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Xiaofang Jiang, PhD

About

Picture of Xiaofang Jiang, PhD

Xiaofang Jiang, PhD

Tenure Track Investigator, NLM IRP

We are a bioinformatics research group that is broadly interested in microbial and viral genomics, with a primary focus on human health and disease.

Contact Information

Building 38A, 8600 Rockville Pike MSC 6075 Bethesda, MD 20894

Tel: (301)827-2055

xiaofang.jiang@nih.gov

Research Interests

Research Topics

Dr. Jiang's laboratory focuses on developing statistical and computational methods to elicit novel biological insights from vast datasets. She is particularly interested to work with experimentalists on the hypothesis-driven investigation of specific biological problems, such as the identification of key genes associated with phenotypic changes, deciphering gene transcriptional regulation, predicting biological interactions and modeling molecular pathways. The current projects of the Jiang lab are to improve functional annotation of prokaryotes and to investigate the genome evolution in coronaviruses.

Biography

Dr. Jiang completed her Ph.D in Genetics, Bioinformatics, and Computational Biology at Virginia Tech. Her research focused on genomics and transcriptomics in mosquitoes. As a postdoc, Dr. Jiang studied the gut microbiome at MIT. Her main projects focused on developing tools to annotate mobile genetic elements from the gut microbiome and understanding how phase variation helps bacteria to colonize the gut.

Publications

Yang Y, Dufault-Thompson K, Salgado Fontenele R, Jiang X. Putative Host-Derived Insertions in the Genomes of Circulating SARS-CoV-2 Variants. mSystems. 2022 Jun 28;7(3):e0017922. doi: 10.1128/msystems.00179-22. Epub 2022 May 18. PubMed PMID: 35582907; PubMed Central PMCID: PMC9239191.

Dufault-Thompson K, Hall B, Jiang X. Taxonomic distribution and evolutionary analysis of the equol biosynthesis gene cluster. BMC Genomics. 2022 Mar 5;23(1):182. doi: 10.1186/s12864-022-08426-7. PubMed PMID: 35247986; PubMed Central PMCID: PMC8898433.

Yan W, Hall AB, Jiang X. Bacteroidales species in the human gut are a reservoir of antibiotic resistance genes regulated by invertible promoters. NPJ Biofilms Microbiomes. 2022 Jan 10;8(1):1. doi: 10.1038/s41522-021-00260-1. PubMed PMID: 35013297; PubMed Central PMCID: PMC8748976.

Olejniczak M, Jiang X, Basczok MM, Storz G. KH domain proteins: Another family of bacterial RNA matchmakers?. Mol Microbiol. 2022 Jan;117(1):10-19. doi: 10.1111/mmi.14842. Epub 2021 Nov 19. Review. PubMed PMID: 34748246; PubMed Central PMCID: PMC8766902.

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