72:928-940. View abstract.
  1284. Ganguly, K., Kundu, P., Banerjee, A., Reiter, R. J., and Swarnakar, S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radic.Biol.Med. 9-15-2006;41:911-925. View abstract.
  1285. Jung, K. K., Lee, H. S., Cho, J. Y., Shin, W. C., Rhee, M. H., Kim, T. G., Kang, J. H., Kim, S. H., Hong, S., and Kang, S. Y. Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 10-19-2006;79:2022-2031. View abstract.
  1286. Krejsgaard, T., Vetter-Kauczok, C. S., Woetmann, A., Lovato, P., Labuda, T., Eriksen, K. W., Zhang, Q., Becker, J. C., and Odum, N. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. Leukemia 2006;20:1759-1766. View abstract.
  1287. Qin, N. Y., Yang, F. Q., Wang, Y. T., and Li, S. P. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharm Biomed.Anal. 1-17-2007;43:486-492. View abstract.
  1288. Chan, W. H. and Wu, H. J. Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Acta Pharmacol Sin. 2006;27:1192-1198. View abstract.
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  1292. Ramassamy, C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur.J Pharmacol 9-1-2006;545:51-64. View abstract.
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  1294. Choi, H., Chun, Y. S., Kim, S. W., Kim, M. S., and Park, J. W. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol.Pharmacol 2006;70:1664-1671. View abstract.
  1295. Chowdhury, P., Sacks, S. H., and Sheerin, N. S. Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clin Exp.Immunol. 2006;145:346-356. View abstract.
  1296. Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., and Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp.Immunol. 2006;145:313-321. View abstract.
  1297. Ng, T. P., Chiam, P. C., Lee, T., Chua, H. C., Lim, L., and Kua, E. H. Curry consumption and cognitive function in the elderly. Am.J Epidemiol. 11-1-2006;164:898-906. View abstract.
  1298. Zhang, M., Deng, C. S., Zheng, J. J., and Xia, J. Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacol Sin. 2006;27:1071-1077. View abstract.
  1299. Wolanin, K., Magalska, A., Mosieniak, G., Klinger, R., McKenna, S., Vejda, S., Sikora, E., and Piwocka, K. Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Mol.Cancer Res 2006;4:457-469. View abstract.
  1300. Farhangkhoee, H., Khan, Z. A., Chen, S., and Chakrabarti, S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr.Metab (Lond) 2006;3:27. View abstract.
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  1304. Vemula, P. K., Li, J., and John, G. Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs. J Am.Chem.Soc. 7-12-2006;128:8932-8938. View abstract.
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  1306. Moon, D. O., Jin, C. Y., Lee, J. D., Choi, Y. H., Ahn, S. C., Lee, C. M., Jeong, S. C., Park, Y. M., and Kim, G. Y. Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets. Biol.Pharm Bull. 2006;29:1470-1475. View abstract.
  1307. Farombi, E. O. and Ekor, M. Curcumin attenuates gentamicin-induced renal oxidative damage in rats. Food Chem.Toxicol 2006;44:1443-1448. View abstract.
  1308. Jackson, J. K., Higo, T., Hunter, W. L., and Burt, H. M. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm.Res 2006;55:168-175. View abstract.
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  1311. Mori, Y., Tatematsu, K., Koide, A., Sugie, S., Tanaka, T., and Mori, H. Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats. Cancer Sci. 2006;97:896-904. View abstract.
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  1316. Tohda, C., Nakayama, N., Hatanaka, F., and Komatsu, K. Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evid.Based.Complement Alternat.Med. 2006;3:255-260. View abstract.
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  1318. Jain, S. K., Rains, J., and Jones, K. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Radic.Biol.Med. 7-1-2006;41:92-96. View abstract.
  1319. Zhou, G., Wang, J. F., Niu, J. Z., Lu, Y. S., Chen, W. T., Li, Z. H., and Lin, T. X. [Experimental study on protective effects of curcumin on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31:570-573. View abstract.
  1320. Parodi, F. E., Mao, D., Ennis, T. L., Pagano, M. B., and Thompson, R. W. Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms. Ann.Vasc.Surg. 2006;20:360-368. View abstract.
  1321. Belkaid, A., Copland, I. B., Massillon, D., and Annabi, B. Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin. FEBS Lett. 6-26-2006;580:3746-3752. View abstract.
  1322. Ndamukong, K. J., Ntonifor, N. N., Mbuh, J., Atemnkeng, A. F., and Akam, M. T. Molluscicidal activity of some Cameroonian plants on Bulinus species. East Afr.Med.J 2006;83:102-109. View abstract.
  1323. Al Omar, F. A., Nagi, M. N., Abdulgadir, M. M., Al Joni, K. S., and Al Majed, A. A. Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem.Res 2006;31:611-618. View abstract.
  1324. Panchatcharam, M., Miriyala, S., Gayathri, V. S., and Suguna, L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol.Cell Biochem. 2006;290(1-2):87-96. View abstract.
  1325. Nieman, D. C. and Bishop, N. C. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. J Sports Sci. 2006;24:763-772. View abstract.
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  1328. Wu, L. X., Xu, J. H., Huang, X. W., Zhang, K. Z., Wen, C. X., and Chen, Y. Z. Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. Acta Pharmacol Sin. 2006;27:694-699. View abstract.
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  1330. Durham, W. J., Arbogast, S., Gerken, E., Li, Y. P., and Reid, M. B. Progressive nuclear factor-kappaB activation resistant to inhibition by contraction and curcumin in mdx mice. Muscle Nerve 2006;34:298-303. View abstract.
  1331. Siddiqui, A. M., Cui, X., Wu, R., Dong, W., Zhou, M., Hu, M., Simms, H. H., and Wang, P. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006;34:1874-1882. View abstract.
  1332. Peschel, D., Koerting, R., and Nass, N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr.Biochem. 2007;18:113-119. View abstract.
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  1334. Vanisree, A. J. and Sudha, N. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Mol.Cell Biochem. 2006;288(1-2):115-123. View abstract.
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  1336. Perez-Arriaga, L., Mendoza-Magana, M. L., Cortes-Zarate, R., Corona-Rivera, A., Bobadilla-Morales, L., Troyo-Sanroman, R., and Ramirez-Herrera, M. A. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop. 2006;98:152-161. View abstract.
  1337. Scapagnini, G., Colombrita, C., Amadio, M., D'Agata, V., Arcelli, E., Sapienza, M., Quattrone, A., and Calabrese, V. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid.Redox.Signal. 2006;8(3-4):395-403. View abstract.
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  1341. Liu, H., Danthi, S. J., and Enyeart, J. J. Curcumin potently blocks Kv1.4 potassium channels. Biochem.Biophys.Res Commun. 6-16-2006;344:1161-1165. View abstract.
  1342. Kang, S. K., Cha, S. H., and Jeon, H. G. Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells. Stem Cells Dev. 2006;15:165-174. View abstract.
  1343. Norez, C., Antigny, F., Becq, F., and Vandebrouck, C. Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells. Traffic. 2006;7:562-573. View abstract.
