Pseudohypoparathyroidism is a genetic disorder in which the body fails to respond to parathyroid hormone.
A related condition is hypoparathyroidism, in which the body does not make enough of the hormone.
The parathyroid glands produce parathyroid hormone, or PTH. PTH helps control calcium, phosphorus, and vitamin D levels within the blood and bone.
If you have pseudohypoparathyroidism, your body produces the right amount of PTH, but is "resistant" to its
effect. This causes low blood calcium levels and high blood phosphate levels.
Pseudohypoparathyroidism is caused by abnormal genes. There are different types of pseudohypoparathyroidism.
All forms of are rare.
Symptoms are related to low levels of calcium and include:
Persons with Albright's hereditary osteodystrophy may have the following symptoms:
Blood tests will be done to check calcium, phosphorus, and PTH levels. You may also need urine tests.
Other tests may include:
Your doctor will recommend calcium and vitamin D supplements to maintain proper calcium levels. If blood phosphate levels are high, you may need to follow a low-phosphorus diet or take medicines called phosphate binders (such as calcium carbonate or calcium acetate).
Low blood calcium in pseudohypoparathyroidism is usually milder than in other forms of hypoparathyroidism.
Low blood calcium in pseudohypoparathyroidism is often milder than in other forms of hypoparathyroidism.
Pseudohypoparathyroidism may be connected to other hormone problems, resulting in:
Call your health care provider if you or your child has any symptoms of low calcium levels or pseudohypoparathyroidism.
Albright's hereditary osteodystrophy; Types 1A and 1B pseudohypoparathyroidism
Wysolmerski JJ, Insogna KL. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Goldman L, Schafer AI. Goldman's Cecil Medicine, 24th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 253.
Bringhurst FR, Demay MB, Kronenberg HM. Disorders of mineral metabolism. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2011:chap 28.
Doyle DA. Hypoparathyroidism. In: Kliegman RM, Stanton BM, St. Geme J, Schor N, Behrman RE, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 565.
Updated by: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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