New and Updated Sources (Expanded Representation Information) - 2018AB Release

General Information:

What's New to the Metathesaurus

For 2018AB, there are four new subsources (NCI_CDISC-GLOSS, NCI_CTCAE_3, NCI_CTCAE_5, and USP) and 97 updated sources (including translation sources and subsources).

NCI_CDISC-GLOSS (CDISC Glossary Terminology) which is maintained and distributed by NCI EVS seeks to harmonize definitions (including acronyms, abbreviations, and initials) used in the various standards initiatives undertaken by CDISC in clinical research. CDISC-GLOSS also serves the community of clinical researchers by selecting and defining terms pertaining to clinical research, particularly eClinical investigations, sponsored by the pharmaceutical industry or a federal agency. It includes references and links to other glossaries, such as regulatory dictionaries and health-related controlled terminologies useful in conducting clinical research, including the CDISC Terminology Project.

NCI_CTCAE_3 (Common Terminology Criteria for Adverse Events 3.0) contains content from version 3 of CTCAE.

NCI_CTCAE_5 (Common Terminology Criteria for Adverse Events 5.0) contains content from version 5 of CTCAE.

USP (USP Compendial Nomenclature), a subsource of RxNorm, helps support naming accuracy for drug substances in electronic environments. USP creates official, nonproprietary names for dosage forms and combination drug products, and develops naming policies.

For detailed information about sources that are new or have had changes made (e.g. new term types, new attribute names, etc.):

Foundational Model of Anatomy Ontolog, FMA4_10
Human Phenotype Ontology, HPO2018_07_23
International Classification of Diseases, 10th Edition, Clinical Modification, ICD10CM_2019
ICD-10-PCS, ICD10PCS_2019
LOINC, German, Austria Edition, LNC-DE-AT_264
LOINC, Portuguese, Brazil Edition, LNC-PT-BR_264
LOINC, LNC264
Medication Reference Terminology, MED-RT_2018_09_04
NCI Thesaurus, NCI2018_03D
Nursing Outcomes Classification (NOC), 6
National Uniform Claim Committee - Health Care Provider Taxonomy, NUCCPT_18.1
Perioperative Nursing Data Set, PNDS_4_2018
RXNORM Vocabulary, RXNORM_18AA_180904F
SNOMED Clinical Terms, Spanish Language Edition, SCTSPA_2018_04_30
US Edition of SNOMED CT, SNOMEDCT_US_2018_09_01
Veterinary Extension to SNOMED CT, SNOMEDCT_VET_2018_04_01

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What's New to the Metathesaurus:

Attribute Name (ATN):
     CONTRIBUTING_AUTHOR
     EUPROSTATE16
     EUPROSTATE27
     IMAGING_DOCUMENT_VALUE_SET
     MONOGRAPH_OFFICIAL_DATE
     MONOGRAPH_STATUS
     NEUROQUANT
     PIRADSV2
     PUBLISH_VALUE_SET
     RXN_BOSS_AI
     RXN_BOSS_AM
     RXN_BOSS_FROM
     RXN_BOSS_STRENGTH_DENOM_UNIT
     RXN_BOSS_STRENGTH_DENOM_VALUE
     RXN_BOSS_STRENGTH_NUM_UNIT
     RXN_BOSS_STRENGTH_NUM_VALUE
     SLOT_SYNONYM
     TERM_BROWSER_VALUE_SET_DESCRIPTION

Relationship Attribute (RELA) | RELA inverse:
     has_concentration_strength_denominator_unit|concentration_strength_denominator_unit_of
     has_concentration_strength_denominator_value|concentration_strength_denominator_value_of
     has_concentration_strength_numerator_unit|concentration_strength_numerator_unit_of
     has_concentration_strength_numerator_value|concentration_strength_numerator_value_of
     has_count_of_base_of_active_ingredient|count_of_base_of_active_ingredient_of
     has_ctcae_5_parent|ctcae_5_parent_of
     has_product_monograph_title|product_monograph_title_of
     has_structural_class|structural_class_of
     neoplasm_has_special_category|special_category_includes_neoplasm

Term Type (TTY):
     LVDN

------------------------------------------

Source: Foundational Model of Anatomy Ontology
VSAB: FMA4_10

1. New term type (TTY) | Suppressible value:
     IS|O

2. New attribute name (ATN):
     CONTRIBUTING_AUTHOR
     EUPROSTATE16
     EUPROSTATE27
     NEUROQUANT
     PIRADSV2
     SLOT_SYNONYM

3. Dropped attribute name (ATN):
     AUTHORITY (STYPE = RUI)
     REFERENCE


Discussion:

TTY = IS (Obsolete Synonym).
------------------------------------------

Source: Human Phenotype Ontology
VSAB: HPO2018_07_23

Dropped term type (TTY):
     OET


Discussion:

