Cladribine injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer.
Cladribine may cause a severe decrease in the number of all types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; or vomited material that looks like coffee grounds.
Cladribine may cause severe nerve damage. Nerve damage may occur more than one month after cladribine injection is given. If you experience any of the following symptoms, call your doctor immediately: pain, burning, numbness, or tingling in the hands or feet; weakness in the arms or legs; or loss of ability to move your arms or legs.
Cladribine may cause serious kidney problems. Tell your doctor if you have or have ever had kidney disease. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin); amphotericin B (Amphotec, Fungizone); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); or nonsteroidal anti-inflammatory medications such as diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), and sulindac (Clinoril). If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after treatment to check your body's response to cladribine.
Cladribine is used to treat hairy cell leukemia (cancer of a certain type of white blood cell). Cladribine is in a class of medications known as purine analogs. It works by works by stopping or slowing the growth of cancer cells.
Cladribine injection comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given slowly over 7 days as a continuous intravenous injection.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Unless your doctor tells you otherwise, continue your normal diet.
loss of appetite
pain, redness, swelling, or sores in the place where the medication was injected
shortness of breath
Cladribine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
swelling of the face, arms, hands, feet, ankles, or lower legs
unusual tiredness or weakness
unusual bleeding or bruising
black and tarry or bloody stools
bloody vomit or vomited material that looks like coffee grounds
fever, sore throat, chills, or other signs of infection
pain, burning, numbness, or tingling in the hands or feet
weakness in the arms or legs.
loss of ability to move the arms or legs.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 11/15/2011
AHFS® Consumer Medication Information. © Copyright, 2015. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.