Russell-Silver syndrome is a disorder present at birth involving poor growth. One side of the body also will appear to be larger than the other.
One in 10 children with this syndrome has a problem involving chromosome 7. In other people with the syndrome, it may affect chromosome 11.
Most of the time, it occurs in people with no family history of the disease.
The estimated number of people who develop this condition varies greatly. Males and females are equally affected.
The condition is usually diagnosed by early childhood. The health care provider will perform a physical exam. Signs include:
There are no specific laboratory tests to diagnose Russell-Silver syndrome. Diagnosis is usually based on the judgment of your child's health care provider. However, the following tests may be done:
Growth hormone replacement may help if this hormone is lacking. Other treatments include:
Many specialists may be involved in treating a person with this condition. They include:
Older children and adults do not show typical features as clearly as infants or younger children. Intelligence may be normal, although the person may have a learning disability.
A person with Russell-Silver syndrome may have these problems:
Call your child's health care provider if signs of Russell-Silver syndrome develop. Make sure your child's height and weight are measured during each well-child visit. The provider may refer you to:
Silver-Russell syndrome; Silver syndrome
Cooke DW, Divall SA, Radovick S. Normal and aberrant growth. In: Melmed S, Polonsky KS, Larsen PR, and Kronenberg HM. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 24.
Updated by: Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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