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NLM Technical Bulletin

NLM Technical Bulletin. 1999 November-December; 311



In This Issue:

Technical Notes - e1

Year-End Processing [corrected 1999/12/02] - e2

dotMeSH Coming Attractions - e3

Fees and New Format for Leasing NLM Databases in 2000 - e4

Scope Expands for PubMed and MEDLINE - e5

Data Changes Expected - e6

Hands On - e7


Appendixes:

2000 Update Schedule for MEDLINE on PubMed and Internet Grateful Med [corrected 1999/12/02]


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MeSH Coming Attractions

New in 2000 MeSH
The following changes and additions are of particular importance and interest for 2000:

  • Nervous System Diseases (C10) were reorganized and the vocabulary was extensively revised to reflect current developments. There were 214 new headings added to the Nervous System Diseases (C10) tree and 24 terms were added to the Central Nervous System tree (A8). New terms in these two trees account for almost half of the new descriptors added this year.
  • Symptoms and General Pathology, the C23 tree, was extensively modified with a number of new terms added. Many terms that are also in other trees were removed from this tree.
  • GTP-Binding Proteins, in the D tree, were expanded with the addition of 16 specific proteins and many associated enzymes along with the rearrangement of closely related concepts.
  • The Plants (B6) tree had 13 new descriptors added to identify plants of medicinal interest.
  • The C21 tree, formerly called Injuries, Poisonings, and Occupational Diseases, has been renamed Disorders of Environmental Origin.

Statistical Summary of Changes to 2000 MeSH
The following table is a brief statistical summary of the changes made to the 2000 MeSH.

552 descriptors were added representing concepts with no directly corresponding descriptors in 1999 MeSH (i.e., new concepts and records)
130 descriptors were replaced with more up-to-date terminology
16 descriptors were deleted
2141 see references (print entry terms) were added

Publication Types and Subheadings
There were no new Publication Types or subheadings added or deleted for 2000. The only change is to the subheading "Drug Therapy" as shown below (the deleted words are italicized):

1999 scope note for "Drug Therapy":
Used with disease headings for the treatment of disease by the administration of drugs, chemicals, and antibiotics. For diet therapy and radiotherapy, use specific subheadings. Excludes immunotherapy and treatment with biologicals for which "therapy" is used.

2000 scope note for "Drug Therapy":
Used with disease headings for the treatment of disease by the administration of drugs, chemicals, and antibiotics. For diet therapy and radiotherapy, use specific subheadings. Excludes immunotherapy for which "therapy" is used.

Previously, treatment of a disease with biological factors and products which are treed in D24, required coordination of the disease with /therapy rather than /drug therapy. With the development of recombinant forms of these drugs, such as Interferons, it became more difficult for both indexers and searchers to recognize whether the substance being prescribed was a "drug" or a "biological product". Thus, we will routinely now coordinate all of these substances with the disease/drug therapy.

For comprehensive searching in PubMed, remember to use the broader subheading "/therapy" since PubMed automatically explodes subheadings and thus will retrive citations indexed using both definitions. For example, to search PubMed to find citations discussing BCG Vaccine (a D24 concept) and the treatment of tuberculosis use the search strategy:

bcg vaccine AND tuberculosis/therapy

If you wished to find citations indexed using one of the two scope notes then use the search strategy:

For citations indexed during or after the 2000 indexing year:

bcg vaccine AND tuberculosis/drug therapy

For citations indexed before the 2000 indexing year:

bcg vaccine AND tuberculosis/therapy [mh:noexp]

2000 MeSH terms for symptoms and related disorders

There are six symptoms for which MeSH has also provided a precoordinated disorder term. The symptoms are in both C10 (Nervous System Diseases) and in C23 (Symptoms and General Pathology), while the disorders are only in C10. In each case, the scope notes for the symptom reminds you that diseases which are characterized by persistence or recurrence of the symptom should be indexed and searched for as the precoordinated disorder.

Symptom Disorder
Chorea (C10, C23)Choreatic Disorders (C10)
Dyskinesias (C10, C23)Dyskenesia Syndromes see Movement Disorders (C10)
Dystonia (C10, C23)Dystonic Disorders (C10)
Facial Pain (C10, C23)Facial Pain Syndromes see Facial Neuralgia (C10)
Headache (C10, C23)Headache Disorders (C10)
Tics (C10, C23)Tic Disorders (C10)

New 2000 MeSH Headings
There were too many new descriptors added to the 2000 MeSH to list them all here. This article highlights new descriptors related to the nervous system, GTP-Binding proteins, plants, fungi, and bacteria. The complete lists of new and modified descriptors are available on the MeSH web site at http://www.nlm.nih.gov/mesh/filelist.html.

