Cidofovir can cause kidney damage. Some people have had kidney failure after taking only one or two doses of cidofovir. These people have needed dialysis or have died. Your doctor will order laboratory tests to check your kidney function within 48 hours before each infusion of cidofovir. Your doctor will adjust the dose of cidofovir according to your kidney function.
Tell your doctor if you are taking any other medications that cause kidney damage, some of which include amikacin (Amikin), amphoteracin B (Fungizone), foscarnet (Foscarvir), gentamicin (Garamycin), pentamidine (Pentam 300), tobramycin (Nebcin), vancomycin (Vancocin) and non-steroidal anti-inflammatory agents (Advil, Aleve, others). You must stop taking these medications at least 7 days before starting to take cidofovir. Be sure to tell your doctor about all drugs, over-the-counter medicines and herbal products you are taking.
Talk to your doctor about taking cidofovir with extra fluids and probenecid.
Cidofovir can cause a decrease in the number of a certain type of white blood cell. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to cidofovir.
Cidofovir should be used only for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS).
Cidofovir has been shown to cause cancer, birth defects, and problems with sperm production in animals.
Talk to your doctor about the possible risks of taking this drug.
Your doctor has ordered cidofovir, an antiviral agent, to help treat your infection. The drug will be added to an intravenous fluid that will drip through a needle or catheter placed in your vein for 1 hour, weekly, or every 2 weeks.
Cidofovir is used to treat cytomegaloviral retinitis (CMV retinitis) in patients with AIDS.
Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
Before you administer cidofovir, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
stomach pain, upset or vomiting
sore mouth or tongue
joint and muscle pain
fever and chills
skin rashes and itching of the skin
eye pain and redness, sensitivity to light, and decreased vision
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Your health care provider may give you one dose at a time; store it as directed. You will be told to store the doses in the refrigerator or freezer.
Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
If you are told to store additional cidofovir in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
Do not refreeze medications.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Last Reviewed - 09/01/2010
AHFS® Consumer Medication Information. © Copyright, 2013. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.