Dropped TTY = OET (Obsolete entry term).
------------------------------------------

Source: International Classification of Diseases, 10th Edition, Clinical Modification
VSAB: ICD10CM_2019

1. Dropped term type (TTY):
     XM

2. Dropped attribute name (ATN):
     FROMRSAB
     FROMVSAB
     MAPSETRSAB
     MAPSETVERSION
     MAPSETVSAB
     MAPSETXRTARGETID
     MTH_MAPFROMCOMPLEXITY
     MTH_MAPFROMEXHAUSTIVE
     MTH_MAPSETCOMPLEXITY
     MTH_MAPTOCOMPLEXITY
     MTH_MAPTOEXHAUSTIVE
     SOS
     TORSAB
     TOVSAB


Discussion:

The General Equivalence Mappings (GEMs) have been discontinued for ICD10CM resulting in the following:

     a. Dropped TTY = XM (Cross mapping set).
     b. Depreated ATNs listed above.
     c. No entries for ICD10CM in MRMAP.RRF and MRSMAP.RRF.
------------------------------------------

Source: ICD-10-PCS
VSAB: ICD10PCS_2019

1. Dropped term type (TTY):
     XM

2. Dropped attribute name (ATN):
     FROMRSAB
     FROMVSAB
     MAPSETRSAB
     MAPSETTYPE
     MAPSETVERSION
     MAPSETVSAB
     MAPSETXRTARGETID
     MTH_MAPFROMCOMPLEXITY
     MTH_MAPFROMEXHAUSTIVE
     MTH_MAPSETCOMPLEXITY
     MTH_MAPTOCOMPLEXITY
     MTH_MAPTOEXHAUSTIVE
     SOS
     TORSAB
     TOVSAB


Discussion:

The General Equivalence Mappings (GEMs) have been discontinued for ICD10PCS resulting in the following:

     a. Dropped TTY = XM (Cross mapping set).
     b. Depreated ATNs listed above.
     c. No entries for ICD10PCS in MRMAP.RRF and MRSMAP.RRF.
------------------------------------------

Source: LOINC, German, Austria Edition
VSAB: LNC-DE-AT_264

New term type (TTY):
     LVDN


Discussion:

New TTY = LVDN (Linguistic Variant Display Name).
------------------------------------------

Source: LOINC, Portuguese, Brazil Edition
VSAB: LNC-PT-BR_264

Dropped term type (TTY):
     LC
     OLC


Discussion:

The 'Long Common Name' field was not populated in this version. TTY = LC and OLC were deprecated.
------------------------------------------

Source: LOINC
VSAB: LNC264

1. New attribute name (ATN):
     IMAGING_DOCUMENT_VALUE_SET

2. Dropped attribute name (ATN):      EXTERNALLY_DEFINED
     EXTERNALLY_DEFINED_CODE_SYSTEM
     EXTERNAL_LIST_LINK


Discussion:

1. The ATN = IMAGING_DOCUMENT_VALUE_SET is a subset of document codes in LOINC that represent imaging procedures and reports. The value of this ATN is set to 'TRUE' when appropriate.

2. The dropped attributes are due to changes in the representation of the Answers data.
------------------------------------------

Source: Medication Reference Terminology
VSAB: MED-RT_2018_09_04

1. New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_structural_class|structural_class_of

2. Dropped relationship | relationship attribute (RELA):
     CHD|has_snomed_parent
     PAR|has_snomed_child
     RO|has_chemical_structure
     RO|has_ingredient
     SY|has_snomed_synonym


Discussion:

1. The following relationship names were changed in the MED-RT data file and the updates were reflected in the UMLS Metathesaurus:

     has_Ingredient -> Synonym Of
     has_Chemical_Structure -> has_SC
     has_SNOMED_parent -> Child Of
     has_SNOMED_child -> Parent Of
     has_SNOMED_synonym -> Synonym Of

2. To facilitate navigation a MED-RT hierarchy was created. MRHIER.RRF only includes Parent/Child relationships between two MED-RT concepts. Parent/Child relationships involving concepts in other sources are included as pairwise relationships in MRREL.RRF. Every MED-RT concept exists in the hierarchy.
---------------------------------------

