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RxNorm Release Notes - December 1, 2025

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.

Sources

The following sources have been updated since the previous RxNorm release:

Source NameSABVersion
Gold Standard Drug DatabaseGSGS_2025_11_18
Multum MediSource LexiconMMSLMMSL_2025_11_18
Micromedex RED BOOKMMXMMX_2025_11_14
Metathesaurus FDA Structured Product LabelsMTHSPLMTHSPL_2025_11_13
FDB MedKnowledge (formerly NDDF Plus)NDDFNDDF_2025_11_19
RxNorm VocabularyRXNORMRXNORM_20AA_251201F
Veterans Health Administration National Drug FileVANDFVANDF_2025_10_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification SystemATCATC_2025_02_10
Vaccines AdministeredCVXCVX_2025_09_23
DrugBankDRUGBANKDRUGBANK5.0_2025_09_04
Metathesaurus CMS Formulary Reference FileMTHCMSFRFMTHCMSFRF_2020
US Edition of SNOMED CTSNOMEDCT_USSNOMEDCT_US_2025_07_31
USP Compendial NomenclatureUSPUSP_2025_01_30

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.

** We did not produce a monthly release for November, and we did not produce weekly releases for October and November. The next RxNorm Monthly Release will be available on Monday, December 1, 2025. Weekly releases will resume on December 3, 2025. **

RxNorm Data Changes

No major changes

Data Counts

Term Type or AttributeNumber
Active RXNORM GPCKs645
Active RXNORM BPCKs747
Active RXNORM SCDs17544
Active RXNORM SBDs9721
Active RXNORM MINs3823
Active RXNORM INs14592
Active RXNORM PINs3611
Active RXNORM BNs5151
Active RXNORM DFs126
Obsolete RXNORM GPCKs260
Obsolete RXNORM BPCKs247
Obsolete RXNORM SCDs19985
Obsolete RXNORM SBDs12225
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6634
Obsolete RXNORM DFs65
Editor-suppressed RXNORM SCDs2160
Editor-suppressed RXNORM SBDs1790
SAB=RXNORM NDCs251092
Distinct SAB=RXNORM NDCs251092

Last Reviewed: November 26, 2025