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Yellow fever

Yellow fever is a viral infection spread by mosquitoes.


Yellow fever is caused by a virus carried by mosquitoes. You can catch this disease if you are bitten by a mosquito infected with this virus. 

This disease is common in South America and in sub-Saharan Africa.

Anyone can get yellow fever, but the elderly have a higher risk of severe infection.

If a person is bitten by an infected mosquito, symptoms usually develop 3 - 6 days later.


Yellow fever has three stages:

  • Stage 1 (infection): Headache, muscle and joint aches, fever, flushing, loss of appetite, vomiting, and jaundice are common. Symptoms often go away briefly after about 3 - 4 days.
  • Stage 2 (remission): Fever and other symptoms go away. Most people will recover at this stage, but others may get worse within 24 hours.
  • Stage 3 (intoxication): Problems with many organs may occur, including the heart, liver, and kidney. Bleeding disorders, seizures, coma, and delirium may also occur.

Symptoms may include:

Exams and Tests

The health care provider will perform a physical examination and request selected blood tests. These blood tests may show liver and kidney failure and shock.

It is important to tell your doctor if you have traveled to areas where the disease is known to thrive. Blood tests can confirm the diagnosis.


There is no specific treatment for yellow fever. Treatment for symptoms can include:

  • Blood products for severe bleeding
  • Dialysis for kidney failure
  • Fluids through a vein (intravenous fluids)

Outlook (Prognosis)

Yellow fever can cause severe problems, including internal bleeding. Death is possible.

When to Contact a Medical Professional

Get medical attention at least 10 - 14 days before traveling to an endemic area for yellow fever to find out whether you should be vaccinated against the disease.

Tell your health care provider right away if you or your child develop fever, headache, muscle aches, vomiting, or jaundice, especially if you have traveled to an area where yellow fever is known to occur. Some countries require proof of vaccination to gain entry.


If you will be traveling to an area where yellow fever is common:

  • Sleep in screened housing
  • Use mosquito repellents
  • Wear clothing that fully covers your body

There is an effective vaccine against yellow fever. Ask your doctor at least 10 - 14 days before traveling if you should be vaccinated against yellow fever.


Bausch DG. Viral hemorrhagic fevers. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 389.

Update Date 11/20/2013

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