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Hypophosphatemia is a low level of phosphorus in the blood.


The following may cause hypophosphatemia:

  • Alcoholism
  • Antacids
  • Certain medicines, including acetazolamide, foscarnet, imatinib, pentamidine, and sorafenib
  • Fanconi syndrome
  • Starvation
  • Too little vitamin D
  • Overactive parathyroid gland (hyperparathyroidism)


Symptoms may include:

  • Bone pain
  • Confusion
  • Muscle weakness

Exams and Tests

Your health care provider will examine you.

The following tests may be done:

  • Kidney function tests
  • Vitamin K blood test

Exam and testing may show:


Treatment depends on the cause. Phosphate can be given by mouth or through a vein (IV).

Outlook (Prognosis)

How well you do depends on what has caused the condition.

When to Contact a Medical Professional

Call your health care provider if you have muscle weakness or confusion.

Alternative Names

Low blood phosphate; Phosphate - low


Yu ASL. Disorders of magnesium and phosphorous. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 121.

Update Date 11/9/2014

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