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RxNorm Release Notes - September 2, 2025

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.

Sources

The following sources have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines AdministeredCVXCVX_2025_08_15
DrugBankDRUGBANKDRUGBANK5.0_2025_08_13
Gold Standard Drug DatabaseGSGS_2025_08_11
Multum MediSource LexiconMMSLMMSL_2025_08_01
Micromedex RED BOOKMMXMMX_2025_08_01
Metathesaurus FDA Structured Product LabelsMTHSPLMTHSPL_2025_08_23
FDB MedKnowledge (formerly NDDF Plus)NDDFNDDF_2025_08_13
RxNorm VocabularyRXNORMRXNORM_20AA_250902F
US Edition of SNOMED CTSNOMEDCT_USSNOMEDCT_US_2025_07_31
Veterans Health Administration National Drug FileVANDFVANDF_2025_07_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification SystemATCATC_2025_02_10
Metathesaurus CMS Formulary Reference FileMTHCMSFRFMTHCMSFRF_2020
USP Compendial NomenclatureUSPUSP_2025_01_30

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.

RxNorm Data Changes

New Qualitative Distinction: Home Admin

We have added a new Qualitative Distinction: Home Admin. It is applied to the Flumist 2025-2026 vaccine to differentiate between the version administered in a clinician setting and the self-administration version. For example:

RXCUISBDSY
2720402influenza A virus A/Norway/31694/2022 (H1N1) antigen 158000000 UNT/ML / influenza A virus A/Perth/722/2024 (H3N2) antigen 158000000 UNT/ML / influenza B virus B/Austria/1359417/2021 antigen 158000000 UNT/ML Nasal Spray [FluMist 2025-2026]FluMist 2025-2026 Formula Nasal Spray
2720400Home Admin influenza A virus A/Norway/31694/2022 (H1N1) antigen 158000000 UNT/ML / influenza A virus A/Perth/722/2024 (H3N2) antigen 158000000 UNT/ML / influenza B virus B/Austria/1359417/2021 antigen 158000000 UNT/ML Nasal Spray [FluMist 2025-2026]FluMist 2025-2026 Formula Nasal Spray (Home Administration)

For more information about Qualitative Distinctions in RxNorm, see https://www.nlm.nih.gov/research/umls/rxnorm/docs/techdoc.html#s10_3.

Data Counts

Term Type or AttributeNumber
Active RXNORM GPCKs636
Active RXNORM BPCKs741
Active RXNORM SCDs17629
Active RXNORM SBDs9721
Active RXNORM MINs3820
Active RXNORM INs14576
Active RXNORM PINs3592
Active RXNORM BNs5135
Active RXNORM DFs126
Obsolete RXNORM GPCKs258
Obsolete RXNORM BPCKs244
Obsolete RXNORM SCDs19784
Obsolete RXNORM SBDs12109
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6596
Obsolete RXNORM DFs65
Editor-suppressed RXNORM SCDs2143
Editor-suppressed RXNORM SBDs1775
SAB=RXNORM NDCs250589
Distinct SAB=RXNORM NDCs250589

Last Reviewed: August 28, 2025