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Computational Molecular Biology

  • BLAST
    • A tool that finds regions of similarity between biological sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance.
  • GenBank
    • A database of nucleotide sequences.
  • Molecular Structure and Function
    • A database of macromolecular 3D structures, as well as tools for their visualization and comparative analysis.
  • Taxonomy Database
    • A database of taxonomic names of lineages of organisms represented in NCBI's sequence databases.
  • Conserved Domain Database (CDD)
    • A database to identify the conserved domains present in a protein sequence.
  • Reference Sequences (RefSeq)
    • A collection of reference sequences for genomes, gene transcripts, and proteins.
  • UniGene
    • Automatic partioning of gene transcripts and proteins.
  • Vector Alignment Search Tool (VAST)
    • A computer algorithm developed at NCBI and used to identify similar protein 3-dimensional structures ("similar structures") by purely geometric criteria, and to identify distant homologs that cannot be recognized by sequence comparison.

 

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