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Appendix 1 - RxNorm Relationships (RELA)

Term Types:

TTY=BN

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
BN reformulated_to BN 'Ocusan' reformulated_to 'Ocusan Reformulated Dec 2019'
BN reformulation_of BN 'Ocusan Reformulated Dec 2019' reformulation_of 'Ocusan'
BN tradename_of IN 'Tylenol' tradename_of 'acetaminophen'
BN has_precise_ingredient PIN 'Tylenol PM' has_precise_ingredient 'diphenhydramine hydrochloride'
BN ingredient_of SBD 'Tylenol' ingredient_of 'acetaminophen 325 MG Oral Tablet [Tylenol]'
BN ingredient_of SBDC 'Tylenol' ingredient_of 'acetaminophen 325 MG [Tylenol]'
BN ingredient_of SBDF 'Tylenol' ingredient_of 'acetaminophen Oral Tablet [Tylenol]'
BN ingredient_of SBDG 'Tylenol' ingredient_of 'Tylenol Pill'

TTY=BPCK

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
BPCK has_dose_form DF '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]' has_dose_form 'Pack'
BPCK tradename_of GPCK '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]' tradename_of '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack'
BPCK contains SBD '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]' contains 'acetaminophen 500 MG Oral Tablet [Tylenol]'
BPCK contains SCD '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]' contains 'acetaminophen 500 MG Oral Tablet'

TTY=DF

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
DF dose_form_of BPCK 'Pack' dose_form_of '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]'
DF isa DFG 'Oral Tablet' isa 'Pill'
DF dose_form_of GPCK 'Pack' dose_form_of '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack'
DF dose_form_of SBD 'Oral Tablet' dose_form_of 'acetaminophen 325 MG Oral Tablet [Tylenol]'
DF dose_form_of SBDF 'Oral Tablet' dose_form_of 'acetaminophen Oral Tablet [Tylenol]'
DF dose_form_of SCD 'Oral Tablet' dose_form_of 'acetaminophen 325 MG Oral Tablet'
DF dose_form_of SCDF 'Oral Tablet' dose_form_of 'acetaminophen Oral Tablet'

TTY=DFG

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
DFG inverse_isa DF 'Pill' inverse_isa 'Oral Tablet'
DFG doseformgroup_of SBDG 'Pill' doseformgroup_of 'Tylenol Pill'
DFG doseformgroup_of SCDG 'Pill' doseformgroup_of 'acetaminophen Pill'

TTY=GPCK

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
GPCK has_tradename BPCK '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack' has_tradename '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]'
GPCK has_dose_form DF '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack' has_dose_form 'Pack'
GPCK contains SCD '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack' contains 'acetaminophen 500 MG Oral Tablet'

TTY=IN

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
IN has_tradename BN 'acetaminophen' has_tradename 'Tylenol'
IN part_of MIN 'acetaminophen' part_of 'acetaminophen / diphenhydramine'
IN has_form PIN 'diphenhydramine' has_form 'diphenhydramine hydrochloride'
IN ingredient_of SCDC 'acetaminophen' ingredient_of 'acetaminophen 325 MG'
IN ingredient_of SCDF 'acetaminophen' ingredient_of 'acetaminophen Oral Tablet'
IN ingredient_of SCDG 'acetaminophen' ingredient_of 'acetaminophen Pill'
IN boss_of SCDFP 'atropine' boss_of 'atropine / pralidoxime chloride Auto-Injector'

TTY=MIN

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
MIN has_part IN 'acetaminophen / diphenhydramine' has_part 'acetaminophen'
MIN has_part PIN 'glucosamine hydrochloride / glucosamine sulfate' has_part 'glucosamine hydrochloride'
(NOTE: When a MIN is composed of precise ingredients, RELAs to the INs are not created.)
MIN ingredients_of SCD 'acetaminophen / diphenhydramine' ingredients_of 'acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet'

TTY=PIN

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
PIN precise_ingredient_of BN 'diphenhydramine hydrochloride' precise_ingredient_of 'Tylenol PM'
PIN form_of IN 'diphenhydramine hydrochloride' form_of 'diphenhydramine'
PIN part_of MIN 'glucosamine hydrochloride' part_of 'glucosamine hydrochloride / glucosamine sulfate'
PIN precise_ingredient_of SCDC 'diphenhydramine hydrochloride' precise_ingredient_of 'diphenhydramine hydrochloride 25 MG'
PIN boss_of SCDFP 'warfarin sodium' boss_of 'warfarin sodium Oral Tablet'

