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Progeria

Progeria is a rare genetic condition that produces rapid aging in children.

Causes

Progeria is a rare condition. It is remarkable because its symptoms strongly resemble normal human aging, but it occurs in young children. In most cases, it is not passed down through families. It is rarely seen in more than one child in a family.

Symptoms

Symptoms include:

Exams and Tests

Your health care provider will perform a physical exam and order laboratory tests. This may show:

  • Insulin resistance
  • Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened)
  • Generally normal cholesterol and triglyceride levels

Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.

Genetic testing can detect changes in the gene (LMNA) that causes progeria.

Treatment

There is no specific treatment for progeria. Aspirin and statin medicines may be used to protect against a heart attack or stroke.

Support Groups

More information and support for people with Progeria and their families can be found at:

Outlook (Prognosis)

Progeria causes early death. People with the condition most often only live to their teenage years (average lifespan of 14 years). However, some can live into their early 20s. The cause of death is very often related to the heart or a stroke.

Possible Complications

Complications may include:

When to Contact a Medical Professional

Contact your provider if your child does not appear to be growing or developing normally.

Alternative Names

Hutchinson-Gilford progeria syndrome; HGPS

References

Gordon LB. Hutchinson-Gilford progeria syndrome (progeria). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 109.

Jones KL, Jones MC, del Campo M. Senile-like appearance. In: Jones KL, Jones MC, del Campo M, eds. Smith's Recognizable Patterns of Human Malformation. 8th ed. Philadelphia, PA: Elsevier; 2022:174-197.

National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Hutchinson-Gilford progeria syndrome. rarediseases.info.nih.gov/diseases/ 7467/hutchinson-gilford-progeria-syndrome. Updated February 2023. Accessed October 17, 2023.

Review Date 9/18/2023

Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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