  1344. Premanand, C., Rema, M., Sameer, M. Z., Sujatha, M., and Balasubramanyam, M. Effect of curcumin on proliferation of human retinal endothelial cells under in vitro conditions. Invest Ophthalmol.Vis.Sci. 2006;47:2179-2184. View abstract.
  1345. Cleary, K. and McFeeters, R. F. Effects of oxygen and turmeric on the formation of oxidative aldehydes in fresh-pack dill pickles. J Agric.Food Chem. 5-3-2006;54:3421-3427. View abstract.
  1346. Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Maity, P., and Banerjee, R. K. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic.Biol.Med. 4-15-2006;40:1397-1408. View abstract.
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  1351. Wang, Y. D., Hu, Y., and Sun, C. Y. [Inhibitory effect of curcumin on angiogenesis induced by brain derived neurotrophic factor from multiple myeloma cells]. Zhongguo Shi Yan.Xue.Ye.Xue.Za Zhi. 2006;14:70-74. View abstract.
  1352. Funk, J. L., Oyarzo, J. N., Frye, J. B., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., and Timmermann, B. N. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat.Prod. 2006;69:351-355. View abstract.
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  1355. Chen, J., Tang, X. Q., Zhi, J. L., Cui, Y., Yu, H. M., Tang, E. H., Sun, S. N., Feng, J. Q., and Chen, P. X. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis. 2006;11:943-953. View abstract.
  1356. Kwak, H. J., Park, M. J., Cho, H., Park, C. M., Moon, S. I., Lee, H. C., Park, I. C., Kim, M. S., Rhee, C. H., and Hong, S. I. Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol.Cancer Res 2006;4:209-220. View abstract.
  1357. Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., and Brenner, D. E. Dose escalation of a curcuminoid formulation. BMC.Complement Altern.Med. 2006;6:10. View abstract.
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  1361. Ono, K. and Yamada, M. Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. J Neurochem. 2006;97:105-115. View abstract.
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  1363. Shapiro, H., Ashkenazi, M., Weizman, N., Shahmurov, M., Aeed, H., and Bruck, R. Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. J Gastroenterol.Hepatol. 2006;21:358-366. View abstract.
  1364. Kukongviriyapan, V., Phromsopha, N., Tassaneeyakul, W., Kukongviriyapan, U., Sripa, B., Hahnvajanawong, V., and Bhudhisawasdi, V. Inhibitory effects of polyphenolic compounds on human arylamine N-acetyltransferase 1 and 2. Xenobiotica 2006;36:15-28. View abstract.
  1365. Mohanty, I., Arya, D. S., and Gupta, S. K. Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. BMC.Complement Altern.Med. 2006;6:3. View abstract.
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  1367. McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., and Wigmore, S. J. Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. Transplantation 2-27-2006;81:623-626. View abstract.
  1368. Atamna, H. and Boyle, K. Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. Proc.Natl.Acad.Sci.U.S A 2-28-2006;103:3381-3386. View abstract.
  1369. Jiang, H., Timmermann, B. N., and Gang, D. R. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromatogr.A 4-7-2006;1111:21-31. View abstract.
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  1372. Sreepriya, M. and Bali, G. Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol.Cell Biochem. 2006;284(1-2):49-55. View abstract.
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  1374. Lu, M., Leng, Q., Egan, M. E., Caplan, M. J., Boulpaep, E. L., Giebisch, G. H., and Hebert, S. C. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 2006;116:797-807. View abstract.
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  1376. Zhou, H., Wong, Y. F., Cai, X., Liu, Z. Q., Jiang, Z. H., Bian, Z. X., Xu, H. X., and Liu, L. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Biol.Pharm Bull. 2006;29:253-260. View abstract.
  1377. Kuwabara, N., Tamada, S., Iwai, T., Teramoto, K., Kaneda, N., Yukimura, T., Nakatani, T., and Miura, K. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006;67:440-446. View abstract.
  1378. Patel, H. J., Su, S. H., Patterson, C., and Nguyen, K. T. A combined strategy to reduce restenosis for vascular tissue engineering applications. Biotechnol.Prog. 2006;22:38-44. View abstract.
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  1383. Lipecka, J., Norez, C., Bensalem, N., Baudouin-Legros, M., Planelles, G., Becq, F., Edelman, A., and Davezac, N. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. J Pharmacol Exp.Ther. 2006;317:500-505. View abstract.
  1384. Gulcubuk, A., Altunatmaz, K., Sonmez, K., Haktanir-Yatkin, D., Uzun, H., Gurel, A., and Aydin, S. Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet.Med.A Physiol Pathol.Clin Med. 2006;53:49-54. View abstract.
  1385. Wootton, L. L. and Michelangeli, F. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. J Biol.Chem. 3-17-2006;281:6970-6976. View abstract.
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  1393. Bernt, C., Vennegeerts, T., Beuers, U., and Rust, C. The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. Biochem.Biophys.Res Commun. 2-17-2006;340:800-806. View abstract.
  1394. Cho, M. L., Jung, Y. O., Moon, Y. M., Min, S. Y., Yoon, C. H., Lee, S. H., Park, S. H., Cho, C. S., Jue, D. M., and Kim, H. Y. Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways. Immunol.Lett. 3-15-2006;103:159-166. View abstract.
  1395. Gupta, S. and Ravishankar, S. A comparison of the antimicrobial activity of garlic, ginger, carrot, and turmeric pastes against Escherichia coli O157:H7 in laboratory buffer and ground beef. Foodborne.Pathog.Dis. 2005;2:330-340. View abstract.
  1396. Wu, A., Ying, Z., and Gomez-Pinilla, F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp.Neurol. 2006;197:309-317. View abstract.
  1397. Shun, C. T., Lin, S. K., Hong, C. Y., Kok, S. H., Juan, Y. H., Wang, C. C., Hsu, M. C., and Liu, C. M. C-C chemokine ligand 2 gene expression in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. Ann.Otol.Rhinol.Laryngol. 2005;114:879-885. View abstract.
  1398. Kawanishi, S., Oikawa, S., and Murata, M. Evaluation for safety of antioxidant chemopreventive agents. Antioxid.Redox.Signal. 2005;7(11-12):1728-1739. View abstract.
  1399. Eybl, V., Kotyzova, D., Leseticky, L., Bludovska, M., and Koutensky, J. The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice. J Appl.Toxicol 2006;26:207-212. View abstract.
  1400. Yang, L., Zhang, L. Y., Chen, W. W., Kong, F., Zhang, P. J., Hu, X. Y., Zhang, J. Y., and Cui, F. A. [Inhibition of the expression of prostate specific antigen by curcumin]. Yao Xue.Xue.Bao. 2005;40:800-803. View abstract.
  1401. Weber-Mzell, D., Zaupa, P., Petnehazy, T., Kobayashi, H., Schimpl, G., Feierl, G., Kotanko, P., and Hollwarth, M. The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats. Pediatr.Surg.Int. 2006;22:43-49. View abstract.
