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NLM Intramural Research Program

NLM’s evolutionary genomics and biomolecular structure research focuses on developing and employing advanced computational methods. These methods compare genomes of all life forms, with the goal of understanding their function and evolution. This area of research includes the comprehensive study of the evolution of viruses and host-parasite coevolution, including the genomic evolution of cancers and development of theoretical models of genome evolution.
Image of Eugene Koonin, PhD

Eugene Koonin, PhD

Senior Investigator, Computational Biology Branch, NCBI

Eugene Koonin, PhD

  • Discovering new types of CRISPR-Cas systems
  • Discovering new families of viruses
  • Developing a general theory of microbial evolution
  • Classifying human cancers by analyzing tumor-mutation networks
  • Expanding metagenomic analyses to discover novel antibiotics, resistance mechanisms, and new mechanisms of microbial immunity
  • Increasing the focus on cancer genomics and evolution
Image of Xiaofang Jiang, PhD

Xiaofang Jiang, PhD

Tenure Track Investigator, NLM IRP

Xiaofang Jiang, PhD

  • Developing LysoPhD, a method to detect active prophages in bacterial genomes using sequencing data
  • Creating a framework for the functional profiling of health-relevant features in microbiome data
Image of Aravind Iyer, PhD

Aravind Iyer, PhD

Senior Investigator, Computational Biology Branch, NCBI

Aravind Iyer, PhD

  • Discovering protein domains and systems involved in nucleic acid repair and protein/nucleic acid modifications
  • Discovering novel effectors systems deployed in biological conflicts and discovering components of eukaryotic and prokaryotic immunity
  • Exploring the unknown biochemical space of proteins
  • Developing a unified molecular evolutionary theory for biological conflicts
Image of Lauren Porter, PhD

Lauren Porter, PhD

Stadtman Tenure Track Investigator, NLM IRP

Lauren Porter, PhD

  • Discovering new fold-switching proteins
  • Developing computational modeling of fold-switching proteins
  • Validating experimental characterizations of the structures, mechanisms, and functions of fold-switching proteins