New and Updated Sources (Expanded Representation Information) - 2019AA Release
General Information:
What's New to the Metathesaurus
For 2019AA, there are three new subsources (NCI_CPTAC, NCI_EDQM-HC, NCI_INC) and 106 updated sources (including translation sources and subsources).
NCI_CPTAC (Clinical Proteomic Tumor Analysis Consortium Terms)
is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome (proteins) and genome (DNA and RNA) analysis technologies to different cancer types. CPTAC is composed of expertise in proteomics, genomics, cancer biology, oncology, and clinical chemistry.
NCI_EDQM-HC (European Directorate for the Quality of Medicines & Healthcare) provides official standards for the manufacture and quality control of medicines in all the signatory states of the Convention on the Elaboration of a European Pharmacopoeia and beyond. The EDQM-HC proposes ethical, safety and quality standards for blood transfusions (collection, preparation, storage, distribution and appropriate use of blood components) and organ, tissue and cell transplantation. In addition, the EDQM-HC provides policies and model approaches for the safe use of medicines, including guidelines on pharmaceutical care.
NCI_INC (International Neonatal Consortium Terms) addresses the need for measurement and assessment of clinical outcomes in neonates. This work enhances the regulatory science for neonates by providing standardized terminology for adverse event reporting.
For detailed information about sources that are new or have had changes made (e.g. new term types, new attribute names, etc.):
LOINC, LNC265
MedlinePlus Health Topics, MEDLINEPLUS_20181108
NCI Thesaurus, NCI2018_12E
Physician Data Query, PDQ_2018_10_27
RXNORM Vocabulary, RXNORM_18AB_190304F
SNOMED Clinical Terms, Spanish Language Edition, SCTSPA_2018_10_31
US Edition of SNOMED CT, SNOMEDCT_US_2019_03_01
Veterinary Extension to SNOMED CT, SNOMEDCT_VET_2018_10_01
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What's New to the Metathesaurus:
Attribute Name (ATN):
EXAMPLE_SI_UCUM_UNITS
Relationship Attribute (RELA) | RELA inverse:
disease_excludes_metastatic_anatomic_site|is_not_metastatic_anatomic_site_of_disease
has_inc_parent|inc_parent_of
has_modification|is_modification_of
has_precise_active_ingredient|precise_active_ingredient_of
has_realization|realization_of
has_unit_of_presentation|unit_of_presentation_of
plays_role|role_played_by
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Source: LOINC
VSAB: LNC265
1. New attribute name (ATN):
EXAMPLE_SI_UCUM_UNITS
2. Dropped attribute name (ATN):
STATUS_REASON
3. New class | Abbreviation
Cardiology | CARD
Duke Anxiety Depression Scale (DUKE-AD) set | PANEL.SURVEY.DUKE-AD
Pain intensity, Enjoyment of life, General activity (PEG) set | PANEL.SURVEY.PEG
Duke Anxiety Depression Scale (DUKE-AD) | SURVEY.DUKE-AD
Pain intensity, Enjoyment of life, General activity (PEG) | SURVEY.PEG
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Source: MedlinePlus Health Topics
VSAB: MEDLINEPLUS_20181108
New attribute name (ATN):
SOS
Discussion:
ATN = SOS contains a short description of the page used for social sharing and external search engines.
