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Factor V deficiency

Factor V deficiency is a condition that is passed down through families, which affects the ability of the blood to clot.


Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.

Factor V deficiency is caused by a lack of Factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.

Factor V deficiency is rare. It may be caused by:

  • A defective Factor V gene passed down through families (inherited)
  • An antibody that interferes with normal Factor V function

You can get an antibody that interferes with Factor V:

  • After giving birth
  • After being treated with a certain type of fibrin glue
  • After surgery
  • With autoimmune diseases and certain cancers

Sometimes the cause is unknown.

The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.


Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include.

Exams and Tests


You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.

Outlook (Prognosis)

The outlook is good with diagnosis and proper treatment.

Possible Complications

Severe bleeding (hemorrhage) could occur.

When to Contact a Medical Professional

Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.

Alternative Names

Parahemophilia; Owren's disease


Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds.Cecil Medicine.

Update Date 2/24/2014

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