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Trans-NIH BioMedical Informatics Coordinating Committee (BMIC)

Open Domain-Specific Data Sharing Repositories

This table lists NIH-supported domain-specific data repositories that make data accessible for reuse and are open for both submitting and accessing data. Submission is typically limited to data of a certain type or related to a certain discipline. The table provides links to information about submitting data to and accessing data from the listed repositories. Repositories in this list have current NIH funding, sustained support, open data submission and access, and open time frame for data deposit, based on information provided by the repository about funding and data availability. This non-exhaustive list is also available in a downloadable Excel version.

Are we missing a domain-specific data sharing repository that should be included in this list? Do you have comments or feedback on this list or the website? Contact us.


ICO Repository Name Repository Description Data Submission Policy Access to Data
Common Fund Metabolomics Workbench (MetWB) The Metabolomics Program's Data Repository and Coordinating Center (DRCC), housed at the San Diego Supercomputer Center (SDSC), University of California, San Diego, has developed the Metabolomics Workbench. MetWB will serve as a national and international repository for metabolomics data and metadata and will provide analysis tools and access to metabolite standards, protocols, tutorials, training, and more. How to submit data to MetWB How to access MetWB data
Common Fund Stimulating Peripheral Activity to Relieve Conditions Portal (SPARC) The SPARC Portal provides interactive access to a growing collection of data, maps, and computational studies that focus on the role of the autonomic nervous system in controlling organ function. These resources are made available to the public with the intent of advancing bioelectronic medicine towards more precise treatment of diseases and conditions. How to submit data to SPARC How to access SPARC data
NCATS BioSystics Analytics Platform (BioSystics-AP) Microphysiology Systems Database, now called the BioSystics Analytics Platform™, captures, manages, analyzes, shares, and computationally models complex data sets from in vitro experimental models, animal studies, and human clinical data, creating actionable knowledge and predicting biological outcomes that optimizes precision medicine, including preclinical trials. Links to internal and external databases provide information on drugs, assays, preclinical and clinical data for model and study design, and to develop computational models. The BioSystics-AP provides a streamlined workflow for selecting in vitro models, implementing studies and capturing data in a central location for efficient review, analyses and computational modeling. The BioSystics-AP facilitates secure data sharing within a lab and organization, with collaborators, government agencies, and the research community. How to submit data to BioSystics-AP How to access BioSystics-AP data
NCATS National COVID Cohort Collaborative (N3C) The NCATS National COVID Cohort Collaborative (N3C) Data Enclave contains harmonized clinical, laboratory and diagnostic data derived from the  EHRs of more than 12 million people who were tested for COVID-19 or had related symptoms. How to submit data to N3C How to access N3C data
NCI Cancer Nanotechnology Laboratory (caNanoLab) caNanoLab is a data sharing portal designed to facilitate information sharing in the biomedical nanotechnology research community to expedite and validate the use of nanotechnology in biomedicine. caNanoLab provides support for the annotation of nanomaterials with characterizations resulting from physico-chemical, in vitro, and in vivo assays and the sharing of these characterizations and associated nanotechnology protocols in a secure fashion. How to submit data to caNanoLab How to access caNanoLab data
NCI Imaging Data Commons The National Cancer Institute (NCI) Cancer Research Data Commons (CRDC) aims to establish a national cloud-based data science infrastructure. Imaging Data Commons (IDC) is a new data repository of CRDC supported by the Cancer Moonshot. The goal of IDC is to enable a broad spectrum of cancer researchers, with and without imaging expertise, to easily access and explore the value of de-identified imaging data and to support integrated analyses with non-imaging data utilizing CRDC Cloud Resources. How to submit data to IDC How to access IDC data
NCI Genomic Data Commons (GDC)  The mission of the GDC is to provide the cancer research community with a unified data repository that enables data sharing across cancer genomic studies in support of precision medicine. The GDC contains clinical, biospecimen, and molecular data from several cancer research programs. How to submit data to GDC How to access GDC data