  1402. Kim, D. C., Kim, S. H., Choi, B. H., Baek, N. I., Kim, D., Kim, M. J., and Kim, K. T. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol.Pharm Bull. 2005;28:2220-2224. View abstract.
  1403. Cai, Y. Z., Mei, Sun, Jie, Xing, Luo, Q., and Corke, H. Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci. 5-15-2006;78:2872-2888. View abstract.
  1404. Shakibaei, M., Schulze-Tanzil, G., John, T., and Mobasheri, A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann.Anat. 2005;187(5-6):487-497. View abstract.
  1405. Liu, A., Lou, H., Zhao, L., and Fan, P. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed.Anal. 2-24-2006;40:720-727. View abstract.
  1406. Yang, C., Wang, Z. G., Chen, L. Y., Zhou, J., Zhu, P. F., and Jiang, J. X. Silencing effect of recombinant plasmids PPARgamma-pSUPER-EGFP on the expression of peroxisome proliferator-activated receptor gamma. Chin J Traumatol. 2005;8:352-357. View abstract.
  1407. Kumar, P. A., Haseeb, A., Suryanarayana, P., Ehtesham, N. Z., and Reddy, G. B. Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch.Biochem.Biophys. 12-15-2005;444:77-83. View abstract.
  1408. Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am.J Physiol Gastrointest.Liver Physiol 2006;290:G883-G893. View abstract.
  1409. Thomas, R. K., Sos, M. L., Zander, T., Mani, O., Popov, A., Berenbrinker, D., Smola-Hess, S., Schultze, J. L., and Wolf, J. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clin Cancer Res 11-15-2005;11:8186-8194. View abstract.
  1410. Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., and Dexter, D. T. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic.Res 2005;39:1119-1125. View abstract.
  1411. Masamune, A., Suzuki, N., Kikuta, K., Satoh, M., Satoh, K., and Shimosegawa, T. Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem. 4-1-2006;97:1080-1093. View abstract.
  1412. Lee, C. W., Lin, W. N., Lin, C. C., Luo, S. F., Wang, J. S., Pouyssegur, J., and Yang, C. M. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation. J Cell Physiol 2006;207:174-186. View abstract.
  1413. Grubb, B. R., Gabriel, S. E., Mengos, A., Gentzsch, M., Randell, S. H., Van Heeckeren, A. M., Knowles, M. R., Drumm, M. L., Riordan, J. R., and Boucher, R. C. SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis. Am.J Respir.Cell Mol.Biol. 2006;34:355-363. View abstract.
  1414. Park, B. S., Kim, J. G., Kim, M. R., Lee, S. E., Takeoka, G. R., Oh, K. B., and Kim, J. H. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric.Food Chem. 11-16-2005;53:9005-9009. View abstract.
  1415. Hu, M., Du, Q., Vancurova, I., Lin, X., Miller, E. J., Simms, H. H., and Wang, P. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med. 2005;33:2571-2578. View abstract.
  1416. Misonou, Y., Asahi, M., Yokoe, S., Miyoshi, E., and Taniguchi, N. Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy. Nitric.Oxide. 2006;14:180-187. View abstract.
  1417. Robben, J. H., Sze, M., Knoers, N. V., and Deen, P. M. Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism. Mol.Biol.Cell 2006;17:379-386. View abstract.
  1418. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci. 3-13-2006;78:1884-1891. View abstract.
  1419. Kempaiah, R. K. and Srinivasan, K. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr.Biochem. 2006;17:471-478. View abstract.
  1420. D'Incalci, M., Steward, W. P., and Gescher, A. J. Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol. 2005;6:899-904. View abstract.
  1421. Khajavi, M., Inoue, K., Wiszniewski, W., Ohyama, T., Snipes, G. J., and Lupski, J. R. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants. Am.J Hum.Genet. 2005;77:841-850. View abstract.
  1422. Kim, H., Park, B. S., Lee, K. G., Choi, C. Y., Jang, S. S., Kim, Y. H., and Lee, S. E. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric.Food Chem. 11-2-2005;53:8537-8541. View abstract.
  1423. Wung, B. S., Hsu, M. C., Wu, C. C., and Hsieh, C. W. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol Res 2006;53:113-122. View abstract.
  1424. Holt, P. R., Katz, S., and Kirshoff, R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig.Dis.Sci. 2005;50:2191-2193. View abstract.
  1425. Yang, X., Thomas, D. P., Zhang, X., Culver, B. W., Alexander, B. M., Murdoch, W. J., Rao, M. N., Tulis, D. A., Ren, J., and Sreejayan, N. Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler.Thromb.Vasc.Biol. 2006;26:85-90. View abstract.
  1426. Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., and Singh, V. K. Immunomodulatory effects of curcumin. Immunopharmacol.Immunotoxicol. 2005;27:485-497. View abstract.
  1427. Tirkey, N., Kaur, G., Vij, G., and Chopra, K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC.Pharmacol 2005;5:15. View abstract.
  1428. Gaedeke, J., Noble, N. A., and Border, W. A. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int. 2005;68:2042-2049. View abstract.
  1429. Majithiya, J. B. and Balaraman, R. Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin. J Cardiovasc.Pharmacol 2005;46:697-705. View abstract.
  1430. Ignjacev-Lazich, I., Kintsurashvili, E., Johns, C., Vitseva, O., Duka, A., Shenouda, S., Gavras, I., and Gavras, H. Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am.J Physiol Heart Circ.Physiol 2005;289:H1814-H1820. View abstract.
  1431. Cao, W. G., Morin, M., Sengers, V., Metz, C., Roger, T., Maheux, R., and Akoum, A. Tumour necrosis factor-alpha up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-kappaB. Hum.Reprod. 2006;21:421-428. View abstract.
  1432. Polytarchou, C., Hatziapostolou, M., and Papadimitriou, E. Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J Biol.Chem. 12-9-2005;280:40428-40435. View abstract.
  1433. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats. J Basic Clin Physiol Pharmacol 2005;16:1-15. View abstract.
  1434. Fan, C. L., Qian, Y., Wo, X. D., Yan, J., and Gao, L. P. [Effect of curcumin on the gene expression of low density lipoprotein receptors]. Chin J Integr.Med. 2005;11:201-204. View abstract.
  1435. Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem.Behav. 2005;82:200-206. View abstract.
  1436. Kim, K. J., Yu, H. H., Cha, J. D., Seo, S. J., Choi, N. Y., and You, Y. O. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus. Phytother.Res 2005;19:599-604. View abstract.
  1437. Liu, X. G., Dai, L., Yang, C., Zhao, Z. H., Zhang, X. R., Zhang, Z. G., and Guo, M. Y. Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin Med.J (Engl) 8-20-2005;118:1374-1379. View abstract.
  1438. Ono, K., Hirohata, M., and Yamada, M. Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Biochem.Biophys.Res Commun. 10-21-2005;336:444-449. View abstract.
  1439. Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138:212-222. View abstract.
