MED-RT (Medication Reference Terminology) - Source Representation

This page lists specific source data elements and provides information on their representation in the UMLS Metathesaurus.

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Summary of Changes:

There have been no changes to the MED-RT release format or Metathesaurus source processing.

Source Provided Files:

All source files, including documentation, are available on the MED-RT download site: https://evs.nci.nih.gov/ftp1/MED-RT/

File	Description
Core_MEDRT_YYYY.MM.DD_XML.xml	Data file
MED-RT Documentation.pdf	Documentation
MED-RT_Schema_v1.xsd	XML schema definition

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Source-Provided Data: Details

The following data is processed for the UMLS; some element values are implied or redundant and are not directly processed

concept

Element	Description	Representation
<name>	Fully-specified concept name, including Concept Type suffix	MRCONSO.STR, TTY = FN
<code>	Code in source identifier	MRCONSO.CODE, MRCONSO.SDUI
<status>	Status	MRSAT.ATN = STATUS, ATV = A
<property><name> = CTY	Concept type: a category or label assigned only to every concept owned by MEDRT. Valid CTY values include: EPC - FDA SPL established pharmacologic class APC - additional pharmacologic class MoA - mechanism of action PE - physiologic effect TC - therapeutic category PK - pharmacokinetics EXT - local terminology extensions HC - local hierarchical concept to aggregate subconcepts, alphabetically or conceptually	MRSAT.ATN = CONCEPT_TYPE
<property><name> = NUI	Alphanumeric unique concept identifier	MRCONSO.CODE, MRCONSO.SDUI (same as "code" value)
<synonym><name>	Valid values are: "Preferred Term" or "Synonym"; corresponds to <preferred> = true	MRCONSO.TTY = PT or SY as indicated
<synonym><to_name>	Every concept may have zero or more synonymous names	MRCONSO.STR; TTY = SY
<synonym><preferred>	Valid values are: "true" or "false"; corresponds to "Preferred Term" or "Synonym" values	MRCONSO.STR; TTY = SY

association

MED-RT association name	MRREL.REL	MRREL.RELA/RELA inverse	Target concept terminology or CTY
CI_ChemClass	RO	contraindicated_class_of/has_contraindicated_class	MeSH
CI_MoA	RO	contraindicated_mechanism_of_action_of/has_contraindicated_mechanism_of_action	CTY: MoA
CI_PE	RO	contraindicated_physiologic_effect_of/has_contraindicated_physiologic_effect	CTY: PE
CI_with	RO	contraindicated_with_disease/has_contraindicated_drug	MeSH
Parent Of	PAR/CHD	parent_of/has_parent; associations between two MED-RT concepts are used to build a MED-RT-only hierarchy. Parent/Child relationships involving concepts in other sources are not included in the hierarchy, they are only included as pairwise relationships in MRREL.RRF	CTY: same CTY as concept of origin (e.g., MoA, PE, EPC, PK, TC, EXT) if MED-RT target, or Target: SNOMED CT US Edition or MeSH if mapped into external terminology hierarchy
effect_may_be_inhibited_by	RO	effect_may_be_inhibited_by/may_inhibit_effect_of	MeSH
has_MoA	RO	has_mechanism_of_action/mechanism_of_action_of	CTY: MoA
has_PE	RO	has_physiologic_effect/physiologic_effect_of	CTY: PE
has_PK	RO	has_pharmacokinetics/pharmacokinetics_of	CTY: PK
has_SC	RO	has_structural_class/structural_class_of	MeSH
has_TC	RO	has_therapeutic_class/therapeutic_class_of	CTY: TC
has_active_metabolites	RO	has_active_metabolites/active_metabolites_of	MeSH
induces	RO	induces/induced_by	MeSH
may_diagnose	RO	may_diagnose/may_be_diagnosed_by	MeSH
may_prevent	RO	may_prevent/may_be_prevented_by	MeSH
may_treat	RO	may_treat/may_be_treated_by	MeSH
site_of_metabolism	RO	site_of_metabolism/metabolic_site_of	CTY: PK
Synonym Of	SY		SNOMED CT US Edition or MeSH

Element	Description	Representation
<from_namespace>	Values are: MED-RT, MeSH, RXNORM	SAB of MRREL.AUI
<from_code>	Code in specified from_namespace (note: a small number of from_code values are invalid in the designated namespace; these are not processed)	CODE or SCUI referenced by MRREL.AUI
<to_namespace>	Values are: MED-RT, MeSH, RXNORM, SNOMED-CT	SAB of MRREL.AUI
<to_code>	Code in specified to_namespace (note: a small number of to_code values are invalid in the designated namespace; these are not processed)	CODE or SCUI reference by MRREL.AUI
<qualifier><name> = Authority	All MED-RT relationships have an Authority qualifier which contains the acronym of its asserting source authority. Conflicting relationships from different authorities can co-exist in the knowledge base. Valid relationship source authorities are: MEDRT - relationship asserted by legacy NDF-RT subject matter experts or by MED-RT FMTSME - relationship recommended by FMT subject matter experts for SPL FDASPL - relationship assigned by FDA SPL to active ingredient moieties NLMUMLS - relationship assigned by NLM to terminology concepts in the UMLS Metathesaurus	MRSAT.ATN = AUTHORITY