NCI Proteomic Data Commons (PDC) The Proteomic Data Commons hosts mass spectra and process data from cancer proteomic experiments.  Many datasets have corresponding genomic and/or imaging data available in other nodes of the Cancer Research Data Commons. How to submit data to PDC How to access PDC data
NCI The Cancer Imaging Archive (TCIA) TCIA is a service which de-identifies and hosts a large archive of medical images of cancer accessible for public download. The data are organized as “Collections”, typically patients related by a common disease (e.g. lung cancer), image modality (MRI, CT, etc) or research focus. DICOM is the primary file format used by TCIA for image storage. Supporting data related to the images such as patient outcomes, treatment details, genomics, pathology, and expert analyses are also provided when available. How to submit data to TCIA How to access TCIA data
NCI The Network Data Exchange (NDEx) NDEx is an online commons where scientists can upload, share, and publicly distribute biological networks and pathway models. The NDEx Project maintains a web-accessible public server, a documentation website, provides seamless connectivity to Cytoscape as well as programmatic access using a variety of languages including Python and Java. NDEx  users can easily create accounts or sign in using their Google credentials thanks to  the supported open authentication (OAUTH2) method  and mint DOIs for their networks to use in publications or include in other resources for long term access.  How to submit data to NDEx How to access NDEx data
NEI NEI Data Commons The NEI Commons is a virtual infrastructure to enable sharing. The Commons portal provides a platform for querying and accessing vision research data and tools for data processing and analysis. It is the central location for NEI generated clinical and basic research data available to the public. Dependent on sub-project How to access NEI Commons data
NHGRI FlyBase: A Drosophila Genomic and Genetic Database Drosophila Genomic and Genetic database that includes proteomics data, microarrays and Tiling BAC's. How to submit data to Flybase How to access Flybase data
NHGRI The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) is a scalable and interoperable resource for the genomic scientific community, that leverages a cloud-based infrastructure for democratizing genomic data access, sharing and computing across large genomic, and genomic-related data sets. How to submit data to AnVIL How to access AnVIL data
NHGRI The Zebrafish Model Organism Database (ZFIN) ZFIN serves as the zebrafish model organism database. It aims to: a) be the community database resource for the laboratory use of zebrafish, b) develop and support integrated zebrafish genetic, genomic and developmental information, c) maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) facilitate the use of zebrafish as a model for human biology, and f) serve the needs of the research community. How to submit data to ZFIN How to access ZFIN data
NHGRI WormBase WormBase is an international consortium of biologists and computer scientists dedicated to providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C. elegans and related nematodes. How to submit data to WormBase How to access WormBase data
NHGRI (NICHD, NCI) Mouse Genome Informatics (MGI) MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. How to submit data to MGI How to access MGI data
NHGRI/NIGMS The Universal Protein Resource (UniProt) The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc). How to submit data to UniProt How to access UniProt data
NHLBI Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) The goal of BioLINCC is to facilitate and coordinate the existing activities of the NHLBI Biorepository and the Data Repository and to expand their scope and usability to the scientific community through a single web-based user interface. How to submit data to BioLINCC How to access BioLINCC data
NHLBI National Sleep Research Resource The NSRR web platform enables sharing of physiological signals and clinical data elements from well-characterized, de-identified,  research cohorts and clinical trials.  Data queries across studies (data pooling) are possible for demographics and data variables with shared common data elements.   How to submit data to NSRR How to access NSRR data
NHLBI Rat Genome Database (RGD) The Rat Genome Database (RGD) was established in 1999 and is the premier site for genetic, genomic, phenotype, and disease data generated from rat research. In addition, it provides easy access to corresponding data for human and mouse, as well as multiple other models such as chinchilla and 13-lined ground squirrel, facilitating cross-species comparisons. RGD’s comprehensive data and innovative software tools make it a valuable resource for researchers worldwide. How to submit data to RGD How to access RGD data
