Factor V deficiency is a condition that is passed down through families, which affects the ability of the blood to clot.
Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.
Factor V deficiency is caused by a lack of Factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.
Factor V deficiency is rare. It may be caused by:
You can get an antibody that interferes with Factor V:
Sometimes the cause is unknown.
You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.
The outlook is good with diagnosis and proper treatment.
Severe bleeding (hemorrhage) could occur.
Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.
Parahemophilia; Owren's disease
Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 167.
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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