  1440. Yoysungnoen, P., Wirachwong, P., Bhattarakosol, P., Niimi, H., and Patumraj, S. Antiangiogenic activity of curcumin in hepatocellular carcinoma cells implanted nude mice. Clin Hemorheol.Microcirc. 2005;33:127-135. View abstract.
  1441. Narang, H. and Krishna, M. Inhibition of radiation induced nitration by curcumin and nicotinamide in mouse macrophages. Mol.Cell Biochem. 2005;276(1-2):7-13. View abstract.
  1442. Shen, F., Fan, X., Liu, B., Jia, X., Du, H., You, B., Ye, M., Huang, C., and Shi, X. Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway. Toxicol Lett. 1-25-2006;160:185-195. View abstract.
  1443. Farid, M., Reid, M. B., Li, Y. P., Gerken, E., and Durham, W. J. Effects of dietary curcumin or N-acetylcysteine on NF-kappaB activity and contractile performance in ambulatory and unloaded murine soleus. Nutr.Metab (Lond) 8-26-2005;2:20. View abstract.
  1444. Romero, M. R., Efferth, T., Serrano, M. A., Castano, B., Macias, R. I., Briz, O., and Marin, J. J. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 2005;68:75-83. View abstract.
  1445. Rukkumani, R., Aruna, K., Varma, P. S., Rajasekaran, K. N., and Menon, V. P. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. J Med.Food 2005;8:256-260. View abstract.
  1446. Mahesh, T., Balasubashini, M. S., and Menon, V. P. Effect of photo-irradiated curcumin treatment against oxidative stress in streptozotocin-induced diabetic rats. J Med.Food 2005;8:251-255. View abstract.
  1447. Kalpana, C., Rajasekharan, K. N., and Menon, V. P. Modulatory effects of curcumin and curcumin analog on circulatory lipid profiles during nicotine-induced toxicity in Wistar rats. J Med.Food 2005;8:246-250. View abstract.
  1448. Li, X. and Liu, X. Effect of curcumin on immune function of mice. J Huazhong.Univ Sci.Technolog.Med.Sci. 2005;25:137-140. View abstract.
  1449. Huang, M. T., Deschner, E. E., Newmark, H. L., Wang, Z. Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol- induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett. 6-15-1992;64:117-121. View abstract.
  1450. Lee, H. S. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Bioresour.Technol. 2006;97:1372-1376. View abstract.
  1451. Mutalik, S., Chetana, M., Sulochana, B., Devi, P. U., and Udupa, N. Effect of Dianex, a herbal formulation on experimentally induced diabetes mellitus. Phytother.Res 2005;19:409-415. View abstract.
  1452. Li, L., Braiteh, F. S., and Kurzrock, R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 9-15-2005;104:1322-1331. View abstract.
  1453. Kumar, P. A., Suryanarayana, P., Reddy, P. Y., and Reddy, G. B. Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin. Mol.Vis. 2005;11:561-568. View abstract.
  1454. Manson, M. M. Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol. Eur.J Cancer 2005;41:1842-1853. View abstract.
  1455. Moon, Y., Glasgow, W. C., and Eling, T. E. Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J Pharmacol Exp.Ther. 2005;315:788-795. View abstract.
  1456. Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., and Yano, S. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol.Pharm Bull. 2005;28:1438-1443. View abstract.
  1457. Matteucci, A., Frank, C., Domenici, M. R., Balduzzi, M., Paradisi, S., Carnovale-Scalzo, G., Scorcia, G., and Malchiodi-Albedi, F. Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca increase. Exp.Brain Res 2005;167:641-648. View abstract.
  1458. Wang, Q., Sun, A. Y., Simonyi, A., Jensen, M. D., Shelat, P. B., Rottinghaus, G. E., MacDonald, R. S., Miller, D. K., Lubahn, D. E., Weisman, G. A., and Sun, G. Y. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci.Res 10-1-2005;82:138-148. View abstract.
  1459. Heath, D. D., Pruitt, M. A., Brenner, D. E., Begum, A. N., Frautschy, S. A., and Rock, C. L. Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 9-25-2005;824(1-2):206-212. View abstract.
  1460. Goto, H., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y., and Komatsu, K. Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat. Am.J Chin Med. 2005;33:449-457. View abstract.
  1461. Jurrmann, N., Brigelius-Flohe, R., and Bol, G. F. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr. 2005;135:1859-1864. View abstract.
  1462. Venkatraman, M., Anto, R. J., Nair, A., Varghese, M., and Karunagaran, D. Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Mol.Carcinog. 2005;44:51-59. View abstract.
  1463. Osawa, T. and Kato, Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann.N.Y Acad.Sci. 2005;1043:440-451. View abstract.
  1464. Kim, H. T., Qiang, W., Liu, N., Scofield, V. L., Wong, P. K., and Stoica, G. Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus. J Neurovirol. 2005;11:166-179. View abstract.
  1465. Chearwae, W., Wu, C. P., Chu, H. Y., Lee, T. R., Ambudkar, S. V., and Limtrakul, P. Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1). Cancer Chemother.Pharmacol 2006;57:376-388. View abstract.
  1466. Ali, B. H., Al Wabel, N., Mahmoud, O., Mousa, H. M., and Hashad, M. Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats. Fundam.Clin Pharmacol 2005;19:473-477. View abstract.
  1467. Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-452. View abstract.
  1468. Strasser, E. M., Wessner, B., Manhart, N., and Roth, E. The relationship between the anti-inflammatory effects of curcumin and cellular glutathione content in myelomonocytic cells. Biochem.Pharmacol 8-15-2005;70:552-559. View abstract.
  1469. Cho, J. W., Park, K., Kweon, G. R., Jang, B. C., Baek, W. K., Suh, M. H., Kim, C. W., Lee, K. S., and Suh, S. I. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp.Mol.Med. 6-30-2005;37:186-192. View abstract.
  1470. Depeille, P., Cuq, P., Passagne, I., Evrard, A., and Vian, L. Combined effects of GSTP1 and MRP1 in melanoma drug resistance. Br.J Cancer 7-25-2005;93:216-223. View abstract.
  1471. Shimizu, M. and Weinstein, I. B. Modulation of signal transduction by tea catechins and related phytochemicals. Mutat.Res 12-11-2005;591(1-2):147-160. View abstract.
  1472. Arafa, H. M. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med.Sci.Monit. 2005;11:BR228-BR234. View abstract.
  1473. Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. The effects of curcumin on depressive-like behaviors in mice. Eur.J Pharmacol 7-25-2005;518:40-46. View abstract.
  1474. Bruzell, E. M., Morisbak, E., and Tonnesen, H. H. Studies on curcumin and curcuminoids. XXIX. Photoinduced cytotoxicity of curcumin in selected aqueous preparations. Photochem.Photobiol.Sci. 2005;4:523-530. View abstract.
  1475. Wuyts, W. A., Vanaudenaerde, B. M., Dupont, L. J., Van Raemdonck, D. E., Demedts, M. G., and Verleden, G. M. Interleukin-17--induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB. J Heart Lung Transplant. 2005;24:875-881. View abstract.
