Tuberculous meningitis is an infection of the tissues covering the brain and spinal cord (meninges).
Tuberculous meningitis is caused by Mycobacterium tuberculosis, the bacteria that cause tuberculosis. The bacteria spread to the brain and spine from another site in the body.
Risk factors include a history of:
Tuberculous meningitis is a very rare disorder in the U.S.
The symptoms usually begin gradually, and may include:
Other symptoms that can occur with this disease:
The doctor or nurse will examine you. This will usually show:
A lumbar puncture ("spinal tap") is an important test in diagnosing meningitis. This test is done to collect a sample of spinal fluid for examination. More than one sample may be needed to make the diagnosis.
Other tests that may be done include:
You will be given several medicines to fight the tuberculosis bacteria. Sometimes, treatment is started even if your doctor thinks you have the disease, but testing hasn't confirmed it yet.
Treatment usually lasts for at least 12 months. Systemic steroids may also be used.
Tuberculous meningitis is life threatening if untreated. Long-term follow-up is needed to detect repeated infections (recurrences).
Call the local emergency number (such as 911) or go to an emergency room if you suspect meningitis in a young child who has the following symptoms:
Call the local emergency number if you develop any of the serious symptoms listed above. Meningitis can quickly become a life-threatening illness.
The BCG vaccine may help prevent severe forms of tuberculosis, such as meningitis, in very young children who live in areas where the disease is common.
Treating people who have signs of a non-active (dormant) tuberculosis infection can prevent the spread of tuberculosis. A PPD test and other tuberculosis tests can be done to tell if you have this type of infection.
Tubercular meningitis; TB meningitis
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Fitzgerald DW, Sterling TR, Haas DW. Mycobacterium tuberculosis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 250.
Swartz MN. Meningitis: bacterial, viral, and other. In:Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 360.
Tunkel AR, Van de Beek D, Scheld WM. Acute meningitis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 84.
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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