Guillain-Barré syndrome is a serious health problem that occurs when the body's defense (immune) system mistakenly attacks part of the nervous system. This leads to nerve inflammation that causes muscle weakness or paralysis and other symptoms.
Guillain-Barré syndrome (GBS) is an autoimmune disorder. With an autoimmune disorder, the body's immune system attacks itself. The exact cause is unknown. GBS can occur at any age. It is most common in people of both sexes between ages 30 and 50.
GBS often follows a minor infection, such as a lung infection or gastrointestinal infection. Most of the time, signs of the infection have disappeared before the symptoms of GBS begin.
The swine flu vaccination in 1976 may have caused rare cases of GBS. The swine flu and the regular flu vaccines used today have not caused more cases of the illness.
GBS damages parts of nerves. This nerve damage causes tingling, muscle weakness, and paralysis. GBS most often affects the nerve's covering (myelin sheath). This damage is called demyelination. It causes nerve signals to move more slowly. Damage to other parts of the nerve can cause the nerve to stop working altogether.
GBS may occur with viral infections such as:
GBS may also occur with other medical conditions such as:
Symptoms of GBS can get worse quickly. It may take only a few hours for the most severe symptoms to appear. But weakness that increases over several days is also common.
Muscle weakness or loss of muscle function (paralysis) affects both sides of the body. In most cases, the muscle weakness starts in the legs and spreads to the arms. This is called ascending paralysis.
If the inflammation affects the nerves of the diaphragm and chest and there is weakness in those muscles, the person may need breathing assistance.
Other typical signs and symptoms of GBS include:
Other symptoms may include:
Emergency symptoms (seek medical help right away):
A history of increasing muscle weakness and paralysis may be a sign of GBS, especially if there was a recent illness.
A medical exam may show muscle weakness. There may also be problems with blood pressure and heart rate. These are functions that are controlled automatically by the nervous system. The examination may also show that reflexes such as the ankle or knee jerk are decreased or missing.
There may be signs of decreased breathing caused by paralysis of the breathing muscles.
The following tests may be ordered:
There is no cure for GBS. Treatment is aimed at reducing symptoms, treating complications, and speeding up recovery.
In the early stages of the illness, treatment called apheresis or plasmapheresis may be given. This treatment involves removing or blocking the proteins, called antibodies, that attack the nerve cells. Other treatment helps reduce inflammation.
When symptoms are severe, treatment in the hospital will be needed. There, breathing support will likely be given.
Other treatments focus on preventing complications:
Guillain-Barré Syndrome Foundation International |www.gbs-cidp.org
Recovery can take weeks, months, or years. Most people survive and recover completely. Mild weakness may persist for some people. Outcome is likely to be good when the symptoms go away within 3 weeks after they first started.
Seek immediate medical help if you have any of the following symptoms:
GBS; Landry-Guillain-Barré syndrome; Acute idiopathic polyneuritis; Infectious polyneuritis; Acute inflammatory polyneuropathy; Acute inflammatory demyelinating polyneuropathy; Ascending paralysis
Katri B, Koontz D. Disorders of the peripheral nerves. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, Pa.: Elsevier Saunders; 2012:chap 76.
Walling AD, Dickson G. Guillain-Barré syndrome. Am Fam Physician. 2013;87:191-197
Yuki N, Hartung HP. Guillain-Barré syndrome. N Engl J Med. 2012;366:2294-2304.
Updated by: Luc Jasmin, MD, PhD, FRCS (C), FACS, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles CA; Department of Surgery at Los Robles Hospital, Thousand Oaks CA; Department of Surgery at Ashland Community Hospital, Ashland OR; Department of Surgery at Cheyenne Regional Medical Center, Cheyenne WY; Department of Anatomy at UCSF, San Francisco CA. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 1997-2014, A.D.A.M., Inc. Duplication for commercial use must be authorized in writing by ADAM Health Solutions.