Islets are cells found in clusters throughout the pancreas. They are made up of several types of cells. One of these is beta cells, which make insulin. Insulin is a hormone that helps the body use glucose for energy. Islet cell transplantation transfers cells from an organ donor into the body of another person. It is an experimental treatment for type 1 diabetes.
In type 1 diabetes, the beta cells of the pancreas no longer make insulin. A person who has type 1 diabetes must take insulin daily to live. Transplanted islet cells, however, can take over the work of the destroyed cells. The beta cells in these islets will begin to make and release insulin. Researchers hope islet transplantation will help people with type 1 diabetes live without daily insulin injections.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
- ClinicalTrials.gov: Islet Cell Transplantation (National Institutes of Health)
- ClinicalTrials.gov: Islets of Langerhans Transplantation (National Institutes of Health)
- Islet Transplantation and Cell Biology (Joslin Diabetes Center)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Total pancreatectomy with islet autotransplantation: summary of an NIDDK workshop.
- Article: Sodium levels of human pancreatic donors are a critical factor...
- Article: Autologous islet transplantation with remote islet isolation after pancreas resection...
- Islet Cell Transplantation -- see more articles
- Organ Procurement and Transplantation Network: Member Directory (Health Resources and Services Administration, United Network for Organ Sharing, Organ Procurement and Transplantation Network)
- Pancreatic Islet Transplantation (National Institute of Diabetes and Digestive and Kidney Diseases)