Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.
Ondansetron comes as a solution (liquid) to be injected intravenously (into a vein) or intramuscularly (into a muscle) by a health care provider in a hospital or clinic. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. Additional doses may be given 4 hours after the first dose of ondansetron and 8 hours after the first dose of ondansetron, if needed. When ondansetron is used to prevent nausea and vomiting caused by surgery, it is usually given just before the surgery. Ondansetron is also sometimes given after surgery to patients who are experiencing nausea and vomiting and who did not receive ondansetron before surgery.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Unless your doctor tells you otherwise, continue your usual diet.
feeling cold or chills
pain, burning, numbness, or tingling in the hand or feet
injection site pain, redness, swelling, warmth, or burning
swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
difficulty breathing or swallowing
shortness of breath
dizziness, light-headedness, or fainting
fast, slow or irregular heartbeat
blurred vision or vision loss
hallucinations (seeing things or hearing voices that do not exist)
nausea, vomiting, or diarrhea
loss of coordination
stiff or twitching muscles
coma (loss of consciousness)
Ondansetron may cause other side effects. Call your doctor if you have any unusual problems while you are using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
This medication will be stored in the hospital or clinic.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
sudden loss of vision for a short time
dizziness or lightheadedness
irregular heart beat
Keep all appointments with your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 01/15/2015
AHFS® Consumer Medication Information. © Copyright, 2015. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.