NIA AD Knowledge Portal The AD Knowledge Portal is an NIH-designated repository and the distribution site for multi-omic data from human samples, cell-based and animal models, analysis results, analytical methodology and research tools generated by multiple National Institute on Aging supported Alzheimer's disease research programs and consortia. Data is available to qualified investigators as open or controlled access depending on the data type and data source. How to submit data to AD Knowledge Portal How to access AD Knowledge Portal data
NIA National Archive of Computerized Data on Aging (NACDA) NACDA acquires and preserves data relevant to gerontological research, processing as needed to promote effective research use, disseminates them to researchers, and facilitates their use. By preserving and making available the largest library of electronic data on aging in the United States, NACDA offers opportunities for secondary analysis on major issues of scientific and policy relevance. How to submit data to NACDA How to access NACDA data
NIA NIDUS Delirium Research Hub A database of completed or ongoing studies that include delirium as an outcome or predictor. The Hub includes study meta-data such as study design, sample characteristics, collected biospecimens, neuroimaging tests, neuropsychological testing and pharmacologic intervention. How to submit data to Delirium Research Hub How to access Delirium Research Hub data
NIA The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)  The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is a national genetics data repository facilitating access to genotypic and phenotypic data for Alzheimer's disease (AD). Data include GWAS, whole genome (WGS) and whole exome (WES), expression, RNA Seq, and CHIP Seq analyses. Data for the Alzheimer’s Disease Sequencing Project (ADSP) are available through a partnership with dbGaP (ADSP at dbGaP). Results are integrated and annotated in the searchable genomics database that also provides access to a variety of software packages, analytic pipelines, online resources, and web-based tools to facilitate analysis and interpretation of large-scale genomic data. Data are available as defined by the NIA Genomics of Alzheimer’s Disease Sharing Policy and the NIH Genomics Data Sharing Policy. Investigators return secondary analysis data to the database in keeping with the NIAGADS Data Distribution Agreement. How to submit data to NIAGADS How to access NIAGADS data
NIA Primate Aging Database (PAD) The Primate Aging Database (PAD) is a web-based searchable database that contains body composition, blood chemistry, and other biological data collected across the lifespans of healthy non-human primates (NHPs) in captivity and in wild populations. The PAD was developed to study aging in NHPs and can be used for analyses of species and sex differences in normal aging processes, the examination of the impact of diet and environment on aging, studies on biomarkers of aging, and the establishment of a normal range for comparison to values obtained from experimental or diseased groups. How to submit data to PAD How to access PAD data
NIAAA NIAAA Data Archive (NIAAA-DA) The National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAA-DA) is a data repository that houses and shares hundreds of human subjects data generated by NIAAA-funded research. NIAAA-DA is housed within the NIMH Data Archive (NDA) which provides infrastructure for sharing research data, tools, methods, and analyses enabling collaborative science and discovery. De-identified human subjects data, harmonized to a common standard, are available to qualified researchers.  Summary data is available to all. How to submit data to NIAAA-DA How to access NIAAA-DA data
NIAID AccessClinicalData@NIAID AccessClinicalData@NIAID is a NIAID cloud-based, controlled access, secure data platform that enables sharing of and access to reports and data sets from NIAID COVID-19 and other sponsored clinical trials for the basic and clinical research community. How to submit data to AccessClinicalData@NIAID How to access AccessClinicalData@NIAID data
NIAID Bacterial and Viral Bioinformatics Resource Center (BV-BRC) The Bacterial and Viral Bioinformatics Resource Center (BV-BRC) is one of two Bioinformatics Resource Centers (BRCs) funded by the US National Institute of Allergy and Infectious Diseases (NIAID). The Bioinformatics Resource Centers (BRCs) for Infectious Diseases program was initiated in 2004 with the main objective of providing public access to computational platforms and analysis tools that enable collecting, archiving, updating, and integrating a variety of genomics and related research data relevant to infectious diseases, and pathogens and their interaction with hosts. How to submit data to BV-BRC How to access BV-BRC data