  1476. Gulcubuk, A., Sonmez, K., Gurel, A., Altunatmaz, K., Gurler, N., Aydin, S., Oksuz, L., Uzun, H., and Guzel, O. Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination. Pancreatology. 2005;5(4-5):345-353. View abstract.
  1477. Ringman, J. M., Frautschy, S. A., Cole, G. M., Masterman, D. L., and Cummings, J. L. A potential role of the curry spice curcumin in Alzheimer's disease. Curr.Alzheimer Res 2005;2:131-136. View abstract.
  1478. Chan, W. H., Wu, H. J., and Hsuuw, Y. D. Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells. Ann.N.Y Acad.Sci. 2005;1042:372-378. View abstract.
  1479. Zahid, Ashraf M., Hussain, M. E., and Fahim, M. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci. 7-8-2005;77:837-857. View abstract.
  1480. Fan, C. L., Wo, X. D., and Luo, Y. [Effect of curcumin on expression of human low density lipoprotein receptors in Xenopus Laevis oocytes]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25:432-435. View abstract.
  1481. Vajragupta, O., Boonchoong, P., Morris, G. M., and Olson, A. J. Active site binding modes of curcumin in HIV-1 protease and integrase. Bioorg.Med.Chem.Lett. 7-15-2005;15:3364-3368. View abstract.
  1482. Okazaki, Y., Iqbal, M., and Okada, S. Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate. Biochim.Biophys.Acta 6-10-2005;1740:357-366. View abstract.
  1483. Pari, L. and Amali, D. R. Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. J Pharm Pharm Sci. 2005;8:115-123. View abstract.
  1484. Kim, G. Y., Kim, K. H., Lee, S. H., Yoon, M. S., Lee, H. J., Moon, D. O., Lee, C. M., Ahn, S. C., Park, Y. C., and Park, Y. M. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 6-15-2005;174:8116-8124. View abstract.
  1485. Kamalakkannan, N., Rukkumani, R., Varma, P. S., Viswanathan, P., Rajasekharan, K. N., and Menon, V. P. Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol 2005;97:15-21. View abstract.
  1486. Ryu, H., Smith, K., Camelo, S. I., Carreras, I., Lee, J., Iglesias, A. H., Dangond, F., Cormier, K. A., Cudkowicz, M. E., Brown, R. H., Jr., and Ferrante, R. J. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem. 2005;93:1087-1098. View abstract.
  1487. Wessler, S., Muenzner, P., Meyer, T. F., and Naumann, M. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection. Biol.Chem. 2005;386:481-490. View abstract.
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  1534. Franck, N., Le Seyec, J., Guguen-Guillouzo, C., and Erdtmann, L. Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome. J Virol. 2005;79:2700-2708. View abstract.
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  1538. Cole, G. M., Morihara, T., Lim, G. P., Yang, F., Begum, A., and Frautschy, S. A. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann.N.Y Acad.Sci. 2004;1035:68-84. View abstract.
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  1543. Barreto, R., Kawakita, S., Tsuchiya, J., Minelli, E., Pavasuthipaisit, K., Helmy, A., and Marotta, F. Metal-induced oxidative damage in cultured hepatocytes and hepatic lysosomal fraction: beneficial effect of a curcumin/absinthium compound. Chin J Dig.Dis. 2005;6:31-36. View abstract.
  1544. Schulze-Tanzil, G., Mobasheri, A., Sendzik, J., John, T., and Shakibaei, M. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann.N.Y Acad.Sci. 2004;1030:578-586. View abstract.
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  1556. Swarnakar, S., Ganguly, K., Kundu, P., Banerjee, A., Maity, P., and Sharma, A. V. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol.Chem. 3-11-2005;280:9409-9415. View abstract.
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  1563. Leclercq, I. A., Farrell, G. C., Sempoux, C., dela, Pena A., and Horsmans, Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol. 2004;41:926-934. View abstract.
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  1575. Smith, P. C., Santibanez, J. F., Morales, J. P., and Martinez, J. Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J Periodontal Res 2004;39:380-387. View abstract.
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  1580. Kellner, C. and Zunino, S. J. Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization. Cancer Lett. 11-8-2004;215:43-52. View abstract.
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  1582. Teijido, O., Martinez, A., Pusch, M., Zorzano, A., Soriano, E., Del Rio, J. A., Palacin, M., and Estevez, R. Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts. Hum.Mol.Genet. 11-1-2004;13:2581-2594. View abstract.
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  1695. Suryanarayana, P., Krishnaswamy, K., and Reddy, G. B. Effect of curcumin on galactose-induced cataractogenesis in rats. Mol.Vis. 6-9-2003;9:223-230. View abstract.
  1696. Shukla, Y. and Arora, A. Suppression of altered hepatic foci development by curcumin in wistar rats. Nutr.Cancer 2003;45:53-59. View abstract.
  1697. Lamb, S. R. and Wilkinson, S. M. Contact allergy to tetrahydrocurcumin. Contact Dermatitis 2003;48:227. View abstract.
  1698. Ukil, A., Maity, S., Karmakar, S., Datta, N., Vedasiromoni, J. R., and Das, P. K. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br.J Pharmacol 2003;139:209-218. View abstract.
  1699. Kim, J. E., Kim, A. R., Chung, H. Y., Han, S. Y., Kim, B. S., and Choi, J. S. In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa. Phytother.Res 2003;17:481-484. View abstract.
  1700. Vietri, M., Pietrabissa, A., Mosca, F., Spisni, R., and Pacifici, G. M. Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues. Xenobiotica 2003;33:357-363. View abstract.
  1701. Mahakunakorn, P., Tohda, M., Murakami, Y., Matsumoto, K., Watanabe, H., and Vajaragupta, O. Cytoprotective and Cytotoxic Effects of Curcumin: Dual Action on HO-Induced Oxidative Cell Damage in NG108-15 Cells. Biol.Pharm.Bull. 2003;26:725-728. View abstract.
  1702. Iqbal, M., Sharma, S. D., Okazaki, Y., Fujisawa, M., and Okada, S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol.Toxicol. 2003;92:33-38. View abstract.
  1703. Caughey, B., Raymond, L. D., Raymond, G. J., Maxson, L., Silveira, J., and Baron, G. S. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J Virol. 2003;77:5499-5502. View abstract.
  1704. Halder, N., Joshi, S., and Gupta, S. K. Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol. 2003;86:113-116. View abstract.
  1705. Chaudhary, L. R. and Hruska, K. A. Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells. J Cell Biochem. 5-1-2003;89:1-5. View abstract.
  1706. Aggarwal, B. B., Kumar, A., and Bharti, A. C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23(1A):363-398. View abstract.
  1707. Chainani-Wu, N. Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa). J Altern.Complement Med. 2003;9:161-168. View abstract.
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  1709. Villasenor, I. M., Simon, M. K., and Villanueva, A. M. Comparative potencies of nutraceuticals in chemically induced skin tumor prevention. Nutr.Cancer 2002;44:66-70. View abstract.