TTY=SBD

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SBD has_ingredient BN 'acetaminophen 325 MG Oral Tablet [Tylenol]' has_ingredient 'Tylenol'
SBD contained_in BPCK 'acetaminophen 500 MG Oral Tablet [Tylenol]' contained_in '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]'
SBD has_dose_form DF 'acetaminophen 325 MG Oral Tablet [Tylenol]' has_dose_form 'Oral Tablet'
SBD quantified_form_of SBD '8 HR acetaminophen 650 MG Extended Release Oral Tablet [Tylenol]' quantified_form_of 'acetaminophen 650 MG Extended Release Oral Tablet [Tylenol]'
SBD has_quantified_form SBD 'acetaminophen 650 MG Extended Release Oral Tablet [Tylenol]' has_quantified_form '8 HR acetaminophen 650 MG Extended Release Oral Tablet [Tylenol]'
SBD consists_of SBDC 'acetaminophen 325 MG Oral Tablet [Tylenol]' consists_of 'acetaminophen 325 MG [Tylenol]'
SBD isa SBDF 'acetaminophen 325 MG Oral Tablet [Tylenol]' isa 'acetaminophen Oral Tablet [Tylenol]'
SBD isa SBDFP 'warfarin sodium 1 MG Oral Tablet [Coumadin]' isa 'warfarin sodium Oral Tablet [Coumadin]'
SBD isa SBDG 'acetaminophen 325 MG Oral Tablet [Tylenol]' isa 'Tylenol Pill'
SBD tradename_of SCD 'acetaminophen 325 MG Oral Tablet [Tylenol]' tradename_of 'acetaminophen 325 MG Oral Tablet'
SBD consists_of SCDC 'acetaminophen 325 MG Oral Tablet [Tylenol]' consists_of 'acetaminophen 325 MG'

TTY=SBDC

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SBDC has_ingredient BN 'acetaminophen 325 MG [Tylenol]' has_ingredient 'Tylenol'
SBDC constitutes SBD 'acetaminophen 325 MG [Tylenol]' constitutes 'acetaminophen 325 MG Oral Tablet [Tylenol]'
SBDC tradename_of SCDC 'acetaminophen 325 MG [Tylenol]' tradename_of 'acetaminophen 325 MG'

TTY=SBDF

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SBDF has_ingredient BN 'acetaminophen Oral Tablet [Tylenol]' has_ingredient 'Tylenol'
SBDF has_dose_form DF 'acetaminophen Oral Tablet [Tylenol]' has_dose_form 'Oral Tablet'
SBDF inverse_isa SBD 'acetaminophen Oral Tablet [Tylenol]' inverse_isa 'acetaminophen 325 MG Oral Tablet [Tylenol]'
SBDF isa SBDG 'acetaminophen Oral Tablet [Tylenol]' isa 'Tylenol Pill'
SBDF tradename_of SCDF 'acetaminophen Oral Tablet [Tylenol]' tradename_of 'acetaminophen Oral Tablet'
SBDF has_form SBDFP 'warfarin Oral Tablet [Coumadin]' has_form 'warfarin sodium Oral Tablet [Coumadin]'

TTY=SBDFP

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SBDFP form_of SBDF 'warfarin sodium Oral Tablet [Coumadin]' form_of 'warfarin Oral Tablet [Coumadin]'
SBDFP tradename_of SCDFP 'warfarin sodium Oral Tablet [Coumadin]' tradename_of 'warfarin sodium Oral Tablet'
SBDFP inverse_isa SBD 'ursodiol Oral Tablet [Urso]' inverse_isa 'ursodiol 250 MG Oral Tablet [Urso]'

TTY=SBDG

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SBDG has_ingredient BN 'Tylenol Pill' has_ingredient 'Tylenol'
SBDG has_doseformgroup DFG 'Tylenol Pill' has_doseformgroup 'Pill'
SBDG inverse_isa SBD 'Tylenol Pill' inverse_isa 'acetaminophen 325 MG Oral Tablet [Tylenol]'
SBDG inverse_isa SBDF 'Tylenol Pill' inverse_isa 'acetaminophen Oral Tablet [Tylenol]'
SBDG tradename_of SCDG 'Tylenol Pill' tradename_of 'acetaminophen Pill'
SBDG tradename_of SCDGP 'Coumadin Pill' tradename_of 'warfarin sodium Pill'

'Xeomin Injectable Product' tradename_of 'incobotulinumtoxinA Injectable Product'

