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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

September Release - 09/02/2014

This release of RxNorm is consistent with the 2014AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm technical documentation.

Sources

The following sources have been updated since the previous RxNorm release:

Source NameSABDate Updated
Gold Standard Drug Database GS 08/01/2014
Medi-Span Master Drug Data Base MDDB 07/30/2014
Multum MediSource Lexicon MMSL 08/01/2014
Micromedex RED BOOK MMX 08/04/2014
FDA Structured Product Labels MTHSPL 08/25/2014
FDB MedKnowledge (formerly NDDF Plus) NDDF 08/06/2014
Veterans Health Administration National Drug File - Reference Terminology NDFRT 09/02/2014
NDFRT FDASPL relationships NDFRT_FDASPL 09/02/2014
NDFRT FMTSME relationships NDFRT_FMTSME 09/02/2014
US Edition of SNOMED CT (drug information) SNOMEDCT_US 07/31/2014
Veterans Health Administration National Drug File VANDF 07/17/2014

 

The following sources have not been updated in this release:

Source NameSABDate Updated
Anatomical Therapeutic Chemical Classification System ATC 2014
Medical Subject Headings (MeSH) MSH 02/10/2014
FDA National Drug Code Directory MTHFDA 06/01/2011

 

Data Changes

Prescribable Names:
This release includes another batch of prescribable names (TTY=PSN) for many drugs with topical dose forms, including some ointments, gels, and foams.

MTHSPL Active Moieties:
In addition to the data already available in RxNorm for the active and inactive ingredients for all structured product labels (SPLs) on DailyMed, RxNorm now includes the active moieties associated with the active ingredients in the DailyMed SPLs. The active moieties are treated in the same way as the active and inactive ingredients in RXNCONSO.RRF, receiving a term type (TTY) value of 'SU' (substance) and a CODE value of the Food and Drug Administration (FDA) unique ingredient identifier (UNII) code found in the SPL.

Along with the active moiety data comes some changes to the relationships between ingredients and drug products in the MTHSPL data. In previous releases, the relationship between active and inactive ingredients and drug products was 'has_ingredient / ingredient_of'. Each of the three types of ingredients will now have unique bidirectional relationships with associated drug products in the RXNREL.RRF file:

  • has_active_ingredient / active_ingredient_of
  • has_active_moiety / active_moiety_of
  • has_inactive_ingredient / inactive_ingredient_of

RXNORM UNII_CODE Attribute:
RxNorm no longer includes the FDA UNII codes as 'UNII_CODE' attributes associated with SAB=RXNORM ingredients in the RXNSAT.RRF file. With the addition of active moiety UNII codes mentioned above, RxNorm now has a robust set of ingredient UNII codes for all drug products on DailyMed in the RXNCONSO.RRF file. You can find these in the CODE field for SAB=MTHSPL, TTY=SU rows.

NDFRT Drug Interactions:
The Veterans Health Administration (VHA) is no longer providing drug interaction concepts, attributes, and relationships in National Drug File - Reference Terminology (NDFRT). As a result, you will not find these data in the RxNorm release files or other RxNorm applications (RxNorm API, RxNav, and RxMix). The National Library of Medicine (NLM) is currently investigating alternative sources for drug interaction information for its applications.

Data Counts

Term Type or AttributeNumber
Active GPCKs 360
Active BPCKs 443
Active SCDs 19766
Active SBDs 10856
Active RXNORM MINs 3892
Active RXNORM INs 10109
Active RXNORM PINs 2345
Active RXNORM BNs 6740
Active RXNORM DFs 103
   
Obsolete GPCKs 120
Obsolete BPCKs 113
Obsolete SCDs 14599
Obsolete SBDs 10357
Obsolete RXNORM MINs 0
Obsolete RXNORM INs 0
Obsolete RXNORM PINs 0
Obsolete RXNORM BNs 9472
Obsolete RXNORM DFs 57
Editor-suppressed SCDs 1077
Editor-suppressed SBDs 947
OCD atoms 330317
   
Source-asserted NDCs 1310383
Distinct source-asserted NDCs 592115
SAB=RXNORM NDCs 200772
Distinct SAB=RXNORM NDCs 200772