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January 11, 2008 [posted]

Carcinogenic Potency Database Now Accessible via TOXNET®

[Editor's Note: This Technical Note is a reprint of an announcement published on NLM-Tox-Enviro-Health-L, an e-mail announcement list available from the NLM Division of Specialized Information Services. To subscribe to this list, please see the NLM-TOX-ENVIRO-HEALTH-L Join, Leave, or Change Options page.]

t he Carcinogenic Potency Database (CPDB) was developed by the Carcinogenic Potency Project at the University of California, Berkeley, and by the Lawrence Berkeley National Laboratory. It reports analyses of animal cancer tests on 1547 chemicals. Results for each chemical are now searchable via the National Library of Medicine® Toxicology Data Network (TOXNET), under the Additional Resource header.

CPDB includes 6540 chronic, long-term animal cancer tests (both positive and negative for carcinogenicity) from the general published literature as well as from the National Cancer Institute and the National Toxicology Program. Such tests are used in support of cancer risk assessments for humans. Information that is important in the interpretation of bioassays is reported in CPDB for each experiment.

Users can search for results on each chemical in TOXNET via chemical name or name fragment, or by Chemical Abstracts Service Registry Number. Results include a summary for each sex-species tested, including carcinogenicity, target organs, and carcinogenic potency values. Detailed results from each experiment on the particular chemical are given in a plot format suitable for screen viewing. Chemical structure, InChI, and SMILES codes are reported.

Carcinogenic Potency Database (CPDB) Now Accessible via TOXNET®. NLM Tech Bull. 2008 Jan-Feb; (360):e4.

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