Source: NCI Thesaurus
VSAB: NCI2018_03D

This version includes:
     NCI2018_BRIDG_1803D (Biomedical Research Integrated Domain Group Model)
     NCI2018_BioC_1803D (BioCarta online maps of molecular pathways, adapted for NCI use)
     NCI2018_CDC_1803D (U.S. Centers for Disease Control and Prevention)
     NCI2018_CDISC-GLOSS_1803D (CDISC Glossary Terminology)
     NCI2018_CDISC_1803D (Clinical Data Interchange Standards Consortium)
     NCI2018_CRCH_1803D (Cancer Research Center of Hawaii Nutrition Terminology)
     NCI2018_CTCAE_1803D (Common Terminology Criteria for Adverse Events)
     NCI2018_CTCAE_3_1803D (Common Terminology Criteria for Adverse Events 3.0)
     NCI2018_CTCAE_5_1803D (Common Terminology Criteria for Adverse Events 5.0)
     NCI2018_CTEP-SDC_1803D (Cancer Therapy Evaluation Program - Simple Disease Classification)
     NCI2018_CTRP_1803D (Clinical Trials Reporting Program)
     NCI2018_CareLex_1803D (Content Archive Resource Exchange Lexicon)
     NCI2018_DCP_1803D (NCI Division of Cancer Prevention Program)
     NCI2018_DICOM_1803D (Digital Imaging Communications in Medicine)
     NCI2018_DTP_1803D (NCI Developmental Therapeutics Program)
     NCI2018_FDA_1803D (U.S. Food and Drug Administration)
     NCI2018_GAIA_1803D (Global Alignment of Immunization Safety Assessment in pregnancy)
     NCI2018_GENC_1803D (Geopolitical Entities, Names, and Codes Standard)
     NCI2018_ICH_1803D (International Conference on Harmonization)
     NCI2018_JAX_1803D (Jackson Laboratories Mouse Terminology, adapted for NCI use)
     NCI2018_KEGG_1803D (KEGG Pathway Database)
     NCI2018_NCI-GLOSS_1803D (NCI Dictionary of Cancer Terms)
     NCI2018_NCI-HGNC_1803D (NCI HUGO Gene Nomenclature Committee)
     NCI2018_NCI-HL7_1803D (NCI Health Level 7)
     NCI2018_NCPDP_1803D (National Council for Prescription Drug Programs)
     NCI2018_NICHD_1803D (National Institute of Child Health and Human Development)
     NCI2018_PI-RADS_1803D (Prostate Imaging Reporting and Data System)
     NCI2018_PID_1803D (National Cancer Institute Nature Pathway Interaction Database)
     NCI2018_RENI_1803D (Registry Nomenclature Information System)
     NCI2018_UCUM_1803D (Unified Code for Units of Measure)
     NCI2018_ZFin_1803D (Zebrafish Model Organism Database)


1. New subsource(s):
     CDISC-GLOSS
     CTCAE_3
     CTCAE_5

2. New relationship | relationship attribute (RELA) | RELA inverse | Source(s):
     RO|has_ctcae_5_parent|ctcae_5_parent_of|NCI2018_03D
     RO|neoplasm_has_special_category|special_category_includes_neoplasm|NCI2018_03D

3. New attribute name (ATN) | Source(s):
     PUBLISH_VALUE_SET|NCI2018_03D
     TERM_BROWSER_VALUE_SET_DESCRIPTION|NCI2018_03D


Discussion:

1. New subsource = NCI_CTCAE_3 (Common Terminology Criteria for Adverse Events 3.0) contains content from version 3 of CTCAE.

2. New subsource = NCI_CTCAE_5 (Common Terminology Criteria for Adverse Events 5.0) contains content from version 5 of CTCAE.

3. SAB = NCI_CTCAE (Common Terminology Criteria for Adverse Events) contains content from a subset of version 4.3 of CTCAE.

4. SAB = CTRP-SDC (Clinical Trials Reporting Program) has been changed to SAB = CTRP.
-----------------------------------------------

Source: Nursing Outcomes Classification (NOC)
VSAB: NOC6

1. Dropped term type (TTY):
     MTH_ID

2. Dropped relationship | relationship attribute (RELA):
     SY|mth_has_expanded_form

3. Dropped attribute name (ATN):
     CITE
     MTH_REF


Discussion:

1. The source is no longer expanding abbreviations resulting in the deprecation of TTY = MTH_ID.

2. The SFO/LFO relationship is no longer needed due to the deprecation of TTY = MTH_ID.

3. ATN = CITE is deprecated because the information is no longer being provided.

4. Non-ascii characters (e.g., trademark sign) are no longer being substituted with ascii characters resulting in the deprecation of ATN = MTH_REF.
---------------------------------------

Source: National Uniform Claim Committee - Health Care Provider Taxonomy
VSAB: NUCCPT_18.1

New term type (TTY):
     MP


Discussion:

TTY = MP (Preferred names of modifiers).
---------------------------------------

Source: Perioperative Nursing Data Set
VSAB: PNDS_4_2018

1. New term type (TTY):
     XM

2. New relationship | relationship attribute (RELA) | RELA inverse:
     RQ|mapped_to

3. New attribute name (ATN):
     FROMRSAB
     FROMVSAB
     MAPSETRSAB
     MAPSETTYPE
     MAPSETVERSION
     MAPSETVSAB
     MTH_MAPFROMCOMPLEXITY
     MTH_MAPFROMEXHAUSTIVE
     MTH_MAPSETCOMPLEXITY
     MTH_MAPTOCOMPLEXITY
     MTH_MAPTOEXHAUSTIVE
     TORSAB
     TOVSAB

4. Dropped attribute name (ATN):
     INTERPRETIVE_STATEMEN
     RETIRED_CODE


Discussion:

1. TTY = XM (Cross mapping set).

2. The dropped attributes are due to changes in the representation of the data.

3. PNDS includes mappings to SNOMEDCT_US. These mappings are represented in MRREL.RRF as well as in MRMAP.RRF and MRSMAP.RRF.

