Major depression is a mental health condition. It is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with daily life for weeks or longer.
Doctors do not know the exact causes of depression. It is believed that chemical changes in the brain are responsible. This may be due to a problem with your genes. Or it may be triggered by certain stressful events. More likely, it is a combination of both.
Some types of depression run in families. Other types occur, even if you have no family history of the illness. Anyone can develop depression, even children and teens.
Depression may be brought on by:
Depression can change or distort the way you see yourself, your life, and those around you.
With depression, you often see everything in a negative way. It is hard for you to imagine that a problem or situation can be solved in a positive way.
Symptoms of depression can include:
Depression in teens may be harder to recognize. Problems with school, behavior, or alcohol or drug use can all be signs.
If depression is very severe, you may have hallucinations and delusions (false beliefs). This condition is called depression with psychotic features.
Your health care provider will ask about your medical history and symptoms. Your answers can help your doctor diagnose depression and determine how severe it may be.
Blood and urine tests may be done to rule out other medical conditions that have symptoms similar to depression.
Depression can be treated. Treatment includes medicines, talk therapy, or both.
If you are thinking about suicide or are very depressed and cannot function, you may need to be treated in a hospital.
After you have been on treatment, if you feel your symptoms are getting worse, talk with your doctor. Your treatment plan may need to be changed.
Antidepressants are medicines used to treat depression. They work by bringing back the chemicals in your brain to the right levels. This helps relieve your symptoms.
If you have delusions or hallucinations, your health care provider may prescribe additional medicines.
Tell your provider about any other medicines you take. Some medicines can change the way antidepressants work in your body.
Allow your medicine time to work. It may take a few weeks before you feel better. Keep taking your medicine as instructed. Do not stop taking it or change the amount (dosage) you are taking without talking to your provider. Ask your doctor about possible side effects, and what to do if you have any.
If you feel your medicine is not working, tell your provider. The medicine or its dosage may need to be changed. Do not stop taking medicines on your own.
WARNING: Children, teens, and young adults should be watched closely for suicidal behavior. This is especially true during the first few months after starting medicines for depression.
Women being treated for depression who are pregnant or thinking about becoming pregnant should not stop taking antidepressants without first talking to their provider.
Beware of natural remedies such as St. John's wort. This is an herb sold without a prescription. It may help some people with mild depression. But it can change the way other medicines work in your body, including antidepressants. Talk to your health care provider before trying this herb.
Talk therapy is counseling to talk about your feelings and thoughts, and help you learn how to deal with them.
Types of talk therapy include:
OTHER TREATMENTS FOR DEPRESSION
You may start feeling better a few weeks after starting treatment. If you take medicine, you will need to stay on the medicine for several months to feel good and prevent depression from returning. If your depression keeps coming back, you may need to stay on your medicine for a long period.
If you have thoughts of suicide or harming yourself or others, call your local emergency number (such as 911) right away. Or go to the hospital emergency room.
You can also call a suicide hotline 24 hours a day: 1-800-SUICIDE or 1-800-999-9999.
Call your doctor right away if:
Do not drink alcohol or use illegal drugs. These substances make depression worse and may lead to thoughts of suicide.
Take your medicine exactly as your doctor instructed. Learn to recognize the early signs that your depression is getting worse.
Keep going to your talk therapy sessions. Counseling is just as effective as taking medicine.
The following tips may help you feel better:
Learn more about depression by contacting a local mental health clinic. Your workplace employee assistance program (EAP) is also a good resource. Online resources can also provide good information.
Depression - major; Depression - clinical; Clinical depression; Unipolar depression; Major depressive disorder
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing. 2013.
American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder. 3rd edition. October 2010. Available at: http://psychiatryonline.org/content.aspx?bookid=28§ionid=1667485. Accessed: March 10, 2014.
Updated by: Timothy Rogge, MD, Medical Director, Family Medical Psychiatry Center, Kirkland, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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