Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that is most common in males. About 1 in 10 African American males in the United States has it. G6PD deficiency mainly affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. The most common medical problem it can cause is hemolytic anemia. That happens when red blood cells are destroyed faster than the body can replace them.
If you have G6PD deficiency, you may not have symptoms. Symptoms happen if your red blood cells are exposed to certain chemicals in food or medicine, certain bacterial or viral infections, or stress. They may include
- Dark urine
- Shortness of breath
- Enlarged spleen
- Rapid heart rate
A blood test can tell if you have it. Treatments include medicines to treat infection, avoiding substances that cause the problem with red blood cells, and sometimes transfusions.
NIH: National Library of Medicine
- G6PD Deficiency (Chicago Center for Jewish Genetic Disorders)
- G6PD Deficiency (Glucose-6-Phosphate Dehydrogenase) (For Parents) (Nemours Foundation)
- G6PD: The Test (American Association for Clinical Chemistry)
- Glucose-6-phosphate dehydrogenase deficiency Available in Spanish
- Glucose-6-Phosphate Dehydrogenase Deficiency Overview (Genetic and Rare Diseases Information Center)
- Jaundice in Newborn Infants (Beyond the Basics) (UpToDate)
- Types of Hemolytic Anemia (National Heart, Lung, and Blood Institute)
- Genetics Home Reference: glucose-6-phosphate dehydrogenase deficiency (National Library of Medicine)
- ClinicalTrials.gov: Glucosephosphate Dehydrogenase Deficiency (National Institutes of Health)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Point-of-Care Quantitative Measure of Glucose-6-Phosphate Dehydrogenase Enzyme Deficiency.
- Article: High Incidence of Malaria Along the Sino-Burmese Border Is Associated...
- Article: Tolerability and safety of weekly primaquine against relapse of Plasmodium...
- G6PD Deficiency -- see more articles