NIAID Immune Epitope Database and Analysis Resource (IEDB) This repository contains antibody/B cell and T cell epitope information and epitope prediction and analysis tools for use by the research community worldwide. Immune epitopes are defined as molecular structures recognized by specific antigen receptors of the immune system, namely antibodies, B cell receptors, and T cell receptors. Immune epitopes from infectious diseases, excluding HIV, and immune-mediated diseases and the accompanying biological information are included. How to submit data to IEDB How to access IEDB data
NIAID ITN TrialShare TrialShare is a transformative approach to data-sharing that enables clinical trial transparency. TrialShare provides clinical trial investigators the unprecedented ability to access de-identified study data, review published analysis methods, and perform real-time, interactive graphical analyses in collaboration with other researchers. Immune Tolerance Network (ITN) TrialShare shares information about ITN's clinical studies and specimen bio-repository. Data and analysis code underlying ITN-published manuscripts are publicly available with the goal of promoting transparency, reproducibility, and scientific collaboration. How to submit data to TrialShare How to access TrialShare data
NIAID TB Portals The TB Portals Program actively collects international TB patient case data, including clinical, imaging, and bacterial genomic information, from both drug-sensitive and resistant cases. These de-identified and integrated data are made publicly available after quality checks and physician-verification. Data within the TB Portals are also linked to case-associated sputum samples stored locally. These samples can be used in additional research studies. How to submit data to TB Portals How to access TB Portals data
NIAID The Immunology Database and Analysis Portal (ImmPort) ImmPort is a public data sharing repository funded by DAIT. The data sources are primarily DAIT-funded clinical trials, associated mechanistic studies, and other basic and applied immunology research programs. How to submit data to ImmPort How to access ImmPort data
NIAID VDJServer Community Data Portal VDJServer is a public analysis and data sharing portal for adaptive immune receptor repertoire sequencing (AIRR-seq) data. The VDJServer Community Data Portal (CDP) is a data repository within the AIRR Data Commons (ADC), which is an internationally distributed set of data repositories for public query and download of AIRR-seq data. The ADC contains post-processed, annotated sequences and study metadata that conforms to the AIRR Community Data Standard, and VDJServer is the primary US-based data repository for NIH-funded studies in the ADC. VDJServer allows users to query, download, analyze, and visualize public AIRR-seq with their own private data. A broad range of analysis tools and visualizations are provided. How to submit data to VDJServer How to access VDJServer data
NIAID VEuPathDB The Eukaryotic Pathogen, Vector, and Host Informatics Resource or the VEuPathDB is one of two Bioinformatics Resource Centers (BRCs) funded by the US National Institute of Allergy and Infectious Diseases (NIAID). The Bioinformatics Resource Centers (BRCs) for Infectious Diseases program was initiated in 2004 with the main objective of providing public access to computational platforms and analysis tools that enable collecting, archiving, updating, and integrating a variety of genomics and related research data relevant to infectious diseases, and pathogens and their interaction with hosts. How to submit data to VEuPathDB How to access VEuPathDB data
NIBIB LONI Database The LONI Image Data Archive (IDA) is a user-friendly environment for archiving, searching, sharing, tracking and disseminating neuroimaging and related clinical data. The IDA is utilized for dozens of neuroimaging research projects across North America and Europe and accommodates MRI, PET, MRA, DTI and other imaging modalities. How to submit data to LONI [PDF] How to access LONI data [PDF]
NIBIB Medical Imaging and Data Resource Center (MIDRC) The Medical Imaging and Data Resource Center (MIDRC) is an NIBIB funded collaboration of leading medical imaging organizations launched in response to the Covid-19 pandemic. MIDRC immediate aim is to develop a high-quality repository for medical images related to acute and long-term Covid-19 and associated clinical data. Data is harmonized and rendered artificial intelligence (AI)-ready to support the development of medical image-based algorithms for use in the detection, diagnosis, prognosis, and monitoring of Covid-19. Although prioritizing the collection of inclusive and representative Covid-19 related medical images, MIDRC is disease agnostic and open to all medical imaging datasets. How to submit data to MIDRC How  to access MIDRC data
