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Unified Medical Language System® (UMLS®)

New and Updated Sources (Expanded Representation Information) - 2016AB Release

General Information:

What's New to the Metathesaurus

For 2016AB, there are 3 new sources (DRUGBANK, DSM-5, NUCCPT), 1 new subsource (NCI-GENC), and 85 updated sources (including translation sources and subsources).

DRUGBANK (Drug & Drug Target Database) is a bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The UMLS includes an ingredients subset of DRUGBANK.

DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), is the standard classification of mental disorders used by mental health professionals in the United States and contains a listing of diagnostic criteria for every psychiatric disorder recognized by the U.S. healthcare system. DSM is used in both clinical settings (inpatient, outpatient, partial hospital, consultation-liaison, clinic, private practice, and primary care) as well as with community populations. In addition to supplying detailed descriptions of diagnostic criteria, DSM is also a necessary tool for collecting and communicating accurate public health statistics about the diagnosis of psychiatric disorders.

NUCCPT (National Uniform Claim Committee - Health Care Provider Taxonomy) is a standardized data set for use by the non-institutional health care community to transmit claim and encounter information to and from all third-party payers.

NCI-GENC (Geopolitical Entities, Names, and Codes (GENC) Standard Edition 1) specifies a profile of ISO 3166 Codes for the representation of names of countries and their subdivisions. This profile addresses unique U.S. Government requirements for: restrictions in recognition of the national sovereignty of a country; identification and recognition of geopolitical entities not included in ISO 3166; and use of names of countries and country subdivisions that have been approved by the U.S. Board on Geographic Names (BGN).The GENC Ed1.0 is the US Government implementation of ISO 3166-1 that conforms to BGN and US Government recognition policy.

For detailed information about sources that are new or have had changes made (e.g. new term types, new attribute names, etc.):

Vaccines Administered, CVX2016_09_07
DrugBank, DRUGBANK5.0_2016_06_22
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), DSM-5_2015
Foundational Model of Anatomy Ontology, FMA4_0
Gene Ontology, GO2016_05_01
HUGO Gene Nomenclature Committee, HGNC2016_04
International Classification of Diseases, 10th Edition, Clinical Modification, ICD10CM_2017
ICD-10-PCS, ICD10PCS_2017
LOINC, LNC256
MEDCIN, MEDCIN3_2016_07_21
Medical Subject Headings, MSH2017_2016_08_12
NCI Thesaurus, NCI2016_02D
National Uniform Claim Committee - Health Care Provider Taxonomy, NUCCPT_16.1
RXNORM Vocabulary, RXNORM_16AA_160906F
US Edition of SNOMED CT, SNOMEDCT_US_2016_09_01


------------------------------------------

What's New to the Metathesaurus:

Term Type (TTY):
     DC10
     DC9

Attribute Name (ATN):
     ASK_AT_ORDER_ENTRY
     AUTHORITY
     CMA_LABEL
     CYTOGENETIC_LOCATION
     DAYS_POST_FERTILIZATION
     ENA
     EPONYM
     GENE_FAM_ID
     GESTATION_AGE_WEEKS
     HAS_DIMENSION
     HAS_DIRECT_CELL_LAYER
     HAS_DIRECT_PLOIDY
     HAS_DIRECT_SHAPE_TYPE
     HAS_INHERENT_3D_SHAPE
     JHU_DTI-81
     JHU_WHITE_MATTER_TRACTOGRAPHY_ATLAS
     OUTDATED_MEANING
     PART_TYPE
     PHYSICAL_STATE
     REFERENCE
     RGD_ID
     RXN_QUALITATIVE_DISTINCTION
     SPECIES
     TA_ID
     TERM_STATUS
     UNIVERSAL_LAB_ORDERS_VALUE_SET