TTY=SCD

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCD contained_in BPCK 'acetaminophen 500 MG Oral Tablet' contained_in '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]) / 50 (acetaminophen 500 MG Oral Tablet [Tylenol]) } Pack [Tylenol Extra Strength Day and Night Pack]'
SCD has_dose_form DF 'acetaminophen 325 MG Oral Tablet' has_dose_form 'Oral Tablet'
SCD contained_in GPCK 'acetaminophen 500 MG Oral Tablet' contained_in '{24 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet) / 50 (acetaminophen 500 MG Oral Tablet) } Pack'
SCD has_ingredients MIN 'acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet' has_ingredients 'acetaminophen / diphenhydramine'
SCD has_tradename SBD 'acetaminophen 325 MG Oral Tablet' has_tradename 'acetaminophen 325 MG Oral Tablet [Tylenol]'
SCD quantified_form_of SCD '8 HR acetaminophen 650 MG Extended Release Oral Tablet' quantified_form_of 'acetaminophen 650 MG Extended Release Oral Tablet'
SCD has_quantified_form SCD 'acetaminophen 650 MG Extended Release Oral Tablet' has_quantified_form '8 HR acetaminophen 650 MG Extended Release Oral Tablet'
SCD consists_of SCDC 'acetaminophen 325 MG Oral Tablet' consists_of 'acetaminophen 325 MG'
SCD isa SCDF 'acetaminophen 325 MG Oral Tablet' isa 'acetaminophen Oral Tablet'
SCD isa SCDG 'acetaminophen 325 MG Oral Tablet' isa 'acetaminophen Pill'
SCD isa SCDFP 'warfarin sodium 1 MG Oral Tablet' isa 'warfarin sodium Oral Tablet'

TTY=SCDC

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCDC has_ingredient IN 'acetaminophen 325 MG' has_ingredient 'acetaminophen'
SCDC has_precise_ingredient PIN 'diphenhydramine hydrochloride 25 MG' has_precise_ingredient 'diphenhydramine hydrochloride'
SCDC constitutes SBD 'acetaminophen 325 MG' constitutes 'acetaminophen 325 MG Oral Tablet [Tylenol]'
SCDC has_tradename SBDC 'acetaminophen 325 MG' has_tradename 'acetaminophen 325 MG [Tylenol]'
SCDC constitutes SCD 'acetaminophen 325 MG' constitutes 'acetaminophen 325 MG Oral Tablet'

TTY=SCDF

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCDF has_dose_form DF 'acetaminophen Oral Tablet' has_dose_form 'Oral Tablet'
SCDF has_ingredient IN 'acetaminophen Oral Tablet' has_ingredient 'acetaminophen'
SCDF has_tradename SBDF 'acetaminophen Oral Tablet' has_tradename 'acetaminophen Oral Tablet [Tylenol]'
SCDF inverse_isa SCD 'acetaminophen Oral Tablet' inverse_isa 'acetaminophen 325 MG Oral Tablet'
SCDF isa SCDG 'acetaminophen Oral Tablet' isa 'acetaminophen Pill'
SCDF has_form SCDFP 'warfarin Oral Tablet' has_form 'warfarin sodium Oral Tablet'

TTY=SCDFP

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCDFP has_tradename SBDFP 'warfarin sodium Oral Tablet' has_tradename 'warfarin sodium Oral Tablet [Coumadin]’
SCDFP inverse_isa SCD 'warfarin sodium Oral Tablet' inverse_isa 'warfarin sodium 1 MG Oral Tablet'
SCDFP form_of SCDF 'warfarin sodium Oral Tablet' form_of 'warfarin Oral Tablet'
SCDFP isa SCDGP 'warfarin sodium Oral Tablet' isa 'warfarin sodium Pill'
SCDFP has_boss IN 'bisoprolol fumarate / hydrochlorothiazide Oral Product' has_boss 'hydrochlorothiazide’
SCDFP has_boss PIN 'warfarin sodium Oral Tablet' has_boss 'warfarin sodium'

TTY=SCDG

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCDG has_doseformgroup DFG 'acetaminophen Pill' has_doseformgroup 'Pill'
SCDG has_ingredient IN 'acetaminophen Pill' has_ingredient 'acetaminophen'
SCDG has_tradename SBDG 'acetaminophen Pill' has_tradename 'Tylenol Pill'
SCDG inverse_isa SCD 'acetaminophen Pill' inverse_isa 'acetaminophen 325 MG Oral Tablet'
SCDG inverse_isa SCDF 'acetaminophen Pill' inverse_isa 'acetaminophen Oral Tablet'
SCDG has_form SCDGP 'warfarin Oral Product' has_form 'warfarin sodium Oral Product'

TTY=SCDGP

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RXNREL
RXCUI2 TTY		 RELA RXNREL
RXCUI1 TTY		 Example with Strings
SCDGP has_tradename SBDG 'warfarin sodium Pill' has_tradename 'Coumadin Pill'
SCDGP inverse_isa SCDFP 'warfarin sodium Pill' inverse_isa 'warfarin sodium Oral Tablet'
SCDGP form_of SCDG 'warfarin sodium Oral Product' form_of 'warfarin Oral Product'

Last Reviewed: November 17, 2025