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Unified Medical Language System® (UMLS®)

New and Updated Sources (Expanded Representation Information) - 2019AA Release

General Information:

What's New to the Metathesaurus

For 2019AA, there are three new subsources (NCI_CPTAC, NCI_EDQM-HC, NCI_INC) and 106 updated sources (including translation sources and subsources).

NCI_CPTAC (Clinical Proteomic Tumor Analysis Consortium Terms) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome (proteins) and genome (DNA and RNA) analysis technologies to different cancer types. CPTAC is composed of expertise in proteomics, genomics, cancer biology, oncology, and clinical chemistry.

NCI_EDQM-HC (European Directorate for the Quality of Medicines & Healthcare) provides official standards for the manufacture and quality control of medicines in all the signatory states of the Convention on the Elaboration of a European Pharmacopoeia and beyond. The EDQM-HC proposes ethical, safety and quality standards for blood transfusions (collection, preparation, storage, distribution and appropriate use of blood components) and organ, tissue and cell transplantation. In addition, the EDQM-HC provides policies and model approaches for the safe use of medicines, including guidelines on pharmaceutical care.

NCI_INC (International Neonatal Consortium Terms) addresses the need for measurement and assessment of clinical outcomes in neonates. This work enhances the regulatory science for neonates by providing standardized terminology for adverse event reporting.

For detailed information about sources that are new or have had changes made (e.g. new term types, new attribute names, etc.):

LOINC, LNC265
MedlinePlus Health Topics, MEDLINEPLUS_20181108
NCI Thesaurus, NCI2018_12E
Physician Data Query, PDQ_2018_10_27
RXNORM Vocabulary, RXNORM_18AB_190304F
SNOMED Clinical Terms, Spanish Language Edition, SCTSPA_2018_10_31
US Edition of SNOMED CT, SNOMEDCT_US_2019_03_01
Veterinary Extension to SNOMED CT, SNOMEDCT_VET_2018_10_01


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What's New to the Metathesaurus:

Attribute Name (ATN):
     EXAMPLE_SI_UCUM_UNITS

Relationship Attribute (RELA) | RELA inverse:
     disease_excludes_metastatic_anatomic_site|is_not_metastatic_anatomic_site_of_disease
     has_inc_parent|inc_parent_of
     has_modification|is_modification_of
     has_precise_active_ingredient|precise_active_ingredient_of
     has_realization|realization_of
     has_unit_of_presentation|unit_of_presentation_of
     plays_role|role_played_by

------------------------------------------

Source: LOINC
VSAB: LNC265

1. New attribute name (ATN):
     EXAMPLE_SI_UCUM_UNITS
2. Dropped attribute name (ATN):
     STATUS_REASON

3. New class | Abbreviation
     Cardiology | CARD
     Duke Anxiety Depression Scale (DUKE-AD) set | PANEL.SURVEY.DUKE-AD
     Pain intensity, Enjoyment of life, General activity (PEG) set | PANEL.SURVEY.PEG
     Duke Anxiety Depression Scale (DUKE-AD) | SURVEY.DUKE-AD
     Pain intensity, Enjoyment of life, General activity (PEG) | SURVEY.PEG
------------------------------------------

Source: MedlinePlus Health Topics
VSAB: MEDLINEPLUS_20181108

New attribute name (ATN):
     SOS


Discussion:

ATN = SOS contains a short description of the page used for social sharing and external search engines.
---------------------------------------