NIBIB (NIMH, NIDA) NeuroImaging Tools and Resources Collaboratory (NITRC) The NeuroImaging Tools and Resources Collaboratory (NITRC) provides free access to data (MRI, EEG, MEG, CT, PET, etc.) and enables pay-per-use cloud-based access to unlimited computing power, enabling worldwide scientific collaboration with minimal startup and cost. With NITRC and its components—the Resources Registry (NITRC-R), Image Repository (NITRC-IR), and Computational Environment (NITRC-CE)—a researcher can obtain pilot or proof-of-concept data to validate a hypothesis for a few dollars. How to submit data to NITRC How to access NITRC data
NICHD Child Language Data Exchange System (CHILDES) CHILDES is a system for sharing and analyzing conversational interactions. How to submit data to CHILDES How to access CHILDES data
NICHD Data and Specimen Hub (DASH) NICHD DASH is a centralized resource for researchers to store and access de-identified data from NICHD funded research studies for the purposes of secondary research use. It serves as a mechanism for NICHD-funded extramural and intramural investigators to share research data from studies in accordance with the NIH Data Sharing Policy and the NIH Genomic Data Sharing Policy. How to submit data to DASH How to access DASH data
NICHD Databrary Databrary is a data library that is specialized for storing and sharing sensitive and identifiable research data especially video and audio recordings and associated metadata. Access to sensitive and identifiable data is restricted to researchers who have been authorized by an institution, but broadly shared with all authorized researchers. All shared materials are labeled with a sharing release level that reflects the permission granted by research participants or their parents or guardians. How to submit data to Databrary How to access Databrary data
NICHD Data Sharing for Demographic Research (DSDR) DSDR is a data sharing project providing curation and archiving services for the demographic and population sciences community.  It focuses on data collected through funding from the NICHD Population Dynamics Branch (PDB), but also provides these services for other data sets that fall within the scientific mission of PDB. How to submit data to DSDR How to access DSDR data
NICHD LDbase LDbase is an open science resource for the educational and developmental science scientific communities, providing a secure place to store and access behavioral data, as well as access materials about aspects of data management and analyses. The aim of LDbase is to be a powerful resource that opens up new areas of research and accelerates discoveries, inspiring innovative research that helps us understand how individuals learn, develop, are different from each other, learn new languages, respond to interventions, and interact with their communities. How to submit data to LDbase How to access LDbase data
NICHD PhonBank PhonBank is an open database for the study of early phonological development using the Phon program. How to submit data to PhonBank How to access PhonBank data
NICHD Xenbase Xenbase is a Xenopus laevis and Xenopus tropicalis biology and genomics resource. How to submit data to Xenbase How to access Xenbase data
NIDA Mouse Phenome Database (MPD) The Mouse Phenome Database (MPD) enables the integration of genomic and phenomic data by providing access to primary experimental data, well-documented data collection protocols and analysis tools. Data are contributed by investigators from around the world and represent a broad scope of behavioral, morphological and physiological disease-related characteristics in naive mice and those exposed to drugs, environmental agents or other treatments. How to submit data to MPD How to access MPD data
NIDA National Addiction & HIV Data Archive Program (NAHDAP) NAHDAP acquires, preserves and disseminates data relevant to drug addiction and HIV research. By preserving and making available an easily accessible library of electronic data on drug addiction and HIV infection in the United States, NAHDAP offers scholars the opportunity to conduct secondary analysis on major issues of social and behavioral sciences and public policy. How to submit data to NAHDAP How to access NAHDAP data
NIDA Neuroscience Information Framework (NIF) Discovery Portal: An innovative semantically-enhanced search engine of the largest collection of neuroscience information that allows users to customize and refine their searches via NIF's terminologies.
The NIF Registry: a core resource of NIF, is a catalog of electronic resources that have been selected by NIF curators, or contributed by the community, as valuable tools for researchers and students in the field of neuroscience.
Date Sharing service: NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. NIF's already established and extensive infrastructure makes sharing your data easy.
LinkOut Broker: NIF provides links between PubMed articles and your data when you register to the Data Federation through the LinkOut Broker. To enable this feature, your data must include PubMed IDs.
Ontology Engineering: Expertise and experience in building and enhancing the main terminologies and ontologies.
