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New Book Added to NCBI Bookshelf

Technical Notes

New Book Added to NCBI Bookshelf

Additional Digitized Back Issues Available in PubMed Central®

New Clinical Alert Issued

ChemIDplus Update

Review of PDA Applications in Toxicology & Environmental Health

New TOXNET Resource: International Toxicity Estimates for Risk (ITER) Database

Changes in MedlinePlus®

Inactive PubMed® Cubby Accounts to be Canceled
[Note Updated 6/10/2004]

"Microbial Diversity: Let's Tell It How It Is" Added to Coffee Break

PubMed for Handhelds Has New URL

NLM Gateway Searches TOXLINE® Special

PubMed® MeSH Database Animated Tutorials

MedlinePlus® Goes Local With Missouri Community Connection
[Editor's Note added 5/20/2010]

PubMed® LinkOut Display for Links to HSDB® Updated

NCBI Bookshelf Adds New Book

Serials Data for Titles in NLM's List of Serials Indexed for Online Users is Now Available in eXtensible Markup Language (XML) Format

March 1, 2004 [posted]

The National Center for Biotechnology Information (NCBI) has recently added a book to the Bookshelf:

Endocrinology: An Integrated Approach.
Nussey, S.S. and Whitehead, S.A.
Oxford, UK: BIOS Scientific Publishers, Ltd; 2001.

The books in Bookshelf may be searched directly from the Bookshelf site, via links from the Links pull-down menu from relevant PubMed® citations, or through the new Entrez Global query feature.

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Additional Digitized Back Issues Available in PubMed Central

March 1, 2004 [posted]

Content from volumes 1987 Jan;84(1) to 1989 Dec;86(12) of Proceedings of the National Academy of Sciences is now available in PubMed Central (PMC) as part of NLM's project to digitize the back issues of PMC participating journals. The coverage of Proceedings of the National Academy of Sciences in PMC had previously begun with 1990 Jan;87(1).

Proceedings of the National Academy of the Sciences of the United States of America
pISSN: 0027-8424
eISSN: 1091-6490
MEDLINE Abbr: Proc Natl Acad Sci U S A
Publisher: Washington DC National Academy of Sciences
NLM ID: 7505867
Full text coverage in PMC: begins with 1997 Jan;84(1).
PMC URL:
http://www.pubmedcentral.nih.gov/tocrender.fcgi?action=archive&journal=2

Content from volumes 1980 Jan:8(1) to 1984 Dec:12(24) and volumes 1989 Jan;17(1) to 1993 Dec;21(25) of Nucleic Acids Research is also now available in PMC.

Nucleic Acids Research
pISSN: 0305-1048
eISSN: 1362-4962
MEDLINE Abbr: Nucleic Acids Res
Publisher: Oxford University Press
NLM ID: 0411011
PMC URL:
http://www.pubmedcentral.nih.gov/tocrender.fcgi?action=archive&journal=4

The full-text of these journals may be searched directly from the PMC site or through the Entrez Global Query feature.

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New Clinical Alert Issued

March 3, 2004 [posted]

The National Heart, Lung, and Blood Institute (NHLBI) has issued a new Clinical Alert:

The National Institutes of Health (NIH) has instructed participants in the estrogen-alone study of the Womens Health Initiative (WHI), a large multi-center trial, to stop taking their study pills and to begin the follow-up phase of the study.

Letters have been sent to all participants in the estrogen-alone study, 11,000 healthy postmenopausal women who have had a hysterectomy, informing them of a recent NIH review of the study data. After careful consideration of the data, NIH has concluded that with an average of nearly 7 years of follow-up completed, estrogen alone does not appear to affect (either increase or decrease) heart disease, a key question of the study. At the same time, estrogen alone appears to increase the risk of stroke and decrease the risk of hip fracture. It has not increased the risk of breast cancer during the time period of the study.

Links to Clinical Alerts can also be found from these NLM Web sites:

  • MEDLINEplus features Clinical Alerts as NIH Press Releases on the appropriate Health Topics page(s).
  • As before, PubMed and the NLM Gateway have a link to the Clinical Alerts on their side bars. In addition, a featured link will now be available from their Home Page for 10 days after a new alert is issued.
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ChemIDplus Update

March 8, 2004 [posted]

[Editor's Note: This Technical Note is a reprint of an announcement published on NLM-Tox-Enviro-Health-L, an e-mail announcement list available from the NLM Division of Specialized Information Services. To subscribe to this list, please see http://sis.nlm.nih.gov/enviro/envirolistserv.html.]

