People who have taken perampanel have developed serious or life-threatening changes in their mental health and behavior, especially increased hostility or aggression toward others. Tell your doctor if you have or have ever had any type of mental illness or aggressive behavior. However, you should know that it is possible to develop these changes in mental health and behavior while taking perampanel even if you have never had any problems with mental health or behavior in the past. You, your family, or your caregiver should call your doctor right away if you experience any changes in mood, behavior, or personality during your treatment with perampanel or for up to a month after stopping your treatment. Your doctor will monitor your mental health closely during your treatment with perampanel, especially when you begin taking this medication and any time that your dose is changed. If you experience any of the following symptoms, call your doctor immediately: aggression, hostility, anger, anxiety, irritability, suspicious or distrustful behavior, and thinking about harming or killing others or threatening or trying to do so. Your doctor may decrease your dose or stop your medication.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with perampanel and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Talk to your doctor about the risks of taking perampanel.
Perampanel is used in combination with other medications to treat certain types of seizures in people who are 12 years of age or older. Perampanel is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.
Perampanel comes as a tablet to take by mouth. It is usually taken once a day at bedtime. Take perampanel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take perampanel exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of perampanel and gradually increase your dose, not more than once every one to two weeks.
Perampanel may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
Perampanel may help control your condition but does not cure it. Do not stop taking perampanel without talking to your doctor. If you suddenly stop taking perampanel, your seizures may become worse. Your doctor will probably decrease your dose gradually.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Unless your doctor tells you otherwise, continue your normal diet.
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss more than one dose, contact your doctor.
dizziness or a sense of spinning
problems with coordination
muscle or joint pain
blurred or double vision
Perampanel may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
unusual changes in behavior or mood
Keep all appointments with your doctor.
Do not let anyone else take your medication. Perampanel is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 02/15/2014
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.