  1710. Xu, J., Fu, Y., and Chen, A. Activation of peroxisome proliferator-activated receptor-{gamma} contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am.J Physiol Gastrointest.Liver Physiol 3-26-2003; View abstract.
  1711. Salh, B. S., Assi, K., Templeman, V., Parhar, K., Owen, D., Gomez-Munoz, A., and Jacobson, K. Curcumin attenuates DNB-induced murine colitis. Am.J Physiol Gastrointest.Liver Physiol 3-13-2003; View abstract.
  1712. Rashmi, R., Santhosh Kumar, T. R., and Karunagaran, D. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett. 3-13-2003;538(1-3):19-24. View abstract.
  1713. Jain, A. and Basal, E. Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine. 2003;10:34-38. View abstract.
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  1715. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl.Toxicol Program.Tech.Rep.Ser. 1993;427:1-275. View abstract.
  1716. Li, H., Cheng, Y., Wang, H., Sun, H., Liu, Y., Liu, K., and Peng, S. Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents. Appl.Radiat.Isot. 2003;58:291-298. View abstract.
  1717. Deshpande, U. R., Joseph, L. J., Patwardhan, U. N., and Samuel, A. M. Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats. Indian J Exp.Biol. 2002;40:735-738. View abstract.
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  1719. Gaddipati, J. P., Sundar, S. V., Calemine, J., Seth, P., Sidhu, G. S., and Maheshwari, R. K. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock 2003;19:150-156. View abstract.
  1720. Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., and Motterlini, R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem.J 5-1-2003;371(Pt 3):887-895. View abstract.
  1721. Zsila, F., Bikadi, Z., and Simonyi, M. Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex. Biochem.Biophys.Res.Commun. 2-14-2003;301:776-782. View abstract.
  1722. Evaluation of certain food additives and contaminants. World Health Organ Tech.Rep.Ser. 2002;909:i-171, back. View abstract.
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  1724. Madan, B. and Ghosh, B. Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock 2003;19:91-96. View abstract.
  1725. Mahady, G. B., Pendland, S. L., Yun, G., and Lu, Z. Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res 2002;22(6C):4179-4181. View abstract.
  1726. Devasena, T., Rajasekaran, K. N., Gunasekaran, G., Viswanathan, P., and Menon, V. P. Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model. Pharmacol.Res. 2003;47:133-140. View abstract.
  1727. Wang, S., Chen, B., and Sun, C. [Regulation effect of curcumin on blood lipids and antioxidation in hyperlipidemia rats]. Wei Sheng Yan.Jiu. 2000;29:240-242. View abstract.
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  1729. Mani, H., Sidhu, G. S., Kumari, R., Gaddipati, J. P., Seth, P., and Maheshwari, R. K. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors 2002;16(1-2):29-43. View abstract.
  1730. Dickinson, D. A., Iles, K. E., Zhang, H., Blank, V., and Forman, H. J. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J 2003;17:473-475. View abstract.
  1731. Zhou, Q., Lan, Y., Wang, Y., Zhao, Y., and Wu, Z. [Activating protein-1 complex regulates oxidized low density lipoprotein-induced overproduction of rat TGF-beta1 at transcriptional level]. Zhonghua Yi.Xue.Za Zhi. 10-10-2002;82:1346-1350. View abstract.
  1732. Kumar, V., Lewis, S. A., Mutalik, S., Shenoy, D. B., Venkatesh, and Udupa, N. Biodegradable microspheres of curcumin for treatment of inflammation. Indian J Physiol Pharmacol 2002;46:209-217. View abstract.
  1733. Gukovsky, I., Reyes, C. N., Vaquero, E. C., Gukovskaya, A. S., and Pandol, S. J. Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am.J Physiol Gastrointest.Liver Physiol 2003;284:G85-G95. View abstract.
  1734. Mukhopadhyay, A., Banerjee, S., Stafford, L. J., Xia, C., Liu, M., and Aggarwal, B. B. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 12-12-2002;21:8852-8861. View abstract.
  1735. Meselhy, M. R. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 2003;62:213-218. View abstract.
  1736. Philip, S. and Kundu, G. C. Osteopontin Induces Nuclear Factor kappa B-mediated Promatrix Metalloproteinase-2 Activation through Ikappa Balpha /IKK Signaling Pathways, and Curcumin (Diferulolylmethane) Down-regulates These Pathways. J Biol.Chem. 4-18-2003;278:14487-14497. View abstract.
  1737. Robinson, T. P., Ehlers, T., Hubbard IV, R. B., Bai, X., Arbiser, J. L., Goldsmith, D. J., and Bowen, J. P. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin. Bioorg.Med.Chem.Lett. 1-6-2003;13:115-117. View abstract.
  1738. Jaiswal, A. S., Marlow, B. P., Gupta, N., and Narayan, S. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 12-5-2002;21:8414-8427. View abstract.
  1739. Sugimoto, K., Hanai, H., Tozawa, K., Aoshi, T., Uchijima, M., Nagata, T., and Koide, Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 2002;123:1912-1922. View abstract.
  1740. Moga, M. M. Alternative treatment of gallbladder disease. Med.Hypotheses 2003;60:143-147. View abstract.
  1741. Heath, D. D., Pruitt, M. A., Brenner, D. E., and Rock, C. L. Curcumin in plasma and urine: quantitation by high-performance liquid chromatography. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 1-5-2003;783:287-295. View abstract.
  1742. Ikonomov, O. C., Sbrissa, D., Mlak, K., and Shisheva, A. Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects. Endocrinology 2002;143:4742-4754. View abstract.
  1743. Jayaprakasha, G. K., Jena, B. S., Negi, P. S., and Sakariah, K. K. Evaluation of antioxidant activities and antimutagenicity of turmeric oil: a byproduct from curcumin production. Z.Naturforsch.C. 2002;57(9-10):828-835. View abstract.
  1744. Yin, K. J., Lee, J. M., Chen, S. D., Xu, J., and Hsu, C. Y. Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells. J Neurosci. 11-15-2002;22:9764-9770. View abstract.
  1745. Yu, Z. F., Kong, L. D., and Chen, Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol. 2002;83(1-2):161-165. View abstract.
  1746. Naito, M., Wu, X., Nomura, H., Kodama, M., Kato, Y., Kato, Y., and Osawa, T. The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits. J Atheroscler.Thromb. 2002;9:243-250. View abstract.
  1747. Bouma, M., Nuijen, B., Jansen, M. T., Sava, G., Bult, A., and Beijnen, J. H. Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A. J Pharm Biomed.Anal. 11-7-2002;30:1287-1296. View abstract.
  1748. Wu, Y., Chen, Y., Xu, J., and Lu, L. Anticancer activities of curcumin on human Burkitt's lymphoma. Zhonghua Zhong.Liu Za Zhi. 2002;24:348-352. View abstract.
  1749. Chen, Z., Clark, S., Birkeland, M., Sung, C. M., Lago, A., Liu, R., Kirkpatrick, R., Johanson, K., Winkler, J. D., and Hu, E. Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. Cancer Lett. 12-15-2002;188(1-2):127-140. View abstract.
