Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.
Normally, red blood cells last for about 120 days in the body. In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal.
Hemolytic anemia occurs when the bone marrow is unable to replace the red blood cells that are being destroyed.
Immune hemolytic anemia occurs when the immune system mistakenly sees your own red blood cells as foreign substances. Antibodies then develop against the red blood cells. These antibodies attack the red blood cells and cause them to break down too early.
Red blood cells may be destroyed due to:
Other causes are:
You may not have symptoms if the anemia is mild. If the problem develops slowly, the first symptoms may be:
If the anemia gets worse, symptoms may include:
A test called a complete blood count (CBC) can help diagnose anemia and offer some hints to the type and cause of the problem. Important parts of the CBC include red blood cell count (RBC), hemoglobin, and hematocrit (HCT).
These tests can identify the type of hemolytic anemia:
Treatment depends on the type and cause of the hemolytic anemia:
In rare cases, surgery is needed to take out the spleen. This is because the spleen acts as a filter that removes abnormal cells from the blood.
Outcome depends on the type and cause of hemolytic anemia. Severe anemia can make heart disease, lung disease, or cerebrovascular disease worse.
Call your health care provider if you develop symptoms of hemolytic anemia.
Anemia - hemolytic
Jager U, Lechner K. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 44.
Price EA, Schrier SS. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 45.
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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