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September 13, 2007 [posted]
November 09, 2007 [Editor's note added]

New Look for

[Editor's Note: The new user interface was launched on November 8, 2007 at //]

in September 2007, will launch a new user interface, which represents the first significant change to the interface since February 2000. The new user interface will run in parallel with the previous version and after appropriate testing, the new user interface will permanently replace the previous version (approximately two to four weeks after launch). This article describes the new features, including highlighted search terms, more display options, and additional capabilities for viewing studies and search results by topic. Improvements were also made to "Advanced Search" and the display by location on the world map. is the NLM®-developed Web-based registry of clinical research studies. It provides patients, clinicians, researchers, and other members of the general public with access to information about interventional and observational studies including clinical trials of drugs, devices and other interventions. As of August 2007, contained over 44,000 clinical research studies in all fifty states and in 150 countries.

As reported previously, the scope of was expanded to accommodate the International Committee of Medical Journal Editors (ICMJE) policy requiring trial registration for publication of research results (NLM Tech Bull. 2005 Jul-Aug;(345):e6). Note that the ICMJE issued an updated statement on trial registration [this link was removed because is it was no longer valid] in June 2007 expanding the requirements to "any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes."

New Features

User Interface Overview
While the new interface enhances site functionality and navigation significantly, the core aspects of have been preserved. The homepage (see Figure 1) now provides explicit links for searching the database (Search for Clinical Trials) and for investigators to register studies (Investigator Instructions). A search box with four navigation links at the top right of each page has replaced the menu bar, allowing new searches for studies to be launched at any time. Pages are now organized by context-sensitive tabs — that is, their labels and functions change as a search progresses from (1) submitting search terms to (2) viewing a list of results to (3) reviewing summaries of individual studies (described below). New features provide users with different options to display results lists and study information based on their needs.

Search Term Highlighting
Search terms and synonyms are now highlighted and bolded in study records. A basic search conducted on heart attack retrieved 829 studies, open and closed to recruitment (see Figures 2a and Figures 2b). Click on the title of a study record on the List Results page to review the details of a study. In the first retrieved record, both heart attack and its related term myocardial infarction are highlighted (see Figure 3). The search terms heart OR attack are highlighted in a different color than the related term myocardial infarction. For additional information on search capabilities of, see previous publications Update: Expanded Search Capabilities. NLM Tech Bull. 2002 Jul-Aug; (327):e5. and Searching NLM Tech Bull. 2000 Sep-Oct;(316)e1.

Display Options

Viewing Studies by Topic/Category

Select a main category and method of viewing (alphabetic or by category) such as "Drug Interventions By Category" (see Figure 8).

Select "Antilipemic Agents," from the list of drug intervention categories to view types and names of drugs classified as "Antilipemic Agents" (see Figure 9) that are part of study records within the search of heart attack.

Select "Ezetimibe" from the drug interventions provided to display a new List Results page (see Figure 10) with a clearly marked search trail at the top of the page: "Found 5 studies with search of: heart attack|"Ezetimibe" (i.e., equivalent to the query: heart attack AND Ezetimibe).

Additional Features
"Advanced Search" (previously "Focused Search") is now accessible by a tab or a link on the Basic Search page (see Figure 2a). Advanced Search includes new items, while retaining many of the features described previously (Update: Expanded Search Capabilties. NLM Tech Bull. 2002 Jul-Aug; (327):e5). Users can now limit search based on recruitment status (open or closed to enrollment), study type (interventional, observational, expanded access), and date study record was first received by In addition, users can search for a specific study sponsor and search multiple locations at once (e.g., Washington DC OR Virginia OR Maryland). The function of Advanced Search can also be applied to a search result by selecting the "Refine Search" tab (previously "Search Within Results") on the List Results page and the user’s original search term(s) will be retained (see Figure 11).

Users can navigate to the next or previous study record from the top of the study record without having to return to the List Results page. The map of study locations is enhanced and users can view the number of registered studies in different regions of the world for a specific search (see Figure 12) or for all studies in the database.

Contact Information
Please send your comments or questions to:

By Rebecca J. Williams
Lister Hill National Center for Biomedical Communications
Tony Tse
Lister Hill National Center for Biomedical Communications

Williams RJ, Tse T. New Look for NLM Tech Bull. 2007 Sep-Oct; (358):e2.

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