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New and Updated Sources (Expanded Representation Information) - 2022AB Release

General Information:  

What's New to the Metathesaurus

For 2022AB, there is one new source (ORPHANET), three new translations (LNC-UK-UA, MDRLAV, MDRSWE), and 65 updated sources (including translation sources and subsources). 

ORPHANET is a resource for gathering and improving knowledge on rare
diseases. Its aim is to improve the diagnosis, care and treatment of patients with rare diseases. 

LNC-UK-UA is the Ukrainian, Ukraine Edition of LOINC (LNC).

MDRLAV is the Latvian Edition of the Medical Dictionary of Regulatory Activities Terminology (MedDRA).

MDRSWE is the Swedish Edition of the Medical Dictionary of Regulatory Activities Terminology (MedDRA).

For detailed information about sources that are new or have had changes made (e.g., new term types, new attribute names, etc.):

    Current Procedural Terminology, CPT2022 
    HUGO Gene Nomenclature Committee, HGNC2022_04
    LOINC, LNC273
    LOINC, German, Germany Edition, LNC-DE-DE_273
    LOINC, Ukrainian, Ukraine Edition, LNC-UK-UA_273
    Medical Dictionary for Regulatory Activities Terminology (MedDRA), Latvian Edition, MDRLAV25_0
    Medical Dictionary for Regulatory Activities Terminology (MedDRA), Swedish Edition, MDRSWE25_0
    German translation of the Medical Subject Headings, MSHGER2022
    NCI Thesaurus, NCI2021_04D
    Orphanet Nomenclature, ORPHANET_2022_06
    SNOMED Clinical Terms, Spanish Language Edition, SCTSPA_2022_04_30
    US Edition of SNOMED CT, SNOMEDCT_US_2022_09_01
    Veterinary Extension to SNOMED CT, SNOMEDCT_VET_2022_04_01
------------------------------------------

What's New to the Metathesaurus:


Attribute Name (ATN):
    GENCC
    MANE_SELECT
    CLINVAR_VARIATION_ID

Relationship Attribute (RELA) | Inverse:
    before|after
    has_dipg_dmg_permissible_value|is_dipg_dmg_permissible_value_for_variable    
    has_pcdc_hl_permissible_value|is_pcdc_hl_permissible_value_for_variable
    has_pcdc_os_permissible_value|is_pcdc_os_permissible_value_for_variable
    partially_equivalent_to|partially_equivalent_to
    possibly_replaced_by|possibly_replaces
    process_acts_on|acted_on_by_process
-------------------------------------------------------

Source: Current Procedural Terminology 
VSAB: CPT2022 

RVU attributes were not available for CPT2022. They will be included in CPT2023.  
-------------------------------------------------------

Source: HUGO Gene Nomenclature Committee 
VSAB: HGNC2022_04 

New attribute name(s) (ATN) | Description:
    GENCC|HGNC ID used within the GenCC database
    MANE_SELECT|NCBI and Ensembl transcript IDs/accessions for one high-quality representative transcript per protein-coding gene.


Discussion:

1. New ATN = GENCC contains the "HGNC ID used within the GenCC 
database as the unique identifier of their gene reports within the 
GenCC database."

2. New ATN = MANE_SELECT contains "NCBI and Ensembl transcript 
IDs/accessions including the version number for one high-quality 
representative transcript per protein-coding gene that is well-
supported by experimental data and represents the biology of the gene". 
-------------------------------------------------------

Source: LOINC
VSAB: LNC273

1. New abbreviation | Class:
    ENDO.PULM|Endo Pulmonary

2. Dropped attribute name(s) (ATN) | Description:
    EXAMPLE_SI_UCUM_UNITS|EXAMPLE_SI_UCUM_UNITS
    UNITS_AND_RANGE|Units and range

3. Refreshed rankings of commonly used LOINC codes in the U.S.


Discussion:

Refreshed rankings of the 20,000 most commonly used LOINC codes in the U.S. These 
rankings replace the previous "Top 2000" lab codes which were out of date and 
included only lab. The new rankings encompass clinical as well and are in the 
COMMON_TEST_RANK field of the Loinc.csv file.
-------------------------------------------------------

Source: LOINC, German, Germany Edition
VSAB: LNC-DE-DE_273

New termtype(s) (TTY) | Description:
    LO|Obsolete official fully specified name
    OLC|Obsolete Long common name


Discussion:

Termtypes LO and OLC have been populated once again after having been
deprecated in previous versions.
-------------------------------------------------------