Source: NCI Thesaurus
VSAB: NCI2018_12E

This version includes:
     NCI2018_BRIDG_1812E (Biomedical Research Integrated Domain Group Model)
     NCI2018_BioC_1812E (BioCarta online maps of molecular pathways, adapted for NCI use)
     NCI2018_CDC_1812E (U.S. Centers for Disease Control and Prevention)
     NCI2018_CDISC-GLOSS_1812E (CDISC Glossary Terminology)
     NCI2018_CDISC_1812E (Clinical Data Interchange Standards Consortium)
     NCI2018_CPTAC_1812E (Clinical Proteomic Tumor Analysis Consortium Terms)
     NCI2018_CRCH_1812E (Cancer Research Center of Hawaii Nutrition Terminology)
     NCI2018_CTCAE_1812E (Common Terminology Criteria for Adverse Events)
     NCI2018_CTCAE_3_1812E (Common Terminology Criteria for Adverse Events 3.0)
     NCI2018_CTCAE_5_1812E (Common Terminology Criteria for Adverse Events 5.0)
     NCI2018_CTEP-SDC_1812E (Cancer Therapy Evaluation Program - Simple Disease Classification)
     NCI2018_CTRP_1812E (Clinical Trials Reporting Program)
     NCI2018_CareLex_1812E (Content Archive Resource Exchange Lexicon)
     NCI2018_DCP_1812E (NCI Division of Cancer Prevention Program)
     NCI2018_DICOM_1812E (Digital Imaging Communications in Medicine)
     NCI2018_DTP_1812E (NCI Developmental Therapeutics Program)
     NCI2018_EDQM-HC_1812E (European Directorate for the Quality of Medicines and Healthcare)
     NCI2018_FDA_1812E (U.S. Food and Drug Administration)
     NCI2018_GAIA_1812E (Global Alignment of Immunization Safety Assessment in pregnancy)
     NCI2018_GENC_1812E (Geopolitical Entities, Names, and Codes (GENC) Standard Edition 1)
     NCI2018_ICH_1812E (International Conference on Harmonization)
     NCI2018_INC_1812E (International Neonatal Consortium)
     NCI2018_JAX_1812E (Jackson Laboratories Mouse Terminology, adapted for NCI use)
     NCI2018_KEGG_1812E (KEGG Pathway Database)
     NCI2018_NCI-GLOSS_1812E (NCI Dictionary of Cancer Terms)
     NCI2018_NCI-HGNC_1812E (NCI HUGO Gene Nomenclature)
     NCI2018_NCI-HL7_1812E (NCI Health Level 7)
     NCI2018_NCPDP_1812E (National Council for Prescription Drug Programs)
     NCI2018_NICHD_1812E (National Institute of Child Health and Human Development)
     NCI2018_PI-RADS_1812E (Prostate Imaging Reporting and Data System)
     NCI2018_PID_1812E (National Cancer Institute Nature Pathway Interaction Database)
     NCI2018_RENI_1812E (Registry Nomenclature Information System)
     NCI2018_UCUM_1812E (Unified Code for Units of Measure)
     NCI2018_ZFin_1812E (Zebrafish Model Organism Database)


1. New subsources:
     NCI_CPTAC_1812E
     NCI_EDQM-HC_1812E
     NCI_INC_1812E

2. New term type (TTY) | Source(s):
     AB | NCI_CPTAC_1812E
     PT | NCI_CPTAC_1812E, NCI_EDQM-HC_1812E, NCI_INC_1812E
     SY | NCI_CPTAC_1812E, NCI_BRIDG_1812E, NCI_EDQM-HC_1812E

3. New relationship | relationship attribute (RELA) | RELA inverse | Source (s)
     RB|mapped_to|mapped_from|NCI2018_12E
     RN|mapped_to|mapped_from|NCI2018_12E
     RO|disease_excludes_metastatic_anatomic_site|is_not_metastatic_anatomic_site_of_disease||NCI2018_12E
     RO|has_inc_parent|inc_parent_of|NCI2018_12E
     RO|mapped_to|mapped_from|NCI2018_12E
     SY|mapped_to|mapped_from|NCI2018_12E


Discussion:

New mapping relationships to ICD9CM, ICD10CM and various versions of MDR.
-----------------------------------------------

Source: Physician Data Query
VSAB: PDQ_2018_10_27

1. New term type (TTY):
     BN

2. Dropped term types (TTY):      BD
     MTH_AB
     MTH_ACR
     MTH_BD
     MTH_CHN
     MTH_LV
     MTH_SY

3. New relationship | relationship attribute (RELA) | RELA inverse:
     RQ|mapped_to|mapped_from

4. Dropped relationship attribute (RELA):
     SY|plain_text_form_of


Discussion:

US brand drug names are represented by TTY = BN rather than TTY = BD because they are non-prescribable.
-----------------------------------------------

Source: RXNORM Vocabulary
VSAB: RXNORM_18AB_190304F

This version includes:
      ATC_2019 (Anatomical Therapeutic Chemical Classification System)
     CVX_2018_10_18_19_03_04 (Vaccines Administered)
     DRUGBANK5.0_2019_01_31 (DrugBank)
     GS_2019_02_05 (Gold Standard Drug Database)
     MMSL_2019_02_01 (Multum MediSource Lexicon)
     MMX_2019_02_04 (Micromedex RED BOOK)
     MTHCMSFRF_2014_19_03_04 (Metathesaurus CMS Formulary Reference File)
     MTHSPL_2019_02_22 (Metathesaurus FDA Structured Product Labels)
     NDDF_2019_01_30 (FDB MedKnowledge)
     USP_2018_12_10_19_03_04 (USP Compendial Nomenclature)
     VANDF_2019_02_01 (Veterans Health Administration National Drug File)


1. Dropped subsources:
     NDFRT (National Drug File)
     NDFRT_FDASPL (National Drug File - FDASPL)
     NDFRT_FMTSME (National Drug File - FMTSME)