Relationship Attribute (RELA) | RELA inverse:
     anatomical_entity_observed_in|has_observed_anatomical_entity
     anterior_to|posterior_to
     connected_to|connected_to
     continuous_distally_with|continuous_proximally_with
     continuous_proximally_with|continuous_distally_with
     derives|derives_from
     derives_from|derives
     developmental_stage_of|has_developmental_stage
     direct_anterior_to|direct_posterior_to
     direct_anteroinferior_to|direct_posterosuperior_to
     direct_anterolateral_to|direct_posteromedial_to
     direct_anteromedial_to|direct_posterolateral_to
     direct_anterosuperior_to|direct_posteroinferior_to
     direct_continuous_with|direct_continuous_with
     direct_distal_to|direct_proximal_to
     direct_inferior_to|direct_superior_to
     direct_inferolateral_to|direct_superomedial_to
     direct_inferomedial_to|direct_superolateral_to
     direct_lateral_to|direct_medial_to
     direct_left_of|direct_right_of
     direct_medial_to|direct_lateral_to
     direct_posterior_to|direct_anterior_to
     direct_posteroinferior_to|direct_anterosuperior_to
     direct_posterolateral_to|direct_anteromedial_to
     direct_posteromedial_to|direct_anterolateral_to
     direct_posterosuperior_to|direct_anteroinferior_to
     direct_proximal_to|direct_distal_to
     direct_right_of|direct_left_of
     direct_superior_to|direct_inferior_to
     direct_superolateral_to|direct_inferomedial_to
     direct_superomedial_to|direct_inferolateral_to
     distal_to|proximal_to
     drains_into|receives_drainage_from
     ends_during|inverse_ends_during
     internal_to|external_to
     forms|formed_by
     fuses_with|fuses_with
     fusion_of|has_fusion
     has_connection_type|connection_type_of
     has_development_type|development_type_of
     has_developmental_stage|developmental_stage_of
     has_diagnostic_criteria|diagnostic_criteria_of
     has_direct_cell_shape|direct_cell_shape_of
     has_direct_constitutional_part|direct_constitution_part_of
     has_direct_part|direct_part_of
     has_direct_regional_part|direct_regional_part_of
     has_full_grown_phenotype|full_grown_phenotype_of
     has_insertion|insertion_of
     has_projection|receives_projection
     has_related_developmental_entity|related_developmental_entity_of
     homonym_for|homonym_of
     homonym_of|homonym_for
     inferior_to|superior_to
     insertion_of|has_insertion
     lateral_to|medial_to
     left_lateral_to|right_medial_to
     left_medial_to|right_lateral_to
     medial_to|lateral_to
     merges_with|merges_with
     posterior_to|anterior_to
     projects_from|projects_to
     projects_to|projects_from
     proximal_to|distal_to
     receives_drainage_from|drains_into
     receives_projection|has_projection
     related_object|related_object
     right_lateral_to|left_medial_to
     right_medial_to|left_lateral_to
     superior_to|inferior_to
     transforms_from|transforms_into
     transforms_into|transforms_from

------------------------------------------

Source: Vaccines Administered
VSAB: CVX2016_09_07


Discussion:

There is a new vaccine status of "Non-US." Entries with this value are assigned TTY = PT or TTY = AB.

------------------------------------------

Source: DrugBank
VSAB: DRUGBANK5.0_2016_06_22

1. New term type (TTY) | Suppressible value:
     IN|N
     SY|N

2. New attribute name (ATN):
     FDA_UNII_CODE
     SID


Discussion:

1. New source.

2. TTY = IN represents the ingredient(s).

3. ATN = SID represents the secondary accession number.

------------------------------------------

Source: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
VSAB: DSM-5_2015

1. New term type (TTY) | Suppressible value:
     DC10|N
     DC9|N

2. New relationship | relationship attribute (RELA) | RELA inverse:
     RQ|has_diagnostic_criteria|diagnostic_criteria_of


Discussion:

This source has not been updated since DSM4_1994 so it is being considered a new source.

