Fact Sheet
Drug-Induced Liver Injury Database (LiverTox^®)

LiverTox provides comprehensive information about liver injury caused by prescription and nonprescription drugs, herbals and dietary supplements. LiverTox provides guidance to healthcare providers on the diagnosis and management of this important cause of liver disease. LiverTox also provides a central repository of information in support of clinical and basic research on the prevention and control of drug-induced liver injury.

LiverTox has three major components:

• Introduction and detailed overview of drug-induced liver injury;
• Specific drug records that provide data on the hepatotoxicity of medications, herbals and dietary supplements; and
• Case submission registry that allows users to submit clinical cases to LiverTox.

The resource's introductory section describes the different clinical patterns (phenotypes) of drug-induced liver injury, diagnostic criteria, assessment of causality and severity, information on management and treatment, and standardized nomenclature. The role of liver biopsy and major histological patterns of drug-induced liver disease are also given.

Drug records are the central component of LiverTox, comprised of several hundred drug class and individual agent records. These records provide concise descriptions of the hepatotoxicity of individual agents. The agents covered are those that are currently approved or available in the United States. On the Home Page, users can search by entering the name of a drug, herbal or dietary supplement, or by clicking on the first letter of the substance name using the A to Z alphabetic links. Users can also search by drug class as above, or by utilizing the Classes of Drugs sidebar link.

The case registry, accessed by the Submit a Case Record sidebar link, is an interactive site that allows the user to submit a case to LiverTox. Registration by name and e-mail address is required to submit a case. The website provides a standard form to submit information on the specific case and generates a structured summary with tables, graphs and calculations of severity and causality scores.

LiverTox is an intra-agency, collaborative effort within the National Institutes of Health. LiverTox content is authored and maintained by professional/scientific staff of the Liver Disease Research Branch, Division of Digestive Diseases and Nutrition of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), with editing, professional and information technology support provided by the Division of Specialized Information Services of the National Library of Medicine (NLM).

Web Access/Searching

LiverTox is accessible, free of charge, at: https://www.livertox.nih.gov. Users can search by drug class or drug name (trade, generic/chemical), herbal or dietary supplement name, or pharmacologic category.

Further Information

For information, comments or questions about LiverTox, contact:

Specialized Information Services
National Library of Medicine
Two Democracy Plaza, Suite 510
6707 Democracy Boulevard, MSC 5467
Bethesda, MD 20892-5467
Telephone: (301) 496-1131
e-mail: livertox@nih.gov
URL: //sis.nlm.nih.gov

For general information on NLM services, contact:

National Library of Medicine
Customer Service
8600 Rockville Pike
Bethesda, MD 20894
Telephone: 1-888-FINDNLM (1-888-346-3656)
e-mail: //www.nlm.nih.gov/contacts/contact.html
NLM Customer Service Form at Contact NLM

A complete list of NLM Fact Sheets is available at:
(alphabetical list) //www.nlm.nih.gov/pubs/factsheets/factsheets.html
(subject list): //www.nlm.nih.gov/pubs/factsheets/factsubj.html

Or write to:

FACT SHEETS
Office of Communications and Public Liaison
National Library of Medicine
8600 Rockville Pike
Bethesda, Maryland 20894

Phone: (301) 496-6308
Fax: (301) 496-4450
email: publicinfo@nlm.nih.gov®®