How to submit data to NIF How to access NIF data
NIDCD AphasiaBank AphasiaBank is a shared database of multimedia interactions for the study of communication in aphasia. Access to the data in AphasiaBank is password protected and restricted to members of the AphasiaBank consortium group. How to submit data to AphasiaBank How to access AphasiaBank data
NIDCD FluencyBank FluencyBank is a shared database for the study of the development of fluency in both normal and disordered populations. Participants include normally-developing monolingual and bilingual children, children with disfluencies (CWD), adults with disfluencies (AWSD), and second language learners. How to submit data to FluencyBank How to access FluencyBank data
NIDCR FaceBase FaceBase is an NIDCR-funded open repository of genetic, molecular, cellular, biological, and imaging data serving dental, oral, and craniofacial research and related research. The repository publicly disseminates data that are generated from animal models, in vitro experimental systems, and humans, and provides web interfaces for data sharing, curation, browsing, and image-based navigation. Data is available via either open-access or controlled-access. Additional resources that FaceBase disseminates include the database of 3D Facial Norms, developmental atlases, the Ontology of Craniofacial Development and Malformation (OCDM), and the Human Genome Analysis Interface (HGAI). How to submit data to FaceBase How to access FaceBase data
NIDCR Human Salivary Proteome Wiki (HSPW) The Human Salivary Proteome Wiki is a a NIDCR-funded collaborative, community-based Web portal to more than 1,000 unique human saliva proteins identified by high-throughput proteomic technologies. The wiki is available for the research community and the public to harness the knowledge in the data and to further enhance the value of the proteome through addtion of their own data. You are very welcome to share your thoughts in the forums; add your own data to the growing database; annotate the proteins; or just explore the site. How to submit data to HSPW How to access HSPW data
NIDDK NIDDK Central Repository The NIDDK Central Repository stores biosamples, genetic and other data collected in designated NIDDK-funded clinical studies. The purpose of the NIDDK Central Repository is to expand the usefulness of these studies by allowing a wider research community to access data and materials beyond the end of the study. How to submit data to NIDDK Central Repository How to access NIDDK Central Repository data
NIDDK NIDDK Information Network (DKnet) The NIDDK Information Network serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of DKnet is to develop a community-based network for integration across disciplines to include the larger DK universe of diseases, investigators, and potential users. How to submit data to DKnet How to access DKnet data
NIDDK The AMP-T2D Knowledge Portal (T2DKP) The AMP-T2D Knowledge Portal is the NIDDK-designated repository being developed as part of the Accelerating Medicines Partnership (AMP), a public-private partnership between the National Institutes of Health (NIH), the U.S. Food and Drug Administration (FDA), 10 biopharmaceutical companies, and multiple non-profit organizations that is managed through the Foundation for the NIH (FNIH) for collection of various types of molecular data such as DNA sequences, functional and epigenomic information, and clinical data from studies on type 2 diabetes and its macro- and microvascular complications from human, cell-based and animal model biosamples, analytical results and research tools towards improving current efforts to develop new therapies for complex, heterogeneous diseases, including type 2 diabetes. How to submit data to T2DKP How to access T2DKP data
NIEHS Chemical Effects in Biological Systems (CEBS) The CEBS database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial, and governmental laboratories. CEBS is designed to display data in the context of biology and study design, and permit data integration across studies for novel meta analysis. How to submit data to CEBS How to access CEBS data
NIGMS The Biological Magnetic Resonance Data Bank (BMRB) The BioMagResBank (BMRB) is the resource that provides access to the information on biomolecules derived from nuclear magnetic resonance (NMR) spectroscopy. These NMR experimental data underlie the three-dimensional structures of many proteins and nucleic acids and provide important insights into their dynamics, chemical properties, and molecular interactions. Data archived at BMRB include primary data sets and derived results, such as chemical shifts, couplings, and cross relaxations associated with three- dimensional structures, parameters that specify local dynamics, pKa values assigned to specific sites, H- exchange rates, and evidence for conformational heterogeneity and molecular interactions. How to submit data to BMRB How to access BMRB data
NIGMS Cell Image Library The Cell Image Library, accepts image data sets that are too large for publishers to store, and provides access to the biomedical community. There are 10,000 datasets in 20TB of uploaded data as of mid-2018.  The  library inherits data from the Cell Centered Database at UCSD.  Since its launch in 2010, the site has had 721,00 visitors and  was cited by 175 research publications. How to submit data to Cell Image Library How to access Cell Image Library data