Source: LOINC, Ukrainian, Ukraine Edition 
VSAB: LNC-UK-UA_273

New termtype(s) (TTY) | Description:
    LC|Long common name
    LN|LOINC official fully specified name
    LVDN|Linguistic variant display name
    OSN|Official short name


Discussion:

New translation source.
-------------------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA), 
Latvian Edition
VSAB:  MDRLAV25_0

1. New termtype(s) (TTY) | Description:
    AB|Abbreviation in any source vocabulary
    HG|High Level Group Term
    HT|Hierarchical term
    LLT|Lower Level Term
    OL|Non-current Lower Level Term
    OS|System-organ class
    PT|Designated preferred name
    SMQ|Standardised MedDRA Query
 
2. New relationship | relationship attribute (RELA) | RELA inverse:
    RO|classifies|classified_as
    RO|has_member|member_of
    RO|member_of|has_member
    SY|expanded_form_of|has_expanded_form
    SY|translation_of|has_translation

3. New attribute name (ATN) | Description:
    MISO|MedDRA Serial Code International SOC Sort Order Digit (01-26)
    MPS|MedDRA primary SOC 
    SMQ_ALGO|Standardised MedDRA Query (SMQ) Algorithm. Boolean expression
    of algorithm for the SMQ.
    SMQ_LEVEL|Standardised MedDRA Query (SMQ) Level. Value between 1 and 5
    identifying the level of the SMQ within the hierarchy of SMQs.
    SMQ_SOURCE|Standardised MedDRA Query (SMQ) Source. Source for the
    development of the SMQ.  
    SMQ_STATUS|Standardised MedDRA Query (SMQ) Status. "A" = active; "I" =
    inactive.
    SMQ_TERM_ADDVERSION|Standardised MedDRA Query (SMQ) Addition Version.
    Version of MedDRA in which term was added to the SMQ.
    SMQ_TERM_CAT|Standardised MedDRA Query (SMQ) Term Category. A single
    alphabetical letter indicating the category of the term for application
    of the SMQ algorithm.
    SMQ_TERM_LEVEL|Standardised MedDRA Query (SMQ) Term Level. The MedDRA
    hierarchy level of a term.  
    SMQ_TERM_LMVERSION|Standardised MedDRA Query (SMQ) Last Modified
    Version. Version of MedDRA in which term was last modified in the SMQ.
    SMQ_TERM_SCOPE|Standardised MedDRA Query (SMQ) Term Scope. Defines the
    MedDRA term as a member of the broad scope (1), narrow scope (2) of the
    SMQ search, or a child SMQ (0) (zero).
    SMQ_TERM_STATUS|Standardised MedDRA Query (SMQ) Term Status. Identifies
    a term as active ("A") or inactive ("I") within this SMQ.
    SMQ_TERM_WEIGHT|Standardised MedDRA Query (SMQ) Term Weight. Used for
    some SMQ algorithms; "0" is used as default. 
    SOS|Scope Statement


Discussion:

New translation source.
----------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
Swedish Edition
VSAB:  MDRSWE25_0

1. New termtype(s) (TTY) | Description:
    AB|Abbreviation in any source vocabulary
    HG|High Level Group Term
    HT|Hierarchical term
    LLT|Lower Level Term
    OL|Non-current Lower Level Term
    OS|System-organ class
    PT|Designated preferred name
    SMQ|Standardised MedDRA Query
 
2. New relationship | relationship attribute (RELA) | RELA inverse:
    RO|classifies|classified_as
    RO|has_member|member_of
    RO|member_of|has_member
    SY|expanded_form_of|has_expanded_form
    SY|translation_of|has_translation

3. New attribute name (ATN) | Description:
    MISO|MedDRA Serial Code International SOC Sort Order Digit (01-26)
    MPS|MedDRA primary SOC 
    SMQ_ALGO|Standardised MedDRA Query (SMQ) Algorithm. Boolean expression
    of algorithm for the SMQ.
    SMQ_LEVEL|Standardised MedDRA Query (SMQ) Level. Value between 1 and 5
    identifying the level of the SMQ within the hierarchy of SMQs.
    SMQ_SOURCE|Standardised MedDRA Query (SMQ) Source. Source for the
    development of the SMQ.  
    SMQ_STATUS|Standardised MedDRA Query (SMQ) Status. "A" = active; "I" =
    inactive.
    SMQ_TERM_ADDVERSION|Standardised MedDRA Query (SMQ) Addition Version.
    Version of MedDRA in which term was added to the SMQ.
    SMQ_TERM_CAT|Standardised MedDRA Query (SMQ) Term Category. A single
    alphabetical letter indicating the category of the term for application
    of the SMQ algorithm.
    SMQ_TERM_LEVEL|Standardised MedDRA Query (SMQ) Term Level. The MedDRA
    hierarchy level of a term.  
    SMQ_TERM_LMVERSION|Standardised MedDRA Query (SMQ) Last Modified
    Version. Version of MedDRA in which term was last modified in the SMQ.
    SMQ_TERM_SCOPE|Standardised MedDRA Query (SMQ) Term Scope. Defines the
    MedDRA term as a member of the broad scope (1), narrow scope (2) of the
    SMQ search, or a child SMQ (0) (zero).
    SMQ_TERM_STATUS|Standardised MedDRA Query (SMQ) Term Status. Identifies
    a term as active ("A") or inactive ("I") within this SMQ.
    SMQ_TERM_WEIGHT|Standardised MedDRA Query (SMQ) Term Weight. Used for
    some SMQ algorithms; "0" is used as default. 
    SOS|Scope Statement


