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TrainingConf2014

2014 NLM Informatics Training Conference banner

Photo of the participants at the 2014 NLM Training Conference.
2014 NLM Training Conference Participants

NLM Informatics Training Conference 2014

National Library of Medicine and the
University of Pittsburgh
Pittsburgh, PA
June 17–18, 2014

The 2014 NLM Informatics Training Conference was hosted by the University of Pittsburgh on June 17-18, 2014 in Pittsburgh, PA. Conference attendees included trainees and faculty from the NLM Biomedical Informatics Research Training Programs, VA informatics trainees, NLM intramural trainees, NIH staff, and guests.

NLM 2014 Informatics Training Conference Awards

Best Presentation

June 17, 2014
Shomir Chaudhuri, Laura Kneale, Thai D Le, Hilaire J Thompson, and George Demiris
University of Washington
Older Adults’ Attitudes towards Fall Detection Devices
Plenary Paper Session 1

Abstract:
Falls and fall related injuries represent a significant threat to the health and independence of older adults (65 years and older). One of the greatest threats involved with falling is the inability to get up after one has fallen, “the long lie”, which can result in more trauma and injury. The faster a person is discovered after a fall has occurred, the better chance they have of survival and recovery. While there are several methods for detecting falls (cameras, pressure sensors, wearable devices) no system has been fully successful in the older adult population; whether the system fails at accurately detecting a fall, or if the user does not accept the system in question, there is still much work to be done with these devices. The purpose of this study was to determine the attitudes of older adults towards fall detection devices after we conducted a systematic literature review of available IT tools to support fall detection. Five focus groups were conducted at 3 different older adult communities around the Puget Sound area for a total of 27 participants. Questions centered on access to such devices as well as different facilitators and barriers to the use of these devices. Transcripts were thematically coded to understand the general opinions people have toward fall detection devices.

Photo of Shomir Chaudri 
Shomir Chaudhuri

June 18, 2014
Rafael D Rosengarten, Marinka Zitnik, Mariko Katoh-Kurasawa, Blaz Zupan, and Gad Shaulsky
Rice University/Baylor College of Medicine
Predicting Gene Regulatory Interactions by Intermediate Data Fusion
Plenary Paper Session 2

Abstract:
A major challenge in biomedical informatics is integrating large sets of heterogeneous data. These may include ‘omics-level sequencing, physiology measurements, and phenotype classifications. Predicting direct interactions or causal relationships requires bridging these data, rather than treating them individually. We introduce a novel method—intermediate data fusion by matrix factorization—to analyze gene regulatory networks in Dictyostelium discoideum. Dictyostelium, a soil amoeba, is an emerging model for bacterial recognition pathways and antimicrobial compound production. Moving forward requires a comprehensive view of gene regulatory networks. To test our computational approach, we analyzed Dictyostelium mutant-phenotype associations during the well-understood processes of multicellular development. We generated RNA-seq (gene expression) profiles throughout development, and ChIP-seq (protein-DNA interaction) data for a critical transcriptional regulator. We integrated these with previous experiments (training set), as well as ontology and literature annotations. The algorithm identified numerous mutants and their associated developmental processes from the validation set. Accuracy scores were consistently higher with the inclusion of additional data types. We are currently verifying novel predictions by creating genetic knockouts of key nodes. This approach will greatly accelerate studies into Dictyostelium’s response to bacterial challenge. More broadly, we demonstrate a predictive modeling solution to the principal concern of big data heterogeneity.

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Photo of Rafael D Rosengarten 
Rafael D Rosengarten

Best Poster

June 17, 2014
Corey F Hryc, Zhao Wang, Paul D Adams, and Wah Chiu
Rice University/Baylor College of Medicine
Validation of Near-atomic Resolution Molecules to Identify Structures for Drug Design
Poster Session Day 1 - Translational/Bioinformatics

Abstract:
Structural biology plays a key role in the development of novel biological inhibitors and drug delivery methods. Recently, structures of large macromolecular complexes ranging from 400 kDa to tens of MDa have been solved by single particle electron cryo-microscopy, resulting in near-atomic resolution structures, however lacking validation. This absence of validation devalues the derived models and their usefulness in drug discovery. Large datasets exist for these structures in various databases, including the Protein Data Bank (PDB) and Electron Microscopy Data Bank (EMDB), but this data must be validated to annotate the level of structural uncertainty prior to their use in translational medicine. By understanding this structural variability, such as atom locations and interactions between molecules, pharmaceutical chemist can target specific domains and interfaces for drug design with confidence. We have repurposed existing crystallographic software for our near-atomic resolution structures determined without crystallography. We can then apply rigorous validation test, as in crystallography, for structures commonly used in drug design. Using this approach, we developed tools to analyze and improve model validity for our near-atomic resolution data. Our early results provide a statistical assessment that can be used in conjunction with fit-to-density and stereochemistry scores to assess model uncertainty.

Photo of Corey F Hryc 
Corey F Hryc

June 18, 2014
Sivan Kinberg, and Carol Friedman
Columbia University
Steroid-induced Diabetes Mellitus in Patients with Inflammatory Bowel Disease
Poster Session Day 2 - Health Care/Public Health

Abstract:
Glucocorticoids are commonly used to treat patients with inflammatory bowel disease (IBD), often for prolonged periods of time. Glucocorticoid toxicity is one of the most common causes of iatrogenic illness associated with chronic inflammatory diseases. In IBD patients, the current knowledge of steroid-induced hyperglycemia and steroid-induced diabetes mellitus (S-DM) is limited. The aim of this study was to use an informatics approach to determine the prevalence and risk factors of S-DM in IBD patients. This was a retrospective study that examined IBD patients treated with glucocorticoids between 2004 and 2012, excluding patients with pre-existing diabetes mellitus. Notes from the electronic health record (EHR) were encoded using a natural language processing system and the output stored in a coded patient database where the relevant data was queried. Our preliminary results indicate that diabetes mellitus was newly diagnosed in 210 (25.8%) of 815 patients treated with glucocorticoids compared with 23 (6.3%) of 366 patients not treated with glucocorticoids. The use of information in the EHR facilitates large-scale clinical studies. S-DM is common among IBD patients, and clinicians should be aware of the possibility of S-DM and should screen patients treated with glucocorticoids for hyperglycemia.

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Photo of Sivan Kinberg 
Sivan Kinberg

Best Open Mic

June 18, 2014
Patricia Yao
Oregon Health & Science University

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Photo of Patricia Yao 
Patricia Yao

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