NIGMS Database of Interacting Proteins (DIP) The DIP database, a founding member of the International Molecular Exchange Consortium (IMEx:,  catalogs experimentally determined interactions between proteins. It combines information from a variety of sources to create a single, consistent set of protein-protein interactions. The data stored within the DIP database are manually curated and include, when available, detailed information on the interacting regions, mutations and post-translational modifications that affect each interaction. How to submit data to DIP How to access DIP data
NIGMS/NIBIB PhysioNet The PhysioNet Resource is intended to stimulate current research and new investigations in the study of complex biomedical and physiologic signals. It offers free web access to large collections of recorded physiologic signals (PhysioBank) and related open-source software (PhysioToolkit). How to submit data to PhysioNet How to access PhysioNet data
NIH Biological General Repository for Interaction Datasets (BioGRID) BioGRID is a curated biological database of protein-protein interactions, genetic interactions, chemical interactions, and post-translational modifications from major model organism species. All interaction data are freely provided through our search index and available via download in a wide variety of standardized formats. How to submit data to BioGRID How to access BioGRID data
NIH (NIA, NICHD, NIDA) Inter-university Consortium for Political and Social Research (ICPSR) ICPSR provides leadership and training in data access, curation, and methods of analysis for the social science research community. ICPSR maintains a data archive of more than 250,000 files of research in the social and behavioral sciences. ICPSR collaborates with a number of funders, including U.S. statistical agencies and foundations, to create thematic data collections and data stewardship and research projects. NICHD (DSDR), NIA (NACDA), and NIDA (NAHDAP) currently support specialty archives that use the ICPSR infrastructure.  How to submit data to ICPSR How to access ICPSR data
NIMH NIMH Data Archive The National Institute of Mental Health Data Archive (NDA) makes available human subjects data collected from hundreds of research projects across many scientific domains. The NDA provides infrastructure for sharing research data, tools, methods, and analyses enabling collaborative science and discovery. De-identified human subjects data, harmonized to a common standard, are available to qualified researchers.  Summary data is available to all. How to submit data to NDA How to access NDA data
NIMH NIMH Repository and Genomics Resources (NRGR) The NIMH Repository and Genomics Resource (NRGR) is the largest biorepository supporting genomics in psychiatry, providing access to biomaterials (DNA, plasma, RNA, lymphoblastoid cell lines, induced pluripotent stem cells, etc.) and phenotypic data collected from nearly 200,000 well-characterized, high-quality control and patient samples from a wide-range of mental illnesses across ancestrally diverse populations. The NRGR also provides access to some genomic data sets, including some which do not have biosamples available in the repository, such as data sets generated by the Psychiatric Genomics Consortium, the CommonMind Consortium, and the PsychENCODE consoritum.  How to submit data to NRGR How to access NRGR data
NIMH OpenNeuro The OpenNeuro database is a public repository of human and non-human brain imaging data collected using several different imaging techniques (MRI, PET, EEG and MEG data). No registration or license agreement is required to obtain the data, which is distributed, by default, using a Public Domain dedication. This is possible because data are anonymized before distribution to protect the confidentiality of participants. How to submit data to OpenNeuro How to access OpenNeuro data
NINDS Archived Clinical Research Datasets The data from NINDS-supported clinical trials are an important scientific resource, made available to the wider scientific community, while ensuring that the confidentiality and privacy of study participants are protected. NINDS requires all investigators seeking access to data from archived NINDS-supported trials to agree to certain terms and conditions.  How to submit data to Archived Clinical Research Data How to access Archived Clinical Research Datasets data
NINDS NeuroMorpho.Org is a centrally curated inventory of digitally reconstructed neurons associated with peer-reviewed publications. It contains contributions from over 400 laboratories worldwide and is continuously updated as new morphological reconstructions are collected, published, and shared. To date, NeuroMorpho.Org is the largest collection of publicly accessible 3D neuronal reconstructions and associated metadata. The goal of NeuroMorpho.Org is to provide dense coverage of available reconstruction data for the neuroscience community. Data sharing through NeuroMorpho.Org enables the full and continuing research potential of existing digital reconstruction data. How to submit data to NeuroMorpho How to access NeuroMorpho data 