New MeSH terms related to the Nervous System

A8 (Nervous System)
Anterior Thalamic Nuclei
Basal Nucleus of Meynert
Diagonal Band of Broca
Entopeduncular Nucleus
Fornix (Brain)
Fourth Ventricle
Internal Capsule
Intralaminar Thalamic
Nuclei Islands of Calleja
Lateral Thalamic Nuclei
Lateral Ventricles
Mediodorsal Thalamic Nucleus
Metencephalon
Midline Thalamic Nuclei
Parahippocampal Gyrus
Posterior Horn Cells
Posterior Thalamic Nuclei
Pulvinar
Septum of Brain
Spinocerebellar Tracts
Subthalamic Nucleus
Subthalamus
Third Ventricle
Ventral Thalamic Nuclei

C10 (Nervous System Diseases)
The complete list of the 214 new terms added to this tree is available within the list of 552 new terms on the MeSH Web site at: http://www.nlm.nih.gov/mesh/filelist.html. Scroll down to New Headings with Scope Notes and click there.

New MeSH Terms Related to GTP-Binding Proteins
(Various Branches of the D tree)
ADP-Ribosylation Factors
cdc42 GTP-Binding Protein
cdc42 GTP-Binding Protein, Yeast
Chimerin Proteins
Chimerin 1
EIF-2B
GTP Phosphohydrolase Activators
GTP Phosphohydrolase-Linked Elongation Factors
GTP Phosphohydrolases
GTP-Binding Protein Regulators
GTPase-Activating Proteins
Guanine Nucleotide Dissociation Inhibitors
Guanine Nucleotide Exchange Factors
Guanine Nucleotide-Releasing Factor 2
Heterotrimeric GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Peptide Elongation Factor G
Peptide Elongation Factor 1
Peptide Elongation Factor 2
p120 GTPase Activating Protein
rab GTP-Binding Proteins
rab1 GTP-Binding Proteins
rab2 GTP-Binding Protein
rab3 GTP-Binding Proteins
rab3A GTP-Binding Protein
rab4 GTP-Binding Proteins
rab5 GTP-Binding Proteins
rac GTP-Binding Proteins
rac1 GTP-Binding Protein
ral GTP-Binding Proteins
ral Guanine Nucleotide Exchange Factor
ran GTP-Binding Protein
rap GTP-Binding Proteins
rap1 GTP-Binding Proteins
ras GTPase-Activating Proteins
RGS Proteins
rho GTP-Binding Proteins
rhoA GTP-Binding Protein
rhoB GTP-Binding Protein
New MeSH Terms Related to Organisms
B3 (Bacteria)
Afipia
alpha Proteobacteria
Alteromonas
Arcobacter
Azoarcus
Azorhizobium
Azorhizobium caulinodans
beta Proteobacteria
Buchnera
Cellvibrio
Comamonas
Comamonas acidovorans
Comamonas testosteroni
delta Proteobacteria
Ectothiorhodospira
Ectothiorhodospira halophila
Ectothiorhodospira shaposhnikovii
Edwardsiella
Edwardsiella ictaluri
Edwardsiella tarda
epsilon Proteobacteria
gamma Proteobacteria
Gluconobacter
Gluconobacter oxydans
Hafnia
Hafnia alvei
Halomonas
Hyphomicrobium
Lawsonia
Methylobacillus
Methylobacterium
Methylobacterium extorquens
Methylococcus
Methylococcus capsulatus
Methylomonas
Methylophilus
Methylophilus methylotrophus
Methylosinus
Methylosinus trichosporium
Morganella
Morganella morganii
Ochrobactrum anthropi
Oxalobacter formigenes
Pantoea
Photorhabdus
Proteobacteria
Rahnella
Rhodomicrobium vannielii
Shewanella
Shewanella putrefaciens
Sinorhizobium
Sphingomonas
Stenotrophomonas
Stenotrophomonas maltophilia
Stigmatella
Stigmatella aurantiaca
Taylorella equigenitalis
Thauera
Thiocapsa
Thiocapsa roseopersicina
Vitreoscilla
Wolbachia
Xanthobacter
Xenorhabdus
B5 (Algae and Fungi)
Reishi
Shiitake Mushrooms
Usnea
New MeSH Terms Related to Medicinal Plants
B6 (Plants)
Calendula
Cat's Claw
Chamomile
Comfrey
Echinacea
Equisetum
Feverfew
Ginger
Hypericum
Kava
Milk Thistle
Taxus
Vitex
--prepared by Jacque-Lynne Schulman
MeSH Section

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