Table of Contents: 2022 SEPTEMBER–OCTOBER No. 448
New MeSH Supplementary Concept Records Related to Monkeypox. NLM Tech Bull. 2022 Sep-Oct;(448):e2.
On August 11, 2022, four new Medical Subject Headings Supplementary Concept Records (MeSH SCR) were added to the 2022 MeSH Browser in response to the U.S. Department of Health and Human Services’ declaration of monkeypox as a Public Health Emergency and the White House’s call for public access to monkeypox research and data:
These SCRs first appeared together in the MeSH export file on August 12, 2022. An XML file for mid-year changes has been added on August 18, 2022, indicating the addition of the entry term "Monkeypox Vaccine" to the existing Smallpox Vaccine descriptor. Please continue to check the MeSH Browser for the most current updates to these SCRs.
Below is a list of new, existing, and recently updated monkeypox-related MeSH records:
| Term | MeSH UI# | Category | Note |
|---|---|---|---|
| Monkeypox | D045908 | disease | |
| Smallpox | D012899 | disease | |
| brincidofovir | C525733 | Drug1 | An antiviral drug approved by the FDA for the treatment of human smallpox disease |
| Cidofovir (Vistide) | D000077404 | Drug1 | An antiviral drug approved by the FDA for the treatment of CMV retinitis in AIDS with CDC expanded access protocol for the treatment of orthopoxviruses (including monkeypox) in an outbreak |
| tecovirimat (TPOXX) | C505045 | Drug1, 2 | An antiviral medication approved by the FDA for the treatment of smallpox with CDC expanded access protocol to treat monkeypox during an outbreak. A part of ASPR Strategic National Stockpile (SNS) Announcement: "SNS Products: Vaccines and Treatment Available for Use in Mpox Response" |
| human intravenous vaccinia immune globulin | C000723097 | Drug1 | NEW SCR. An antiviral drug with an expanded access protocol that allows use for treatment of orthopoxviruses (including monkeypox) in an outbreak for the treatment of complications due to vaccinia vaccination (see Vaccinia) |
| Smallpox Vaccine | D012900 | Vaccine3 | Updated with subcons on Monkeypox Vaccine. Because the Monkeypox Virus and Smallpox Virus are both Orthopoxvirus and are closely related, smallpox vaccines provide effective Cross Protection against Monkeypox |
| imvamune (JYNNEOS) | C527606 | Vaccine2, 3, 4 | Monkeypox vaccine used in the US and is a part of ASPR’s Strategic National Stockpile (SNS) Announcement: "SNS Products: Vaccines and Treatment Available for Use in Mpox Response" |
| ACAM2000 | C000588544 | Vaccine3 | ASPR’s Strategic National Stockpile (SNS) Announcement: "SNS Products: Vaccines and Treatment Available for Use in Mpox Response" |
| Aventis Pasteur smallpox vaccine | C000723127 | Vaccine3, 4 | NEW SCR. |
| ACAM3000 | C000723096 | Vaccine3 | NEW SCR. An investigational smallpox vaccine with evidence of cross-protection against monkeypox |
| DryVax vaccine | C078786 | Vaccine3 | |
| smallpox vaccine LC16m8 | C539069 | Vaccine3 | |
| Monkeypox virus | D008993 | virus | Causative agent for monkeypox |
| Variola virus | D012901 | virus | Causative agent for smallpox. Note entry term: Smallpox Virus |
| Vaccinia virus | D014616 | virus | Used in smallpox/monkeypox vaccines |
| Modified Vaccinia Ankara virus | C000723095 | virus | NEW SCR. Used in third generation smallpox/monkeypox vaccine3 formulation, e.g., Imvamune |
| Orthopoxvirus | D018155 | virus | Genus of monkeypox and smallpox viruses |
| Poxviridae | D011212 | virus | Family of Orthopoxvirus |
1 Medical Countermeasures Available for the Treatment of Monkeypox: Currently there is no treatment approved specifically for monkeypox virus infections. However, antivirals developed for use in patients with smallpox may prove beneficial against monkeypox. Medical countermeasures are currently available from the Strategic National Stockpile (SNS) as options for the treatment of monkeypox.
2 Part of ASPR’s Strategic National Stockpile (SNS) announcement of vaccines and treatment available for use in monkeypox response.
3 Yoshikawa T. Third-generation smallpox vaccine strain-based recombinant vaccines for viral hemorrhagic fevers. Vaccine. 2021 Oct 1;39(41):6174-6181. doi: 10.1016/j.vaccine.2021.09.001. Epub 2021 Sep 11. PMID: 34521550. There are three generations of smallpox vaccines: first generation (original smallpox vaccine); second generation (based on replication-competent vaccinia virus, e.g., ACAM2000); and third generation (based on replication-incompetent vaccinia virus, e.g., JYNNEOS).
4 Current Vaccinia (Smallpox) Vaccines
