Endometrial biopsy is the removal of a small piece of tissue from the lining of the uterus (endometrium) for examination.
This procedure may be done with or without anesthesia. This is medicine that allows you to sleep.
An instrument is gently passed through the cervix into the uterus to collect the tissue sample.
The instruments may feel cold. You may feel some pain when the cervix is grasped. You may have some cramping as the instruments enter the uterus and the sample is collected.
The test is done to find the cause of:
The test is usually done in women over age 35.
This test can also be used to test for endometrial cancer.
The biopsy is normal if the cells in the sample are not abnormal.
Abnormal menstrual periods may be caused by:
Other conditions under which the test may be performed:
Risks of endometrial biopsy include:
Biopsy - endometrium
Choby BA. Endometrial biopsy. In: Pfenninger JL, Fowler GC, eds. Pfenninger & Fowler’s Procedures for Primary Care. 3rd ed. Philadelphia, Pa: Elsevier Mosby; 2010:chap 143.
Lentz GM. Endoscopy: hysteroscopy and laparoscopy: indications, contraindications and complications. In Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds. Comprehensive Gynecology. 6th ed. Philadelphia, Pa: Elsevier Mosby; 2012:chap 10.
Updated by: Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Bellevue, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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