------------------------------------------

Source: Foundational Model of Anatomy Ontology
VSAB: FMA4_0

1. New term type (TTY) | Suppressible value:
     AB|Y

2. Dropped term type (TTY):
     IS

3. New relationship | relationship attribute (RELA) | RELA inverse:
     RO|anatomical_entity_observed_in|has_observed_anatomical_entity
     RO|anterior_to|posterior_to
     RO|connected_to|connected_to
     RO|continuous_distally_with|continuous_proximally_with
     RO|continuous_proximally_with|continuous_distally_with
     RO|derives|derives_from
     RO|derives_from|derives
     RO|developmental_stage_of|has_developmental_stage
     RO|direct_anterior_to|direct_posterior_to
     RO|direct_anteroinferior_to|direct_posterosuperior_to
     RO|direct_anterolateral_to|direct_posteromedial_to
     RO|direct_anteromedial_to|direct_posterolateral_to
     RO|direct_anterosuperior_to|direct_posteroinferior_to
     RO|direct_continuous_with|direct_continuous_with
     RO|direct_distal_to|direct_proximal_to
     RO|direct_inferior_to|direct_superior_to
     RO|direct_inferolateral_to|direct_superomedial_to
     RO|direct_inferomedial_to|direct_superolateral_to
     RO|direct_lateral_to|direct_medial_to
     RO|direct_left_of|direct_right_of
     RO|direct_medial_to|direct_lateral_to
     RO|direct_posterior_to|direct_anterior_to
     RO|direct_posteroinferior_to|direct_anterosuperior_to
     RO|direct_posterolateral_to|direct_anteromedial_to
     RO|direct_posteromedial_to|direct_anterolateral_to
     RO|direct_posterosuperior_to|direct_anteroinferior_to
     RO|direct_proximal_to|direct_distal_to
     RO|direct_right_of|direct_left_of
     RO|direct_superior_to|direct_inferior_to
     RO|direct_superolateral_to|direct_inferomedial_to
     RO|direct_superomedial_to|direct_inferolateral_to
     RO|distal_to|proximal_to
     RO|drains_into|receives_drainage_from
     RO|external_to|internal_to
     RO|forms|formed_by
     RO|fuses_with|fuses_with
     RO|fusion_of|has_fusion
     RO|has_connection_type|connection_type_of
     RO|has_development_type|development_type_of
     RO|has_developmental_stage|developmental_stage_of
     RO|has_direct_cell_shape|direct_cell_shape_of
     RO|has_direct_constitutional_part|direct_constitution_part_of
     RO|has_direct_part|direct_part_of
     RO|has_direct_regional_part|direct_regional_part_of
     RO|has_full_grown_phenotype|full_grown_phenotype_of
     RO|has_insertion|insertion_of
     RO|has_origin|origin_of
     RO|has_projection|receives_projection
     RO|has_related_developmental_entity|related_developmental_entity_of
     RO|homonym_for|homonym_of
     RO|homonym_of|homonym_for
     RO|inferior_to|superior_to
     RO|insertion_of|has_insertion
     RO|lateral_to|medial_to
     RO|left_lateral_to|right_medial_to
     RO|left_medial_to|right_lateral_to
     RO|medial_to|lateral_to
     RO|member_of|has_member
     RO|merges_with|merges_with
     RO|muscle_origin_of|has_muscle_origin
     RO|posterior_to|anterior_to
     RO|projects_from|projects_to
     RO|projects_to|projects_from
     RO|proximal_to|distal_to
     RO|receives_attachment_from|attaches_to
     RO|receives_drainage_from|drains_into
     RO|receives_projection|has_projection
     RO|related_object|related_object
     RO|right_lateral_to|left_medial_to
     RO|right_medial_to|left_lateral_to
     RO|superior_to|inferior_to
     RO|transforms_from|transforms_into
     RO|transforms_into|transforms_from
     SY|has_expanded_form|expanded_form_of

