Urine melanin is a test to determine the abnormal presence of melanin in the urine.
A clean-catch urine sample is needed.
No special preparation is needed.
The test involves only normal urination.
This test is used to diagnose melanoma, a type of skin cancer that produces melanin. If the cancer spreads (especially within the liver), the cancer may produce enough of this substance that it shows up in the urine.
Normally, melanin is not present in urine.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
If melanin is present in the urine, malignant melanoma is suspected.
There are no risks associated with this test.
This test is rarely done to diagnose melanoma because there are better tests available.
Thormahlen's test; Melanin - urine
McPherson RA, Ben-Ezra J, Zhao S. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 27.
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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