2. Dropped term type (TTY) | Source(s):
     AB|NDFRT_2018_02_05_18_09_04
     FN|NDFRT_2018_02_05_18_09_04
     HT|NDFRT_2018_02_05_18_09_04
     PT|NDFRT_2018_02_05_18_09_04
     SY|NDFRT_2018_02_05_18_09_04

3. Dropped relationship | relationship attribute (RELA) | Source(s):
     RO|active_metabolites_of|has_active_metabolites|NDFRT_2018_02_05_18_09_04
     RO|chemical_structure_of|has_chemical_structure|NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
     RO|contraindicated_with_disease|has_contraindicated_drug|NDFRT_2018_02_05_18_09_04
     RO|contraindicating_class_of|has_contraindicating_class|NDFRT_2018_02_05_18_09_04
     RO|contraindicating_mechanism_of_action_of|has_contraindicating_mechanism_of_action|NDFRT_2018_02_05_18_09_04
     RO|contraindicating_physiologic_effect_of|has_contraindicating_physiologic_effect|NDFRT_2018_02_05_18_09_04
     RO|effect_may_be_inhibited_by|may_inhibit_effect_of|NDFRT_2018_02_05_18_09_04
     RO|has_mechanism_of_action|mechanism_of_action_of|
     RO|has_pharmacokinetics|pharmacokinetics_of|NDFRT_2018_02_05_18_09_04, NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
     RO|has_physiologic_effect|physiologic_effect_of|NDFRT_2018_02_05_18_09_04, NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
     RO|has_product_component|product_component_of|NDFRT_2018_02_05_18_09_04
     RO|has_therapeutic_class|therapeutic_class_of|NDFRT_FMTSME_2018_02_05
     RO|induced_by|induces|NDFRT_2018_02_05_18_09_04
     RO|site_of_metabolism|metabolic_site_of|NDFRT_2018_02_05_18_09_04
     RO|may_be_diagnosed_by|may_diagnose|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05
     RO|may_be_prevented_by|may_prevent|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05
     RO|may_be_treated_by|may_treat|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05

4. Dropped Attributes (ATN) | Source(s):
     EXPORT_ONLY|MTHSPL_2018_08_24
     IND|MTHSPL_2018_08_24
     LEVEL|NDFRT_2018_02_05_18_09_04
     MESH_DEFINITION|NDFRT_2018_02_05_18_09_04
     MESH_DUI|NDFRT_2018_02_05_18_09_04
     MESH_NAME|NDFRT_2018_02_05_18_09_04
     MESH_UI|NDFRT_2018_02_05_18_09_04
     NDFRT_KIND|NDFRT_2018_02_05_18_09_04
     NDF_UNITS|NDFRT_2018_02_05_18_09_04
     NUI|NDFRT_2018_02_05_18_09_04
     SNOMED_CHILD|NDFRT_2018_02_05_18_09_04
     SNOMED_CID|NDFRT_2018_02_05_18_09_04
     SNOMED_PARENT|NDFRT_2018_02_05_18_09_04
     STRENGTH|NDFRT_2018_02_05_18_09_04
     VANDF_RECORD|NDFRT_2018_02_05_18_09_04
     VA_IEN|NDFRT_2018_02_05_18_09_04
     VUID|NDFRT_2018_02_05_18_09_04


Discussion:

NDFRT is superseded by MED-RT and is no longer being updated. The final version of NDFRT (2018_02_05_18_12_03) is included in 2019AA for transition purposes, however, NDFRT is no longer included in RXNORM. Going forward, NDFRT will not be released in the UMLS.
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Source: SNOMED Clinical Terms, Spanish Language Edition
VSAB: SCTSPA_2018_10_31

New relationship | relationship attribute (RELA) | RELA inverse:      RO|has_concentration_strength_denominator_unit|concentration_strength_denominator_unit_of|
     RO|concentration_strength_denominator_value_of|has_concentration_strength_denominator_value|
     RO|concentration_strength_numerator_unit_of|has_concentration_strength_numerator_unit|
     RO|concentration_strength_numerator_value_of|has_concentration_strength_numerator_value|
     RO|has_count_of_base_of_active_ingredient|count_of_base_of_active_ingredient_of|
     RO|has_precise_active_ingredient|precise_active_ingredient_of|
     RO|unit_of_presentation_of|rela_inverse|has_unit_of_presentation|
     RO|is_modification_of|rela_inverse|has_modification|
---------------------------------------------------------------------

Source: US Edition of SNOMED CT
VSAB: SNOMEDCT_US_2019_03_01 

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_realization|realization_of
     RO|plays_role|role_played_by
-----------------------------------------------

Source: Veterinary Extension to SNOMED CT
VSAB: SNOMEDCT_VET_2018_10_01

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|is_modification_of|has_modification
-----------------------------------------------

Last Reviewed: May 3, 2019