4. PNDS also includes atoms which represent "Nursing Problems". The codes are prefixed with "NP" and the atoms are assigned the TTY = PT.
---------------------------------------

Source: RXNORM Vocabulary
VSAB: RXNORM_18AA_180904F

This version includes:
     ATC_2018_18_09_04 (Anatomical Therapeutic Chemical Classification System)
     CVX_2018_06_22_18_09_0 (Vaccines Administered)
     DRUGBANK5.0_2018_07_31 (DrugBank)
     GS_2018_08_01 (Gold Standard Drug Database)
     MMSL_2018_08_01 (Multum MediSource Lexicon)
     MMX_2018_07_31 (Micromedex RED BOOK)
     MTHCMSFRF_2014_18_09_04 (Metathesaurus CMS Formulary Reference File)
     MTHSPL_2018_08_24 (Metathesaurus FDA Structured Product Labels)
     NDDF_2018_08_08 (FDB MedKnowledge)
     NDFRT_2018_02_05_18_09_04 (National Drug File)
     NDFRT_FDASPL_2018_02_05_18_09_04 (National Drug File - FDASPL)
     NDFRT_FMTSME_2018_02_05_18_09_04 (National Drug File - FMTSME)
     USP_2018_08_27 (USP Compendial Nomenclature)
     VANDF_2018_08_01 (Veterans Health Administration National Drug File)

1. New subsource:
     USP_2018_08_27

2. New term type (TTY) | Source(s):
     IN|USP_2018_08_27
     CD|USP_2018_08_27

3. New relationship | relationship attribute (RELA) | RELA inverse | Source(s):
     RO|has_product_monograph_title|product_monograph_title_of|USP_2018_08_27

4. New attribute name (ATN) | Source(s):
     MONOGRAPH_OFFICIAL_DATE|USP_2018_08_27
     MONOGRAPH_STATUS|USP_2018_08_27
     RXN_BOSS_AI|RXNORM_18AA_180904F
     RXN_BOSS_AM|RXNORM_18AA_180904F
     RXN_BOSS_FROM|RXNORM_18AA_180904F
     RXN_BOSS_STRENGTH_DENOM_UNIT|RXNORM_18AA_180904F
     RXN_BOSS_STRENGTH_DENOM_VALUE|RXNORM_18AA_180904F
     RXN_BOSS_STRENGTH_NUM_UNIT|RXNORM_18AA_180904F
     RXN_BOSS_STRENGTH_NUM_VALUE|RXNORM_18AA_180904F


Discussion:

1. TTY = IN (Name for an ingredient).

2. TTY = CD (Clinical Drug).

3. Selected portions of MSH and SNOMEDCT_US are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes.
---------------------------------------------------------------------

Source: SNOMED Clinical Terms, Spanish Language Edition
VSAB: SCTSPA_2018_04_30

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_basic_dose_form|basic_dose_form_of
     RO|has_disposition|disposition_of
     RO|has_dose_form_administration_method|dose_form_administration_method_of
     RO|has_dose_form_intended_site|dose_form_intended_site_of
     RO|has_dose_form_release_characteristic|dose_form_release_characteristic_of
     RO|has_dose_form_transformation|dose_form_transformation_of
     RO|has_state_of_matter|state_of_matter_of
     RO|temporally_related_to|temporally_related_to
---------------------------------------------------------------------

Source: US Edition of SNOMED CT
VSAB: SNOMEDCT_US_2018_09_01

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_concentration_strength_denominator_unit|concentration_strength_denominator_unit_of
     RO|has_concentration_strength_denominator_value|concentration_strength_denominator_value_of
     RO|has_concentration_strength_numerator_unit|concentration_strength_numerator_unit_of
     RO|has_concentration_strength_numerator_value|concentration_strength_numerator_value_of
     RO|has_count_of_base_of_active_ingredient|count_of_base_of_active_ingredient_of
     RO|has_precise_active_ingredient|precise_active_ingredient_of
     RO|has_unit_of_presentation|unit_of_presentation_of
     RO|is_modification_of|has_modification
-----------------------------------------------

Source: Veterinary Extension to SNOMED CT
VSAB: SNOMEDCT_VET_2018_04_01

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_disposition|disposition_of

-----------------------------------------------