ChemIDplus "Lite"
A new front end to ChemIDplus was released on October 10, 2003. This new version, called ChemIDplus Lite, allows users to search compound identifiers such as chemical name or CAS Registry Number on the NLM ChemIDplus database of over 370,000 chemicals.

Unlike the original ChemIDplus database, the Lite version does not allow structure searching and thus needs no plugins or special display software. Chemical structures are displayed as GIF images.

ChemIDplus Lite is available at http://chem2.sis.nlm.nih.gov/chemidplus/chemidlite.jsp, a search page similar to other TOXNET search pages. Just type the name of a substance of interest to you, or its CAS Registry Number, into the search box. Right truncation ("starts with") is available by using the asterisk (*) at the end of a search term. More advanced data and structure searching can be done at the main ChemIDplus page: http://chem.sis.nlm.nih.gov/chemidplus/.

More information about ChemIDplus Lite can be found at http://chem2.sis.nlm.nih.gov/chemidplus/html/help.jsp.

New ChemIDplus Spell Checker
For exact name searches that retrieve no hits, ChemIDplus will now try a type of 'fuzzy' match. If available, a list of near match chemical names will be presented. You can chose one of these and browse the record directly or redo the search. (Note: the name-matching software is designed to help users in the case of close misspellings. There are situations in which it will not be able to find a match. Also, the desired name may not be first on the list.)

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Review of PDA Applications in Toxicology and Environmental Health

March 12, 2004 [posted]

[Editor's Note: This Technical Note is a reprint of an announcement published on NLM-Tox-Enviro-Health-L, an e-mail announcement list available from the NLM Division of Specialized Information Services. To subscribe to this list, please see http://sis.nlm.nih.gov/enviro/envirolistserv.html.]

Review of PDA Applications in Toxicology and Environmental Health
[This link was removed because it is no longer relevant]

The National Library of Medicine's Division of Specialized Information Services (SIS) has introduced the "Review of PDA Applications in Toxicology and Environmental Health,"
[This link was removed because it is no longer relevant]an ongoing descriptive review of selected PDA applications in the fields of toxicology and environmental health.

Individual reports in the review series are based on downloadable demo versions of selected PDA applications. Each review typically covers: General Information, Intended Users, Authorship/Data Source, Contents, Navigation, Requirements, Application Type/Price, Availability, Useful Web Links, and Updates when applicable.

SIS staff welcomes any comments on completed reviews or suggestions for additional reviews of other such applications not currently included (tehip@teh.nlm.nih.gov).

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New TOXNET Resource: International Toxicity Estimates for Risk (ITER) Database

March 12, 2004 [posted]

[Editor's Note: This Technical Note is a reprint of an announcement published on NLM-Tox-Enviro-Health-L, an e-mail announcement list available from the NLM Division of Specialized Information Services. To subscribe to this list, please see http://sis.nlm.nih.gov/enviro/envirolistserv.html.]

NLM has announced the addition of a new database to the TOXNET system:

The International Toxicity Estimates for Risk (ITER) Database

The International Toxicity Estimates for Risk (ITER) database was added to NLM's Division of Specialized Information Services (SIS)'s TOXNET system on January 22 (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?iter).

ITER is a database of human health risk values from major organizations worldwide for over 600 chemicals of environmental concern. It is a product of Toxicology Excellence for Risk Assessment (TERA), a non-profit group whose mission is to protect public health by developing and communicating risk assessment values, improving risk methods through research, and educating the public on risk assessment issues.

The risk values are included from: the Environmental Protection Agency (EPA), USA ; the Agency for Toxic Substances and Disease Registry (ATSDR), USA; Health Canada; the International Agency for Research on Cancer; the National Institute of Public Health and Environment (RIVM), the Netherlands; and various other groups (e.g. industry, consultants, academia) after an independent peer review.

These independent values are available only on ITER. The list will likely expand over the coming years as TERA identifies new global risk information resources.

