RxNorm Release Notes - August 4, 2025
For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.
Sources
The following sources have been updated since the previous RxNorm release:
| Source Name | Source Abbreviation (SAB) | Version |
|---|---|---|
| DrugBank | DRUGBANK | DRUGBANK5.0_2025_07_03 |
| Gold Standard Drug Database | GS | GS_2025_07_10 |
| Multum MediSource Lexicon | MMSL | MMSL_2025_07_01 |
| Micromedex RED BOOK | MMX | MMX_2025_07_06 |
| Metathesaurus FDA Structured Product Labels | MTHSPL | MTHSPL_2025_07_28 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2025_07_09 |
| RxNorm Vocabulary | RXNORM | RXNORM_20AA_250804F |
| Veterans Health Administration National Drug File | VANDF | VANDF_2025_06_30 |
The following sources have not been updated since the previous RxNorm release:
| Source Name | Source Abbreviation (SAB) | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2025_02_10 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2020 |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2025_01_31 |
| USP Compendial Nomenclature | USP | USP_2025_01_30 |
*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.
RxNorm Data Changes
New Qualitative Distinction: Hyponatremia
We have added a new Qualitative Distinction: Hyponatremia. This is based on feedback from users requesting new RXCUIs to differentiate the generic tolvaptan 15 mg and 30 mg tablets. For example:
| RXCUI | Term Type (TTY) | Name |
|---|---|---|
| 849831 | SBD | Hyponatremia tolvaptan 15 MG Oral Tablet [Samsca] |
| 849835 | SBD | Hyponatremia tolvaptan 30 MG Oral Tablet [Samsca] |
| 2044355 | SBD | tolvaptan 15 MG Oral Tablet [Jynarque] |
| 2044357 | SBD | tolvaptan 30 MG Oral Tablet [Jynarque] |
| 849827 | SCD | Hyponatremia tolvaptan 15 MG Oral Tablet |
| 849833 | SCD | Hyponatremia tolvaptan 30 MG Oral Tablet |
| 2719335 | SCD | tolvaptan 15 MG Oral Tablet |
| 2719337 | SCD | tolvaptan 30 MG Oral Tablet |
For more information about Qualitative Distinctions in RxNorm, see https://www.nlm.nih.gov/research/umls/rxnorm/docs/techdoc.html#s10_3.
New Dose Form Group: Intravesical Product
RxNorm includes a new dose form group: Intravesical Product. The new Dose Forms within this Dose Form Group are:
- Powder for Intravesical Solution - a powder, which, upon the addition of suitable vehicles, yields a solution intended to be administered via the bladder
- Powder for Intravesical Suspension - a powder, which, upon the addition of suitable vehicles, yields a suspension intended to be administered via the bladder
- Intravesical Solution - a solution intended for instillation into the bladder
- Intravesical Suspension - a suspension intended for instillation into the bladder
For more information about Dose Forms (TTY=DF) and Dose Form Groups (TTY=DFG), please see the RxNorm Technical Documentation Appendix 2 and Appendix 3, respectively.
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active RXNORM GPCKs | 633 |
| Active RXNORM BPCKs | 738 |
| Active RXNORM SCDs | 17611 |
| Active RXNORM SBDs | 9708 |
| Active RXNORM MINs | 3820 |
| Active RXNORM INs | 14569 |
| Active RXNORM PINs | 3587 |
| Active RXNORM BNs | 5126 |
| Active RXNORM DFs | 126 |
| Obsolete RXNORM GPCKs | 258 |
| Obsolete RXNORM BPCKs | 244 |
| Obsolete RXNORM SCDs | 19767 |
| Obsolete RXNORM SBDs | 12093 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 6590 |
| Obsolete RXNORM DFs | 65 |
| Editor-suppressed RXNORM SCDs | 2139 |
| Editor-suppressed RXNORM SBDs | 1769 |
| SAB=RXNORM NDCs | 250908 |
| Distinct SAB=RXNORM NDCs | 250908 |
Last Reviewed: August 4, 2025