4. Dropped relationship | relationship attribute (RELA):
     RO|attributed_continuous_with
     RO|continuous_with_distally
     RO|continuous_with_proximally
     RO|has_attributed_constitutional_part
     RO|has_attributed_part
     RO|has_attributed_regional_part
     RO|has_cell_connecting_part
     RO|has_cell_shape
     RO|has_cell_surface_specialization
     RO|has_eipthelial_cell_shape
     RO|has_fascicular_architecture
     RO|has_muscle_attachment
     RO|has_orientation
     RO|has_physical_state
     RO|has_segmental_composition
     RO|has_segmental_supply
     RO|has_shape
     RO|has_systemic_part
     RO|member_of_cluster
     RO|receives_attachment
     RO|systemic_part_of

5. New attribute name (ATN):
     AUTHORITY
     CMA_LABEL
     COMMENT
     DATE_LAST_MODIFIED
     DAYS_POST_FERTILIZATION
     EPONYM
     GESTATION_AGE_WEEKS
     HAS_DIMENSION
     HAS_DIRECT_CELL_LAYER
     HAS_DIRECT_PLOIDY
     HAS_DIRECT_SHAPE_TYPE
     HAS_INHERENT_3D_SHAPE
     JHU_DTI-81
     JHU_WHITE_MATTER_TRACTOGRAPHY_ATLAS
     OUTDATED_MEANING
     PART_TYPE
     PHYSICAL_STATE
     REFERENCE
     SPECIES
     TALAIRACH_TERM
     TA_ID
     TERM_STATUS
     TRANSLATION

6. Dropped attribute name (ATN):
     ADJACENT
     ANATOMICAL_OR_ARBITRARY
     CELL_LAYER
     CONNECTED_TO
     CONNECTION_TYPE
     CONTACT_TYPE
     MUSCLE_INSERTION
     MUSCLE_ORIGIN
     SHAPE_TYPE
     SHARED_OR_UNSHARED
     TALAIRACH
     TALAIRACH_ID


Discussion:

1. Abbreviations provided by FMA have been assigned the TTY = AB.

2. "Other English equivalents" are assigned TTY = SY.

3. Latin language entries are assigned TTY = SY with an associated ATN = LANGUAGE.

4. RELA = 'continuous_distally_with'and its inverse 'continuous_proximally_with' was formerly 'continuous_with_distally' and 'continuous_with_proximally'.

------------------------------------------

Source: Gene Ontology
VSAB: GO2016_05_01

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|ends_during|inverse_ends_during

------------------------------------------

Source: HUGO Gene Nomenclature Committee
VSAB: HGNC2016_04

1. New attribute name (ATN):
     CYTOGENETIC_LOCATION
     ENA
     GENE_FAM_ID
     RGD_ID

2. Dropped attribute name (ATN):
     ACCESSION_NO
     CHROMOSOME
     DB_XR
     GENE_FAM
     MAPPED_ENSEMBLGENE_ID
     MAPPED_ENTREZGENE_ID
     MAPPED_MGD_ID
     MAPPED_REFSEQ_ID
     MAPPED_RGD_ID
     RECORD_TYPE


Discussion:

1. ATN = ENA represents the International Nucleotide Sequence Database Collaboration accession number(s).

2. ATN = RGD_ID represents the Rat genome database gene ID.

------------------------------------------

Source: International Classification of Diseases, 10th Edition, Clinical Modification
VSAB: ICD10CM_2017

Dropped attribute name (ATN):
     ALT_SORT_CODE
     NOTE

------------------------------------------

Source: ICD-10-PCS
VSAB: ICD10PCS_2017

New attribute name (ATN):
     MAPSETTYPE

------------------------------------------

Source: LOINC
VSAB: LNC256

1. New attribute name (ATN):
     ASK_AT_ORDER_ENTRY
     UNIVERSAL_LAB_ORDERS_VALUE_SET

2. Dropped attribute name (ATN):
     TOP_300_COMMON_LAB_ORDERS_US


Discussion:

ATN = TOP_300_COMMON_LAB_ORDERS_US has been replaced by ATN = UNIVERSAL_LAB_ORDERS_VALUE_SET.