  1750. Bharti, A. C., Donato, N., Singh, S., and Aggarwal, B. B. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2-1-2003;101:1053-1062. View abstract.
  1751. Nanji, A. A., Jokelainen, K., Tipoe, G. L., Rahemtulla, A., Thomas, P., and Dannenberg, A. J. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am.J Physiol Gastrointest.Liver Physiol 2003;284:G321-G327. View abstract.
  1752. Periyasamy, S. and Sanchez, E. R. Antagonism of glucocorticoid receptor transactivity and cell growth inhibition by transforming growth factor-beta through AP-1-mediated transcriptional repression. Int.J Biochem.Cell Biol. 2002;34:1571-1585. View abstract.
  1753. Oldenhof, A. D., Shynlova, O. P., Liu, M., Langille, B. L., and Lye, S. J. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am.J Physiol Cell Physiol 2002;283:C1530-C1539. View abstract.
  1754. Okamoto, T., Yamagishi, S., Inagaki, Y., Amano, S., Koga, K., Abe, R., Takeuchi, M., Ohno, S., Yoshimura, A., and Makita, Z. Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin. FASEB J 2002;16:1928-1930. View abstract.
  1755. Rinaldi, A. L., Morse, M. A., Fields, H. W., Rothas, D. A., Pei, P., Rodrigo, K. A., Renner, R. J., and Mallery, S. R. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Cancer Res 10-1-2002;62:5451-5456. View abstract.
  1756. Gururaj, A. E., Belakavadi, M., Venkatesh, D. A., Marme, D., and Salimath, B. P. Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem.Biophys.Res Commun. 10-4-2002;297:934-942. View abstract.
  1757. Park, S. Y. and Kim, D. S. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease. J Nat.Prod. 2002;65:1227-1231. View abstract.
  1758. Sun, Y., Wilson, M. P., and Majerus, P. W. Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. J Biol.Chem. 11-29-2002;277:45759-45764. View abstract.
  1759. Stohs, S. J., Ohia, S., and Bagchi, D. Naphthalene toxicity and antioxidant nutrients. Toxicology 10-30-2002;180:97-105. View abstract.
  1760. Han, S. S., Keum, Y. S., Seo, H. J., and Surh, Y. J. Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem.Mol.Biol. 5-31-2002;35:337-342. View abstract.
  1761. Wegener, T. [The status of herbal antilipemic agents]. Wien.Med.Wochenschr. 2002;152(15-16):412-417. View abstract.
  1762. Nakamura, K., Yasunaga, Y., Segawa, T., Ko, D., Moul, J. W., Srivastava, S., and Rhim, J. S. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int.J Oncol. 2002;21:825-830. View abstract.
  1763. Molero, L., Garcia-Duran, M., Diaz-Recasens, J., Rico, L., Casado, S., and Lopez-Farre, A. Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen. Cardiovasc.Res 2002;56:43-51. View abstract.
  1764. Ghoneim, A. I., Abdel-Naim, A. B., Khalifa, A. E., and El Denshary, E. S. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 2002;46:273-279. View abstract.
  1765. Rukkumani, R., Sri, Balasubashini M., Vishwanathan, P., and Menon, V. P. Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia. Pharmacol Res 2002;46:257-264. View abstract.
  1766. Sakano, K. and Kawanishi, S. Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes. Arch.Biochem.Biophys. 9-15-2002;405:223-230. View abstract.
  1767. Hidaka, H., Ishiko, T., Furuhashi, T., Kamohara, H., Suzuki, S., Miyazaki, M., Ikeda, O., Mita, S., Setoguchi, T., and Ogawa, M. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer 9-15-2002;95:1206-1214. View abstract.
  1768. Xia, W., Xiao, X., Liu, F., Su, Z., and Qiao, C. [Determination on chemical constituents of Curcuma L. produced in China]. Zhongguo Zhong.Yao Za Zhi. 1999;24:423-4, 434, 447. View abstract.
  1769. Tonnesen, H. H., Masson, M., and Loftsson, T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int.J Pharm 9-5-2002;244(1-2):127-135. View abstract.
  1770. Temkin, V., Kantor, B., Weg, V., Hartman, M. L., and Levi-Schaffer, F. Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release. J Immunol. 9-1-2002;169:2662-2669. View abstract.
  1771. Kempaiah, R. K. and Srinivasan, K. Integrity of erythrocytes of hypercholesterolemic rats during spices treatment. Mol.Cell Biochem. 2002;236(1-2):155-161. View abstract.
  1772. Sun, Y. M., Zhang, H. Y., Chen, D. Z., and Liu, C. B. Theoretical elucidation on the antioxidant mechanism of curcumin: a DFT study. Org Lett. 8-22-2002;4:2909-2911. View abstract.
  1773. Anuchapreeda, S., Leechanachai, P., Smith, M. M., Ambudkar, S. V., and Limtrakul, P. N. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem.Pharmacol 8-15-2002;64:573-582. View abstract.
  1774. Yoshida, S., Kawaguchi, H., Sato, S., Ueda, R., and Furukawa, K. An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn.J Cancer Res 2002;93:816-824. View abstract.
  1775. Grundman, M., Grundman, M., and Delaney, P. Antioxidant strategies for Alzheimer's disease. Proc.Nutr.Soc. 2002;61:191-202. View abstract.
  1776. Sowa, H., Kaji, H., Yamaguchi, T., Sugimoto, T., and Chihara, K. Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol.Chem. 9-27-2002;277:36024-36031. View abstract.
  1777. Sawada, H., Ibi, M., Kihara, T., Honda, K., Nakamizo, T., Kanki, R., Nakanishi, M., Sakka, N., Akaike, A., and Shimohama, S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology 2002;42:1056-1064. View abstract.
  1778. Galati, G., Sabzevari, O., Wilson, J. X., and O'Brien, P. J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 8-1-2002;177:91-104. View abstract.
  1779. Grandjean-Laquerriere, A., Gangloff, S. C., Le Naour, R., Trentesaux, C., Hornebeck, W., and Guenounou, M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 5-7-2002;18:168-177. View abstract.
  1780. Immune boosters. Curcumin and the immune system. TreatmentUpdate. 2000;11:7. View abstract.
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  1782. Park, M. J., Kim, E. H., Park, I. C., Lee, H. C., Woo, S. H., Lee, J. Y., Hong, Y. J., Rhee, C. H., Choi, S. H., Shim, B. S., Lee, S. H., and Hong, S. I. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int.J Oncol. 2002;21:379-383. View abstract.
  1783. Quiles, J. L., Mesa, M. D., Ramirez-Tortosa, C. L., Aguilera, C. M., Battino, M., Gil, A., and Ramirez-Tortosa, M. C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler.Thromb.Vasc.Biol. 7-1-2002;22:1225-1231. View abstract.
  1784. Li, D., Zimmerman, T. L., Thevananther, S., Lee, H. Y., Kurie, J. M., and Karpen, S. J. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J Biol.Chem. 8-30-2002;277:31416-31422. View abstract.