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Changes in MedlinePlus®

March 12, 2004 [posted]

On February 18, NLM introduced some changes to MedlinePlus. In the new design, MedlinePlus appears in upper/lower case lettering, replacing "MEDLINEplus" throughout the site. This capitalization format better reflects common use of the site name. There is also a new tagline, "Trusted Health Information for You". You can now link to the home pages of the National Library of Medicine and the National Institutes of Health from the text in the banner on every MedlinePlus page. Most notable is the relocation of the "Home" tab on each secondary page beside the other navigational tabs. Also, the "printer-friendly version" and "e-mail to friend" icons are now colored more brightly to draw users' attention to these handy features.

If you have questions or comments, please use the "Contact Us" link that appears on every MedlinePlus page.

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Inactive PubMed® Cubby Accounts to be Canceled
[Note Updated 6/10/2004]

March 17, 2004 [posted]

Several new features, including automatic e-mailing of stored search results, will soon be added to PubMed's Cubby. In order to continue to provide an efficient NCBI Cubby service, inactive Cubby accounts will not be transitioned to the new system. Cubby accounts that have not been used (logged into) for the past nine months will be canceled in April when the new Cubby system is expected to be installed. There will be a limited period after April during which canceled accounts can be re-activated by NCBI.

[Editor's Note: Cancellation of inactive accounts has been postponed until Summer 2004.]

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"Microbial Diversity: Let's Tell It How It Is" Added to Coffee Break

March 17, 2004 [posted]

NCBI's Coffee Break is a collection of short stories and interactive tutorials about recent biomedical discoveries. These snapshots of science are short enough to be enjoyed over a cup of coffee but also give a detailed report on a molecular topic.

The latest Coffee Break, "Microbial Diversity: Let's Tell It How It Is," describes a new approach to environmental sampling of bacteria, using whole genome shotgun (WGS) sequencing. This approach to sampling "wild" microorganisms obviates the need to isolate each organism before sequencing can begin, possibly providing shortcuts to the discovery of new genes.

Two Coffee Breaks were added in 2003, "Talking About the Genetics of Talking: The Discovery of the First Speech and Language Gene," in November, and "Variations on a Gene: Investigating the Genetic Basis of Iron Overload," in August.

You can read more about Coffee Break in the NLM Technical Bulletin article, Dean L. Take a Coffee Break. NLM Tech Bull. 2003 Nov-Dec;(335):e5, as well as at About Coffee Break.

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PubMed for Handhelds Has New URL

March 17, 2004 [posted]

PubMed for Handhelds has a new, easier-to-remember URL:
pubmedhh.nlm.nih.gov.

If you're looking for a link to this handheld tool while in PubMed, go to PubMed's FAQ page, which has a new Q&A, "Can I use PubMed on my handheld device?" PubMed's Overview also has a link to this FAQ.

To read more about PubMed for Handhelds, please see: Stetson JS. PubMed® Available for Use on Handheld, Wireless Devices. NLM Tech Bull. 2003 Jul-Aug;(333):e5.

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NLM Gateway Searches TOXLINE® Special

March 29, 2004 [posted]

A new version of the NLM Gateway was released March 24, 2004, with a new collection, TOXLINE Special, added in the Journal Citations category.

TOXLINE Special is a collection of bibliographic information covering the biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals. The information comes from specialized journals and other sources, supplementing related references in MEDLINE®. For more information on those sources, see http://www.nlm.nih.gov/pubs/factsheets/toxlinfs.html.

In this latest version of the Gateway, users will also find that MeSH Qualifiers (subheadings) are now available via the "Find Terms" feature and that direct links for free fulltext articles—whether from PubMed Central or at the producer site—have been added on the Results, Expanded Item, and Document Ordering pages for PubMed®.

For additional details on Gateway's new version, please see What's New on the NLM Gateway sidebar.

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PubMed® MeSH Database Animated Tutorials

March 29, 2004 [posted]

NLM is pleased to announce new animated presentations for users who wish to learn how to use the Entrez MeSH Database in conjunction with searching PubMed. These demos were produced with Qarbon.com Inc.'s Viewlet technology. There are three presentations:

  • Searching with the MeSH Database
  • Combining MeSH Terms Using the MeSH Database
  • Applying Subheadings and Other Features of the MeSH Database

Viewlets are SWF files (based on Flash 5 technology) that play via a browser with a Flash 5 (or later) plugin. There is an automatic audio narrative. If you wish to mute the sound, this may be accomplished from the Volume control on your desktop.

These demos are currently available from within the MeSH Database section of PubMed's Help and from the NLM Web site at: http://www.nlm.nih.gov/bsd/dist_edu.html.

