Cabozantinib may cause you to develop a fistula (abnormal connection between 2 organs inside your body, or between an organ and the outside of your body) or a tear in the wall of your stomach or intestine. These conditions are serious and may be life-threatening. Call your doctor immediately if you experience severe stomach pain or if you begin to cough, gag, or choke, especially while you are eating or drinking.
Cabozantinib may cause serious or life-threatening bleeding. Tell your doctor if you have recently had any episodes of unusual or heavy bleeding and if you have been coughing up blood. If you experience any of the following symptoms, call your doctor immediately: coughing up blood or blood clots, vomiting material that is bloody or that looks like coffee grounds, blood in stool, black and tarry stools, heavy menstrual bleeding, or other unusual bruising or bleeding.
Talk to your doctor about the risks of taking cabozantinib.
Cabozantinib is used to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. Cabozantinib is in a class of medications called tyrosine kinase inhibitors. It works by slowing or stopping the growth of cancer cells.
Cabozantinib comes as a capsule to take by mouth. It is usually taken once a day on an empty stomach, at least 1 hour before and 2 hours after eating. Take cabozantinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cabozantinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole with a full glass (8 ounces, 240 mL) of water. Do not split, chew, or crush them.
Your doctor may decrease your dose of cabozantinib or tell you to stop taking the medication for a time or permanently if you experience serious side effects. Be sure to talk to your doctor about how you are feeling during your treatment with cabozantinib.
The length of your treatment depends on how well you respond to the medication and the side effects you experience. Continue to take cabozantinib even if you feel well. Do not stop taking cabozantinib without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Do not drink grapefruit juice or eat grapefruit or any foods or supplements that contain grapefruit or grapefruit juice while you are taking this medication.
If you remember more than 12 hours before your next scheduled dose, take the missed dose as soon as you remember it and take your next dose at the scheduled time. However, if you remember less than 12 hours before your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
change in ability to taste food
redness, swelling, or pain in your mouth or throat
loss of appetite
tiredness or weakness
muscle pain or spasms
numbness, burning, or tingling in the hands, arms, feet, or legs
patchy thickening of the skin
redness, pain, swelling, or blistering on the palms or the soles
hair color turning lighter or gray
voice changes or hoarseness
swelling or pain in the arms or legs
shortness of breath
lightheadedness or fainting
numbness or weakness of the face, arm, or leg on one side of your body
difficulty with balance or coordination
sudden, severe headache
difficulty thinking clearly
difficulty eating or drinking due to mouth sores or nausea and vomiting
Cabozantinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to cabozantinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 04/15/2013
AHFS® Consumer Medication Information. © Copyright, 2013. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.