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Grants and Funding: Extramural Programs (EP)

PHS 2020-02 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) (PA-20-260) 


PHS 2020-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) (PA-20-265) 


The National Library of Medicine (NLM) offers support for research and development projects in biomedical informatics and data science. NLM defines biomedical informatics as the science of optimal organization, management, presentation and utilization of information relevant to medicine and biology. The informatics projects of interest to NLM involve the application of computer and information sciences to information problems in a biomedical domain. For additional information about areas of interest to NLM and a listing of NLM funded applications, please visit // Business concerns interested in exploring SBIR/STTR grant opportunities with NLM are encouraged to contact the NLM representatives prior to submitting an application. 
NLM’s SBIR/STTR grant programs are focused on areas of particular interest from small business. The following narrative indicates the scope of projects suitable for the SBIR/STTR program that fit within the mission of NLM. They are not listed in priority order.

  • Approaches to help consumers and patients visualize their health data in the context of social and behavioral determinants
  • Tools for modeling the impact of behavior and social determinants of health on physiological systems
  • Tools and approaches for data integration of large disparate data resources
  • Technological approaches to protecting confidentiality while storing, sharing and using biomedical data
  • AI techniques for annotating, curating and managing biomedical data resources
  • Self -managing, self-documenting datasets
  • Tools to enhance security of biomedical data, including personal health data, for multi-party use (meaning, two or more users using the data at once)
  • New Technologies that facilitate real-time decisions in clinical practice and public health, using personal health data in electronic records or clinical trials
  • Use of formal and informal data sources to track disease outbreaks, pandemics
  • Tools for understanding and predicting climate and environmental effects on human health
  • AI techniques for characterizing and minimizing the impact of errors or incompleteness in a health data set


NLM Contact

Dr. Jane Ye,


January 5, April 5, September 5 each year
Full listing of deadlines for competing applications: //

This FOA expires on April 6, 2021. 

Last Reviewed: July 16, 2020