Cushing syndrome is a disorder that occurs when your body has a high level of the hormone cortisol.
The most common cause of Cushing syndrome is taking too much glucocorticosteroid medicine. Prednisone, dexamethasone, and prednisolone are examples of this type of medicine. Glucocorticoids mimic the action of the body’s natural hormone cortisol. These drugs are used to treat conditions such as asthma, skin inflammation, cancer, bowel disease, joint pain, rheumatoid arthritis.
Other people develop Cushing syndrome because their bodies produce too much cortisol. This hormone is made in the adrenal glands. Causes of too much cortisol are:
Most people with Cushing syndrome will have:
Skin changes that are often seen:
Muscle and bone changes include:
Women with Cushing syndrome often have:
Men may have:
Other symptoms that may occur with this disease:
The health care provider will perform a physical exam and ask about your symptoms and the medicines you are taking. Tell the provider about all medicines you have been taking for the past several months.
Laboratory tests that may be done to diagnose Cushing syndrome and identify the cause are:
Tests to determine the cause or complications may include:
Treatment depends on the cause.
With Cushing syndrome caused by a pituitary or a tumor that releases ACTH (Cushing disease), you may need:
Removing the tumor may lead to full recovery, but there is a chance that the condition will return.
Survival for people with ectopic tumors depends on the tumor type. Untreated, Cushing syndrome can be life-threatening.
Call your health care provider if you have symptoms of Cushing syndrome.
If you take a corticosteroid, know the signs and symptoms of Cushing syndrome. Getting treated early can help prevent any long-term effects of Cushing syndrome. If you use inhaled steroids, you can decrease your exposure to the steroids by using a spacer and by rinsing your mouth after breathing in the steroids.
Hypercortisolism; Cortisol excess
McGee S. Cushing syndrome. In: Evidence-Based Physical Diagnosis. 3rd ed. Philadelphia, Pa: Elsevier Saunders. 2012:chap 13.
Stewart PM, Krone NP. The adrenal cortex. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 15.
Susmeeta TS, Nieman LK. Cushing's syndrome: all variants, detection, and treatment. Endocrinol Metab Clin N Am. 2011;40:379-391.
Updated by: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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