  1785. Rafiee, P., Shi, Y., Kong, X., Pritchard, K. A., Jr., Tweddell, J. S., Litwin, S. B., Mussatto, K., Jaquiss, R. D., Su, J., and Baker, J. E. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. Circulation 7-9-2002;106:239-245. View abstract.
  1786. Ramachandran, C., Fonseca, H. B., Jhabvala, P., Escalon, E. A., and Melnick, S. J. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 10-8-2002;184:1-6. View abstract.
  1787. Somasundaram, S., Edmund, N. A., Moore, D. T., Small, G. W., Shi, Y. Y., and Orlowski, R. Z. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 7-1-2002;62:3868-3875. View abstract.
  1788. Fenton, J. I., Wolff, M. S., Orth, M. W., and Hord, N. G. Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype. Carcinogenesis 2002;23:1065-1070. View abstract.
  1789. Inano, H. and Onoda, M. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int.J Radiat.Oncol.Biol.Phys. 7-1-2002;53:735-743. View abstract.
  1790. Natarajan, C. and Bright, J. J. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol. 6-15-2002;168:6506-6513. View abstract.
  1791. Lukita-Atmadja, W., Ito, Y., Baker, G. L., and McCuskey, R. S. Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 2002;17:399-403. View abstract.
  1792. Liacini, A., Sylvester, J., Li, W. Q., and Zafarullah, M. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol. 2002;21:251-262. View abstract.
  1793. Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M., and Cheng, A. L. Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem.Pharmacol 5-1-2002;63:1709-1716. View abstract.
  1794. Literat, A., Su, F., Norwicki, M., Durand, M., Ramanathan, R., Jones, C. A., Minoo, P., and Kwong, K. Y. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci. 12-7-2001;70:253-267. View abstract.
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  1829. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., and Hsieh, C. Y. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001;21(4B):2895-2900. View abstract.
  1830. Phan, T. T., See, P., Lee, S. T., and Chan, S. Y. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001;51:927-931. View abstract.
  1831. Hozumi, A., Nishimura, Y., Nishiuma, T., Kotani, Y., and Yokoyama, M. Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway. Am.J Physiol Lung Cell Mol.Physiol 2001;281:L1444-L1452. View abstract.
  1832. Chang, D. M. Curcumin: a heat shock response inducer and potential cytoprotector. Crit Care Med. 2001;29:2231-2232. View abstract.
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  1835. Shih, S. C. and Claffey, K. P. Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. Growth Factors 2001;19:19-34. View abstract.
  1836. Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 11-1-2001;21:8370-8377. View abstract.
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  1840. Mendez-Samperio, P., Palma, J., and Vazquez, A. Roles of intracellular calcium and NF-kappaB in the Bacillus Calmette-Guerin-induced secretion of interleukin-8 from human monocytes. Cell Immunol. 8-1-2001;211:113-122. View abstract.
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  1843. Cipriani, B., Borsellino, G., Knowles, H., Tramonti, D., Cavaliere, F., Bernardi, G., Battistini, L., and Brosnan, C. F. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol. 9-15-2001;167:3454-3462. View abstract.
  1844. Shahed, A. R., Jones, E., and Shoskes, D. Quercetin and curcumin up-regulate antioxidant gene expression in rat kidney after ureteral obstruction or ischemia/reperfusion injury. Transplant.Proc. 2001;33:2988. View abstract.
  1845. Koh, Y. H., Che, W., Higashiyama, S., Takahashi, M., Miyamoto, Y., Suzuki, K., and Taniguchi, N. Osmotic stress induces HB-EGF gene expression via Ca/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem. 2001;130:351-358. View abstract.
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  1849. Prucksunand, C., Indrasukhsri, B., Leethochawalit, M., and Hungspreugs, K. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer. Southeast Asian J Trop Med Public Health 2001;32:208-215. View abstract.
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  1852. Nakayama, K., Furusu, A., Xu, Q., Konta, T., and Kitamura, M. Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway. J Immunol. 8-1-2001;167:1145-1150. View abstract.
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  1855. Akhand, A. A., Hossain, K., Mitsui, H., Kato, M., Miyata, T., Inagi, R., Du, J., Takeda, K., Kawamoto, Y., Suzuki, H., Kurokawa, K., and Nakashima, I. Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells. Free Radic.Biol.Med. 7-1-2001;31:20-30. View abstract.
  1856. Lee, S. K., Kim, B. S., Yang, W. S., Kim, S. B., Park, S. K., and Park, J. S. High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Kidney Int. 2001;60:55-64. View abstract.
  1857. Wuthi-udomlert, M., Grisanapan, W., Luanratana, O., and Caichompoo, W. Antifungal activity of Curcuma longa grown in Thailand. Southeast Asian J Trop.Med.Public Health 2000;31 Suppl 1:178-182. View abstract.
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  1859. Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 6-1-2001;47:293-303. View abstract.
  1860. Renard, P., Delaive, E., Van Steenbrugge, M., Remacle, J., and Raes, M. Is the effect of interleukin-1 on glutathione oxidation in cultured human fibroblasts involved in nuclear factor-kappaB activation? Antioxid.Redox.Signal. 2001;3:329-340. View abstract.
  1861. Moragoda, L., Jaszewski, R., and Majumdar, A. P. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 2001;21(2A):873-878. View abstract.
  1862. Bian, Z. M., Elner, V. M., Yoshida, A., Kunkel, S. L., and Elner, S. G. Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE cells. Invest Ophthalmol.Vis.Sci. 2001;42:1660-1668. View abstract.
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  1865. Oguro, T. and Yoshida, T. Effect of ultraviolet A on ornithine decarboxylase and metallothionein gene expression in mouse skin. Photodermatol.Photoimmunol.Photomed. 2001;17:71-78. View abstract.
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  1870. Jayaprakasha, G. K., Negi, P. S., Anandharamakrishnan, C., and Sakariah, K. K. Chemical composition of turmeric oil--a byproduct from turmeric oleoresin industry and its inhibitory activity against different fungi. Z.Naturforsch.C. 2001;56(1-2):40-44. View abstract.
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  1872. Bech-Otschir, D., Kraft, R., Huang, X., Henklein, P., Kapelari, B., Pollmann, C., and Dubiel, W. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J 4-2-2001;20:1630-1639. View abstract.
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  1879. Araujo, M. C., Antunes, L. M., and Takahashi, C. S. Protective effect of thiourea, a hydroxyl-radical scavenger, on curcumin-induced chromosomal aberrations in an in vitro mammalian cell system. Teratog.Carcinog.Mutagen. 2001;21:175-180. View abstract.
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  1894. Ramirez-Bosca, A., Soler, A., Carrion, M. A., Diaz-Alperi, J., Bernd, A., Quintanilla, C., Quintanilla, Almagro E., and Miquel, J. An hydroalcoholic extract of curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech.Ageing Dev. 10-20-2000;119(1-2):41-47. View abstract.
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Last reviewed - 04/16/2015