Voriconazole is used to treat serious fungal infections such as invasive aspergillosis (a fungal infection that begins in the lungs and spreads through the bloodstream to other organs) and esophageal candidiasis (infection by a yeast-like fungus that may cause white patching in the mouth and throat). Voriconazole is in a class of antifungal medications called triazoles. It works by slowing the growth of the fungi that cause infection.
Voriconazole comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken every 12 hours on an empty stomach, at least 1 hour before or 1 hour after a meal. To help you remember to take voriconazole, take it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take voriconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking voriconazole suspension, shake the closed bottle for about 10 seconds before each use to mix the medication evenly. Do not mix the suspension with any other medications, water, or any other liquid. Always use the measuring device that comes with your medication. You may not get the right amount of medication if you use a household spoon to measure your dose.
At the beginning of your treatment, you may receive voriconazole by intravenous (into a vein) injection. When you begin taking voriconazole by mouth, your doctor may start you on a low dose and increase your dose if your condition does not improve. Your doctor also may decrease your dose if you experience side effects from voriconazole.
The length of your treatment depends on your general health, the type of infection you have, and how well you respond to the medication. If you are taking voriconazole for esophageal candidiasis, you will take it for at least 14 days. If you are taking voriconazole for aspergillosis, you may take it for several months or longer. Continue to take voriconazole even if you feel well. Do not stop taking voriconazole without talking to your doctor.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
blurred or abnormal vision
difficulty seeing colors
sensitivity to bright light
chills or shaking
unusual bruising or bleeding
lack of energy
loss of appetite
pain in the upper right part of the stomach
yellowing of the skin or eyes
hallucinations (seeing things or hearing voices that do not exist)
difficulty breathing or swallowing
swelling of the hands, feet, ankles, or lower legs
Voriconazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not refrigerate or freeze the medication. Throw away any medication that is outdated or no longer needed. Throw away any unused suspension after 14 days. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
sensitivity to light
widened pupils (black circles in the middle of the eyes)
loss of balance while moving
shortness of breath
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to voriconazole.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. If you still have symptoms of infection after you finish the voriconazole, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 01/01/2010
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.