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Source: NCI Thesaurus
VSAB: NCI2018_12E
This version includes:
NCI2018_BRIDG_1812E (Biomedical Research Integrated Domain Group Model)
NCI2018_BioC_1812E (BioCarta online maps of molecular pathways, adapted for NCI use)
NCI2018_CDC_1812E (U.S. Centers for Disease Control and Prevention)
NCI2018_CDISC-GLOSS_1812E (CDISC Glossary Terminology)
NCI2018_CDISC_1812E (Clinical Data Interchange Standards Consortium)
NCI2018_CPTAC_1812E (Clinical Proteomic Tumor Analysis Consortium Terms)
NCI2018_CRCH_1812E (Cancer Research Center of Hawaii Nutrition Terminology)
NCI2018_CTCAE_1812E (Common Terminology Criteria for Adverse Events)
NCI2018_CTCAE_3_1812E (Common Terminology Criteria for Adverse Events 3.0)
NCI2018_CTCAE_5_1812E (Common Terminology Criteria for Adverse Events 5.0)
NCI2018_CTEP-SDC_1812E (Cancer Therapy Evaluation Program - Simple Disease Classification)
NCI2018_CTRP_1812E (Clinical Trials Reporting Program)
NCI2018_CareLex_1812E (Content Archive Resource Exchange Lexicon)
NCI2018_DCP_1812E (NCI Division of Cancer Prevention Program)
NCI2018_DICOM_1812E (Digital Imaging Communications in Medicine)
NCI2018_DTP_1812E (NCI Developmental Therapeutics Program)
NCI2018_EDQM-HC_1812E (European Directorate for the Quality of Medicines and Healthcare)
NCI2018_FDA_1812E (U.S. Food and Drug Administration)
NCI2018_GAIA_1812E (Global Alignment of Immunization Safety Assessment in pregnancy)
NCI2018_GENC_1812E (Geopolitical Entities, Names, and Codes (GENC) Standard Edition 1)
NCI2018_ICH_1812E (International Conference on Harmonization)
NCI2018_INC_1812E (International Neonatal Consortium)
NCI2018_JAX_1812E (Jackson Laboratories Mouse Terminology, adapted for NCI use)
NCI2018_KEGG_1812E (KEGG Pathway Database)
NCI2018_NCI-GLOSS_1812E (NCI Dictionary of Cancer Terms)
NCI2018_NCI-HGNC_1812E (NCI HUGO Gene Nomenclature)
NCI2018_NCI-HL7_1812E (NCI Health Level 7)
NCI2018_NCPDP_1812E (National Council for Prescription Drug Programs)
NCI2018_NICHD_1812E (National Institute of Child Health and Human Development)
NCI2018_PI-RADS_1812E (Prostate Imaging Reporting and Data System)
NCI2018_PID_1812E (National Cancer Institute Nature Pathway Interaction Database)
NCI2018_RENI_1812E (Registry Nomenclature Information System)
NCI2018_UCUM_1812E (Unified Code for Units of Measure)
NCI2018_ZFin_1812E (Zebrafish Model Organism Database)
1. New subsources:
NCI_CPTAC_1812E
NCI_EDQM-HC_1812E
NCI_INC_1812E
2. New term type (TTY) | Source(s):
AB | NCI_CPTAC_1812E
PT | NCI_CPTAC_1812E, NCI_EDQM-HC_1812E, NCI_INC_1812E
SY | NCI_CPTAC_1812E, NCI_BRIDG_1812E, NCI_EDQM-HC_1812E
3. New relationship | relationship attribute (RELA) | RELA inverse | Source (s)
RB|mapped_to|mapped_from|NCI2018_12E
RN|mapped_to|mapped_from|NCI2018_12E
RO|disease_excludes_metastatic_anatomic_site|is_not_metastatic_anatomic_site_of_disease||NCI2018_12E
RO|has_inc_parent|inc_parent_of|NCI2018_12E
RO|mapped_to|mapped_from|NCI2018_12E
SY|mapped_to|mapped_from|NCI2018_12E
Discussion:
New mapping relationships to ICD9CM, ICD10CM and various versions of MDR.
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Source: Physician Data Query
VSAB: PDQ_2018_10_27
1. New term type (TTY):
BN
2. Dropped term types (TTY): BD
MTH_AB
MTH_ACR
MTH_BD
MTH_CHN
MTH_LV
MTH_SY
3. New relationship | relationship attribute (RELA) | RELA inverse:
RQ|mapped_to|mapped_from
4. Dropped relationship attribute (RELA):
SY|plain_text_form_of
Discussion:
US brand drug names are represented by TTY = BN rather than TTY = BD because they are non-prescribable.
