MedlinePlus Drug Information: Spironolactone

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Other drug names:	A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9

Spironolactone

(speer on oh lak' tone)

Contents of this page:
Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?	What side effects can this medication cause? What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know? Brand names Brand names of combination products

IMPORTANT WARNING: Return to top

Spironolactone has caused tumors in laboratory animals. Talk to your doctor about the risks and benefits of using this medication for your condition.

Why is this medication prescribed? Return to top

Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; and in patients with edema (fluid retention) caused by various conditions, including heart, liver, or kidney disease. Spironolactone is also used alone or with other medications to treat high blood pressure. Spironolactone is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine, but reduces the loss of potassium from the body.

How should this medicine be used? Return to top

Spironolactone comes as a tablet to take by mouth. It usually is taken once a day in the morning or sometimes twice a day . Take spironolactone at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take spironolactone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of spironolactone and gradually increase your dose.

Spironolactone controls high blood pressure and hyperaldosteronism, but does not cure these conditions.. It may take about 2 weeks or longer before the full effect of spironolactone occurs. Continue to take spironolactone even if you feel well. Do not stop taking spironolactone without talking to your doctor.

Other uses for this medicine Return to top

Spironolactone also is used in combination with other medicines to treat precocious puberty (a condition causing children to enter puberty too soon, resulting in the development of sexual characteristics in girls usually younger than 8 years of age and in boys usually younger than 9 years of age) or myasthenia gravis (MG, a disease in which the nerves do not function properly and patients may experience weakness; numbness; loss of muscle coordination; and problems with vision, speech, and bladder control). Spironolactone also may be used to treat certain female patients with abnormal facial hair. Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow? Return to top

Before taking spironolactone,

tell your doctor and pharmacist if you are allergic to spironolactone; any other medications; or the ingredients in spironolactone tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking amiloride (Midamor), potassium supplements, triamterene (Dyrenium). Your doctor may tell you not to take spironolactone if you are taking one or more of these medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDS) such as ibuprofen (Advil, Motrin), indomethacin (Indocin), and naproxen (Aleve, Naprosyn); barbiturates such as phenobarbital; digoxin (Digitek, Lanoxicaps, Lanoxin); diuretics ('water pills'); lithium (Eskalith, Lithobid); medications to treat high blood pressure; narcotic medications for pain; and oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone).
tell your doctor if you have kidney disease. Your doctor may tell you not to take spironolactone.
tell your doctor if you have or have ever had liver disease.
tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking spironolactone, call your doctor. Do not breastfeed if you are taking spironolactone.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking spironolactone.
you should know that drinking alcohol with this medication may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. Talk to your doctor about drinking alcohol while you are taking spironolactone.

What special dietary instructions should I follow? Return to top

Follow your doctor's directions for your meals, including advice for a reduced-salt(sodium) diet and daily exercise program. Avoid potassium-containing salt substitutes while you are taking this medication. Talk with your doctor about the amount of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) that you may have in your diet.

What should I do if I forget a dose? Return to top

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? Return to top

Spironolactone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

vomiting
diarrhea
stomach pain or cramps
dry mouth
thirst
dizziness
unsteadiness
headache
enlarged or painful breasts in men or women
irregular menstrual periods
vaginal bleeding in post-menopausal ('after the change of life', the end of monthly menstrual periods) women
difficulty maintaining or achieving an erection
deepening of voice
increased hair growth on parts of the body
drowsiness
tiredness
restlessness

If you experience any of the following symptoms, call your doctor immediately:

muscle weakness, pain, or cramps
pain, burning, numbness, or tingling in the hands or feet
inability to move arms or legs
changes in heartbeat
confusion
nausea
extreme tiredness
unusual bleeding or bruising
lack of energy
loss of appetite
pain in the upper right part of the stomach
yellowing of the skin or eyes
fever, sore throat, cough, chills, and other signs of infection
flu-like symptoms
cold, gray skin
rash
hives
itching
difficulty breathing or swallowing
vomiting blood
blood in stools
decreased urination
blurred vision
fainting

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine? Return to top

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medicine that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medicine.

In case of emergency/overdose Return to top

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

drowsiness
confusion
rash
nausea
vomiting
dizziness
diarrhea
tingling in arms and legs
loss of muscle tone
weakness or heaviness in legs
confusion
lack of energy
cold, gray skin
irregular or slow heartbeat

What other information should I know? Return to top

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to spironolactone.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking spironolactone.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names Return to top

Aldactone®

Brand names of combination products Return to top

Aldactazide® containing Spironolactone and Hydrochlorthiazide

Last Revised - 05/01/2007
Last Reviewed - 08/01/2007

American Society of Health-System Pharmacists, Inc. Disclaimer