Research of Interest
We are interested in understanding the evolution of life. To obtain glimpses of such understanding, we employ existing and new methods of computational biology to perform research in several major areas.
Group Leader
Eugene V. Koonin, PhD
Chief, Computational Biology Branch Bioinformatics of Chromatin Structure NCBI, NLM
Dr. Koonin graduated from Moscow State University, Moscow, Russia and received his Ph.D. in Molecular Biology in 1983. He has been working in the fields of Computational Biology and Evolutionary Genomics since 1984. Dr. Koonin moved to the US in 1991, first, as a Visiting Scientist, and then, as a Senior Investigator at the National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD.
Contact Information
Building 38A, 8600 Rockville Pike MSC 6075 Bethesda, MD 20894
Tel: 301-594-2445
Members
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Title Computational Biology Branch
Publication Highlights
Role of the pre-initiation complex in Mediator recruitment and dynamics.
Knoll ER, Zhu ZI, Sarkar D, Landsman D, Morse RH - PMID: 30540252
The Mediator complex stimulates the cooperative assembly of a pre-initiation complex (PIC) and recruitment of RNA Polymerase II (Pol II) for gene activation.
Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M. - PMID: 30532006
The dynamic nature of the chromatin epigenetic landscape plays a key role in the establishment and maintenance of cell identity, yet the factors that affect the dynamics of the epigenome are not fully known.
Structural interpretation of DNA-protein hydroxyl-radical footprinting experiments with high resolution using HYDROID.
Shaytan AK, Xiao H, Armeev GA, Gaykalova DA, Komarova GA, Wu C, Studitsky VM, Landsman D, Panchenko AR - PMID: 30341436
Hydroxyl-radical footprinting (HRF) is a powerful method for probing structures of nucleic acid-protein complexes with single-nucleotide resolution in solution.
Selected Publications
Project Highlights
Role of the pre-initiation complex in Mediator recruitment and dynamics
Knoll ER, Zhu Zi, Sarkar D, Landsman D, Morse RH