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Periactin overdose

Periactin is an antihistamine, which is a drug used to relieve allergy symptoms. A periactin overdose occurs when someone takes too much of this drug.

This is for information only and not for use in the treatment or management of an actual poison exposure. If you have an exposure, you should call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222.

Poisonous Ingredient


Where Found

The generic drug name for Periactin is cyproheptadine hydrochloride. This medicine may also be sold under the following brand names:

  • Klarivitina
  • Nuran
  • Periatinol

This list may not be all-inclusive.


Symptoms of periactin overdose may include:

Before Calling Emergency

The following information is helpful for emergency assistance:

  • Person's age, weight, and condition
  • Name of the product (ingredients and strengths, if known)
  • Time it was swallowed
  • Amount swallowed
  • If the medicine was prescribed for the person

However, DO NOT delay calling for help if this information is not immediately available.

Poison Control

In the United States, call 1-800-222-1222 to speak with a local poison control center. This hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

What to Expect at the Emergency Room

The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The person may receive:

  • Activated charcoal
  • Airway support, including oxygen, breathing tube through the mouth (intubation), and breathing machine (ventilator)
  • Blood and urine tests
  • Chest x-ray
  • EKG (electrocardiogram, or heart tracing)
  • Fluids through a vein (intravenous or IV)
  • Laxative
  • Medicines to treat symptoms

Outlook (Prognosis)

If the person lives the first 24 hours, survival is likely. People with an irregular heart rhythm and seizures are at highest risk for a serious outcome. Few people actually die from an antihistamine overdose.

Alternative Names

Cyproheptadine hydrochloride overdose


Goldfrank LR, ed. Goldfrank's Toxicologic Emergencies. 8th ed. New York, NY: McGraw Hill; 2006.

Velez LI, Seng Y-F. Anticholinergics. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 150.

Update Date 1/17/2015

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