NLM is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. How to submit data to How to access data
NLM ClinVar ClinVar is a freely accessible, public archive of submitted reports about the relationships among human variations and phenotypes, with supporting evidence. How to submit data to ClinVar How to access ClinVar data
NLM database of Genotypes and Phenotypes (dbGaP) The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the data and results from studies that have investigated the interaction of genotype and phenotype in Humans. How to submit data to dbGaP How to access dbGaP data
NLM dbSNP dbSNP is a general public archive of all short sequence variation, not just single nucleotide substitutions that occur frequently enough in a population to be termed polymorphic, but also rare variants, including those with clinical assertions in ClinVar. dbSNP includes a broad collection of simple genetic variations such as single-base nucleotide substitutions, small-scale multi-base deletions or insertions, and microsatellite repeats. How to submit data to dbSNP How to access dbSNP data
NLM dbVar dbVar is a NCBI database of genomic structural variation. How to submit data to dbVar How to access dbVar data
NLM GenBank GenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is designed to provide and encourage access within the scientific community to the most up to date and comprehensive DNA sequence information. How to submit data to GenBank  How to access GenBank data
NLM Gene Expression Omnibus (GEO) Gene Expression Omnibus is a public functional genomics data repository supporting MIAME-compliant submissions of array- and sequence-based data. Tools are provided to help users query and download experiments and curated gene expression profiles. How to submit data to GEO How to access GEO data
NLM NIH Genetic Testing Registry (GTR) The NIH Genetic Testing Registry (GTR) is freely accessible database of clinical and research genetic test descriptions and the laboratories that provide them. Scope includes molecular, biochemical and cytogenetic tests as well as serologic and molecular microbe tests. Test descriptions include the test targets and the conditions the tests are for, methodology, clinical and analytical validity, clinical utility and ordering information. How to submit data to GTR How to access GTR data
NLM PubChem PubChem provides information on the biological activities of small molecules. PubChem is organized as three linked databases (bioassay, compound, and substance data) within the NCBI's Entrez information retrieval system. How to submit data to PubChem How to access PubChem data
NLM Sequence Read Archive (SRA) The SRA is NIH's primary archive of high-throughput sequencing data and is part of the International Nucleotide Sequence Database Collaboration (INSDC) that includes at the NCBI Sequence Read Archive (SRA), the European Bioinformatics Institute (EBI), and the DNA Database of Japan (DDBJ). Data submitted to any of the three organizations are shared among them. How to submit data to SRA How to access SRA data
NIH openICPSR openICPSR is a self-publishing repository for social, behavioral, and health sciences research data. A service of the Inter-university Consortium for Political and Social Research (ICPSR), openICPSR is particularly well-suited for the deposit of replication data sets for researchers who need to publish their raw data associated with a journal article so that other researchers can replicate their findings.  ICPSR does not improve or alter datasets deposited in openICPSR in any way. Data are preserved as-is and distributed in the same condition and format submitted by the depositor.  How to submit data to openICPSR How to access openICPSR data
OD (NHLBI,  NIA, NICHD) INCLUDE Data Hub The INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project is an NIH-wide collaboration that seeks to improve health and quality-of-life for people with Down syndrome. The INCLUDE Project Data Coordinating Center and partners created the INCLUDE Data Hub, a centralized data resource that allows access to large-scale clinical and multi-omics datasets specific to Down syndrome and supports collaborative, cloud-based analysis to accelerate scientific discoveries related to Down syndrome and its co-occurring conditions. How to submit data to INCLUDE How to access INCLUDE data
OD Monarch Initiative The Monarch Initiative is an integrative data and analytic platform connecting phenotypes to genotypes across species, bridging basic and applied research with semantics-based analysis. The correlation of phenotypic outcomes and disease with genetic variation and environmental factors is a core pursuit in biology and biomedicine. We have created or currently contribute to many essential bio-ontologies that together enable sophisticated and semantically integrated computational analysis across gene, genotype, variant, disease, and phenotype data. We have developed algorithms and tools that are in use by multiple communities for tasks including the identification of animal models of human disease through phenotypic similarity, phenotype-driven computational support for differential diagnostics, and translational research. How to submit data to Monarch Initiative How to access Monarch Initiative data

Last Reviewed: September 16, 2022