Carfilzomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with at least two other medications. Carfilzomib is in a class of medications called proteasome inhibitors. It works by stopping or slowing the growth of cancer cells in your body.
Carfilzomib comes as a powder to be mixed with liquid to be injected intravenously (into a vein). Carfilzomib is given by a doctor or nurse in a medical office or clinic. It is usually given two days in a row each week for three weeks followed by a 12-day rest period. The length of treatment will depend on how well your body responds to the medication.
Be sure to tell your doctor how you are feeling during your treatment. Your doctor may stop your treatment for a while or decrease your dose of carfilzomib if you experience side effects of the medication.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Drink plenty of fluids every day during your treatment with carfilzomib, especially if you vomit or have diarrhea.
pain in the arms or legs
changes in the sense of touch
chills or shivering
chest pain or tightness
swelling of the feet of legs
shortness of breath or difficulty breathing
joint or muscle pain
flushing or swelling of the face
pain, burning, numbness, or tingling in the hands or feet
unusual bleeding or bruising
lack of energy
loss of appetite
pain in the upper right part of the stomach
yellowing of the skin or eyes
bloody or black, tarry stools
vomiting blood or brown material that resembles coffee grounds
rash of pinpoint-sized reddish-purple spots, usually on the lower legs
blood in the urine
Carfilzomib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to carfilzomib.
Ask your pharmacist any questions you have about carfilzomib.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 12/15/2012
AHFS® Consumer Medication Information. © Copyright, 2013. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.