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MedlinePlus® Goes Local With Missouri Community Connection

April 21, 2004 [posted]

[Editor's note added on May 20, 2010: Go Local hyperlinks have been removed. For more information see NLM® to Discontinue Support of MedlinePlus® Go Local.]

Missourians have a new way to connect to local health services. MedlinePlus now includes "Go Local" links to Missouri's Community Connection online services directory. The "Go Local" links bring users of MedlinePlus health topic pages to related health services throughout Missouri and link Missourians directly to authoritative, reliable health information from the National Institutes of Health and other quality sources.

The Missouri "Go Local" Project is a partnership of the National Network of Libraries of Medicine-Midcontinental Region, Missouri Foundation for Health, and the University of Missouri-Columbia, including MU Extension, the Office of Social and Economic Data Analysis, the J. Otto Lottes Health Science Library, and Health Management and Informatics program.

The North Carolina site, NCHealthInfo.org, from the University of North Carolina at Chapel Hill (UNC), was the first "Go Local" site. Other states will follow by the end of 2004.

For more information, visit "Go Local" - A Project of MedlinePlus at: [link removed].

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PubMed® LinkOut Display for Links to HSDB® Updated

April 21, 2004 [posted]

[Editor's Note: This Technical Note is a reprint of an announcement published on NLM-Tox-Enviro-Health-L, an e-mail announcement list available from the NLM Division of Specialized Information Services. To subscribe to this list, please see http://sis.nlm.nih.gov/enviro/envirolistserv.html.]

PubMed's LinkOut display for links to chemicals found in TOXNET's HSDB (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB) has been updated. The links now appear as specific chemical name/s, replacing the phrase "Hazardous Substance Data Bank from NLM".

LinkOut provides PubMed users with connections to web-accessible resources, including full-text articles, consumer health information, and supplementary data, related to a PubMed citation. These resources expand on the information in the citation.

PubMed users have had access to information for over 3,000 Hazardous Substances Data Bank (HSDB®) chemical substances via LinkOut since September 2003. HSDB is a factual data file that focuses on the toxicology of potentially hazardous chemicals. In addition to toxicity data, HSDB provides information in the areas of emergency handling procedures, industrial hygiene, environmental fate, human exposure, detection methods, and regulatory requirements.

How to use LinkOut to retrieve HSDB information:

  • Click on the word "Links" to the right of each citation
  • Choose "LinkOut" from the menu that appears
  • Look for the heading, "MOLECULAR BIOLOGY DATABASES"
  • HSDB links, if present, will appear under the "Hazardous Substances Data Bank" heading (now, with specific chemical name/s)

MOLECULAR BIOLOGY DATABASES:

  • Structure:
    • Hazardous Substances Data Bank
    • Chemical Name/s
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NCBI Bookshelf Adds New Book

April 23, 2004 [posted]

The National Center for Biotechnology Information (NCBI) has recently added a book to the Bookshelf:

Historical Works: Medicine in the Americas.
History of Medicine Division.
Bethesda (MD): National Library of Medicine(US); 2004 Mar.
Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books

The books in Bookshelf may be searched directly from the Bookshelf site, via links from the Links pull-down menu from relevant PubMed® citations, or through the new Entrez cross-database search page.

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Serials Data for Titles in NLM's List of Serials Indexed for Online Users is Now Available in eXtensible Markup Language (XML) Format

April 23, 2004 [posted]

The 2004 List of Serials Indexed for Online Users (LSI) is now available in XML format. This is the first edition of the LSI to be produced in XML. The Serials Document Type Definition (DTD) to be used with the serials XML data is available at http://www.nlm.nih.gov/databases/dtd/

The 2004 edition of the LSI contains 10,372 serial titles, including 4,780 titles currently indexed for MEDLINE.

You must agree to the Terms and Conditions of use to download NLM serials data for both the LSI, available PDF and XML formats, and the List of Journals Indexed in Index Medicus (LJI), available in PDF format. Downloading the data indicates acceptance of the stated Terms and Conditions.

The National Library of Medicine (NLM) designed the lists of serials products to provide bibliographic information for serials from which articles are indexed with the MeSH® vocabulary and cited in MEDLINE®, the backbone of NLM's PubMed® database. More detailed bibliographic data and information about indexing coverage for serials cited in PubMed can be found in LocatorPlus, NLM's online catalog, at http://locatorplus.gov.

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