Discussion:

New translation source.
----------------------------------------

Source: German translation of the Medical Subject Headings 
VSAB: MSHGER2022

Dropped attribute name (ATN) | Description:
    TERMUI|Term unique identifier
----------------------------------------

Source: NCI Thesaurus 
VSAB: NCI2022_04D


1. Subsources are no longer included in the UMLS.  To access NCI subsources, refer to the NCI Metathesaurus (https://ncim.nci.nih.gov/ncimbrowser/).

2. New relationship | relationship attribute (RELA) | RELA inverse:
    RO|has_dipg_dmg_permissible_value|is_dipg_dmg_permissible_value_for_variable
    RO|has_pcdc_hl_permissible_value|is_pcdc_hl_permissible_value_for_variable
    RO|has_pcdc_os_permissible_value|is_pcdc_os_permissible_value_for_variable

3. New attribute name (ATN) | Description:
    CLINVAR_VARIATION_ID|CLINVAR VARIATION ID


Discussion:

All subsource content has been removed from NCI Thesaurus in the UMLS, however, 
a list of the subsources can be found on the NCI Thesaurus source 
vocabulary documentation page (https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/NCI/index.html).

Users interested in the codes and names from the NCI Thesaurus 
subsources can still find them in the NCI Thesaurus
(https://ncit.nci.nih.gov/ncitbrowser/) or the NCI Metathesuarus 
(https://ncim.nci.nih.gov/ncimbrowser/). 
-----------------------------------------------

Source: Orphanet Nomenclature 
VSAB: ORPHANET_2022_06

New termtype(s) (TTY) | Description:
    PT|Designated preferred name
    SY|Designated synonym


Discussion:

New source.
----------------------------------------

Source: RXNORM Vocabulary
VSAB: RXNORM_20AA_220906F

This version includes:
    ATC_2022_22_09_06 (Anatomical Therapeutic Chemical Classification System)
    CVX_2022_06_23_22_09_06 (Vaccines Administered)
    DRUGBANK5.0_2022_08_01 (DrugBank)
    GS_2022_08_05 (Gold Standard Drug Database)
    MMSL_2022_08_01 (Multum MediSource Lexicon)
    MMX_2022_08_08 (Micromedex RED BOOK)
    MTHCMSFRF_2020_22_09_06 (Metathesaurus CMS Formulary Reference File)
    MTHSPL_2022_08_26 (Metathesaurus FDA Structured Product Labels)
    NDDF_2022_08_10 (FDB MedKnowledge)
    USP_2022_08_12 (USP Compendial Nomenclature)
    VANDF_2022_07_29 (Veterans Health Administration National Drug File)
-----------------------------------------------

Source: SNOMED Clinical Terms, Spanish Language Edition 
VSAB: SCTSPA_2022_04_30

New attribute name (ATN) | Description:
    REFSET_PATTERN|Refset pattern
----------------------------------------

Source: US Edition of SNOMED CT
VSAB: SNOMEDCT_US_2022_09_01 

New relationship | relationship attribute (RELA) | RELA inverse:
    RO|before|after
    RO|partially_equivalent_to|partially_equivalent_to
    RO|possibly_replaced_by|possibly_replaces
    RO|process_acts_on|acted_on_by_process
---------------------------------------------------------------------

Source: Veterinary Extension to SNOMED CT 
VSAB: SNOMEDCT_VET_2022_04_01

New attribute name (ATN) | Description:
    LANGUAGECODE|SNOMED CT string identifying a language and, if appropriate,
    a dialect in which this description is valid.
 


Last Reviewed: November 6, 2022