Topical bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) that could not be treated with other medications. Bexarotene is in a class of medications called retinoids. It works by stopping the growth of cancer cells.
Topical bexarotene comes as a gel to apply to the skin. It is usually applied once every other day at first and gradually applied more frequently up to two to four times a day. Use topical bexarotene at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use bexarotene exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of topical bexarotene and gradually increase your dose, not more often than once a week. Your doctor may decrease your dose if you experience side effects.
Your condition may improve as soon as 4 weeks after you begin to use topical bexarotene, or it may take several months before you notice any improvement. Continue to use topical bexarotene after you notice improvement; your condition may continue to improve. Do not stop using topical bexarotene without talking to your doctor.
Bexarotene gel may catch fire. Do not use this medication near a source of heat or near an open flame such as a cigarette.
Bexarotene gel is for external use only. Do not swallow the medication and keep the medication away from your eyes, nostrils, mouth, lips, vagina, tip of penis, rectum, and anus.
You may bathe, shower, or swim during your treatment with topical bexarotene, but you should use only a mild, non-deodorant soap. You should wait at least 20 minutes after bathing or showering before applying topical bexarotene. After you apply the medication, do not bathe, swim, or shower for at least 3 hours.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Wash your hands.
If you are using a new tube of bexarotene gel, remove the cap and check that the opening of the tube is covered with a metal safety seal. Do not use the tube if you do not see the safety seal or if the seal has been punctured. If you do see the safety seal, turn the cap upside down and use the sharp point to puncture the seal.
Use a clean finger to apply a generous layer of gel to the area to be treated only. Be careful not to get any gel on the healthy skin around the affected area. Do not rub the gel into the skin. You should be able to see some gel on the affected area after you are finished applying it.
Do not cover the treated area with a tight bandage or dressing unless you were told to do so by your doctor.
Wipe the finger that you used to apply the gel with a tissue and throw the tissue away. Wash your hands with soap and water.
Allow the gel to dry for 5-10 minutes before covering with loose clothing. Do not wear tight clothing over the affected area.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Talk to your doctor about eating grapefruit and drinking grapefruit juice while using this medicine.
Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra gel to make up for a missed dose.
redness, burning, irritation, or scaling of the skin
swelling of the arms, hands, feet, ankles, or lower legs
sore throat, fever, chills, or other signs of infection
Bexarotene may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach and sight of children. Store it at room temperature and away from light, excess heat, open flames, and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Keep all appointments with your doctor.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Reviewed - 09/01/2010
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.