Oxymorphone may cause serious or life-threatening breathing problems, especially during the first 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take oxymorphone extended-release tablets. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema), a head injury, any condition that increases the amount of pressure in your brain, sleep apnea (condition in which breathing stops or becomes shallow during sleep);or kyphoscoliosis (curving of the spine that may cause breathing problems). The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.
Taking certain medications other medications with oxymorphone may increase the risk that you will develop serious or life-threatening breathing problems. Tell your doctor and pharmacist if you are taking or plan to take any of the following medications: antidepressants; cimetidine (Tagamet); other narcotic pain medications; medications for anxiety, seizures, mental illness, or nausea; muscle relaxants; sedatives; sleeping pills; and tranquilizers.
Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with oxycodone increases the risk that you will experience serious, life-threatening side effects. Talk to your doctor about the risks of drinking alcohol during your treatment.
Swallow oxymorphone extended-release tablets whole; do not break, chew, dissolve, or crush them. If you take broken, chewed, dissolved, or crushed extended-release tablets, you may receive the entire dose of oxymorphone at once, instead of slowly over 12 hours. This may cause serious problems, including overdose and death. Tell your doctor if you are unable to swallow the tablets whole. Your doctor may prescribe a different medication.
Oxymorphone may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time, or in a different way than prescribed by your doctor. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse oxymorphone if you have or have ever had any of these conditions.
Do not allow anyone else to take your medication. Oxymorphone may harm or cause death to other people who take your medication, especially children. Store oxymorphone in a safe place so that no one else can take it accidentally or on purpose. Be especially careful to keep oxymorphone out of the reach of children. Keep track of how many tablets, or capsules are left so you will know if any medication is missing. Dispose of any unneeded tablets and extended-release tablets properly according to instructions. (See STORAGE and DISPOSAL).
Tell your doctor if you are pregnant or plan to become pregnant. If you take oxymorphone regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.
Talk to your doctor about the risks of taking oxymorphone.
If you are taking the extended-release tablets, your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with oxymorphone and each time you fill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Oxymorphone is used to relieve moderate to severe pain. Oxymorphone extended-release tablets are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. Oxymorphone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the body responds to pain.
Oxymorphone comes as a tablet and an extended-release tablet to take by mouth on an empty stomach, at least 1 hour before or 2 hours after meals. The regular tablet is usually taken every 4 to 6 hours. The extended-release tablet is usually taken every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxymorphone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking the extended-release tablets, swallow them one at a time with plenty of water. Swallow each extended-release tablet right after putting it in your mouth. Do not presoak, wet, or lick the tablets before you put them in your mouth.
Your doctor will probably start you on a low dose of oxymorphone and gradually increase your dose until your pain is controlled. Your doctor may adjust your dose at any time during your treatment if your pain is not controlled. If you feel that your pain is not controlled, call your doctor. Do not change the dose of your medication without talking to your doctor.
Do not stop taking oxymorphone without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking oxymorphone, you may experience withdrawal symptoms such as restlessness; watery eyes; runny nose; yawning; sweating; chills; muscle, joint, or back pain; enlarged pupils (black circles in the centers of the eyes); irritability; anxiety; weakness; stomach cramps; difficulty falling asleep or staying asleep; nausea; vomiting; diarrhea; loss of appetite; fast heartbeat; and fast breathing.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Unless your doctor tells you otherwise, continue your normal diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
loss of appetite
difficulty falling asleep or staying asleep
swelling of the eyes, face, lips, mouth, tongue or throat
difficulty breathing or swallowing
lightheadedness when changing positions
Oxymorphone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Flush any medication that is outdated or no longer needed down the toilet so that others will not take it. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
difficulty breathing or slowed or stopped breathing
bluish-tinged skin, lips, or fingernails
cold, clammy skin
increase or decrease in pupil (dark circle in the eye) size
limp or weak muscles
loss of consciousness
Keep all appointments with your doctor.
This prescription is not refillable. If you are taking oxymorphone to control your pain on a long term basis, be sure to schedule appointments with your doctor regularly so that you do not run out of medication. If you are taking oxymorphone on a short term basis, call your doctor if you continue to have pain after you finish the medication.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 08/15/2014
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.