The cause of acrodermatitis is poorly understood, but its link with other infections is well-documented.
In Italian children, acrodermatitis is seen frequently with hepatitis B, but this link is rarely seen in the United States. Epstein-Barr virus (EBV, mononucleosis) is the virus most often associated with acrodermatitis. Other associated viruses include cytomegalovirus, coxsackie viruses, parainfluenza virus, respiratory syncytial virus (RSV), and some live virus vaccines.
A rare, genetic form of acrodermatitis is acrodermatitis enteropathica. In this disorder, zinc is poorly absorbed from the diet. Adding zinc supplements to the diet improves the condition. This form of the disorder can be associated with other abnormalities and development delays.
Other symptoms that may appear include:
Your doctor can diagnose this condition by looking at the skin and rash. The liver, spleen, and lymph nodes may be swollen.
The following tests may be done to confirm the diagnosis or rule out other conditions:
Acrodermatitis by itself is not treated. Infections associated with this condition, such as hepatitis B and Epstein-Barr, are treated. Cortisone creams may help with itching and irritation.
Acrodermatitis enteropathica improves when the zinc levels in the body is returned to normal.
Acrodermatitis usually disappears on its own without treatment or complication. Associated conditions must be watched carefully.
Complications occur as a result of associated conditions, rather than as a result of acrodermatitis.
Call your health care provider if your child has signs of this condition.
Papular acrodermatitis of childhood; Gianotti-Crosti syndrome; Acrodermatitis - infantile lichenoid; Acrodermatitis - papular infantile; Papulovesicular acro-located syndrome; Acrodermatitis enteropathica
Mancini AJ, Shani-Adir A. Other viral diseases. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 81.
Morelli JG. Nutritional dermatoses. In: Kliegman RM, Stanton BF, St. Geme, JW III, et al., eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 663.
Updated by: Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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