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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

June Release - 06/01/2015

This release of RxNorm is consistent with the 2015AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm technical documentation.

Sources

The following sources have been updated since the previous RxNorm release:

Source NameSABDate Updated
Gold Standard Drug Database GS 05/14/2015
Medi-Span Master Drug Data Base MDDB 05/06/2015
Multum MediSource Lexicon MMSL 05/01/2015
Micromedex RED BOOK MMX 05/04/2015
FDA Structured Product Labels MTHSPL 05/22/2015
FDB MedKnowledge (formerly NDDF Plus) NDDF 05/13/2015
Veterans Health Administration National Drug File - Reference Terminology NDFRT 06/01/2015
NDFRT FDASPL relationships NDFRT_FDASPL 06/01/2015
NDFRT FMTSME relationships NDFRT_FMTSME 06/01/2015
Veterans Health Administration National Drug File VANDF 04/16/2015

 

The following sources have not been updated in this release:

Source NameSABDate Updated
Anatomical Therapeutic Chemical Classification System ATC 2015
Medical Subject Headings (MeSH) MSH 01/26/2015
CMS Formulary Reference File MTHCMSFRF 2014
FDA National Drug Code Directory MTHFDA 06/01/2011
US Edition of SNOMED CT (drug information) SNOMEDCT_US 01/31/2015

 

Data Changes

Ingredient Splits
Two base ingredients (TTY=IN), doxycycline and nitrofurantoin, now have related precise ingredients (TTY=PIN). Doxycycline exists as doxycycline hyclate and doxycycline monohydrate. Nitrofurantoin exists as nitrofurantoin monohydrate and nitrofurantoin macrocrystals. Where applicable, drugs (TTY=SCD/SBD/GPCK/BPCK) including the base ingredients now include the precise ingredients instead.

New Injectable Dose Forms
As part of the ongoing prescribable names (TTY=PSN) work, we will be modifying the RxNorm model for normalized names for injectable products. Currently, injectable products in RxNorm fall into one of four dose forms: -Prefilled Syringe -Injectable Solution -Injectable Suspension -Injectable Foam

For prescribable names of injectable products, more granularity is required. To achieve this, the set of dose forms for injectable products will be expanded to nine dose forms: -Prefilled Syringe -Injectable Solution -Injectable Suspension -Injectable Foam -Auto-Injector -Cartridge -Injection -Jet Injector -Pen Injector

Injectable products, currently grouped into four dose forms, will be split into the proposed nine dose forms. We will split 'Auto-Injector', 'Jet Injector', 'Cartridge', and 'Pen Injector' products out from 'Prefilled Syringe' products. We will split 'Injection' products out from 'Injectable Solution' and 'Injectable Suspension' products. ‘Injectable Foam’ products will remain unchanged. Where possible, we will preserve RXCUIs, though drugs moved to new dose forms will require new RXCUIs.

Currently, single-use and multi-use injectable solutions and suspensions have their strengths expressed as a concentration, such as milligrams per milliliter (MG/ML). For single-use solutions and suspensions, we will begin expressing the total quantity of medication rather than the concentration. The dose form for these products will be 'Injection'. For example, a 500 MG single-use vial of ceftazidime will have 'Ceftazidime 500 MG Injection' as a normalized name.

For the June release, RxNorm includes three of the new injectable dose forms: Auto-Injector, Cartridge, and Injection. These new dose forms occur in a few new drugs and some drugs that were in line to be modified in RxNorm already.

We will release more of these changes in batches in the monthly releases. We expect to complete this injectables project by early 2016.

We would like to thank the RxNorm stakeholders who provided input on the proposed changes to the RxNorm model for injectable products. We welcome any additional feedback: rxnorminfo@nlm.nih.gov

Data Counts

Term Type or AttributeNumber
Active GPCKs 363
Active BPCKs 417
Active SCDs 20021
Active SBDs 10666
Active RXNORM MINs 3959
Active RXNORM INs 10562
Active RXNORM PINs 2419
Active RXNORM BNs 6460
Active RXNORM DFs 106
   
Obsolete GPCKs 123
Obsolete BPCKs 109
Obsolete SCDs 14670
Obsolete SBDs 9857
Obsolete RXNORM MINs 0
Obsolete RXNORM INs 0
Obsolete RXNORM PINs 0
Obsolete RXNORM BNs 9172
Obsolete RXNORM DFs 57
Editor-suppressed SCDs 1150
Editor-suppressed SBDs 1008
OCD atoms 336413
   
Source-asserted NDCs 1355311
Distinct source-asserted NDCs 614088
SAB=RXNORM NDCs 206178
Distinct SAB=RXNORM NDCs 206178