------------------------------------------

Source: MEDCIN
VSAB: MEDCIN3_2016_07_21

New relationship | relationship attribute (RELA) | RELA inverse:
     RO|has_procedure_context|procedure_context_of
     RO|has_temporal_context|temporal_context_of


Discussion:

New SNOMEDCT_US relationships added.

------------------------------------------

Source: Medical Subject Headings
VSAB: MSH2017_2016_08_12

Dropped attribute name (ATN):
     RM (Record Maintainer)
     RO (Record Originator)

------------------------------------------

Source: NCI Thesaurus
VSAB: NCI2016_02D

This version includes:
     NCI2015_BioC_1602D
     NCI2015_BRIDG_1602D
     NCI2015_CareLex_1602D
     NCI2015_CDC_1602D
     NCI2015_CDISC_1602D
     NCI2015_CRCH_1602D
     NCI2015_CTCAE_1602D
     NCI2015_CTEP-SDC_1602D
     NCI2015_DCP_1602D
     NCI2015_DICOM_1602D
     NCI2015_DTP_1602D
     NCI2015_FDA_1602D
     NCI2015_GENC_1602D
     NCI2015_ICH_1602D
     NCI2015_JAX_1602D
     NCI2015_KEGG_1602D
     NCI2015_NCI-GLOSS_1602D
     NCI2015_NCI-HL7_1602D
     NCI2015_NCPDP_1602D
     NCI2015_NICHD_1602D
     NCI2015_PID_1602D
     NCI2015_RENI_1602D
     NCI2015_UCUM_1602D
     NCI2015_ZFIN_1602D

New term type (TTY) | Suppressible value | Source(s):
     CA2|N|NCI2016_GENC_1602D
     CA3|N|NCI2016_GENC_1602D
     PT|N|NCI2016_GENC_1602D


Discussion:

1. New subsource: Geopolitical Entities, Names, and Codes (GENC) Standard Edition 1.

2. TTY = CA2 represents the ISO 3166-1 standard country code in the alpha-2 (two-letter) format.

3. TTY = CA3 represents the ISO 3166-1 standard country code in the alpha-3 (three-letter) format.

-----------------------------------------------

Source: National Uniform Claim Committee - Health Care Provider Taxonomy
VSAB: NUCCPT_16.1

New term type (TTY) | Suppressible value:
     PT|N


Discussion:

This is a new source.

-----------------------------------------------

Source: RXNORM Vocabulary
VSAB: RXNORM_16AA_160906F

This version includes:
     ATC_2016_16_09_06 (Anatomical Therapeutic Chemical Classification System)
     GS_2016_07_29 (Gold Standard Drug Database)
     MDDB_2016_07_27 (Master Drug Data Base)
     MMSL_2016_08_01 (Multum MediSource Lexicon)
     MMX_2016_07_25 (Micromedex RED BOOK)
     MTHSPL_2016_08_24 (FDA Structured Product Labels)
     NDDF_2016_07_27 (FDB MedKnowledge)
     NDFRT_2016_09_06 (National Drug File)
     NDFRT_FDASPL_2016_09_06 (National Drug File - FDASPL)
     NDFRT_FMTSME_2016_09_06 (National Drug File - FMTSME)
     VANDF_2016_07_22 (Veterans Health Administration National Drug File)

New attribute (ATN) | Source:
     RXN_QUALITATIVE_DISTINCTION|RXNORM_16AA_160906F


Discussion:

Selected portions of MSH and SNOMEDCT_US are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes.

-----------------------------------------------

Source: US Edition of SNOMED CT
VSAB: SNOMEDCT_US_2016_09_01

Dropped relationship | relationship attribute (RELA):
     RB|mapped_to
     RN|mapped_to
     RQ|mapped_to


Discussion:

The deprecated RELA = mapped_to represented relationships between ICD9CM and SNOMEDCT_US.