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Source: RXNORM Vocabulary
VSAB: RXNORM_18AB_190304F
This version includes:
ATC_2019 (Anatomical Therapeutic Chemical Classification System)
CVX_2018_10_18_19_03_04 (Vaccines Administered)
DRUGBANK5.0_2019_01_31 (DrugBank)
GS_2019_02_05 (Gold Standard Drug Database)
MMSL_2019_02_01 (Multum MediSource Lexicon)
MMX_2019_02_04 (Micromedex RED BOOK)
MTHCMSFRF_2014_19_03_04 (Metathesaurus CMS Formulary Reference File)
MTHSPL_2019_02_22 (Metathesaurus FDA Structured Product Labels)
NDDF_2019_01_30 (FDB MedKnowledge)
USP_2018_12_10_19_03_04 (USP Compendial Nomenclature)
VANDF_2019_02_01 (Veterans Health Administration National Drug File)
1. Dropped subsources:
NDFRT (National Drug File)
NDFRT_FDASPL (National Drug File - FDASPL)
NDFRT_FMTSME (National Drug File - FMTSME)
2. Dropped term type (TTY) | Source(s):
AB|NDFRT_2018_02_05_18_09_04
FN|NDFRT_2018_02_05_18_09_04
HT|NDFRT_2018_02_05_18_09_04
PT|NDFRT_2018_02_05_18_09_04
SY|NDFRT_2018_02_05_18_09_04
3. Dropped relationship | relationship attribute (RELA) | Source(s):
RO|active_metabolites_of|has_active_metabolites|NDFRT_2018_02_05_18_09_04
RO|chemical_structure_of|has_chemical_structure|NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
RO|contraindicated_with_disease|has_contraindicated_drug|NDFRT_2018_02_05_18_09_04
RO|contraindicating_class_of|has_contraindicating_class|NDFRT_2018_02_05_18_09_04
RO|contraindicating_mechanism_of_action_of|has_contraindicating_mechanism_of_action|NDFRT_2018_02_05_18_09_04
RO|contraindicating_physiologic_effect_of|has_contraindicating_physiologic_effect|NDFRT_2018_02_05_18_09_04
RO|effect_may_be_inhibited_by|may_inhibit_effect_of|NDFRT_2018_02_05_18_09_04
RO|has_mechanism_of_action|mechanism_of_action_of|
RO|has_pharmacokinetics|pharmacokinetics_of|NDFRT_2018_02_05_18_09_04, NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
RO|has_physiologic_effect|physiologic_effect_of|NDFRT_2018_02_05_18_09_04, NDFRT_FDASPL_2018_02_05, NDFRT_FMTSME_2018_02_05
RO|has_product_component|product_component_of|NDFRT_2018_02_05_18_09_04
RO|has_therapeutic_class|therapeutic_class_of|NDFRT_FMTSME_2018_02_05
RO|induced_by|induces|NDFRT_2018_02_05_18_09_04
RO|site_of_metabolism|metabolic_site_of|NDFRT_2018_02_05_18_09_04
RO|may_be_diagnosed_by|may_diagnose|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05
RO|may_be_prevented_by|may_prevent|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05
RO|may_be_treated_by|may_treat|NDFRT_2018_02_05_18_09_04, NDFRT_FMTSME_2018_02_05
4. Dropped Attributes (ATN) | Source(s):
EXPORT_ONLY|MTHSPL_2018_08_24
IND|MTHSPL_2018_08_24
LEVEL|NDFRT_2018_02_05_18_09_04
MESH_DEFINITION|NDFRT_2018_02_05_18_09_04
MESH_DUI|NDFRT_2018_02_05_18_09_04
MESH_NAME|NDFRT_2018_02_05_18_09_04
MESH_UI|NDFRT_2018_02_05_18_09_04
NDFRT_KIND|NDFRT_2018_02_05_18_09_04
NDF_UNITS|NDFRT_2018_02_05_18_09_04
NUI|NDFRT_2018_02_05_18_09_04
SNOMED_CHILD|NDFRT_2018_02_05_18_09_04
SNOMED_CID|NDFRT_2018_02_05_18_09_04
SNOMED_PARENT|NDFRT_2018_02_05_18_09_04
STRENGTH|NDFRT_2018_02_05_18_09_04
VANDF_RECORD|NDFRT_2018_02_05_18_09_04
VA_IEN|NDFRT_2018_02_05_18_09_04
VUID|NDFRT_2018_02_05_18_09_04
Discussion:
NDFRT is superseded by MED-RT and is no longer being updated. The final version of NDFRT (2018_02_05_18_12_03) is included in 2019AA for transition purposes, however, NDFRT is no longer included in RXNORM. Going forward, NDFRT will not be released in the UMLS.
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Source: SNOMED Clinical Terms, Spanish Language Edition
VSAB: SCTSPA_2018_10_31
New relationship | relationship attribute (RELA) | RELA inverse: RO|has_concentration_strength_denominator_unit|concentration_strength_denominator_unit_of|
RO|concentration_strength_denominator_value_of|has_concentration_strength_denominator_value|
RO|concentration_strength_numerator_unit_of|has_concentration_strength_numerator_unit|
RO|concentration_strength_numerator_value_of|has_concentration_strength_numerator_value|
RO|has_count_of_base_of_active_ingredient|count_of_base_of_active_ingredient_of|
RO|has_precise_active_ingredient|precise_active_ingredient_of|
RO|unit_of_presentation_of|rela_inverse|has_unit_of_presentation|
RO|is_modification_of|rela_inverse|has_modification|
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Source: US Edition of SNOMED CT
VSAB: SNOMEDCT_US_2019_03_01
New relationship | relationship attribute (RELA) | RELA inverse:
RO|has_realization|realization_of
RO|plays_role|role_played_by
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Source: Veterinary Extension to SNOMED CT
VSAB: SNOMEDCT_VET_2018_10_01
New relationship | relationship attribute (RELA) | RELA inverse:
RO|is_modification_of|has_modification
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Last Reviewed: May 3, 2019